January 2022 PMID 35082658

Association of Circulating Magnesium Levels in Patients With Alzheimer's Disease From 1991 to 2021: A Systematic Review and Meta-Analysis.

Ke Du, Xi Zheng, Zi-Tai Ma, Jun-Ya Lv, Wen-Juan Jiang, Ming-Yan Liu

Download social card

Mentions

Peak: 7 in Feb 2023

across 3 sources since Jan 2022

Extended reach

426,068

potential audience

Total likes

5,439

Video views

184,739

Mentions per month

Jan 2022 – Nov 2025

Where it's discussed

X / Twitter12 posts
YouTube3 videos
News3 articles

AI synopsis

What people are saying

Discussions reveal a moderate level of interest and engagement, with posts supporting the research’s conclusions about magnesium deficiency's link to Alzheimer's and highlighting potential treatment implications. The tone balances scientific references and calls for increased magnesium intake, reflecting appreciation for the study's significance and practical relevance.

AgreementModerate agreement

Many discussions align with the study's findings, emphasizing the link between magnesium deficiency and Alzheimer's disease, with references to the importance of Mg supplementation.

InterestModerate interest

The topic of magnesium's role in neurodegeneration attracts moderate interest, as evidenced by multiple mentions and the sharing of specific research details.

EngagementModerate engagement

Participants actively reference mechanisms, like low extracellular pH and cell resistance, and recent meta-analyses, indicating thoughtful engagement beyond surface-level reactions.

ImpactModerate impact

The discussions highlight potential clinical and research impacts, emphasizing magnesium as a risk factor and therapeutic avenue, which suggests recognition of its significance.

Abstract in brief

The systematic review and meta-analysis of 21 studies from 1991 to 2021 found that blood levels of magnesium (Mg) are significantly lower in patients with Alzheimer's disease (AD) compared to healthy controls, suggesting a possible link between Mg deficiency and AD risk.
There was no significant difference in magnesium levels in cerebrospinal fluid (CSF) between AD patients and controls, although a decreasing trend was observed.
Combining data from serum, plasma, and CSF, the overall circulating magnesium levels were significantly reduced in AD patients, indicating that magnesium deficiency might be a risk factor, and Mg supplementation could potentially serve as a supportive treatment for AD.]

Read the full abstract

All mentions

The Role of Magnesium in Brain Health and Alzheimer's Prevention

Magnesium is crucial for brain health. This video discusses the effectiveness of magnesium forms in crossing the blood-brain barrier and highlights magnesium threonate's potential to prevent cognitive decline and…

Dr. med. Ulrich Selz · Nov 11, 2025 92,982 views

Magnesium's Role in Alzheimer's Disease Protection

Magnesium is essential for our brain health, and its deficiency can negatively affect memory and dementia protection. Magnesium L-Threonate, particularly in its Magtein form, effectively crosses the blood-brain barrier…

Dr. med. Ulrich Selz · Oct 19, 2025 57,362 views

The Role of Magnesium in Alzheimer's Disease Prevention

Magnesium is crucial for brain health. However, traditional forms of magnesium fail to cross the blood-brain barrier. This video discusses the effectiveness of Magnesium L-Threonate in protecting against cognitive…

Dr. med. Ulrich Selz · Oct 31, 2025 34,395 views

Paulo Vaz

@SubatomicHealth · X

@lowcarbGP MG+ deficiency is also assosiated with AD. https://t.co/RDJTfSGXZQ Mechanism: Low Mg+ -> Low extracelular pH -> Cell uptake resistence -> Early death of cell (neurons)

Jan 2, 2025 · 71 followers View post →

Nicole Laurent, LMHC

@KetoCounselor · X

May 13, 2023 · 10 likes · 9,099 followers View post →

Nathalie Yellow Sun

@Nathali21126284 · X