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Cell Stem Cell February 2022 PMID 35077667

Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing.

Shamik Mascharak, Heather E Talbott, Michael Januszyk, Michelle Griffin, Kellen Chen, Michael F Davitt, Janos Demeter, Dominic Henn, Clark A Bonham, Deshka S Foster, Nancie Mooney, Ran Cheng, Peter K Jackson, Derrick C Wan, Geoffrey C Gurtner

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Mentions

38
Peak: 29 in Jan 2022
across 2 sources since Jan 2022

Extended reach

145,016
potential audience

Total likes

1,238

Video views

38,145

Mentions per month

Jan 2022 – Jul 2024

Where it's discussed

  • X / Twitter36 posts
  • YouTube2 videos

AI synopsis

What people are saying

Several discussions quote the core findings, including phrases like 'divergent molecular events' and 'potential targets for therapies', which reflect curiosity about the scientific breakthroughs. The tone varies from supportive acknowledgment to interest in practical applications, with words like 'appreciate' and 'see' indicating recognition of the study’s relevance, though the language remains relatively neutral and informational rather than highly emotional or urgent.

AgreementModerate agreement

Most posts appear to acknowledge the significance of the research, with some expressing support or recognition of its importance, though not in an overly enthusiastic manner.

InterestHigh interest

The posts demonstrate high curiosity, focusing on keywords like 'multi-omic analysis', 'divergent molecular events', and 'wound healing', indicating strong interest.

EngagementModerate engagement

There are references to specific techniques and implications, such as mentioning 'single-cell RNA sequencing' and 'potential therapies', showing a moderate level of detailed engagement.

ImpactModerate impact

The overall tone suggests that the discussion recognizes the research's potential influence on future treatments or scientific understanding but stops short of claiming it to be revolutionary.

Abstract in brief

  • This study uses multiomic techniques, including single-cell RNA sequencing and proteomics, to compare the molecular processes involved in skin healing that lead to either scarring or regeneration, revealing distinct pathways and cellular behaviors.
  • Researchers found that inhibiting YAP mechanotransduction promotes regenerative healing by activating specific signals like Trps1 and Wnt in fibroblasts, which help shift the healing process away from fibrosis.
  • By experimentally manipulating Trps1 in vivo, the study shows that this gene is essential and partly enough to promote wound regeneration, offering potential targets for therapies that could reduce scarring and improve tissue repair.
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Most liked on X and Bluesky
Cell Stem Cell
@CellStemCell · X

New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing https://t.co/xYLJAgzVgp

Jan 24, 2022 · 67 likes · 24 shares · 58,445 followers View post →
Stanford Plastic Surgery
@StanfordPlastic · X

Feb 10, 2022 · 6 likes · 3 shares · 5,061 followers View post →
Kursad Turksen
@kursadturksen · X

#SINGLECELL #SKIN #WOUNDHEALING Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing https://t.co/96OGig0TBZ

Jan 26, 2022 · 2 likes · 1 share · 231 followers View post →
Stanford Surgery
@StanfordSurgery · X

RT @StanfordPlastic:

Feb 10, 2022 · 3 shares · 8,682 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @kursadturksen: #SINGLECELL #SKIN #WOUNDHEALING Multi-omic analysis reveals divergent molecular events in scarring and regenerative wou…

Jan 26, 2022 · 1 share · 8,157 followers View post →
PK Stefanopoulos, MD
@StefanoPPK · X

RT @StanfordPlastic:

Feb 10, 2022 · 3 shares · 4,666 followers View post →

All mentions

Juhyun Kim
@juhyunk_ · X

RT @juhyunk_: Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing https://t.co/p2UvkLFiTO

Feb 11, 2022 · 1 share · 1,403 followers View post →
PK Stefanopoulos, MD
@StefanoPPK · X

RT @StanfordPlastic:

Feb 10, 2022 · 3 shares · 4,666 followers View post →
Stanford Surgery
@StanfordSurgery · X

RT @StanfordPlastic:

Feb 10, 2022 · 3 shares · 8,682 followers View post →
Jason Wong
@Docj88 · X

RT @StanfordPlastic:

Feb 10, 2022 · 3 shares · 2,030 followers View post →
Stanford Plastic Surgery
@StanfordPlastic · X

Feb 10, 2022 · 6 likes · 3 shares · 5,061 followers View post →
Juhyun Kim
@juhyunk_ · X

Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing https://t.co/p2UvkLFiTO

Feb 7, 2022 · 1 share · 1,403 followers View post →
ぼっとくん
@dogface2016 · X

2022年2月1日: Pythonで送る最新のCell Press Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing https://t.co/2eOVsPDnyt

Feb 1, 2022 · 162 followers View post →
RRID Robot
@RobotRrid · X

A paper using https://t.co/1Kgsk88Xay (from @Proteintech) was just published in Cell Stem Cell, see "Multi-omic analysis reveals divergent molecular ev…": https://t.co/dydUvBFbuu (https://t.co/orXCBTMn0t). We appreciate the author's support of reproducibility. #OpenScience #RRID

Jan 30, 2022 · 1 share · 161 followers View post →
Марина КУЗЬМИНЫХ
@YHL1MptofUMfeXS · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 30, 2022 · 24 shares · 1 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @kursadturksen: #SINGLECELL #SKIN #WOUNDHEALING Multi-omic analysis reveals divergent molecular events in scarring and regenerative wou…

Jan 26, 2022 · 1 share · 8,157 followers View post →
Kursad Turksen
@kursadturksen · X

#SINGLECELL #SKIN #WOUNDHEALING Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing https://t.co/96OGig0TBZ

Jan 26, 2022 · 2 likes · 1 share · 231 followers View post →
Kursad Turksen
@kursadturksen · X

#SKIN Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing https://t.co/96OGig0TBZ

Jan 26, 2022 · 231 followers View post →
MDMD
@Michael__Davitt · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 26, 2022 · 24 shares · 35 followers View post →
Kevin Tharp
@Derpology · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 26, 2022 · 24 shares · 1,223 followers View post →
ぼっとくん
@dogface2016 · X

2022年1月25日: Pythonで送る最新のCell Press Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing https://t.co/2eOVsPDnyt

Jan 25, 2022 · 162 followers View post →
Daniela Panakova
@DanielaPanakova · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 25, 2022 · 24 shares · 483 followers View post →
Mahmoud A.Metwalei
@AMetwalei · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 25, 2022 · 24 shares · 156 followers View post →
Dr. Aarón Ramírez
@AaronRamirez02 · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 25, 2022 · 24 shares · 163 followers View post →
LAMR
@LAMR07_mcdrol · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 25, 2022 · 24 shares · 163 followers View post →
Bart Smeets
@BartSmeets11 · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 25, 2022 · 24 shares · 119 followers View post →
ちけらぼ Chike Lab.
@chik_sci · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 25, 2022 · 24 shares · 46 followers View post →
Dr. Claire McCarthy (she/her)
@cemccarthy02 · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 24, 2022 · 24 shares · 1,998 followers View post →
yiqunj
@yiqunj1 · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 24, 2022 · 24 shares · 33 followers View post →
Piotr Konieczny
@KoniecznPiotr · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 24, 2022 · 24 shares · 354 followers View post →
Nabil Djouder
@NabilDjouder · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 24, 2022 · 24 shares · 426 followers View post →
Erika Faraoni
@erifaraoni · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 24, 2022 · 24 shares · 60 followers View post →
Stephan Clavel
@ClavelStephan · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 24, 2022 · 24 shares · 208 followers View post →
Walko Lab
@walko_lab · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 24, 2022 · 24 shares · 553 followers View post →
Maryada Sharma
@sharma_maryada · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 24, 2022 · 24 shares · 356 followers View post →
Sarthak Sinha, MD, PhD
@sarthak_s · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 24, 2022 · 24 shares · 3,430 followers View post →
Arshad Ayyaz
@Dr_ArshadAyyaz · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 24, 2022 · 24 shares · 215 followers View post →
Homaira Hamidzada
@Homaira_H · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 24, 2022 · 24 shares · 334 followers View post →
Jo Nguyen
@jonguyenz · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 24, 2022 · 24 shares · 153 followers View post →
Duy Phan MD, PhD
@Phan_Q_Duy · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 24, 2022 · 24 shares · 739 followers View post →
Alexis Lomakin, Ph.D. (אל) אַלעקסיס לאָמאַקין
@Alexis_Lomakin · X

RT @CellStemCell: New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative…

Jan 24, 2022 · 24 shares · 3,644 followers View post →
Cell Stem Cell
@CellStemCell · X

New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing https://t.co/xYLJAgzVgp

Jan 24, 2022 · 67 likes · 24 shares · 58,445 followers View post →