Intensive Care Med March 2022 PMID 35129643

Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock.

Wulfran Bougouin, Kaci Slimani, Marie Renaudier, Yannick Binois, Marine Paul, Florence Dumas, Lionel Lamhaut, Thomas Loeb, Sofia Ortuno, Nicolas Deye, Sebastian Voicu, Frankie Beganton, Daniel Jost, Armand Mekontso-Dessap, Eloi Marijon

Mentions

130
Peak: 55 in Feb 2022
across 4 sources since Feb 2022

Extended reach

484,849
potential audience

Total likes

819

Video views

267

Mentions per month

Feb 2022 – Jul 2024

Where it's discussed

  • X / Twitter117 posts
  • Blogs6 articles
  • Facebook5 posts
  • YouTube2 videos

AI synopsis

What people are saying

Several discussions highlight critical points from the study, with comments like 'adrenaline gets a bad rap in post ROSC patients' and references to data indicating a preference for norepinephrine. The choice of words such as 'interesting,' 'fascinating,' and 'game changer' conveys excitement and urgency, while questioning phrases like 'I don’t quite understand' illustrate the complexity and the need for further discussion about the findings' implications.

AgreementModerate agreement

Most discussions reflect a general support for the findings of the publication, though some posts express concern or questions regarding its implications.

InterestHigh interest

There is a notable level of curiosity toward the study, as many comments reference the relevance of the findings to ongoing practice in emergency medicine.

EngagementModerate engagement

While many posts simply acknowledge the study, a few engage deeply with the data, questioning and analyzing specific aspects of the research.

ImpactHigh impact

The consensus suggests that the findings could significantly influence treatment approaches for post-resuscitation shock, garnering a strong perception of importance.

Abstract in brief

  • The study compared the effects of epinephrine versus norepinephrine in patients who experienced postresuscitation shock after out-of-hospital cardiac arrest, focusing on outcomes like hospital mortality and neurological function.
  • The findings revealed that patients receiving epinephrine had significantly higher all-cause and cardiovascular-specific mortality rates compared to those treated with norepinephrine.
  • Based on these results, the authors suggest that healthcare providers may consider using norepinephrine instead of epinephrine for managing postresuscitation shock in these patients until more data is obtained.

Top posts

Most liked on X and Bluesky
Intensive Care Medicine
@yourICM · X

Dec 30, 2022 · 420 likes · 140 shares · 75,365 followers View post →
Intensive Care Medicine
@yourICM · X

Noradrenaline better vs adrenaline in cardiac arrest pts with post #resus shock?

Feb 24, 2022 · 247 likes · 122 shares · 75,365 followers View post →
こーすけ@救急医
@FlightDocKosuke · X

ROSC後の低血圧へのアドレナリン,ノルアドレナリンの持続投与と予後について,多施設観察研究. 5病院766名中,37%がAd,63%がNad投与. 死亡率はAd群で有意に高く(OR2.6),CPC3-5も多かった. Adを持続投与しないともたない場合の予後はやっぱり悪い,という事なんでしょうね... https://t.co/BN2eXhDBiT

Feb 8, 2022 · 46 likes · 1 share · 3,748 followers View post →
ACCP EMED PRN
@accpemedprn · X

Dr. Megan Vandergriend, EM PGY2 resident @ Denver Health will also present during our JC. She will be discussing "Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock." Intensive Care Med published March 2022.

Mar 20, 2022 · 42 likes · 2 shares · 5,452 followers View post →
Victoria Stephen
@EMcardiac · X

https://t.co/OjmahpRUNl All-cause and cardiac mortality, and neuro outcomes alarmingly worse in pts treated with adrenaline versus norad. About time that norad was a registered medication with easy accessibility in South Africa @HartJedd @SAHPRA1 @Edbuggie

Mar 18, 2022 · 17 likes · 2 shares · 7,774 followers View post →
ケースケ@LessIsMoreICU
@lessismoreicu · X

古来よりPCAS病態はsepsis like syndromeなんて言われたりすることもありますが、そんなこんなで、蘇生後は昇圧薬の1stは今んとこNADで良さそうということを再確認。 https://t.co/bRSIqjGhuw

Mar 4, 2022 · 9 likes · 5,971 followers View post →

All mentions

Nick Johnson
@NickJohnsonMD · X

@OneArmWonder @CatherineCounts @EmmaWender @SayreMR @SeattleFire @uwmnewsroom @UWashEM @mollyvandyke I don’t quite understand how one infusion is simpler than another especially when evidence suggests otherwise: https://t.co/AxtoMHE2ru

Dec 5, 2023 · 3 likes · 6,548 followers View post →
Ben Clayton
@benclayton247 · X

@NickJohnsonMD @CatherineCounts More on-the-money data from this amazing group. Corroborates existing suggestion: https://t.co/lxNMdzgGwY

Dec 5, 2023 · 2 likes · 89 followers View post →
Matthew Stampfl
@MatthewStampfl · X

@WardiGabriel @NickJohnsonMD @itisRebeccaSell @BenjaminAbella Definitely have to include DOSE VF. And I think the research around epi vs norepi for post-resuscitation shock is interesting (though nowhere near definitive) https://t.co/DoeLPjmtO6

Feb 20, 2023 · 4 likes · 70 followers View post →
Renato Herrera
@RenatoJHG · X

RT @yourICM:

Dec 30, 2022 · 140 shares · 104 followers View post →
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@ClarensParis · X

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@LalidaKo · X

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@DSemple5 · X

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@ya100boy · X

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@Alf_Peral · X

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@AkshayVijayara1 · X

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Dra. Martha Lizbeth Sanchez Grijalva
@MARTHALIZBETHSG · X

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Dec 30, 2022 · 140 shares · 3 followers View post →
Susan Shaw Wear a Mask Save a Life
@drsusanshaw · X

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Dec 30, 2022 · 140 shares · 6,170 followers View post →
AP
@TonyCCM22 · X

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Dec 30, 2022 · 140 shares · 40 followers View post →
WesElyMD
@WesElyMD · X

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Roberto E Lopez Mata
@relm_11969 · X

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Alejandro Moya
@alemoyaal · X

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Oscar Aspiazu Segovia. MD. ESP. MFYC| MsC.MPH
@opolito8514 · X

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Dec 30, 2022 · 140 shares · 279 followers View post →
Roger Gonzalez
@Rogerogonzalezc · X

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Shakrit
@R_shakrit · X

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Dr Francisco cruz
@franciscocruz98 · X

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@jzalkin · X

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Angie Viviana
@Angie95V · X

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Björn Jäschke
@clamorlaetus · X

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Dec 30, 2022 · 140 shares · 1,017 followers View post →
Volker Huge MD
@vdrhuge · X

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Dec 30, 2022 · 140 shares · 29 followers View post →
Giuseppe Citerio
@Dr_Cit · X

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Dec 30, 2022 · 140 shares · 7,990 followers View post →
Edgar Reyes
@edgarreyesgar · X

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Dec 30, 2022 · 140 shares · 198 followers View post →
M Velia Antonini
@FOAMecmo · X

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Dec 30, 2022 · 140 shares · 14,667 followers View post →
David de Andrade Nunes
@daviddeanunes · X

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Iván Bajaña
@IvanReneBajana · X

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Dec 30, 2022 · 140 shares · 152 followers View post →
Intensive Care Medicine
@yourICM · X

Dec 30, 2022 · 420 likes · 140 shares · 75,365 followers View post →
levanlam
@levanlam0202 · X

https://t.co/a6y9cZEs5T

Dec 10, 2022 · 8 followers View post →
armyemdoc
@armyemdoc · X

Bougouin et al, Epinephrine versus norepinephrine in cardiac arrest patients with post‑resuscitation shock URL: https://t.co/UOkiddPehT #emergency #emergencymedicine #emergencyroom #erlife #icu #iculife #criticalcare #medicine #medic #paramedic #nurse https://t.co/l2QerRqsVF

Sep 27, 2022 · 4,640 followers View post →
Alex Sanders-Page
@prehospit_al · X

@bentaylor42 @ross_moy Thanks both, that makes sense. Got thinking about it after this paper https://t.co/28cPLPiuG7.

Jun 21, 2022 · 1 like · 2,124 followers View post →
Alex Sanders-Page
@prehospit_al · X

@Beth_Barton_ @EmrtsWales Thanks Beth, interesting. Context was after reading this paper. https://t.co/28cPLPiuG7.

Jun 21, 2022 · 2,124 followers View post →
陈凯莉
@chenkaili888 · X

RT @intensivecare_c: 院外心肺停止後のショックにはエピネフリン?ノルエピネフリン? エピネフリン群の方が死亡率が高いという結果になっています。 https://t.co/klCxPa20G5 https://t.co/O8Q9rJ2Y39

Jun 2, 2022 · 6 shares · 684 followers View post →
Thomas Shanahan (Dr.) MRCEM
@clifford0584 · X

Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock - PubMed https://t.co/UCLJMyQaoB

May 29, 2022 · 6,072 followers View post →
UK ICU Pharmacy
@UKCritCarePharm · X

RT @SCCM_CPP: Blake Robbins (@UKCritCarePharm) will present: Epinephrine versus norepinephrine in cardiac arrest patients with post-resusci…

May 18, 2022 · 2 shares · 1,860 followers View post →
Blake Robbins
@brobbinspharmd · X

RT @SCCM_CPP: Blake Robbins (@UKCritCarePharm) will present: Epinephrine versus norepinephrine in cardiac arrest patients with post-resusci…

May 17, 2022 · 2 shares · 297 followers View post →
SCCM Clinical Pharmacy and Pharmacology Section
@SCCM_CPP · X

Blake Robbins (@UKCritCarePharm) will present: Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock. https://t.co/w77U5PRDVr #PharmICU

May 16, 2022 · 3 likes · 2 shares · 3,419 followers View post →
Syed Shahrul Naz
@drshahrul80 · X

RT @iceman_ex: @Prof_XMonnet Adrenaline gets a bad rap in post ROSC patients- observational data suggests increased mortality https://t.co…

May 13, 2022 · 1 share · 6,928 followers View post →
Segun Olusanya (He/Him) iceman_ex@critcare.social
@iceman_ex · X

@Prof_XMonnet Adrenaline gets a bad rap in post ROSC patients- observational data suggests increased mortality https://t.co/UeEJ12xS6o #LIVES40

May 12, 2022 · 3 likes · 1 share · 19,581 followers View post →
城西村由
@emephysimed99 · X

RT @intensivecare_c: 院外心肺停止後のショックにはエピネフリン?ノルエピネフリン? エピネフリン群の方が死亡率が高いという結果になっています。 https://t.co/klCxPa20G5 https://t.co/O8Q9rJ2Y39

May 7, 2022 · 6 shares · 146 followers View post →
Gustavo Flores
@gflores911 · X

Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock https://t.co/wSaEoLpXJG

Apr 18, 2022 · 3,916 followers View post →
Syed Shahrul Naz
@drshahrul80 · X

RT @MDKrunalP: We’ve got some data regarding Epi vs Norepi for Post Resuscitative Shock!Seems like norepi is favored over epi for OHCA + po…

Apr 15, 2022 · 6 shares · 6,928 followers View post →
Sa'ad Lahri
@slahri7 · X

@Dr_Leo_SA https://t.co/KLfFlaWxOa

Apr 3, 2022 · 1,929 followers View post →
Syed Shahrul Naz
@drshahrul80 · X

RT @MDKrunalP: We’ve got some data regarding Epi vs Norepi for Post Resuscitative Shock!Seems like norepi is favored over epi for OHCA + po…

Mar 30, 2022 · 6 shares · 6,928 followers View post →
Tommaso Scquizzato, MD
@tscquizzato · X

RT @MDKrunalP: We’ve got some data regarding Epi vs Norepi for Post Resuscitative Shock!Seems like norepi is favored over epi for OHCA + po…

Mar 29, 2022 · 6 shares · 5,128 followers View post →
Giovanni Landoni, MD
@giovannilandoni · X

RT @MDKrunalP: We’ve got some data regarding Epi vs Norepi for Post Resuscitative Shock!Seems like norepi is favored over epi for OHCA + po…

Mar 29, 2022 · 6 shares · 4,676 followers View post →
ResusBot
@Resus_Bot · X

RT @MDKrunalP: We’ve got some data regarding Epi vs Norepi for Post Resuscitative Shock!Seems like norepi is favored over epi for OHCA + po…

Mar 29, 2022 · 6 shares · 181 followers View post →
Cardiac Arrest Center - Ospedale San Raffaele
@SRCardiacArrest · X

RT @MDKrunalP: We’ve got some data regarding Epi vs Norepi for Post Resuscitative Shock!Seems like norepi is favored over epi for OHCA + po…

Mar 29, 2022 · 6 shares · 591 followers View post →
Krunal H. Patel ⚕️
@MDKrunalP · X

We’ve got some data regarding Epi vs Norepi for Post Resuscitative Shock!Seems like norepi is favored over epi for OHCA + post resus shock by a lot!! Can’t wait for more data on this to come out. Long live Norepi

Mar 29, 2022 · 4 likes · 6 shares · 1,047 followers View post →
Cory Schlobohm PharmD BCEMP
@cbohm21 · X

@PharmD_intheED And fresh off the press, more specific to ROSC: https://t.co/PfcMLc0ySp

Mar 26, 2022 · 2 likes · 244 followers View post →
Ryan Feldman (empoisonpharmd.bsky.social)
@EMPoisonPharmD · X

@JTDesJardin @MSharifpourMD Don’t forget NE>DA in TCA OD: https://t.co/MLPdW4RnSW (Direct vs “indirect” pressor) NE>EPI Post ROSC: https://t.co/0dNJae6ynt & https://t.co/oS0yGjpksY (not squeezing sick heart may be good) Probably ideal prehospital pressor!: https://t.co/5Tv2FXUMVo

Mar 25, 2022 · 4 likes · 4,698 followers View post →
U of Maryland Emergency Med
@UMEmergencyMed · X

Read the latest Educational Pearl on Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock at https://t.co/40zfqZdNBI

Mar 23, 2022 · 3 likes · 11,835 followers View post →
Lance Ray
@LRayRx · X

RT @accpemedprn: Dr. Megan Vandergriend, EM PGY2 resident @ Denver Health will also present during our JC. She will be discussing "Epinephr…

Mar 22, 2022 · 2 shares · 1,084 followers View post →
Mohammad alhajji
@tahajji · X

RT @accpemedprn: Dr. Megan Vandergriend, EM PGY2 resident @ Denver Health will also present during our JC. She will be discussing "Epinephr…

Mar 21, 2022 · 2 shares · 165 followers View post →
ACCP EMED PRN
@accpemedprn · X

Dr. Megan Vandergriend, EM PGY2 resident @ Denver Health will also present during our JC. She will be discussing "Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock." Intensive Care Med published March 2022.

Mar 20, 2022 · 42 likes · 2 shares · 5,452 followers View post →
Becca Hart
@WatersCrystal24 · X

RT @EMcardiac: https://t.co/OjmahpRUNl All-cause and cardiac mortality, and neuro outcomes alarmingly worse in pts treated with adrenaline…

Mar 19, 2022 · 2 shares · 363 followers View post →
Julie Wiid
@WiidJulie · X

RT @EMcardiac: https://t.co/OjmahpRUNl All-cause and cardiac mortality, and neuro outcomes alarmingly worse in pts treated with adrenaline…

Mar 18, 2022 · 2 shares · 490 followers View post →
Victoria Stephen
@EMcardiac · X

https://t.co/OjmahpRUNl All-cause and cardiac mortality, and neuro outcomes alarmingly worse in pts treated with adrenaline versus norad. About time that norad was a registered medication with easy accessibility in South Africa @HartJedd @SAHPRA1 @Edbuggie

Mar 18, 2022 · 17 likes · 2 shares · 7,774 followers View post →
ケースケ@LessIsMoreICU
@lessismoreicu · X

古来よりPCAS病態はsepsis like syndromeなんて言われたりすることもありますが、そんなこんなで、蘇生後は昇圧薬の1stは今んとこNADで良さそうということを再確認。 https://t.co/bRSIqjGhuw

Mar 4, 2022 · 9 likes · 5,971 followers View post →
Fernando RMA
@mcfdomtz · X

RT @yourICM: Noradrenaline better vs adrenaline in cardiac arrest pts with post #resus shock?

Feb 24, 2022 · 122 shares · 2,221 followers View post →
Edgar López Bernal
@EdgarLpezBerna1 · X

RT @yourICM: Noradrenaline better vs adrenaline in cardiac arrest pts with post #resus shock?

Feb 24, 2022 · 122 shares · 1 followers View post →
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@BellidoFa · X

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@luisemmaespin · X

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@GhassanDahrouj · X

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南宁外围/南宁资源/南宁上门/南宁约炮/南宁兼职/南宁楼凤/南宁母狗
@almoskow · X

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@jpr_dr · X

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@augustoraulhm · X

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Segun Olusanya (He/Him) iceman_ex@critcare.social
@iceman_ex · X

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@jmsirvent3 · X

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Cardiac Arrest Center - Ospedale San Raffaele
@SRCardiacArrest · X

RT @yourICM: Noradrenaline better vs adrenaline in cardiac arrest pts with post #resus shock?

Feb 24, 2022 · 122 shares · 591 followers View post →
M Velia Antonini
@FOAMecmo · X

RT @yourICM: Noradrenaline better vs adrenaline in cardiac arrest pts with post #resus shock?

Feb 24, 2022 · 122 shares · 14,667 followers View post →
Intensive Care Medicine
@yourICM · X

Noradrenaline better vs adrenaline in cardiac arrest pts with post #resus shock?

Feb 24, 2022 · 247 likes · 122 shares · 75,365 followers View post →
ともサンキュー
@tomo3asa · X

RT @intensivecare_c: 院外心肺停止後のショックにはエピネフリン?ノルエピネフリン? エピネフリン群の方が死亡率が高いという結果になっています。 https://t.co/klCxPa20G5 https://t.co/O8Q9rJ2Y39

Feb 24, 2022 · 6 shares · 65 followers View post →
Nelson Giraldo
@nelsongiraldor · X

Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock | SpringerLink https://t.co/5ZVD3M2EZc

Feb 23, 2022 · 95 followers View post →
Satoru Mitsuboshi
@3stars67664378 · X

RT @pinacol: 【観察研究】院外心停止後の蘇生後ショック患者において、アドレナリンの使用は、ノルアドレナリンの使用と比較して、全原因院内死亡のリスク増加と関連した。 #ペ読 https://t.co/SEkfOAj1RZ

Feb 13, 2022 · 1 share · 1,780 followers View post →
pinacol
@pinacol · X

【観察研究】院外心停止後の蘇生後ショック患者において、アドレナリンの使用は、ノルアドレナリンの使用と比較して、全原因院内死亡のリスク増加と関連した。 #ペ読 https://t.co/SEkfOAj1RZ

Feb 12, 2022 · 2 likes · 1 share · 1,615 followers View post →
FAISAL ALSHAHRANI; MD, MBBS, SBACCM, MHE, EMins
@drfaisal1990 · X

RT @PragueICU: ⚠️⚠️⚠️ Among patients with post‑resuscitation shock after out‑of‑hospital cardiac arrest, use of epinephrine was associated…

Feb 9, 2022 · 1 share · 623 followers View post →
Prague ICU_Michal Pazdernik
@PragueICU · X

⚠️⚠️⚠️ Among patients with post‑resuscitation shock after out‑of‑hospital cardiac arrest, use of epinephrine was associated with higher all‑cause and cardiovascular‑specific mortality, compared with norepinephrine infusion. https://t.co/gqlXOFcSRe @WondrMedical

Feb 9, 2022 · 2 likes · 1 share · 4,048 followers View post →
Hospital Medicine Virtual Journal Club
@HMVJC · X

Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock https://t.co/jYs1O3qt8O #medtwitter

Feb 8, 2022 · 630 followers View post →
こーすけ@救急医
@FlightDocKosuke · X

ROSC後の低血圧へのアドレナリン,ノルアドレナリンの持続投与と予後について,多施設観察研究. 5病院766名中,37%がAd,63%がNad投与. 死亡率はAd群で有意に高く(OR2.6),CPC3-5も多かった. Adを持続投与しないともたない場合の予後はやっぱり悪い,という事なんでしょうね... https://t.co/BN2eXhDBiT

Feb 8, 2022 · 46 likes · 1 share · 3,748 followers View post →
SECIP
@lasecip · X

Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock https://t.co/R5MTHdTZpX #IntCareMed

Feb 7, 2022 · 5,613 followers View post →