February 2022 PMID 35194047

Randomized controlled trial for time-restricted eating in healthy volunteers without obesity.

Zhibo Xie, Yuning Sun, Yuqian Ye, Dandan Hu, Hua Zhang, Zhangyuting He, Haitao Zhao, Huayu Yang, Yilei Mao

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Mentions

124
Peak: 52 in Feb 2022
across 5 sources since Feb 2022

Extended reach

183,435
potential audience

Total likes

532

Video views

9,962

Mentions per month

Feb 2022 – Sep 2025

Where it's discussed

  • X / Twitter68 posts
  • News50 articles
  • YouTube3 videos
  • Facebook2 posts
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions demonstrate strong interest and agreement by referencing the study’s key findings, such as early time-restricted eating improving insulin sensitivity, and use of phrases like 'more effective' and 'beneficial.' The tone suggests optimism about the research’s potential influence on health practices, with some posts emphasizing the importance of respecting the circadian clock and timing of meals.

AgreementModerate agreement

Many posts support the findings that early time-restricted eating (eTRE) is more effective, indicating general agreement with the study’s conclusions.

InterestHigh interest

The discussion highlights widespread curiosity about the benefits of eating earlier in the day, showing high interest in the study and its implications.

EngagementModerate engagement

Posts often refer directly to the research methods and results, such as mentioning insulin sensitivity and metabolic benefits, suggesting active engagement.

ImpactModerate impact

The emphasis on the potential for dietary strategies to improve health points to moderate impact, but most awareness remains within the scientific and health communities.

Abstract in brief

  • The study was a five-week randomized trial comparing early time-restricted feeding (eTRF) and midday time-restricted feeding (mTRF) in healthy volunteers without obesity, showing that eTRF more effectively improved insulin sensitivity, fasting glucose, body mass, adiposity, inflammation, and gut microbial diversity.
  • Both regimens were well-tolerated with no serious adverse events, but only eTRF demonstrated significant benefits across multiple metabolic health markers.
  • The trial suggests that restricting food intake to the early part of the day may have greater metabolic benefits than limiting intake to midday, providing insights for optimizing dietary strategies for metabolic health.]

Top posts

Most liked on X and Bluesky
Joseph Takahashi
@CircadianClocks · X

Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is beneficial. Randomized controlled trial for time-restricted eating in healthy volunteers without obesity ⁦⁦⁦⁦@SRBR_Outreach⁩ https://t.co/YXFSYTwTlT

Feb 22, 2022 · 130 likes · 33 shares · 5,090 followers View post →
Jim Johnson, PhD
@JimJohnsonSci · X

Randomized controlled trial for time-restricted eating in healthy volunteers without obesity | Nature Communications https://t.co/aabgUyMXgS

Feb 22, 2022 · 27 likes · 4 shares · 12,799 followers View post →
Agingdoc
@agingdoc1 · X

Randomized controlled trial for time-restricted eating in healthy volunteers without obesity https://t.co/pqGWk1UFI9 @NatureComms

Feb 23, 2022 · 14 likes · 1 share · 41,315 followers View post →
htw
@heniek_htw · X

Randomized controlled trial for time-restricted eating in healthy volunteers without obesity https://t.co/QscjoEPXvS @SatchinPanda, @CircadianClocks, @HealthyFellow, @Grimhood, @nick_krontiris, @Tweet_Nutrition

Feb 22, 2022 · 13 likes · 4 shares · 11,262 followers View post →
Pon|食と健康
@PonNutr · X

#論文紹介 プチ断食で肥満や炎症を改善! ☑️6-15:00に食事をするeTRF ☑️11-20:00に食事をするmTRF をコントロール群と比較しています。 結果は圧倒的にeTRFが良く、インスリン、血糖コントロール、肥満や炎症のマーカー、腸内細菌に至るまでeTRFが良かったようです。 https://t.co/qsKdzbXKms https://t.co/fWnp9cgQ9C

Feb 27, 2022 · 13 likes · 1 share · 2,614 followers View post →
AuB株式会社
@AuBinc_official · X

午前中に寄せる時間制限の方が、インスリン抵抗性や体の代謝を改善したという結果 https://t.co/vg5xh02aji

Dec 18, 2022 · 6 likes · 1 share · 2,035 followers View post →

All mentions

Christophe Berg
@kristofberg.bsky.social · Bluesky

The inconvenient truth about Time Restricted Eating. 5-week randomized controlled trial for time-restricted eating in healthy volunteers shows that eTRE (06am to 3pm) is more effective than mTRE (11am to 8pm). www.nature.com/articles/s41... kristofberg.medium.com/the-inconven...

Jan 14, 2025 · 1 like View post →
Christophe Berg | Nomadic Trail Runner
@kristofberg · X

The inconvenient truth about Time Restricted Eating. 5-week randomized controlled trial for time-restricted eating in healthy volunteers shows that eTRE (06am to 3pm) is more effective than mTRE (11am to 8pm). https://t.co/oQKkIfvw1d https://t.co/LpaukmFFma

Jan 14, 2025 · 1 like · 1,126 followers View post →
Emily Manoogian
@EmilyManoogian · X

@ethanjweiss @CMichaelGibson @doctorveera Here are a few: Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: … https://t.co/uEGtP0KP3n Randomized controlled trial for time-restricted eating in healthy volunteers without obesity https://t.co/YyagQDGFtp

Mar 20, 2024 · 2 likes · 2,242 followers View post →
Six Pack Billy
@AbsurdlyWise · X

@CharismaKings 100% huh? https://t.co/4btsJSLaTq

Oct 8, 2023 · 115 followers View post →
Shannon Mccullar
@ShannonMccu11ar · X

Randomized Controlled Trial For Time-Restricted Eating In Healthy Volunteers Without Obesity https://t.co/Cwky4YMUFj

Aug 12, 2023 · 180 followers View post →
Andrew Maclennan
@getfaststrong · X

@Rob_NBF Yeah a lot of the time restricted eating research now shows it's way better to get the food in earlier in the day over later. https://t.co/kwVmBFg1x0.

Feb 4, 2023 · 1 like · 231 followers View post →
A
@Am_Lou64 · X

@Ayn_alaql رابط الدراسة: https://t.co/JQFWcTFuJg Randomized controlled trial for time-restricted eating in healthy volunteers without obesity

Dec 25, 2022 · 47 followers View post →
むえり
@goll_n · X

RT @AuBinc_official: 午前中に寄せる時間制限の方が、インスリン抵抗性や体の代謝を改善したという結果 https://t.co/vg5xh02aji

Dec 18, 2022 · 1 share · 262 followers View post →
AuB株式会社
@AuBinc_official · X

午前中に寄せる時間制限の方が、インスリン抵抗性や体の代謝を改善したという結果 https://t.co/vg5xh02aji

Dec 18, 2022 · 6 likes · 1 share · 2,035 followers View post →
D r a k o
@darko_edm · X

RT @jorgepadillamx: ¡Respeta tu reloj biológico!

Aug 25, 2022 · 2 shares · 261 followers View post →
Oscar Andres
@OscarAndresMD · X

RT @jorgepadillamx: ¡Respeta tu reloj biológico!

Aug 24, 2022 · 2 shares · 556 followers View post →
Jorge Padilla
@drjorgepadilla · X

¡Respeta tu reloj biológico!

Aug 24, 2022 · 3 likes · 2 shares · 551 followers View post →
Andrew Maclennan
@getfaststrong · X

@ChrisPalmerMD @meganjramos @drjasonfung @_CynthiaThurlow Randomized controlled trial for time-restricted eating in healthy volunteers without obesity Zhibo Xie et al... Seems to imply that the eating period is important, with early morning 7am-3pm much more effective than later in the day.

Aug 15, 2022 · 231 followers View post →
Fitcart.com
@fitcartofficial · X

RT @PhD_Leigh: Many people restrict their eating window to support #health (Time-Restricted Feeding). #Eating earlier in the day seems effe…

Apr 22, 2022 · 2 shares · 245 followers View post →
Villa
@Villa_M_J · X

RT @PhD_Leigh: Many people restrict their eating window to support #health (Time-Restricted Feeding). #Eating earlier in the day seems effe…

Apr 20, 2022 · 2 shares · 155 followers View post →
Leigh A. Frame
@PhD_Leigh · X

Many people restrict their eating window to support #health (Time-Restricted Feeding). #Eating earlier in the day seems effective while later in the day may not. Read the #science in this recent #research study: https://t.co/LaoIPY3Qat #nutrition #fasting #biohacking #lifestyle https://t.co/DVB7ElID7I

Apr 19, 2022 · 2 shares · 4,928 followers View post →
Greg Potter
@GregPotterPhD · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Mar 8, 2022 · 33 shares · 919 followers View post →
Mike Murray
@MikeMurrayRD · X

Early time-restricted eating was more effective than mid-day time-restricted eating at improving insulin sensitivity in participants with an average BMI of ~22. https://t.co/1n9IolFtrD

Feb 28, 2022 · 3 likes · 184 followers View post →
humanest
@humanest5 · X

RT @Pon_yurublog: #論文紹介 プチ断食で肥満や炎症を改善! ☑️6-15:00に食事をするeTRF ☑️11-20:00に食事をするmTRF をコントロール群と比較しています。 結果は圧倒的にeTRFが良く、インスリン、血糖コントロール、肥満や炎症のマーカ…

Feb 27, 2022 · 1 share · 313 followers View post →
Pon|食と健康
@PonNutr · X

#論文紹介 プチ断食で肥満や炎症を改善! ☑️6-15:00に食事をするeTRF ☑️11-20:00に食事をするmTRF をコントロール群と比較しています。 結果は圧倒的にeTRFが良く、インスリン、血糖コントロール、肥満や炎症のマーカー、腸内細菌に至るまでeTRFが良かったようです。 https://t.co/qsKdzbXKms https://t.co/fWnp9cgQ9C

Feb 27, 2022 · 13 likes · 1 share · 2,614 followers View post →
Santiago Rodríguez Seguí
@RSeguiLab · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 26, 2022 · 33 shares · 178 followers View post →
Kevin Davy
@davykevinp · X

Are we really ready to write home about this? Randomized controlled trial for time-restricted eating in healthy volunteers without obesity | Nature Communications https://t.co/oKm98SYZ8V

Feb 23, 2022 · 1,308 followers View post →
Ranjan Nanda
@RanjanN2022 · X

RT @agingdoc1: Randomized controlled trial for time-restricted eating in healthy volunteers without obesity https://t.co/pqGWk1UFI9 @Natu…

Feb 23, 2022 · 1 share · 382 followers View post →
Nemanja Milicevic
@nemanja_milicev · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 23, 2022 · 33 shares · 278 followers View post →
Bilal Chaudhry
@bchaudhry21 · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 23, 2022 · 33 shares · 99 followers View post →
ChronoBeforeBlueSky
@R_Dallmann · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 23, 2022 · 33 shares · 956 followers View post →
Linda Galliher
@LindaGalliher · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 23, 2022 · 33 shares · 840 followers View post →
Dinesh B. Jadhav
@Jdinesh525 · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 23, 2022 · 33 shares · 541 followers View post →
Bokai Zhu lab
@LabZhu · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 23, 2022 · 33 shares · 527 followers View post →
Sunset HQ
@SunsetHQBC · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 23, 2022 · 33 shares · 15 followers View post →
Güler Lab
@GulerLab · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 23, 2022 · 33 shares · 232 followers View post →
Yung-Chih Chen, PhD
@YungChih_CHEN · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 23, 2022 · 33 shares · 415 followers View post →
Matei Bolborea
@MateiBolborea · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 23, 2022 · 33 shares · 472 followers View post →
Adipose Papers
@adipose_papers · X

Randomized controlled trial for time-restricted eating in healthy volunteers without obesity https://t.co/FnFCaNGqPr https://t.co/P5GcdDCVZ1

Feb 23, 2022 · 1 like · 2,443 followers View post →
Agingdoc
@agingdoc1 · X

Randomized controlled trial for time-restricted eating in healthy volunteers without obesity https://t.co/pqGWk1UFI9 @NatureComms

Feb 23, 2022 · 14 likes · 1 share · 41,315 followers View post →
Carlos Colmenero
@colme99 · X

RT @nick_krontiris: Randomized controlled trial for time-restricted eating in healthy volunteers without obesity (open access) https://t.c…

Feb 23, 2022 · 2 shares · 77 followers View post →
John Andrew Todd
@ProfJohnATodd · X

RT @JimJohnsonSci: Randomized controlled trial for time-restricted eating in healthy volunteers without obesity | Nature Communications htt…

Feb 23, 2022 · 4 shares · 1,025 followers View post →
Eve Beavers
@espacetimeCO · X

RT @nick_krontiris: Randomized controlled trial for time-restricted eating in healthy volunteers without obesity (open access) https://t.c…

Feb 23, 2022 · 2 shares · 902 followers View post →
Dongyin Guan
@DongyinGuan · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 23, 2022 · 33 shares · 480 followers View post →
Nick Krontiris
@nick_krontiris · X

Randomized controlled trial for time-restricted eating in healthy volunteers without obesity (open access) https://t.co/1GG541wu1w #weightloss #nutrition #diet

Feb 23, 2022 · 1 like · 2 shares · 18,979 followers View post →
Lum Lab
@lum_lab · X

RT @JimJohnsonSci: Randomized controlled trial for time-restricted eating in healthy volunteers without obesity | Nature Communications htt…

Feb 22, 2022 · 4 shares · 1,208 followers View post →
Public Journal Club Neurobiology
@PJCNeurobiology · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 657 followers View post →
Han Wang
@twzhw09 · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 593 followers View post →
Dr. Helen E. Collins
@DrHelenECollin1 · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 2,194 followers View post →
Cristina de la Mata
@Crisirenedlm · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 282 followers View post →
Harry Pantazopoulos
@HarryPantazopo1 · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 174 followers View post →
Eve Beavers
@espacetimeCO · X

RT @JimJohnsonSci: Randomized controlled trial for time-restricted eating in healthy volunteers without obesity | Nature Communications htt…

Feb 22, 2022 · 4 shares · 902 followers View post →
Lauren Douma, PhD
@DoumaPhD · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 421 followers View post →
John Hogenesch
@jbhclock · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 2,981 followers View post →
Catalina Ramírez-Contreras
@cataramirezc · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 446 followers View post →
Jonathan Johnston
@JJ_clock · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 666 followers View post →
Dr. Girish Melkani
@DrMelkani · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 125 followers View post →
Jonathan Cedernaes
@JCedernaes · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 3,125 followers View post →
Society for Research on Biological Rhythms
@SRBR_Outreach · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 5,455 followers View post →
Juhana Harju
@JuhanaHarju · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 1,690 followers View post →
Omar Hammouda
@HammoudaOm · X

RT @heniek_htw: Randomized controlled trial for time-restricted eating in healthy volunteers without obesity https://t.co/QscjoEPXvS @Satc…

Feb 22, 2022 · 4 shares · 807 followers View post →
Aguilar-Arnal lab
@lwrena · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 566 followers View post →
Javier Cavieres Lepe
@Javi__Cavieres · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 192 followers View post →
Prashant
@p7p8p9p · X

RT @heniek_htw: Randomized controlled trial for time-restricted eating in healthy volunteers without obesity https://t.co/QscjoEPXvS @Satc…

Feb 22, 2022 · 4 shares · 192 followers View post →
J P Fanton
@HealthyFellow · X

RT @heniek_htw: Randomized controlled trial for time-restricted eating in healthy volunteers without obesity https://t.co/QscjoEPXvS @Satc…

Feb 22, 2022 · 4 shares · 26,022 followers View post →
Christophe Berg | Nomadic Trail Runner
@kristofberg · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 1,126 followers View post →
Carlos Colmenero
@colme99 · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 77 followers View post →
licmartinduraes
@licmartinduraes · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 173 followers View post →
Ryan Logan
@wickedneuro · X

RT @CircadianClocks: Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is benef…

Feb 22, 2022 · 33 shares · 2,933 followers View post →
Joseph Takahashi
@CircadianClocks · X

Don’t skip breakfast if you are using time-restricted eating. Nice to see evidence that early phase of eating is beneficial. Randomized controlled trial for time-restricted eating in healthy volunteers without obesity ⁦⁦⁦⁦@SRBR_Outreach⁩ https://t.co/YXFSYTwTlT

Feb 22, 2022 · 130 likes · 33 shares · 5,090 followers View post →
Amaya Lopez-Pascual
@amayalpzp · X

RT @JimJohnsonSci: Randomized controlled trial for time-restricted eating in healthy volunteers without obesity | Nature Communications htt…

Feb 22, 2022 · 4 shares · 274 followers View post →
Jim Johnson, PhD
@JimJohnsonSci · X

Randomized controlled trial for time-restricted eating in healthy volunteers without obesity | Nature Communications https://t.co/aabgUyMXgS

Feb 22, 2022 · 27 likes · 4 shares · 12,799 followers View post →
Carlos Colmenero
@colme99 · X

RT @heniek_htw: Randomized controlled trial for time-restricted eating in healthy volunteers without obesity https://t.co/QscjoEPXvS @Satc…

Feb 22, 2022 · 4 shares · 77 followers View post →
htw
@heniek_htw · X

Randomized controlled trial for time-restricted eating in healthy volunteers without obesity https://t.co/QscjoEPXvS @SatchinPanda, @CircadianClocks, @HealthyFellow, @Grimhood, @nick_krontiris, @Tweet_Nutrition

Feb 22, 2022 · 13 likes · 4 shares · 11,262 followers View post →