Am J Cardiol March 2022 PMID 35039162

Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality.

Chang Liu, Devinder Dhindsa, Zakaria Almuwaqqat, Yan V Sun, Arshed A Quyyumi

Mentions

74
Peak: 31 in Mar 2022
across 4 sources since Jan 2022

Extended reach

220,139
potential audience

Total likes

249

Video views

3,006

Mentions per month

Jan 2022 – Mar 2025

Where it's discussed

  • X / Twitter54 posts
  • News15 articles
  • YouTube3 videos
  • Blogs2 articles

AI synopsis

What people are saying

The overall tone of the discussions indicates strong agreement with the study's implications, as seen in comments about the need to reevaluate HDL assumptions and the potential for this research to impact clinical testing. The interest is driven by questions about underlying mechanisms and environmental influences, while the engagement reflects users actively analyzing the study's implications for practice and future research, highlighting its potential high impact.

AgreementModerate agreement

Most discussions acknowledge the study's findings that very high HDL levels are associated with increased cardiovascular risks, reflecting a consensus that this challenges traditional views.

InterestHigh interest

The posts show high curiosity, with users asking for thoughts, discussing mechanisms, and referencing specific factors like environmental toxins or alcohol consumption.

EngagementModerate engagement

Some discussions delve into methodological and clinical implications, indicating moderate to deep engagement with the research's significance.

ImpactHigh impact

Several posts emphasize that these findings could significantly change how lipid levels are interpreted in clinical settings, suggesting a high potential influence on medical practices.

Abstract in brief

  • Very high levels of HDL cholesterol (80-100 mg/100ml) are linked to increased risks of all-cause and cardiovascular death, especially in men, after accounting for various health and lifestyle factors.
  • The study, based on nearly 415,416 UK Biobank participants over approximately 9 years, found that these risks were significantly present in men but not in women, even after considering genetic factors related to HDL levels.
  • These findings suggest that very high HDL levels do not always indicate protective health effects and may be associated with adverse outcomes, particularly in men, challenging previous assumptions about HDL's benefits.]

Top posts

Most liked on X and Bluesky
Thomas Dayspring
@Drlipid · X

Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age, gender, race, BMI, HTN, smoking, TG, LDL-C, CVA & MI history, diabetes, eGFR, & alcohol use (defined as ≥3 times/week) https://t.co/RDCZHYrlu9 https://t.co/ChB6Sc0vyb

Mar 30, 2022 · 125 likes · 28 shares · 41,888 followers View post →
Almudena Castro Conde
@almucastro01 · X

Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=

Dec 7, 2022 · 38 likes · 12 shares · 16,009 followers View post →
Kamil Paprotny
@Kamil_Paprotny · X

Nazywanie HDL dobrym cholesterolem jest co najmniej nietrafione. Stężenia >80 mg/dl związane są z ⬆️ ryzykiem śmierci i chorób serc-nacz, także po uwzględnieniu, st. LDL, TG, eGFR, cukrzycy, nadciśnienia, palenia papierosów, alkoholu, BMI, rasy i płci https://t.co/d2vzXYmkTr

Mar 31, 2022 · 3 likes · 1,512 followers View post →
Jeff Novick
@JNovickRD · X

Very high HDL-C levels are associated with an increased risk of all-cause death and cardiovascular death among men but not in women in the general population free of coronary artery disease. https://t.co/9OutNCGada

Mar 31, 2022 · 2 likes · 1 share · 6,282 followers View post →
ECCRI
@EmoryCCRI · X

Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality @DevinderDhindsa @Zakaria34a @emory_heart https://t.co/V3NjvHC9fm

Dec 5, 2022 · 2 likes · 1 share · 568 followers View post →
Simon Hill MSc, BSc
@theproof · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 30, 2022 · 28 shares · 34,076 followers View post →

All mentions

Dr.ChikiDatos
@Em12016e · X

En: 1. Liu C, et. al. Am J Cardiol. 2022;167:43-53. doi:10.1016/j.amjcard.2021.11.041 2. Mørland JG, et al. Int J Epidemiol. 2023;52(4):1257-1267. doi:10.1093/ije/dyad011 3. Mamede I, et. al. J Clin Lipidol. 2024;18(5):e701-e709. doi:10.1016/j.jacl.2024.06.002

Mar 27, 2025 · 89 followers View post →
Scotty Kirkpatrick M.D.
@drscottyk · X

@JohnKastelein @lipo_fan @DawnInPinehurst Thanks for sharing this @lipo_fan and @JohnKastelein. Curious your thoughts on this analysis which did show increased CV mortality with High HDL after adjusting for numerous factors including >3 EtOH drinks weekly. https://t.co/cdVDQZoJD3.

Mar 7, 2024 · 2,800 followers View post →
Orlando_uy
@Orlando_uy · X

Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality - American Journal of Cardiology https://t.co/fd6XQcUC4y

Jan 25, 2024 · 690 followers View post →
Saketh Vinjamuri
@saketh_vinj · X

@cathavale @KamathGurudutt Also Very high HDL-C levels are associated with an increased risk of all-cause death and cardiovascular death among men but not in women in the general population free of coronary artery disease. https://t.co/4HYSdfDGM4

Feb 26, 2023 · 94 followers View post →
Resi de Cardio
@RCardiologia · X

RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=

Dec 12, 2022 · 12 shares · 154 followers View post →
DiObemir
@diabemir · X

RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=

Dec 11, 2022 · 12 shares · 939 followers View post →
Antonio Palomar
@GarcPalomar · X

RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=

Dec 8, 2022 · 12 shares · 4,185 followers View post →
Almudena Castro Conde
@almucastro01 · X

RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=

Dec 8, 2022 · 12 shares · 16,009 followers View post →
Victor Adrian
@adriaan00 · X

RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=

Dec 7, 2022 · 12 shares · 61 followers View post →
Silvia González Martínez
@endo_silvia · X

RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=

Dec 7, 2022 · 12 shares · 298 followers View post →
J.David Garcia
@JDavid_MD · X

RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=

Dec 7, 2022 · 12 shares · 433 followers View post →
Rosa Fernandez
@MAROSFO · X

RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=

Dec 7, 2022 · 12 shares · 3,309 followers View post →
LipidMIR
@lipidmir · X

RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=

Dec 7, 2022 · 12 shares · 749 followers View post →
Celia Oreja-Guevara
@C_OrejaGuevara · X

RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=

Dec 7, 2022 · 12 shares · 4,428 followers View post →
Pilar Rodríguez Ledo #MFenEsencia
@Pilar_RguezLedo · X

RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=

Dec 7, 2022 · 12 shares · 3,193 followers View post →
Almudena Castro Conde
@almucastro01 · X

Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=

Dec 7, 2022 · 38 likes · 12 shares · 16,009 followers View post →
Zakaria Almuwaqqat
@Zakaria34a · X

RT @EmoryCCRI: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality @DevinderDhindsa @Zakaria34a @emory_heart…

Dec 5, 2022 · 1 share · 776 followers View post →
ECCRI
@EmoryCCRI · X

Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality @DevinderDhindsa @Zakaria34a @emory_heart https://t.co/V3NjvHC9fm

Dec 5, 2022 · 2 likes · 1 share · 568 followers View post →
Terra Finis
@OpenOur3y3s · X

1) another reason why physicians gotta start testing lipid particle type and size 2) hdl > 90mg/dl likely indicative of toxin exposure (environmental) Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality - PubMed https://t.co/OYZ2hnog5E

May 26, 2022 · 257 followers View post →
Nick Krontiris
@nick_krontiris · X

Refs: https://t.co/xgQs6n2kvA https://t.co/nGK8aRHL7z https://t.co/zayxwcBwXx

May 19, 2022 · 18,979 followers View post →
Beth Jackson
@LipidCNS · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Apr 3, 2022 · 28 shares · 750 followers View post →
Chen Cihong
@CCihong · X

RT @JNovickRD: Very high HDL-C levels are associated with an increased risk of all-cause death and cardiovascular death among men but not i…

Apr 1, 2022 · 1 share · 65 followers View post →
Prof Kausik Ray FMedSci
@ProfKausikRay · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 5,966 followers View post →
Paul Williams
@PaulWil40857916 · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 368 followers View post →
Michael Joseph
@Nutradvance · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 11,775 followers View post →
Hanna Crow
@HCrowDO · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 80 followers View post →
Claudio Chinaglia
@claudiochinagli · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 119 followers View post →
Surenjav Chimed
@surenjav_ch · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 205 followers View post →
John Osborne, MD, PhD, FACC, FNLA
@SOTHCardiology · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 1,136 followers View post →
Mehmet Birhan YILMAZ
@cardioceptor · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 2,262 followers View post →
Scotty Kirkpatrick M.D.
@drscottyk · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 2,800 followers View post →
Jeff Novick
@JNovickRD · X

Very high HDL-C levels are associated with an increased risk of all-cause death and cardiovascular death among men but not in women in the general population free of coronary artery disease. https://t.co/9OutNCGada

Mar 31, 2022 · 2 likes · 1 share · 6,282 followers View post →
Kamil Paprotny
@Kamil_Paprotny · X

Nazywanie HDL dobrym cholesterolem jest co najmniej nietrafione. Stężenia >80 mg/dl związane są z ⬆️ ryzykiem śmierci i chorób serc-nacz, także po uwzględnieniu, st. LDL, TG, eGFR, cukrzycy, nadciśnienia, palenia papierosów, alkoholu, BMI, rasy i płci https://t.co/d2vzXYmkTr

Mar 31, 2022 · 3 likes · 1,512 followers View post →
Michael Mindrum, MD
@MichaelMindrum · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 9,569 followers View post →
Alper Aydın (Dietitian )
@aydinnalper · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 1,427 followers View post →
Nicolas Renna, MD PhD ISHF FESC
@nicolasrennamd · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 935 followers View post →
KanLi NDn - Holistic Approach, Learn & Teach
@CalinNadasan · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 131 followers View post →
Rene Rodriguez
@renecardio4 · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 1,164 followers View post →
Professor Scott Wright
@ScottWrightMD · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 1,385 followers View post →
Pathik Joshi
@pathikj80 · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 31, 2022 · 28 shares · 3,118 followers View post →
Henry Gaviria
@henrygav5 · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 30, 2022 · 28 shares · 257 followers View post →
Alonso Barrios
@CardioAlonso · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 30, 2022 · 28 shares · 109 followers View post →
Viet Le DMSc PA-C FACC FAHA HF-Cert
@VietHeartPA · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 30, 2022 · 28 shares · 9,790 followers View post →
CarlosAguilarSalinas
@caguilarsalinas · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 30, 2022 · 28 shares · 1,639 followers View post →
Akekaluk
@xgaluck · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 30, 2022 · 28 shares · 189 followers View post →
Jacob M. Hands
@jacobmhands · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 30, 2022 · 28 shares · 174 followers View post →
DesiDoc.MD
@DesidocMD · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 30, 2022 · 28 shares · 119 followers View post →
Ian Buckingham
@PalaceIan · X

Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality - PubMed https://t.co/sw4jjnLShj via @rightrelevance thanks @drlipid

Mar 30, 2022 · 805 followers View post →
Simon Hill MSc, BSc
@theproof · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 30, 2022 · 28 shares · 34,076 followers View post →
Joseph DeBoe
@LipidDNP24 · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 30, 2022 · 28 shares · 598 followers View post →
Mendel Roth
@MendelRoth · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 30, 2022 · 28 shares · 281 followers View post →
Sivaprakasam Chinnarasu, PhD
@sivabdubio · X

RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…

Mar 30, 2022 · 28 shares · 102 followers View post →
Thomas Dayspring
@Drlipid · X

Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age, gender, race, BMI, HTN, smoking, TG, LDL-C, CVA & MI history, diabetes, eGFR, & alcohol use (defined as ≥3 times/week) https://t.co/RDCZHYrlu9 https://t.co/ChB6Sc0vyb

Mar 30, 2022 · 125 likes · 28 shares · 41,888 followers View post →
Patricia Lasseter
@PLasseter · X

Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality - ScienceDirect https://t.co/xVtm2tlt8R

Jan 26, 2022 · 118 followers View post →