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Many discussions highlight specific aspects of the study, such as the impact of transient OSKM reprogramming on metabolic markers, with phrases like 'game changer' and 'amazing paper' reflecting excitement. The choice of impactful vocabulary and expressions of potential future applications contribute to a positive and engaged sentiment regarding the publication's implications.
Most discussions express overall support for the publication's findings, although some caution against premature conclusions.
A strong curiosity and enthusiasm for the publication is evident, with many participants discussing potential applications and implications.
While many posts delve into specifics, some appear to be more casual, lacking deep technical discussion.
There is a consensus that the publication could have significant ramifications for the field of aging research.
What happens if you only express the Yamanaka factors in mice for 1 week? i explore the recent multi-omic analysis paper here --> https://t.co/JA5lnJLeNa #scicomm #AcademicYouTube #aging https://t.co/RPy8U7XwUD
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming Dafni Chondronasiou, Manuel Serrano & colleagues including @MariaAbadMendez @ReikLab @Diljeet_Gill @altos_labs @biorxivpreprint
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/ZSZZ49vSzU
Paper alert! 'Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming' is now out @AgingCell - congratulations to all involved, including Reik Lab @Diljeet_Gill!
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/Yil6jN0mnf
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/H8VAw9J9fL
The power of the four Yamanaka factors OSKM can reverse aging markers without changing cell identity. This video explores how a single cycle of transient expression affects gene expression, DNA methylation, and…
@pzura @IntEngineering https://t.co/NnveYM76tV Maybe they achieved to increase mice lifespan since! Another thing: the "rejuvenation" technique used here relies on a genetic system which has to be inserted in the target's genome, currently we are decades away from being able to do so in an adult human
@SchonfeldGaston @BioProtocol
@BrendaN64146511 @BioProtocol
@A___whm1
@AnotherDNF2 @BioProtocol
@IDanihernandez @BioProtocol
@robert_exponent @aubreydegrey @BioProtocol ⚠️ Pancreas takes the hit first! Transient OSKM (0.2 mg/mL dox, 1 week) causes focal dysplasia and loss of differentiation markers there, but critically these changes reverse within 2 weeks (DOI: 10.1111/acel.13578). The safety window is narrow: full pluripotency markers like
@AmvSakura
@brdkig
@smdh1231 The liver acts as the body's metabolic command center - rejuvenating it triggers systemic benefits. OSKM reprogramming in mouse liver improved serum markers and shifted four aging metabolites toward youthful levels systemically (DOI: 10.1111/acel.13578). Young plasma restored
@amogsuadsa @BioProtocol Transient OSKM reprogramming already triggers metabolic resets - four aging metabolites shifted toward youthful levels in aged mice (DOI: 10.1111/acel.13578). The recovery phase proved critical for durable epigenetic changes. Stacking deliberate metabolic interventions
@icedlatte2304 @BioProtocol Transient OSKM cycles reverse age methylation without causing pluripotency - the recovery phase between cycles proves critical for durable epigenetic changes (DOI: 10.1111/acel.13578). SB000 factor achieves transcriptomic rejuvenation while maintaining somatic identity scores,
@MJk9656 @BioProtocol Liver-first OSKM is our metabolic command center hack. Single-cycle hepatocyte reprogramming reversed aging markers across pancreas, liver, spleen, blood—shifting metabolites toward youth (DOI: 10.1111/acel.13578). While mitochondrial import pathways respond to targeted
@Julius_vibe OSKM transients already reverse age methylation in pancreas (DOI: 10.1111/acel.13578), but cancer risk lurks. REGene data (DOI: 10.1038/srep23167) confirms the terrifying overlap—regeneration genes ARE cancer genes. Your hypothesis works IF we target non-oncogenic epigenetic
@MJk9656 @BioProtocol
@NunzioCuzzucoli There’s no near-ready in vivo OSKM reprogramming via drinking water. We’ve seen a youth signature in liver & can theorise why. The heart + blood -unchanged. Any de facto rejuv. method in vivo via reprogramming is not evidenced until reversal of BM age; https://t.co/QcYBGCySVy
山中先生のiPS細胞を作る過程を、マウス個体に一時的に起こすと、老化とともに起こる遺伝子の「使い方」がリセットされ、「若返る」らしい✨ https://t.co/4oL0HbOdCW
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/7BCC1epWGk #ScientiaVH
Reprogramming - pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM). These observations indicate that a single period of OSKM expression can drive epigenetic and transcriptomic changes toward a younger configuration in multiple tissues and in the serum. https://t.co/1kMK7wbRu7
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/fUJh5lik1C #hvhebron #onco [Text complet]
PubMed-https://t.co/39pvXgMLIv Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming @HUCA_Asturias #publiHUCA @FINBAsturias @IUOPA
RT @MASogorb: Logran rejuvenecer órganos mediante reprogramación celular https://t.co/3SnLkPp063 Más información: Multi-omic rejuvenation o…
Logran rejuvenecer órganos mediante reprogramación celular https://t.co/3SnLkPp063 Más información: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/9GhoKUAH2E
An interesting paper from Reik's lab at the Babraham Institute that may open the road to identify genes that rejuvenate without reprogramming, and specifically target those to reduce the effects of ageing. #ageing #epigenetics https://t.co/rLcZmxoMFL
10.Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming - https://t.co/SazPbgDhhy
RT @msmelanoma: Wow! Rejuvenation of various tissues and organs in naturally aged mice! Reversión parcial de efectos del envejecimiento. En…
RT @msmelanoma: Wow! Rejuvenation of various tissues and organs in naturally aged mice! Reversión parcial de efectos del envejecimiento. En…
Wow! Rejuvenation of various tissues and organs in naturally aged mice! Reversión parcial de efectos del envejecimiento. En modelos experimentales, pero con múltiples implicaciones!
RT @YuanchengLu: Comprehensive paper from Serrano group and @ReikLab, showing that one week of OSKM induction in 1y-old-mice rejuvenates…
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/VWgYP6Qt3b To gain mechanistic insights into ageing and longevity: https://t.co/Sw8UbalWKl https://t.co/ujJwFcZlBD https://t.co/nGUrK4yt3S https://t.co/FA8rkC5Za7 https://t.co/BLOXcKZ6vD
2 recent papers use limited Yamanaka factor reprogramming to rejuvenate mice. Serrano's group achieved better aging phenotypes in more varied tissues than Izpisua Belmonte's. Likely due to differing OSKM expresson patterns in doxy inducible mouse strains! https://t.co/zKEtSqiTiu
@CharlesMBrenner Thanks — good insights. This was actually the BETTER of the two papers published almost scientifically: the one I'm haranguing @agingdoc1 about is https://t.co/rwpyeC2ojY
Two papers out on cellular reprogramming altering #age-related molecular changes in mice: Jasper lab @genentech Belmonte lab @salkinstitute @NatureAging https://t.co/joMvKm9SP3 Serrano lab #BIST #ICREA @AgingCell https://t.co/EvBdOyhtV2
RT @EleanorSheekey: What happens if you only express the Yamanaka factors in mice for 1 week? i explore the recent multi-omic analysis pap…
RT @YuanchengLu: Comprehensive paper from Serrano group and @ReikLab, showing that one week of OSKM induction in 1y-old-mice rejuvenates…
RT @YuanchengLu: Comprehensive paper from Serrano group and @ReikLab, showing that one week of OSKM induction in 1y-old-mice rejuvenates…
RT @YuanchengLu: Comprehensive paper from Serrano group and @ReikLab, showing that one week of OSKM induction in 1y-old-mice rejuvenates…
RT @FrezzaLab: Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/Yil6jN0mnf
RT @EleanorSheekey: What happens if you only express the Yamanaka factors in mice for 1 week? i explore the recent multi-omic analysis pap…
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/Yil6jN0mnf
RT @ReikLab: Paper alert! 'Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming' is now out @Agin…
RT @EleanorSheekey: What happens if you only express the Yamanaka factors in mice for 1 week? i explore the recent multi-omic analysis pap…
RT @EleanorSheekey: What happens if you only express the Yamanaka factors in mice for 1 week? i explore the recent multi-omic analysis pap…
RT @EleanorSheekey: What happens if you only express the Yamanaka factors in mice for 1 week? i explore the recent multi-omic analysis pap…
What happens if you only express the Yamanaka factors in mice for 1 week? i explore the recent multi-omic analysis paper here --> https://t.co/JA5lnJLeNa #scicomm #AcademicYouTube #aging https://t.co/RPy8U7XwUD
RT @YuanchengLu: Comprehensive paper from Serrano group and @ReikLab, showing that one week of OSKM induction in 1y-old-mice rejuvenates…
RT @YuanchengLu: Comprehensive paper from Serrano group and @ReikLab, showing that one week of OSKM induction in 1y-old-mice rejuvenates…
RT @YuanchengLu: Comprehensive paper from Serrano group and @ReikLab, showing that one week of OSKM induction in 1y-old-mice rejuvenates…
RT @YuanchengLu: Comprehensive paper from Serrano group and @ReikLab, showing that one week of OSKM induction in 1y-old-mice rejuvenates…
RT @YuanchengLu: Comprehensive paper from Serrano group and @ReikLab, showing that one week of OSKM induction in 1y-old-mice rejuvenates…
https://t.co/Fik8iEZRUh
RT @ReikLab: Paper alert! 'Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming' is now out @Agin…
RT @BabrahamInst: Congratulations to @Diljeet_Gill @ReikLab and collaborators at @IRBBarcelona on their latest publication looking at the e…
#FightAging #EndAging #Lifespan #Healthspan https://t.co/meTJU5VqRE?
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming - Chondronasiou - - Aging Cell - Wiley Online Library https://t.co/uLh93eo1SC
RT @YuanchengLu: Comprehensive paper from Serrano group and @ReikLab, showing that one week of OSKM induction in 1y-old-mice rejuvenates…
Comprehensive paper from Serrano group and @ReikLab, showing that one week of OSKM induction in 1y-old-mice rejuvenates DNAm and transcription patterns in multiple internal organs and even restores several serum metabolites. #invivoreprogramming https://t.co/87CdpB1vqD
https://t.co/rWZ90e8Fp4
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogrammin... https://t.co/3SQK6uYECr
RT @ReikLab: Paper alert! 'Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming' is now out @Agin…
RT @ReikLab: Paper alert! 'Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming' is now out @Agin…
RT @Metabbot: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. Aging Cell #metabolomics http…
RT @AgingBiology: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/H8VAw9J9fL
RT @ReikLab: Paper alert! 'Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming' is now out @Agin…
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. Aging Cell #metabolomics https://t.co/5g4u8iYrhq
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/LH1gWsOXOp To gain mechanistic insights into ageing and longevity: https://t.co/ev3fKAzN5D https://t.co/Sw8UbalWKl https://t.co/ujJwFcZlBD
Might be of interest to my #longevity peeps. However... - Effect on lifespan uncertain - Epigenetic reprogramming far from complete compared to 'young' status. Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/lGDiaE3pcD
RT @BabrahamInst: Congratulations to @Diljeet_Gill @ReikLab and collaborators at @IRBBarcelona on their latest publication looking at the e…
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/H8VAw9J9fL
Congratulations to @Diljeet_Gill @ReikLab and collaborators at @IRBBarcelona on their latest publication looking at the effect of #reprogramming on reversing age-associated methylation in different tissues in mice Read here: https://t.co/Bf8uIFUtYW #Epigenetics #Ageing
RT @ReikLab: Paper alert! 'Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming' is now out @Agin…
RT @agingdoc1: Preprint below is now published @AgingCell Multi-omic rejuvenation of naturally aged tissues by a single cycle of transien…
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/fUJh5lik1C #hvhebron #onco [Text complet]
RT @mcollado_CHUS: A new paper by Serrano´s group @IRBBarcelona on rejuvenation by reprogramming. Congrats to first author @DChondronasiou…
RT @mcollado_CHUS: A new paper by Serrano´s group @IRBBarcelona on rejuvenation by reprogramming. Congrats to first author @DChondronasiou…
Paper alert! 'Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming' is now out @AgingCell - congratulations to all involved, including Reik Lab @Diljeet_Gill!
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming - Chondronasiou - - Aging Cell - Wiley Online Library https://t.co/vw5VFbFNpb
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/xVallZnuaX 小鼠体内短暂的OSKM山中因子表达，就足以逆转胰腺、肝脏、脾脏和血液中的DNA甲基化，并且衰老导致的血清代谢物和生物标志物在重编程后也恢复到年轻水平。
RT @mcollado_CHUS: A new paper by Serrano´s group @IRBBarcelona on rejuvenation by reprogramming. Congrats to first author @DChondronasiou…
RT @mcollado_CHUS: A new paper by Serrano´s group @IRBBarcelona on rejuvenation by reprogramming. Congrats to first author @DChondronasiou…
RT @mcollado_CHUS: A new paper by Serrano´s group @IRBBarcelona on rejuvenation by reprogramming. Congrats to first author @DChondronasiou…
A new paper by Serrano´s group @IRBBarcelona on rejuvenation by reprogramming. Congrats to first author @DChondronasiou and all the team: "Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming" https://t.co/rnfPTmrPcK
RT @agingdoc1: Preprint below is now published @AgingCell Multi-omic rejuvenation of naturally aged tissues by a single cycle of transien…
RT @agingdoc1: Preprint below is now published @AgingCell Multi-omic rejuvenation of naturally aged tissues by a single cycle of transien…
Preprint below is now published @AgingCell Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
RT @epicancerpapers: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/93XH8elbwv
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/93XH8elbwv
New article: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/yAhKL0Lrvx #livercancer #oncology https://t.co/lhoFo9RcSz
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/A3vicXNK3Z
RT @ReikLab: Preprint alert!
RT @pundhir_sachin: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/pgMaTTMIKW…
RT @AgingBiology: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/ZSZZ49vSzU
Amazing paper!
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @pundhir_sachin: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/pgMaTTMIKW…
RT @ReikLab: Preprint alert!
RT @ReikLab: Preprint alert!
RT @AgingBiology: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/ZSZZ49vSzU
RT @AgingBiology: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/ZSZZ49vSzU
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/ZSZZ49vSzU
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/pgMaTTMIKW @Diljeet_Gill @ReikLab
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming Dafni Chondronasiou, Manuel Serrano & colleagues including @MariaAbadMendez @ReikLab @Diljeet_Gill @altos_labs @biorxivpreprint
RT @ReikLab: Preprint alert!
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @ReikLab: Preprint alert!
RT @ReikLab: Preprint alert!
RT @martinperaJAX: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/d8GJDND8t7
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @ReikLab: Preprint alert!
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming https://t.co/Il2s2tC9yi
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @ReikLab: Preprint alert!
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @ReikLab: Preprint alert!
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @mcollado_CHUS: "Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming". Nuevo ejemplo de rejuv…
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @ReikLab: Preprint alert!
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming #Altoslabs @altos_labs https://... https://t.co/xX9UlNYJS7
RT @MartinD79: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming. New preprint by @altos_labs…
RT @ReikLab: Preprint alert!
RT @ReikLab: Preprint alert!