June 2022 PMID 35050717

Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy.

Jesse Ory, Sirpi Nackeeran, Navin C Balaji, Joshua M Hare, And Ranjith Ramasamy

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Mentions

28
Peak: 10 in Feb 2022
across 5 sources since Jan 2022

Extended reach

398,929
potential audience

Total likes

4,232

Video views

215,522

Mentions per month

Jan 2022 – Jul 2025

Where it's discussed

  • X / Twitter23 posts
  • YouTube2 videos
  • Facebook1 posts
  • Reddit1 posts
  • News1 articles

AI synopsis

What people are saying

The discussions express strong agreement with the findings, especially noting that high hematocrit levels (>52%) pose increased risks, as seen in phrases like 'danger' and 'must consider.' The tone is serious and clinical, often highlighting implications for patient safety and practice adjustments, which underscores the high interest and impact in the message.

AgreementModerate agreement

Many posts acknowledge the study's findings and emphasize the increased risks associated with polycythemia during testosterone therapy.

InterestHigh interest

Posts demonstrate high engagement with the topic, referencing specific risk factors and clinical implications.

EngagementModerate engagement

Discussions include practical advice, referencing clinical management like dose reduction and phlebotomy, indicating active involvement.

ImpactHigh impact

The groups acknowledge that the study's insights could influence clinical practices and patient safety protocols, reflecting significant impact.

Abstract in brief

  • This study examined whether men receiving testosterone therapy (TT) who develop secondary polycythemia (high hematocrit levels) are at increased risk of serious heart and blood clot events in the first year of treatment.
  • Researchers used a large database to compare men on TT who developed polycythemia with those who did not, finding that those with polycythemia had a significantly higher risk of major adverse cardiovascular events (MACE) and venous thromboembolism (VTE).
  • The findings suggest that developing polycythemia during TT is an independent risk factor for serious health risks, highlighting the need for future studies to consider hematocrit levels when evaluating TT safety.

Top posts

Most liked on X and Bluesky
Journal of Urology
@JUrology · X

"Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events & Venous Thromboembolism in the 1st Year of Therapy" Full Journal: https://t.co/v4Ys6giDrj Authored by: @SirpiNackeeran, @ranjithramamd, & more https://t.co/4n71ljUzbZ

Feb 21, 2022 · 24 likes · 6 shares · 41,675 followers View post →
Journal of Urology
@JUrology · X

"Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy" Full Journal ➡️ https://t.co/cHFKywxXUX Authored by: @jesse_ory, @SirpiNackeeran, @ranjithramamd, & MORE

Feb 15, 2022 · 17 likes · 2 shares · 41,675 followers View post →
Journal of Urology
@JUrology · X

"Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the 1st Year of Therapy"

May 24, 2022 · 14 likes · 4 shares · 41,675 followers View post →
SMSNA
@SMSNA_ORG · X

In the 1st yr of #TRT, secondary polycythemia appears to increase risk of major adverse CVE and VTE. #testosterone https://t.co/Fdrlg90ypk

Feb 7, 2022 · 8 likes · 4 shares · 4,371 followers View post →
Jonathan Beilan
@JonBeilan · X

A worthy read for any #testosterone -rx'ing clinician. Take home message: Polycythemia secondary to TRT in the 1st year of therapy can increase the risk of MACE/VTE in these pts. >52% Hct = danger Consider dose reduction +/- therapeutic phlebotomy https://t.co/u8jit0vwaP

Aug 8, 2022 · 4 likes · 1 share · 941 followers View post →
Giray Ergin
@gerginuro · X

Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy | Journal of Urology https://t.co/oWkfvr7gle

Jan 21, 2022 · 1 like · 731 followers View post →

All mentions

Jack Jeng
@JackJeng · X

If you’re on TRT or considering it, do it under the guidance of an experienced provider! They can monitor for adverse effects and adjust treatment if needed. Link to study: https://t.co/g2DAjZa3bQ

Mar 2, 2023 · 1 like · 218 followers View post →
Kevin Campbell
@KJCampbellMD · X

RT @JonBeilan: A worthy read for any #testosterone -rx'ing clinician. Take home message: Polycythemia secondary to TRT in the 1st year of t…

Aug 8, 2022 · 1 share · 836 followers View post →
Jonathan Beilan
@JonBeilan · X

A worthy read for any #testosterone -rx'ing clinician. Take home message: Polycythemia secondary to TRT in the 1st year of therapy can increase the risk of MACE/VTE in these pts. >52% Hct = danger Consider dose reduction +/- therapeutic phlebotomy https://t.co/u8jit0vwaP

Aug 8, 2022 · 4 likes · 1 share · 941 followers View post →
Saeid Shamsian MD
@evarellcorp · X

Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy | Journal of Urology - MashupMD https://t.co/CvFdvMNlvS

May 24, 2022 · 63 followers View post →
Sirpi Nackeeran, MD, MPH
@SirpiNackeeran · X

RT @JUrology: "Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venou…

May 24, 2022 · 4 shares · 343 followers View post →
Jesse Ory
@jesse_ory · X

RT @JUrology: "Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venou…

May 24, 2022 · 4 shares · 290 followers View post →
Amer. Urol. Assn.
@AmerUrological · X

RT @JUrology: "Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venou…

May 24, 2022 · 4 shares · 46,824 followers View post →
Jonathan Pavlinec, MD
@jpavs17 · X

RT @JUrology: "Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venou…

May 24, 2022 · 4 shares · 686 followers View post →
Journal of Urology
@JUrology · X

"Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the 1st Year of Therapy"

May 24, 2022 · 14 likes · 4 shares · 41,675 followers View post →
Maurício Hachul
@mauriciohachul · X

Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy | Journal of Urology https://t.co/ONM2gQ0eUP

May 10, 2022 · 94 followers View post →
Cheryl Hilty Orr, MD, FASA, DFPM
@HILTYORR_MD · X

@Bloodman @aoglasser @BobbieJeanSwei1 Putting this one here too. I love Twitter learning. #medtwitter https://t.co/empcOvmgce

Mar 18, 2022 · 359 followers View post →
Cheryl Hilty Orr, MD, FASA, DFPM
@HILTYORR_MD · X

@Bloodman @aoglasser @BobbieJeanSwei1 Just found this too-chart came to me today so THANK YOU for your input on this. Now for proper timing of holding preop testosterone - harder as pts don't want to stop, but DVT risk (mostly total joint patients) must be regarded with proper consideration. https://t.co/empcOvmgce

Mar 18, 2022 · 1 like · 359 followers View post →
kajal Khodamoradi, Ph.D.,HCLD, CC (ABB)
@kajalkmdi · X

RT @JUrology: "Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events & Venous…

Feb 22, 2022 · 6 shares · 229 followers View post →
Jesse Ory
@jesse_ory · X

RT @JUrology: "Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events & Venous…

Feb 21, 2022 · 6 shares · 290 followers View post →
Saeid Shamsian MD
@evarellcorp · X

https://t.co/YTFKldAk1Y

Feb 21, 2022 · 63 followers View post →
Emad Ibrahim, MD, HCLD
@ibrahimmdum1 · X

RT @JUrology: "Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events & Venous…

Feb 21, 2022 · 6 shares · 684 followers View post →
Sirpi Nackeeran, MD, MPH
@SirpiNackeeran · X

RT @JUrology: "Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events & Venous…

Feb 21, 2022 · 6 shares · 343 followers View post →
Luis A. Morales Ojeda, M.D
@DrLuismorales90 · X

RT @JUrology: "Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events & Venous…

Feb 21, 2022 · 6 shares · 438 followers View post →
Journal of Urology
@JUrology · X

"Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events & Venous Thromboembolism in the 1st Year of Therapy" Full Journal: https://t.co/v4Ys6giDrj Authored by: @SirpiNackeeran, @ranjithramamd, & more https://t.co/4n71ljUzbZ

Feb 21, 2022 · 24 likes · 6 shares · 41,675 followers View post →
Saeid Shamsian MD
@evarellcorp · X

Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy | Journal of Urology - MashupMD https://t.co/hcsN3S4fcm

Feb 15, 2022 · 63 followers View post →
Journal of Urology
@JUrology · X

"Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy" Full Journal ➡️ https://t.co/cHFKywxXUX Authored by: @jesse_ory, @SirpiNackeeran, @ranjithramamd, & MORE

Feb 15, 2022 · 17 likes · 2 shares · 41,675 followers View post →
SMSNA
@SMSNA_ORG · X

In the 1st yr of #TRT, secondary polycythemia appears to increase risk of major adverse CVE and VTE. #testosterone https://t.co/Fdrlg90ypk

Feb 7, 2022 · 8 likes · 4 shares · 4,371 followers View post →
Giray Ergin
@gerginuro · X

Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy | Journal of Urology https://t.co/oWkfvr7gle

Jan 21, 2022 · 1 like · 731 followers View post →
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