Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis.

Jamal Rahmani, Alberto Montesanto, Edward Giovannucci, Hamid Zand, Meisam Barati, John J Kopchick, Mario G Mirisola, Vincenzo Lagani, Hiba Bawadi, Raffaele Vardavas, Alessandro Laviano, Kaare Christensen, Giuseppe Passarino, Valter D Longo

February 2022 Aging Cell

Synopsis of Social media discussions

The overall sentiment exhibits a strong interest in understanding how IGF-1 levels relate to mortality and longevity. Posts employ tone emphasizing significance, as seen in phrases like 'important data' and questions such as 'Are you balancing your IGF-1 levels?', indicating an eagerness to apply these insights practically. Despite some criticism of research flaws, comments generally recognize the potential influence of the study on health strategies and nutritional guidance.

A
Agreement
 Moderate agreement

Most discussions acknowledge the key finding that both high and low IGF-1 levels are linked to increased mortality, with some explicitly citing the optimal range (120-160 ng/mL).

I
Interest
 High level of interest

Posts show active curiosity about the implications, with phrases like 'Are You Balancing Your IGF-1 Levels?' and references to adapting diets or protein intake, indicating engagement with practical aspects.

E
Engagement
 Moderate level of engagement

Several comments critique methodological flaws or highlight implications, e.g., 'This study has SO many flaws,' or emphasize mechanistic insights, reflecting a moderate depth of engagement.

I
Impact
 Moderate level of impact

Some comments suggest the findings could influence dietary and health strategies, with mentions like 'gain mechanistic insights into longevity,' implying awareness of potential high-impact effects.

Social Mentions

YouTube

4 Videos

Facebook

4 Posts

Twitter

41 Posts

News

5 Articles

Metrics

Video Views

12,606

Total Likes

444

Extended Reach

508,078

Social Features

54

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

IGF-1 Levels and Mortality Risk: A Comprehensive Meta-Analysis

IGF-1 Levels and Mortality Risk: A Comprehensive Meta-Analysis

This video explores the relationship between IGF-1 levels and overall mortality, highlighting a U-shaped link where both low and high IGF-1 levels increase death risk, with optimal range identified between 120-160 ng/mL.

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May 6, 2023

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IGF-1 Levels and Their Impact on Mortality Risk Analyzed

IGF-1 Levels and Their Impact on Mortality Risk Analyzed

This video explores how IGF-1 levels are associated with all-cause mortality, revealing a U-shaped relationship where both low and high levels increase risk. Diet influences IGF-1, highlighting the importance of balanced nutrition for health.

The Candida Slayer - Naturopathe

October 27, 2024

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Growth Hormone and Cancer Risk: What You Need to Know

Growth Hormone and Cancer Risk: What You Need to Know

There's been discussion about growth hormone and cancer risk. This video explores recent studies, the relationship between IGF1 levels and mortality, and clarifies misconceptions about the potential link.

Dr. Ryan - SummaUp

December 26, 2022

1,221 views

Five Key Blood Tests for Proactive Health Management

Five Key Blood Tests for Proactive Health Management

This video explains five essential blood tests, including HbA1c, IGF-1, hsCRP, lipoprotein(a), and fasting insulin, to detect health issues early and monitor disease risk, emphasizing the importance of regular testing for optimal health.

Alina Zimmermann

March 14, 2025

62 views

  • DrJosephAntoun
    @DrJosephAntoun (Twitter)

    @nntaleb @alexbakus Bravo Nassim for quoting true science and the work of Valter Longo. The best protien intake to balance muscle and longevity is described here with IGF at 140-160: https://t.co/nZKXBlMzwE
    view full post

    June 15, 2025

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  • Madam Mitochondria
    @Madam_Mito (Twitter)

    @AgingBiology https://t.co/l8cjglemII The optimal range to reduce mortality isn’t particularly high.
    view full post

    December 16, 2023

  • Alex
    @AlexViKu (Twitter)

    Association between IGF‐1 levels ranges and all‐cause mortality: A meta‐analysis - Rahmani - 2022 - Aging Cell - Wiley Online Library https://t.co/ayWnCHYVV0
    view full post

    October 13, 2023

  • Chidambara .ML.
    @chidambara09 (Twitter)

    RT @NutrioSci: Associations between quintiles of macronutrient (a), micronutrient (b) and food (c) intakes and IGF-1 serum concentrations…
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    August 4, 2023

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  • Top Biomedical Science
    @imedverse (Twitter)

    RT @NutrioSci: Associations between quintiles of macronutrient (a), micronutrient (b) and food (c) intakes and IGF-1 serum concentrations…
    view full post

    August 4, 2023

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  • Nutrition Science
    @NutrioSci (Twitter)

    Associations between quintiles of macronutrient (a), micronutrient (b) and food (c) intakes and IGF-1 serum concentrations #MedEd #MedTwitter #Nutrition https://t.co/T4aj0hFUA9 https://t.co/7p4m4JpO4R
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    August 4, 2023

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  • Ben Greenfield
    @bengreenfield (Twitter)

    This study has SO many flaws (especially regarding "danger" of high protein/meat), but there is one major takeaway: eat more protein as you get older: https://t.co/Nk1Zoz8zCE https://t.co/3ABkPFbypw
    view full post

    September 29, 2022

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  • Julia B.
    @JuliaB_fitness (Twitter)

    @jacobmhands @mackinprof @foundmyfitness Also: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Valter Longo et al. 2022 «Both high and low levels of IGF-1 increase mortality risk, with a specific 120–160 ng/ml range being associated with the lowest mortality.» https://t.co/lnzdI7WDYU
    view full post

    July 8, 2022

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  • Carlos Colmenero
    @colme99 (Twitter)

    RT @Orlando_uy: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Both high and low levels of IGF-1 increas…
    view full post

    June 23, 2022

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  • SystematicReviewBot
    @EvidenceRobot (Twitter)

    RT @Orlando_uy: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Both high and low levels of IGF-1 increas…
    view full post

    June 22, 2022

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  • @Orlando_uy (Twitter)

    Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Both high and low levels of IGF-1 increase mortality risk, with a specific 120–160 ng/ml range being associated with the lowest mortality. https://t.co/j8zrG23uMw
    view full post

    June 22, 2022

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  • Nanci Guest PhD, RD, CSCS
    @NanciGuestRDPhD (Twitter)

    @trader2201 @drmatthewnagra @Switch4GoodNFT Seems to be milk, yogurt maybe not cheese. High/low IGF-1 linked to mortality. Not clear yet what to limit/avoid. https://t.co/f2PuSgUQVQ
    view full post

    June 11, 2022

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  • SystematicReviewBot
    @EvidenceRobot (Twitter)

    RT @mike_lustgarten: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/BeOq1pXGK0
    view full post

    April 10, 2022

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  • Mike Lustgarten, PhD
    @mike_lustgarten (Twitter)

    Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/BeOq1pXGK0
    view full post

    April 10, 2022

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  • Joel "Heart Prevention" Kahn MD, FACC
    @drjkahn (Twitter)

    Imporant Data. Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/pbR2fsi6eW
    view full post

    February 28, 2022

  • John Greene
    @Greene_Thoughts (Twitter)

    RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…
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    February 14, 2022

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  • Maria Konovalenko
    @mkonovalenko (Twitter)

    RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…
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    February 7, 2022

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  • Immortalists Magazine
    @immortalistsmag (Twitter)

    RT @longevitywiki: Now, Are You Balancing Your IGF-1 Levels?
    view full post

    February 6, 2022

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  • Andreas Melhede bio/acc
    @AMelhede (Twitter)

    RT @longevitywiki: Now, Are You Balancing Your IGF-1 Levels?
    view full post

    February 5, 2022

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  • ciro iuorno
    @medicojunghiano (Twitter)

    Association between IGF‐1 levels ranges and all‐cause mortality: A meta‐analysis https://t.co/pZdYlnQeLy
    view full post

    February 3, 2022

  • Fábio L Orsatti, PhD
    @fabiorsatti (Twitter)

    RT @Osteoporosis_NL: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Jamal Rahmani et al. Aging Cell 20 J…
    view full post

    January 30, 2022

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  • Osteoporosis-NL @osteoporosis-nl.bsky.social
    @Osteoporosis_NL (Twitter)

    Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Jamal Rahmani et al. Aging Cell 20 Jan 2022 https://t.co/3sjg2Qp9BY … both high and low levels of IGF-1 increase mortality risk, with the lowest mortality (120-160 ng/ml) https://t.co/HMcGz3hMKa
    view full post

    January 30, 2022

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  • TimePie (focus on anti-aging science)
    @TimePieChina (Twitter)

    Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/LgIWMmgN9z 据《Aging Cell》发布的研究，意大利科研人员荟萃分析发现，胰岛素样生长因子 (IGF) 与死亡率呈U型关系，水平太高或太低都会增加死亡风险。
    view full post

    January 28, 2022

  • UCSF Bakar Aging Research Institute
    @UCSFAging (Twitter)

    RT @AgingBiology: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/AbHPZQdKcV
    view full post

    January 27, 2022

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  • Dr. Ugis Kletnieks
    @Ugis06209578 (Twitter)

    RT @AgingBiology: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/AbHPZQdKcV
    view full post

    January 27, 2022

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  • Fay
    @fay90028966 (Twitter)

    RT @AgingBiology: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/AbHPZQdKcV
    view full post

    January 27, 2022

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  • Aging Science News
    @AgingBiology (Twitter)

    Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/AbHPZQdKcV
    view full post

    January 27, 2022

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  • Nick Krontiris
    @nick_krontiris (Twitter)

    Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis (open access) https://t.co/LwtFuoCMGg #nutrition #diet #Obesity #Cholesterol #Triglycerides #Dyslipidemia #MetabolicSyndrome #hormones
    view full post

    January 25, 2022

    3

  • Longevity Wiki
    @longevitywiki (Twitter)

    RT @longevitywiki: Now, Are You Balancing Your IGF-1 Levels?
    view full post

    January 24, 2022

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  • Dr L Boominathan PhD
    @DrLBoominathan (Twitter)

    This study suggests that both high & low levels of IGF1 increase mortality risk, with a specific 120–160ng/ml range being associated with the lowest mortality. https://t.co/FXAHCuZxs1 To gain mechanistic insights into longevity: https://t.co/ev3fKAzN5D https://t.co/Sw8UbalWKl https://t.co/Spe2EX82AH
    view full post

    January 23, 2022

  • Società Italiana di Gerontologia e Geriatria
    @GeriSocITA (Twitter)

    Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis.: https://t.co/FHfMYD72Qy
    view full post

    January 21, 2022

  • Silvana Duran
    @Silviduranort (Twitter)

    RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…
    view full post

    January 20, 2022

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  • Yisell Soto
    @Yisell_Soto_ (Twitter)

    RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…
    view full post

    January 20, 2022

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  • Carlos Colmenero
    @colme99 (Twitter)

    RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…
    view full post

    January 20, 2022

    10

  • Emma
    @emmaaquarian (Twitter)

    RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…
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    January 20, 2022

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  • Vincenzo Domina, M.eng
    @enz0benz0 (Twitter)

    RT @longevitywiki: Now, Are You Balancing Your IGF-1 Levels?
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    January 20, 2022

    4

  • The Phoenix Lab
    @The_Phoenix_Lab (Twitter)

    RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…
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    January 20, 2022

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  • Mike Lustgarten, PhD
    @mike_lustgarten (Twitter)

    RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…
    view full post

    January 20, 2022

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  • Longevity Wiki
    @longevitywiki (Twitter)

    Now, Are You Balancing Your IGF-1 Levels?
    view full post

    January 20, 2022

    4

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  • @Orlando_uy (Twitter)

    RT @agingdoc1: Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https:…
    view full post

    January 20, 2022

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  • Agingdoc
    @agingdoc1 (Twitter)

    Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis https://t.co/p3946xBKHP @AgingCell https://t.co/3KElLxK5Zf
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    January 20, 2022

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Abstract Synopsis

  • The meta-analysis examined how IGF1 levels relate to overall risk of death, finding that both very low and very high IGF1 levels are linked to increased mortality, showing a U-shaped relationship.
  • Higher IGF1 levels compared to middle-range levels do not significantly increase mortality risk, but both low and high IGF1 are associated with higher mortality, with the lowest risk found in a specific IGF1 range (120-160 ng/mL).
  • The study also suggests that IGF1 levels are influenced by diet, including protein and vitamin intake, which might help explain why both low and high levels are harmful, clarifying previous conflicting research.]