Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age, gender, race, BMI, HTN, smoking, TG, LDL-C, CVA & MI history, diabetes, eGFR, & alcohol use (defined as ≥3 times/week) https://t.co/RDCZHYrlu9 https://t.co/ChB6Sc0vyb
Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality.
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Jan 2022 – Mar 2025Where it's discussed
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X / Twitter54 posts
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AI synopsis
What people are saying
The overall tone of the discussions indicates strong agreement with the study's implications, as seen in comments about the need to reevaluate HDL assumptions and the potential for this research to impact clinical testing. The interest is driven by questions about underlying mechanisms and environmental influences, while the engagement reflects users actively analyzing the study's implications for practice and future research, highlighting its potential high impact.
Most discussions acknowledge the study's findings that very high HDL levels are associated with increased cardiovascular risks, reflecting a consensus that this challenges traditional views.
The posts show high curiosity, with users asking for thoughts, discussing mechanisms, and referencing specific factors like environmental toxins or alcohol consumption.
Some discussions delve into methodological and clinical implications, indicating moderate to deep engagement with the research's significance.
Several posts emphasize that these findings could significantly change how lipid levels are interpreted in clinical settings, suggesting a high potential influence on medical practices.
Abstract in brief
- Very high levels of HDL cholesterol (80-100 mg/100ml) are linked to increased risks of all-cause and cardiovascular death, especially in men, after accounting for various health and lifestyle factors.
- The study, based on nearly 415,416 UK Biobank participants over approximately 9 years, found that these risks were significantly present in men but not in women, even after considering genetic factors related to HDL levels.
- These findings suggest that very high HDL levels do not always indicate protective health effects and may be associated with adverse outcomes, particularly in men, challenging previous assumptions about HDL's benefits.]
Top posts
Most liked on X and BlueskyVery High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=
Nazywanie HDL dobrym cholesterolem jest co najmniej nietrafione. Stężenia >80 mg/dl związane są z ⬆️ ryzykiem śmierci i chorób serc-nacz, także po uwzględnieniu, st. LDL, TG, eGFR, cukrzycy, nadciśnienia, palenia papierosów, alkoholu, BMI, rasy i płci https://t.co/d2vzXYmkTr
Very high HDL-C levels are associated with an increased risk of all-cause death and cardiovascular death among men but not in women in the general population free of coronary artery disease. https://t.co/9OutNCGada
Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality @DevinderDhindsa @Zakaria34a @emory_heart https://t.co/V3NjvHC9fm
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
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En: 1. Liu C, et. al. Am J Cardiol. 2022;167:43-53. doi:10.1016/j.amjcard.2021.11.041 2. Mørland JG, et al. Int J Epidemiol. 2023;52(4):1257-1267. doi:10.1093/ije/dyad011 3. Mamede I, et. al. J Clin Lipidol. 2024;18(5):e701-e709. doi:10.1016/j.jacl.2024.06.002
@JohnKastelein @lipo_fan @DawnInPinehurst Thanks for sharing this @lipo_fan and @JohnKastelein. Curious your thoughts on this analysis which did show increased CV mortality with High HDL after adjusting for numerous factors including >3 EtOH drinks weekly. https://t.co/cdVDQZoJD3.
Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality - American Journal of Cardiology https://t.co/fd6XQcUC4y
@cathavale @KamathGurudutt Also Very high HDL-C levels are associated with an increased risk of all-cause death and cardiovascular death among men but not in women in the general population free of coronary artery disease. https://t.co/4HYSdfDGM4
RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=
RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=
RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=
RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=
RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=
RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=
RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=
RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=
RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=
RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=
RT @almucastro01: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=
Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality HDL=
RT @EmoryCCRI: Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality @DevinderDhindsa @Zakaria34a @emory_heart…
Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality @DevinderDhindsa @Zakaria34a @emory_heart https://t.co/V3NjvHC9fm
1) another reason why physicians gotta start testing lipid particle type and size 2) hdl > 90mg/dl likely indicative of toxin exposure (environmental) Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality - PubMed https://t.co/OYZ2hnog5E
Refs: https://t.co/xgQs6n2kvA https://t.co/nGK8aRHL7z https://t.co/zayxwcBwXx
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @JNovickRD: Very high HDL-C levels are associated with an increased risk of all-cause death and cardiovascular death among men but not i…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
Very high HDL-C levels are associated with an increased risk of all-cause death and cardiovascular death among men but not in women in the general population free of coronary artery disease. https://t.co/9OutNCGada
Nazywanie HDL dobrym cholesterolem jest co najmniej nietrafione. Stężenia >80 mg/dl związane są z ⬆️ ryzykiem śmierci i chorób serc-nacz, także po uwzględnieniu, st. LDL, TG, eGFR, cukrzycy, nadciśnienia, palenia papierosów, alkoholu, BMI, rasy i płci https://t.co/d2vzXYmkTr
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality - PubMed https://t.co/sw4jjnLShj via @rightrelevance thanks @drlipid
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
RT @Drlipid: Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age…
Careful what you wish for: ⬆️HDLc >80 mg/dL was associated with ⬆️risk of all-cause death & CV death after adjustment for age, gender, race, BMI, HTN, smoking, TG, LDL-C, CVA & MI history, diabetes, eGFR, & alcohol use (defined as ≥3 times/week) https://t.co/RDCZHYrlu9 https://t.co/ChB6Sc0vyb
Very High High-Density Lipoprotein Cholesterol Levels and Cardiovascular Mortality - ScienceDirect https://t.co/xVtm2tlt8R