PubHawk
February 2022 PMID 35172714

CROPSR: an automated platform for complex genome-wide CRISPR gRNA design and validation.

Hans Müller Paul, Dave D Istanto, Jacob Heldenbrand, Matthew E Hudson

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Mentions

29
Peak: 11 in Feb 2022
across 4 sources since Oct 2021

Extended reach

194,097
potential audience

Total likes

29

Video views

507

Mentions per month

Oct 2021 – Jan 2023

Where it's discussed

  • X / Twitter15 posts
  • News11 articles
  • Facebook2 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions focus on CROPSR's potential to improve gRNA design in complex crop genomes, with terms like 'accelerate genetic discoveries' and 'game changer' indicating perceived high impact. Comments also reflect a tone of cautious optimism, considering both its innovative features and potential for wider adoption in bioinformatics.

AgreementModerate agreement

Many discussions express support or positive recognition of CROPSR's usefulness, with comments highlighting its advantages for crop research and genome editing.

InterestModerate interest

The social discussions show moderate interest, with several tweets referencing developments and potential applications, but not in an overly enthusiastic or critical manner.

EngagementModerate engagement

Users actively share the article's main points, retweet, and comment on its implications, indicating a engaged but not deeply analytical interaction.

ImpactModerate impact

The mentions suggest that CROPSR is viewed as a promising tool that could significantly influence crop genetics and bioinformatics research, though some comments call for further evaluation.

Abstract in brief

  • CROPSR is an open-source platform designed to streamline the process of creating and validating guide RNA (gRNA) sequences for CRISPR gene editing in complex crop genomes, especially those with polyploid and repetitive regions.
  • Unlike existing tools mainly built for mammalian genomes, CROPSR is tailored for crop genomes, offering improved accuracy in predicting effective gRNAs and handling difficult genomic regions, which helps researchers save time and reduce failed experiments.
  • The tool employs a new machine learning model that enhances gRNA scoring accuracy across various genome types, providing a faster, more reliable workflow for crop geneticists to develop targeted genetic modifications for crop improvement.]
Read the full abstract

Top posts

Most liked on X and Bluesky
CRISP_SCIENCE
@ScienceCrisp · X

"CROPSR: an automated platform for complex genome-wide CRISPR gRNA design and validation" Paul HM, Istant DD, Heldenbrand J, Hudson ME. BMC Bioinformatics 2022-02-16. https://t.co/YAvl8retbe CROPSR reduces the challenges of working in crops ... https://t.co/jFMoMA4lpz

Feb 26, 2022 · 3 likes · 2 shares · 1,922 followers View post →
MΛRCOS COLEBROOK
@MColebrook · X

CROPSR: An Automated Platform for Complex Genome-Wide CRISPR gRNA Design and Validation https://t.co/oqWL7RLdpF > #BioInformatics #Bioinformática #Genomics https://t.co/ltxTv4UBKA

Oct 18, 2021 · 3 likes · 2 shares · 1,428 followers View post →
(((JReuben1)))
@jreuben1 · X

CROPSR: an automated platform for complex genome-wide CRISPR gRNA design and validation https://t.co/0QOHgbT8jY #bioinformatics

Feb 17, 2022 · 2 likes · 2 shares · 1,953 followers View post →
Leonardo Galindo-González
@leogg231 · X

#sgRNAdesign #CRISPR https://t.co/7xa9gG4LKS

Jun 2, 2022 · 2 likes · 32 followers View post →
Andrew Revkin
@Revkin · X

If we get to a world in which bioenergy is not a land-sparing, sustainable successor to fossil fuels, CROPSR sure looks like a key tool. Paper: https://t.co/2pqAfyiOMH Interested to hear pros/cons (will write at https://t.co/wXbES8P9jy). Part of @energy's https://t.co/xGYYYfPgNc https://t.co/rA7Ti7Yb7b

Feb 19, 2022 · 1 like · 84,821 followers View post →
BMC
@BioMedCentral · X

An article published in #BMCBioinformatics introduces CROPSR, an open-source tool for genome-wide design and evaluation of gRNA sequences for CRISPR. https://t.co/v5TaCnBb8r

Feb 26, 2022 · 1 like · 1 share · 75,401 followers View post →

All mentions

Leonardo Galindo-González
@leogg231 · X

#sgRNAdesign #CRISPR https://t.co/7xa9gG4LKS

Jun 2, 2022 · 2 likes · 32 followers View post →
Brian Jones
@bjj12345 · X

RT @ScienceCrisp: "CROPSR: an automated platform for complex genome-wide CRISPR gRNA design and validation" Paul HM, Istant DD, Heldenbrand…

Feb 27, 2022 · 2 shares · 432 followers View post →
Apriadi Situmorang
@ApriadiSitumor1 · X

RT @ScienceCrisp: "CROPSR: an automated platform for complex genome-wide CRISPR gRNA design and validation" Paul HM, Istant DD, Heldenbrand…

Feb 26, 2022 · 2 shares · 81 followers View post →
CRISP_SCIENCE
@ScienceCrisp · X

"CROPSR: an automated platform for complex genome-wide CRISPR gRNA design and validation" Paul HM, Istant DD, Heldenbrand J, Hudson ME. BMC Bioinformatics 2022-02-16. https://t.co/YAvl8retbe CROPSR reduces the challenges of working in crops ... https://t.co/jFMoMA4lpz

Feb 26, 2022 · 3 likes · 2 shares · 1,922 followers View post →
BMC
@BioMedCentral · X

An article published in #BMCBioinformatics introduces CROPSR, an open-source tool for genome-wide design and evaluation of gRNA sequences for CRISPR. https://t.co/v5TaCnBb8r

Feb 26, 2022 · 1 like · 1 share · 75,401 followers View post →
APCoAB
@APCoAB · X

CROPSR: A New Tool to Accelerate Genetic Discoveries in Crops https://t.co/BIdMVNnsGK https://t.co/vrmEaadcjP

Feb 23, 2022 · 1 like · 315 followers View post →
Andrew Revkin
@Revkin · X

If we get to a world in which bioenergy is not a land-sparing, sustainable successor to fossil fuels, CROPSR sure looks like a key tool. Paper: https://t.co/2pqAfyiOMH Interested to hear pros/cons (will write at https://t.co/wXbES8P9jy). Part of @energy's https://t.co/xGYYYfPgNc https://t.co/rA7Ti7Yb7b

Feb 19, 2022 · 1 like · 84,821 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

https://t.co/HXYvYozG66

Feb 17, 2022 · 2,568 followers View post →
CompChemBio Bot
@CompChemBioBot · X

RT @SeqComplete: #BioIT #BioInformatics CROPSR: an automated platform for complex genome-wide CRISPR gRNA design and validation https://t.c…

Feb 17, 2022 · 1 share · 2,761 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @jreuben1: CROPSR: an automated platform for complex genome-wide CRISPR gRNA design and validation https://t.co/0QOHgbT8jY #bioinformati…

Feb 17, 2022 · 2 shares · 8,157 followers View post →
CompChemBio Bot
@CompChemBioBot · X

RT @jreuben1: CROPSR: an automated platform for complex genome-wide CRISPR gRNA design and validation https://t.co/0QOHgbT8jY #bioinformati…

Feb 17, 2022 · 2 shares · 2,761 followers View post →
(((JReuben1)))
@jreuben1 · X

CROPSR: an automated platform for complex genome-wide CRISPR gRNA design and validation https://t.co/0QOHgbT8jY #bioinformatics

Feb 17, 2022 · 2 likes · 2 shares · 1,953 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @MColebrook: CROPSR: An Automated Platform for Complex Genome-Wide CRISPR gRNA Design and Validation https://t.co/oqWL7RLdpF > #BioInfor…

Oct 18, 2021 · 2 shares · 8,157 followers View post →
CompChemBio Bot
@CompChemBioBot · X

RT @MColebrook: CROPSR: An Automated Platform for Complex Genome-Wide CRISPR gRNA Design and Validation https://t.co/oqWL7RLdpF > #BioInfor…

Oct 18, 2021 · 2 shares · 2,761 followers View post →
MΛRCOS COLEBROOK
@MColebrook · X

CROPSR: An Automated Platform for Complex Genome-Wide CRISPR gRNA Design and Validation https://t.co/oqWL7RLdpF > #BioInformatics #Bioinformática #Genomics https://t.co/ltxTv4UBKA

Oct 18, 2021 · 3 likes · 2 shares · 1,428 followers View post →