PubHawk
Aging Cell February 2022 PMID 35048526

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis.

Jamal Rahmani, Alberto Montesanto, Edward Giovannucci, Hamid Zand, Meisam Barati, John J Kopchick, Mario G Mirisola, Vincenzo Lagani, Hiba Bawadi, Raffaele Vardavas, Alessandro Laviano, Kaare Christensen, Giuseppe Passarino, Valter D Longo

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Mentions

54
Peak: 21 in Jan 2022
across 4 sources since Jan 2022

Extended reach

508,078
potential audience

Total likes

444

Video views

12,606

Mentions per month

Jan 2022 – Jun 2025

Where it's discussed

  • X / Twitter41 posts
  • News5 articles
  • YouTube4 videos
  • Facebook4 posts

AI synopsis

What people are saying

The overall sentiment exhibits a strong interest in understanding how IGF-1 levels relate to mortality and longevity. Posts employ tone emphasizing significance, as seen in phrases like 'important data' and questions such as 'Are you balancing your IGF-1 levels?', indicating an eagerness to apply these insights practically. Despite some criticism of research flaws, comments generally recognize the potential influence of the study on health strategies and nutritional guidance.

AgreementModerate agreement

Most discussions acknowledge the key finding that both high and low IGF-1 levels are linked to increased mortality, with some explicitly citing the optimal range (120-160 ng/mL).

InterestHigh interest

Posts show active curiosity about the implications, with phrases like 'Are You Balancing Your IGF-1 Levels?' and references to adapting diets or protein intake, indicating engagement with practical aspects.

EngagementModerate engagement

Several comments critique methodological flaws or highlight implications, e.g., 'This study has SO many flaws,' or emphasize mechanistic insights, reflecting a moderate depth of engagement.

ImpactModerate impact

Some comments suggest the findings could influence dietary and health strategies, with mentions like 'gain mechanistic insights into longevity,' implying awareness of potential high-impact effects.

Abstract in brief

  • The meta-analysis examined how IGF1 levels relate to overall risk of death, finding that both very low and very high IGF1 levels are linked to increased mortality, showing a U-shaped relationship.
  • Higher IGF1 levels compared to middle-range levels do not significantly increase mortality risk, but both low and high IGF1 are associated with higher mortality, with the lowest risk found in a specific IGF1 range (120-160 ng/mL).
  • The study also suggests that IGF1 levels are influenced by diet, including protein and vitamin intake, which might help explain why both low and high levels are harmful, clarifying previous conflicting research.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https://t.co/3KElLxK5Zf

Jan 20, 2022 · 34 likes · 10 shares · 41,613 followers View post →
Nutrition Science
@NutrioSci · X

Associations between quintiles of macronutrient (a), micronutrient (b) and food (c) intakes and IGF-1 serum concentrations #MedEd #MedTwitter #Nutrition https://t.co/T4aj0hFUA9 https://t.co/7p4m4JpO4R

Aug 4, 2023 · 20 likes · 2 shares · 63,831 followers View post →
Ben Greenfield
@bengreenfield · X

This study has SO many flaws (especially regarding "danger" of high protein/meat), but there is one major takeaway: eat more protein as you get older: https://t.co/Nk1Zoz8zCE https://t.co/3ABkPFbypw

Sep 29, 2022 · 11 likes · 95,016 followers View post →
Aging Science News
@AgingBiology · X

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/AbHPZQdKcV

Jan 27, 2022 · 8 likes · 3 shares · 30,573 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/BeOq1pXGK0

Apr 10, 2022 · 8 likes · 1 share · 9,718 followers View post →
Osteoporosis-NL @osteoporosis-nl.bsky.social
@Osteoporosis_NL · X

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Jamal Rahmani et al. Aging Cell 20 Jan 2022 https://t.co/3sjg2Qp9BY … both high and low levels of IGF-1 increase mortality risk, with the lowest mortality (120-160 ng/ml) https://t.co/HMcGz3hMKa

Jan 30, 2022 · 8 likes · 1 share · 3,381 followers View post →

All mentions

DrJosephAntoun
@DrJosephAntoun · X

@nntaleb @alexbakus Bravo Nassim for quoting true science and the work of Valter Longo. The best protien intake to balance muscle and longevity is described here with IGF at 140-160: https://t.co/nZKXBlMzwE

Jun 15, 2025 · 2 likes · 23,122 followers View post →
Madam Mitochondria
@Madam_Mito · X

@AgingBiology https://t.co/l8cjglemII The optimal range to reduce mortality isn’t particularly high.

Dec 16, 2023 · 10,502 followers View post →
Alex
@AlexViKu · X

Association between IGF‐1 levels ranges and all‐cause mortality: A meta‐analysis - Rahmani - 2022 - Aging Cell - Wiley Online Library https://t.co/ayWnCHYVV0

Oct 13, 2023 · 96 followers View post →
Chidambara .ML.
@chidambara09 · X

RT @NutrioSci: Associations between quintiles of macronutrient (a), micronutrient (b) and food (c) intakes and IGF-1 serum concentrations…

Aug 4, 2023 · 2 shares · 11,709 followers View post →
Top Biomedical Science
@imedverse · X

RT @NutrioSci: Associations between quintiles of macronutrient (a), micronutrient (b) and food (c) intakes and IGF-1 serum concentrations…

Aug 4, 2023 · 2 shares · 90,440 followers View post →
Nutrition Science
@NutrioSci · X

Associations between quintiles of macronutrient (a), micronutrient (b) and food (c) intakes and IGF-1 serum concentrations #MedEd #MedTwitter #Nutrition https://t.co/T4aj0hFUA9 https://t.co/7p4m4JpO4R

Aug 4, 2023 · 20 likes · 2 shares · 63,831 followers View post →
Ben Greenfield
@bengreenfield · X

This study has SO many flaws (especially regarding "danger" of high protein/meat), but there is one major takeaway: eat more protein as you get older: https://t.co/Nk1Zoz8zCE https://t.co/3ABkPFbypw

Sep 29, 2022 · 11 likes · 95,016 followers View post →
Julia B.
@JuliaB_fitness · X

@jacobmhands @mackinprof @foundmyfitness Also: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Valter Longo et al. 2022 «Both high and low levels of IGF-1 increase mortality risk, with a specific 120–160 ng/ml range being associated with the lowest mortality.» https://t.co/lnzdI7WDYU

Jul 8, 2022 · 4 likes · 2,273 followers View post →
Carlos Colmenero
@colme99 · X

RT @Orlando_uy: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Both high and low levels of IGF-1 increas…

Jun 23, 2022 · 2 shares · 77 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @Orlando_uy: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Both high and low levels of IGF-1 increas…

Jun 22, 2022 · 2 shares · 6,712 followers View post →
Orlando_uy
@Orlando_uy · X

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Both high and low levels of IGF-1 increase mortality risk, with a specific 120–160 ng/ml range being associated with the lowest mortality. https://t.co/j8zrG23uMw

Jun 22, 2022 · 2 likes · 2 shares · 693 followers View post →
Nanci Guest PhD, RD, CSCS
@NanciGuestRDPhD · X

@trader2201 @drmatthewnagra @Switch4GoodNFT Seems to be milk, yogurt maybe not cheese. High/low IGF-1 linked to mortality. Not clear yet what to limit/avoid. https://t.co/f2PuSgUQVQ

Jun 11, 2022 · 1 like · 10,516 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @mike_lustgarten: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/BeOq1pXGK0

Apr 10, 2022 · 1 share · 6,712 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/BeOq1pXGK0

Apr 10, 2022 · 8 likes · 1 share · 9,718 followers View post →
Joel "Heart Prevention" Kahn MD, FACC
@drjkahn · X

Imporant Data. Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/pbR2fsi6eW

Feb 28, 2022 · 32,275 followers View post →
John Greene
@Greene_Thoughts · X

RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…

Feb 14, 2022 · 10 shares · 1,690 followers View post →
Maria Konovalenko
@mkonovalenko · X

RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…

Feb 7, 2022 · 10 shares · 7,358 followers View post →
Immortalists Magazine
@immortalistsmag · X

RT @longevitywiki: Now, Are You Balancing Your IGF-1 Levels?

Feb 6, 2022 · 4 shares · 867 followers View post →
Andreas Melhede bio/acc
@AMelhede · X

RT @longevitywiki: Now, Are You Balancing Your IGF-1 Levels?

Feb 5, 2022 · 4 shares · 1,639 followers View post →
ciro iuorno
@medicojunghiano · X

Association between IGF‐1 levels ranges and all‐cause mortality: A meta‐analysis https://t.co/pZdYlnQeLy

Feb 3, 2022 · 3,098 followers View post →
Fábio L Orsatti, PhD
@fabiorsatti · X

RT @Osteoporosis_NL: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Jamal Rahmani et al. Aging Cell 20 J…

Jan 30, 2022 · 1 share · 646 followers View post →
Osteoporosis-NL @osteoporosis-nl.bsky.social
@Osteoporosis_NL · X

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Jamal Rahmani et al. Aging Cell 20 Jan 2022 https://t.co/3sjg2Qp9BY … both high and low levels of IGF-1 increase mortality risk, with the lowest mortality (120-160 ng/ml) https://t.co/HMcGz3hMKa

Jan 30, 2022 · 8 likes · 1 share · 3,381 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/LgIWMmgN9z 据《Aging Cell》发布的研究，意大利科研人员荟萃分析发现，胰岛素样生长因子 (IGF) 与死亡率呈U型关系，水平太高或太低都会增加死亡风险。

Jan 28, 2022 · 694 followers View post →
UCSF Bakar Aging Research Institute
@UCSFAging · X

RT @AgingBiology: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/AbHPZQdKcV

Jan 27, 2022 · 3 shares · 1,349 followers View post →
Dr. Ugis Kletnieks
@Ugis06209578 · X

RT @AgingBiology: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/AbHPZQdKcV

Jan 27, 2022 · 3 shares · 11 followers View post →
Fay
@fay90028966 · X

RT @AgingBiology: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/AbHPZQdKcV

Jan 27, 2022 · 3 shares · 142 followers View post →
Aging Science News
@AgingBiology · X

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/AbHPZQdKcV

Jan 27, 2022 · 8 likes · 3 shares · 30,573 followers View post →
Nick Krontiris
@nick_krontiris · X

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis (open access) https://t.co/LwtFuoCMGg #nutrition #diet #Obesity #Cholesterol #Triglycerides #Dyslipidemia #MetabolicSyndrome #hormones

Jan 25, 2022 · 3 likes · 19,058 followers View post →
Longevity Wiki
@longevitywiki · X

RT @longevitywiki: Now, Are You Balancing Your IGF-1 Levels?

Jan 24, 2022 · 4 shares · 554 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

This study suggests that both high & low levels of IGF1 increase mortality risk, with a specific 120–160ng/ml range being associated with the lowest mortality. https://t.co/FXAHCuZxs1 To gain mechanistic insights into longevity: https://t.co/ev3fKAzN5D https://t.co/Sw8UbalWKl https://t.co/Spe2EX82AH

Jan 23, 2022 · 880 followers View post →
Società Italiana di Gerontologia e Geriatria
@GeriSocITA · X

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis.: https://t.co/FHfMYD72Qy

Jan 21, 2022 · 725 followers View post →
Silvana Duran
@Silviduranort · X

RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…

Jan 20, 2022 · 10 shares · 75 followers View post →
Yisell Soto
@Yisell_Soto_ · X

RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…

Jan 20, 2022 · 10 shares · 43 followers View post →
Carlos Colmenero
@colme99 · X

RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…

Jan 20, 2022 · 10 shares · 77 followers View post →
Emma
@emmaaquarian · X

RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…

Jan 20, 2022 · 10 shares · 5,527 followers View post →
Vincenzo Domina, M.eng
@enz0benz0 · X

RT @longevitywiki: Now, Are You Balancing Your IGF-1 Levels?

Jan 20, 2022 · 4 shares · 310 followers View post →
The Phoenix Lab
@The_Phoenix_Lab · X

RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…

Jan 20, 2022 · 10 shares · 210 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…

Jan 20, 2022 · 10 shares · 9,718 followers View post →
Longevity Wiki
@longevitywiki · X

Now, Are You Balancing Your IGF-1 Levels?

Jan 20, 2022 · 4 likes · 4 shares · 554 followers View post →
Orlando_uy
@Orlando_uy · X

RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…

Jan 20, 2022 · 10 shares · 693 followers View post →
Agingdoc
@agingdoc1 · X

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https://t.co/3KElLxK5Zf

Jan 20, 2022 · 34 likes · 10 shares · 41,613 followers View post →