JAMA February 2022 PMID 35133415

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial.

Dominik Dahl, Yukiko Onishi, Paul Norwood, Ruth Huh, Ross Bray, Hiren Patel, Ángel Rodríguez

Mentions

177
Peak: 58 in Feb 2022
across 5 sources since Feb 2022

Extended reach

1,225,849
potential audience

Total likes

285

Video views

8,447

Mentions per month

Feb 2022 – Aug 2023

Where it's discussed

  • News93 articles
  • X / Twitter68 posts
  • Blogs8 articles
  • Facebook6 posts
  • YouTube2 videos

AI synopsis

What people are saying

Many discussions highlight key findings from the SURPASS-5 trial, noting the significant reductions in HbA1c levels and improvements in glycemic control. Phrases like 'outstanding weight loss' and 'good effect on A1c' reflect a positive sentiment, while terms such as 'great plenary' suggest that the findings are being broadly acknowledged and discussed in professional circles.

AgreementModerate agreement

The majority of discussions indicate support for the trial's findings, with many users expressing a positive outlook towards tirzepatide's role in managing type 2 diabetes.

InterestHigh interest

There is a notable excitement surrounding the publication, as participants demonstrate curiosity about the research implications and the efficacy of tirzepatide.

EngagementModerate engagement

While not all posts delve deeply into the study, several reference specific methods and outcomes, indicating a level of engagement with the content.

ImpactHigh impact

Many users believe that this research carries significant implications for diabetes treatment, highlighting its potential to improve patient outcomes.

Abstract in brief

  • The SURPASS5 trial investigated the effects of tirzepatide, a medication for type 2 diabetes, when added to insulin glargine therapy, focusing on its efficacy and safety.
  • The study involved 475 adults with type 2 diabetes who had inadequate glycemic control, with participants randomly assigned to receive different doses of tirzepatide or a placebo over 40 weeks.
  • Results showed significant improvements in glycemic control, with the 10 mg and 15 mg doses of tirzepatide leading to substantial reductions in HbA1c levels compared to the placebo group.

Top posts

Most liked on X and Bluesky
JAMA
@JAMA_current · X

Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous tirzepatide, vs placebo, to titrated insulin glargine resulted in statistically significant improvements in glycemic control after 40 wk. https://t.co/LlO1c0GpRr https://t.co/IqHycbTJAF

Feb 8, 2022 · 60 likes · 16 shares · 488,764 followers View post →
Karl Nadolsky
@DrKarlNadolsky · X

#tirzepatide + glargine resulted in outstanding weight loss and glycemic improvements in those with #ibesity and type 2 #diabetes JAMA. 2022;327(6):534-545. doi:10.1001/jama.2022.0078 https://t.co/hC10azu0Py https://t.co/zNomWMcYJ3

Feb 9, 2022 · 35 likes · 10 shares · 5,869 followers View post →
Diego Segura-Rodríguez
@SeguraCardio · X

Feb 8, 2022 · 34 likes · 11 shares · 25,836 followers View post →
Cristobal Morales
@CristobMorales · X

https://t.co/7YIwZ6gIzl Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes #SURPASS5trial Orgulloso de la participación de centros Españoles en esta gran innovación @SEDiabetes @LillyES https://t.co/2LldT4yKzp

Feb 8, 2022 · 27 likes · 11 shares · 17,088 followers View post →
Billy Silverstein
@WKSilverstein · X

Great plenary by @JohnFralick8 on the top 5 papers in GIM! Here are the take away points and links! https://t.co/IJmGoz0TSJ https://t.co/GOOtyKPpDq https://t.co/LOsck9UJ5D https://t.co/q4hGEKeQIP https://t.co/OWMshjdjlz https://t.co/fTuCBfT1iq

Oct 13, 2022 · 15 likes · 5 shares · 1,365 followers View post →
JAMA
@JAMA_current · X

Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous tirzepatide, vs placebo, to titrated insulin glargine resulted in statistically significant improvements in glycemic control after 40 wk. https://t.co/BFDnS4UTjX https://t.co/Hp3qoATtWG

Feb 8, 2022 · 8 likes · 3 shares · 488,764 followers View post →

All mentions

Beverly G. Tchang, MD
@BevTchangMD · X

- "In this pt with uncontrolled #diabetes, A1c 7.4, we decreased glargine by 10% [when we started tirzepatide]"

May 4, 2023 · 1 like · 6,142 followers View post →
John
@joltdude · X

RT @BevTchangMD: SURPASS-5: tirzepatide + basal insulin vs. placebo Method: If baseline A1c<8, ⬇️long acting insulin dose by 20% at start…

Jan 29, 2023 · 2 shares · 3,007 followers View post →
Dr.Lama Amer, MD
@Dr_Lama_Amer · X

RT @BevTchangMD: SURPASS-5: tirzepatide + basal insulin vs. placebo Method: If baseline A1c<8, ⬇️long acting insulin dose by 20% at start…

Jan 28, 2023 · 2 shares · 4,289 followers View post →
Beverly G. Tchang, MD
@BevTchangMD · X

SURPASS-5: tirzepatide + basal insulin vs. placebo Method: If baseline A1c<8, ⬇️long acting insulin dose by 20% at start of study Result: At end of study, insulin was ⬇️11% for 15-mg tirzepatide group vs. ⬆️75% for placebo https://t.co/kmmdLyinNb 2/ https://t.co/AE4drdzqE3

Jan 28, 2023 · 7 likes · 2 shares · 6,142 followers View post →
Amanda Gardhouse
@AGardhouse · X

RT @WKSilverstein: Great plenary by @JohnFralick8 on the top 5 papers in GIM! Here are the take away points and links! https://t.co/IJmGo…

Oct 13, 2022 · 5 shares · 1,145 followers View post →
Khalid Alayed
@Ibnayedoon · X

RT @WKSilverstein: Great plenary by @JohnFralick8 on the top 5 papers in GIM! Here are the take away points and links! https://t.co/IJmGo…

Oct 13, 2022 · 5 shares · 2,468 followers View post →
UofTGIM
@GIMtoronto · X

RT @WKSilverstein: Great plenary by @JohnFralick8 on the top 5 papers in GIM! Here are the take away points and links! https://t.co/IJmGo…

Oct 13, 2022 · 5 shares · 1,200 followers View post →
Michael Fralick
@FralickMike · X

RT @WKSilverstein: Great plenary by @JohnFralick8 on the top 5 papers in GIM! Here are the take away points and links! https://t.co/IJmGo…

Oct 13, 2022 · 5 shares · 3,993 followers View post →
John Fralick
@JohnFralick8 · X

RT @WKSilverstein: Great plenary by @JohnFralick8 on the top 5 papers in GIM! Here are the take away points and links! https://t.co/IJmGo…

Oct 13, 2022 · 5 shares · 272 followers View post →
Billy Silverstein
@WKSilverstein · X

Great plenary by @JohnFralick8 on the top 5 papers in GIM! Here are the take away points and links! https://t.co/IJmGoz0TSJ https://t.co/GOOtyKPpDq https://t.co/LOsck9UJ5D https://t.co/q4hGEKeQIP https://t.co/OWMshjdjlz https://t.co/fTuCBfT1iq

Oct 13, 2022 · 15 likes · 5 shares · 1,365 followers View post →
JAMA Network
@JAMANetwork · X

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial, from @JAMA_current, free to read online during #ADA2022 https://t.co/ggzNuo2QcZ https://t.co/widykMlU93

Jun 4, 2022 · 3 likes · 19,672 followers View post →
IMA Family Medicine
@_familymedicine · X

https://t.co/SyIDlYChB5

Feb 23, 2022 · 5,585 followers View post →
Rodolfo J. Galindo MD
@RodolfoJGalindo · X

RT @DrBobGabbay: Nice to see a new med for #T2D #diabetes with good effect on A1c and weight loss https://t.co/CjeVE3BkyR

Feb 12, 2022 · 7 shares · 1,105 followers View post →
Irene Caballero
@irenecabmat · X

RT @CristobMorales: https://t.co/7YIwZ6gIzl Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Co…

Feb 10, 2022 · 11 shares · 995 followers View post →
Joshua Neumiller
@JoshuaNeumiller · X

RT @DrBobGabbay: Nice to see a new med for #T2D #diabetes with good effect on A1c and weight loss https://t.co/CjeVE3BkyR

Feb 10, 2022 · 7 shares · 151 followers View post →
Filip K. Knop
@Filip_Knop · X

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial | Clinical Pharmacy and Pharmacology | JAMA | JAMA Network https://t.co/UmlUzSME48

Feb 10, 2022 · 3 likes · 2,517 followers View post →
Ana Sanchez Bao
@ana_sanchez_bao · X

RT @CristobMorales: https://t.co/7YIwZ6gIzl Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Co…

Feb 10, 2022 · 11 shares · 1,093 followers View post →
Apostolos Tsapas
@atsapas · X

RT @DrBobGabbay: Nice to see a new med for #T2D #diabetes with good effect on A1c and weight loss https://t.co/CjeVE3BkyR

Feb 10, 2022 · 7 shares · 424 followers View post →
Johnson Thomas, MD, FACE
@JohnsonThomasMD · X

RT @DrKarlNadolsky: #tirzepatide + glargine resulted in outstanding weight loss and glycemic improvements in those with #ibesity and type 2…

Feb 10, 2022 · 10 shares · 2,336 followers View post →
Lorenzo Bertomeu
@BertomeuLorenzo · X

RT @CristobMorales: https://t.co/7YIwZ6gIzl Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Co…

Feb 9, 2022 · 11 shares · 1,411 followers View post →
Samar Hafida,MD
@Samarhafida · X

RT @DrKarlNadolsky: #tirzepatide + glargine resulted in outstanding weight loss and glycemic improvements in those with #ibesity and type 2…

Feb 9, 2022 · 10 shares · 605 followers View post →
Martín López de la Torre
@elendocrino · X

RT @CristobMorales: https://t.co/7YIwZ6gIzl Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Co…

Feb 9, 2022 · 11 shares · 2,951 followers View post →
Omar Meza
@Mezzled · X

RT @DrBobGabbay: Nice to see a new med for #T2D #diabetes with good effect on A1c and weight loss https://t.co/CjeVE3BkyR

Feb 9, 2022 · 7 shares · 66 followers View post →
American Diabetes Association - DiabetesPro
@ADA_DiabetesPro · X

RT @DrBobGabbay: Nice to see a new med for #T2D #diabetes with good effect on A1c and weight loss https://t.co/CjeVE3BkyR

Feb 9, 2022 · 7 shares · 27,073 followers View post →
Dr. Bob
@DrBobGabbay · X

Nice to see a new med for #T2D #diabetes with good effect on A1c and weight loss https://t.co/CjeVE3BkyR

Feb 9, 2022 · 6 likes · 7 shares · 1,330 followers View post →
Rishi Raj MD
@DrRishi_Raj · X

RT @DrKarlNadolsky: #tirzepatide + glargine resulted in outstanding weight loss and glycemic improvements in those with #ibesity and type 2…

Feb 9, 2022 · 10 shares · 678 followers View post →
Miguel A. Maria. Medico de Familia
@Miguel_A_Maria · X

The SURPASS-5 Randomized Clinical Trial https://t.co/DnY7pM92wl Tirzepatide añadido a Glargina Excelentes resultados ⤵️⤵️⤵️

Feb 9, 2022 · 1,328 followers View post →
McMaster Heart Function Education
@MacHeartFailure · X

RT @SeguraCardio:

Feb 9, 2022 · 11 shares · 512 followers View post →
Mike
@michaelscally · X

RT @DrKarlNadolsky: #tirzepatide + glargine resulted in outstanding weight loss and glycemic improvements in those with #ibesity and type 2…

Feb 9, 2022 · 10 shares · 894 followers View post →
Beverly G. Tchang, MD
@BevTchangMD · X

RT @DrKarlNadolsky: #tirzepatide + glargine resulted in outstanding weight loss and glycemic improvements in those with #ibesity and type 2…

Feb 9, 2022 · 10 shares · 6,142 followers View post →
Doc Gerry Tan
@docgerrytan · X

RT @DrKarlNadolsky: #tirzepatide + glargine resulted in outstanding weight loss and glycemic improvements in those with #ibesity and type 2…

Feb 9, 2022 · 10 shares · 310 followers View post →
Manuel Beltrán
@ManoloBeltranR · X

RT @CristobMorales: https://t.co/7YIwZ6gIzl Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Co…

Feb 9, 2022 · 11 shares · 581 followers View post →
Austin Baraki, MD
@AustinBaraki · X

RT @DrKarlNadolsky: #tirzepatide + glargine resulted in outstanding weight loss and glycemic improvements in those with #ibesity and type 2…

Feb 9, 2022 · 10 shares · 4,880 followers View post →
jiyrt
@jyrtp · X

RT @DrKarlNadolsky: #tirzepatide + glargine resulted in outstanding weight loss and glycemic improvements in those with #ibesity and type 2…

Feb 9, 2022 · 10 shares · 4 followers View post →
Deepak Ghimire
@Madlydeepak · X

RT @DrKarlNadolsky: #tirzepatide + glargine resulted in outstanding weight loss and glycemic improvements in those with #ibesity and type 2…

Feb 9, 2022 · 10 shares · 58 followers View post →
Karl Nadolsky
@DrKarlNadolsky · X

#tirzepatide + glargine resulted in outstanding weight loss and glycemic improvements in those with #ibesity and type 2 #diabetes JAMA. 2022;327(6):534-545. doi:10.1001/jama.2022.0078 https://t.co/hC10azu0Py https://t.co/zNomWMcYJ3

Feb 9, 2022 · 35 likes · 10 shares · 5,869 followers View post →
Physician Wall
@physicianwall · X

https://t.co/1EcKcHcWqD

Feb 9, 2022 · 42 followers View post →
Beatriz González Aguilera
@beatrizgonz86 · X

RT @CristobMorales: https://t.co/7YIwZ6gIzl Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Co…

Feb 9, 2022 · 11 shares · 666 followers View post →
Julián Alberto Hernández
@jualher81 · X

RT @CristobMorales: https://t.co/7YIwZ6gIzl Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Co…

Feb 9, 2022 · 11 shares · 319 followers View post →
Chema Fernandez
@chemachir · X

RT @CristobMorales: https://t.co/7YIwZ6gIzl Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Co…

Feb 9, 2022 · 11 shares · 3,837 followers View post →
JORGE FERNANDEZ
@drjorfer · X

Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial | Clinical Pharmacy and Pharmacology | JAMA | JAMA Network ✅✅✅

Feb 9, 2022 · 1,019 followers View post →
Angela Romero Zarante, MD
@ANGELARZ28 · X

RT @SeguraCardio:

Feb 8, 2022 · 11 shares · 311 followers View post →
Lorenzo Bertomeu
@BertomeuLorenzo · X

RT @SeguraCardio:

Feb 8, 2022 · 11 shares · 1,411 followers View post →
Carlos Perez.
@perez_busso · X

RT @SeguraCardio:

Feb 8, 2022 · 11 shares · 129 followers View post →
Italo Kumamoto
@fikkumamoto · X

RT @JAMA_current: Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous ti…

Feb 8, 2022 · 16 shares · 8,802 followers View post →
fausto heredia z.
@drfherediaz · X

RT @JAMA_current: Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous ti…

Feb 8, 2022 · 16 shares · 4,359 followers View post →
xxxichiroxxx_ID
@xxxichiroxxx_ID · X

RT @JAMA_current: Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous ti…

Feb 8, 2022 · 3 shares · 158 followers View post →
Juan Carlos Obaya
@jcobaya69 · X

RT @SeguraCardio:

Feb 8, 2022 · 11 shares · 858 followers View post →
Bernadette Toolan
@btoolanod · X

RT @JAMA_current: Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous ti…

Feb 8, 2022 · 16 shares · 989 followers View post →
DiObemir
@diabemir · X

RT @SeguraCardio:

Feb 8, 2022 · 11 shares · 939 followers View post →
Cristina Tejera
@cristinatejerap · X

RT @CristobMorales: https://t.co/7YIwZ6gIzl Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Co…

Feb 8, 2022 · 11 shares · 11,491 followers View post →
Javier Escalada #Yoelijoendocrino
@fjavesc · X

RT @CristobMorales: https://t.co/7YIwZ6gIzl Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Co…

Feb 8, 2022 · 11 shares · 3,625 followers View post →
Cristobal Morales
@CristobMorales · X

https://t.co/7YIwZ6gIzl Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes #SURPASS5trial Orgulloso de la participación de centros Españoles en esta gran innovación @SEDiabetes @LillyES https://t.co/2LldT4yKzp

Feb 8, 2022 · 27 likes · 11 shares · 17,088 followers View post →
CardioEd Bot
@CardioBot · X

RT @SeguraCardio:

Feb 8, 2022 · 11 shares · 1,207 followers View post →
Manuel Gaxiola
@cardiogax · X

RT @SeguraCardio:

Feb 8, 2022 · 11 shares · 7,995 followers View post →
Stefania Arciello
@StefaniaArciell · X

RT @SeguraCardio:

Feb 8, 2022 · 11 shares · 1,942 followers View post →
Dr. Sue Gross
@DrSueGross · X

RT @JAMA_current: Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous ti…

Feb 8, 2022 · 16 shares · 3,031 followers View post →
R Giovanni Diaz-Zavala
@DrGiovanniD · X

RT @SeguraCardio:

Feb 8, 2022 · 11 shares · 16,001 followers View post →
Diego Segura-Rodríguez
@SeguraCardio · X

Feb 8, 2022 · 34 likes · 11 shares · 25,836 followers View post →
Jose Daniel Mosquera Lozano
@jdmosqueral · X

RT @JAMA_current: Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous ti…

Feb 8, 2022 · 16 shares · 233 followers View post →
Anest_ArrietaO
@MariArrietaO1 · X

RT @JAMA_current: Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous ti…

Feb 8, 2022 · 3 shares · 592 followers View post →
Medical Research Library of Brooklyn
@DMCLibraryBKLYN · X

RT @JAMA_current: Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous ti…

Feb 8, 2022 · 16 shares · 328 followers View post →
Iridescent Ashes (Iridescent-Ashes at b sky)
@IridescentAshes · X

RT @JAMA_current: Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous ti…

Feb 8, 2022 · 3 shares · 1,409 followers View post →
UT Healthcare
@UTDHC · X

RT @JAMA_current: Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous ti…

Feb 8, 2022 · 16 shares · 1,859 followers View post →
Pub Health Monitor
@monitor_PH · X

RT @JAMA_current: Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous ti…

Feb 8, 2022 · 16 shares · 1,824 followers View post →
JAMA
@JAMA_current · X

Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous tirzepatide, vs placebo, to titrated insulin glargine resulted in statistically significant improvements in glycemic control after 40 wk. https://t.co/LlO1c0GpRr https://t.co/IqHycbTJAF

Feb 8, 2022 · 60 likes · 16 shares · 488,764 followers View post →
Pub Health Monitor
@monitor_PH · X

RT @JAMA_current: Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous ti…

Feb 8, 2022 · 3 shares · 1,824 followers View post →
JAMA
@JAMA_current · X

Study found, in pts w diabetes & inadequate glycemic control despite use of insulin glargine, addition of subcutaneous tirzepatide, vs placebo, to titrated insulin glargine resulted in statistically significant improvements in glycemic control after 40 wk. https://t.co/BFDnS4UTjX https://t.co/Hp3qoATtWG

Feb 8, 2022 · 8 likes · 3 shares · 488,764 followers View post →