positive results in small NR phase I trial for Parkinson’s disease. larger trial started https://t.co/6ckMM8bVN7
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease.
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Mar 2022 – Aug 2025Where it's discussed
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X / Twitter89 posts
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News29 articles
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Blogs6 articles
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Facebook4 posts
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Reddit4 posts
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AI synopsis
What people are saying
Several discussions highlight key findings from the NADPARK study, such as the mention of increased NAD levels and mild clinical improvements. For instance, users expressed sentiments like 'promising results' and noted the 'first small positive result in human Parkinson's,' employing a tone that conveys cautious optimism. However, some posts raised concerns about data interpretation, using phrases like 'disappointing that...' which reflects a nuanced perspective on the study's outcomes.
The majority of discussions generally express support for the findings of the NADPARK study, although some posts voice skepticism about the study's efficacy.
There is a high level of curiosity surrounding the topic, with many individuals engaging with the research and its implications for Parkinson's treatment.
While some posts provide detailed analysis and reference methodology, others show a more surface-level engagement with the results.
Although there is some optimism about the potential applications of nicotinamide riboside, a portion of discussions suggests a belief that the overall significance may be limited.
Abstract in brief
- We conducted a phase I clinical trial to assess the safety and efficacy of nicotinamide riboside (NR) for boosting NAD levels in Parkinson's disease patients.
- NR treatment was well tolerated, leading to a significant increase in cerebral NAD levels and associated metabolic changes, which correlated with mild clinical improvements.
- The study suggests that NR may offer neuroprotective benefits for Parkinson's disease, highlighting the need for further research.
Top posts
Most liked on X and BlueskyIn @Cell_Metabolism “The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease” https://t.co/wJFqErXPNl
Encouraging results from our phase-I trial! The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://t.co/v6j6Clh9vR
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://t.co/WCLuHXeS32
NADの前駆体はNRニコチンアミドリボシド 経口NRでも血液脳関門を通過して脳NADレベル増加 パーキンソン病だとミトコンドリアの電子伝達系がイカれてるから、それをNRが回復させて神経保護作用を示してるっぽい。サイトカインも減って炎症が和らいでる 脂肪合成も減る https://t.co/OrPHaaL2CV
Phase I double blind study of NAD in Parkinson: "Boosting cellular levels nicotinamide adenine dinucleotide may confer neuroprotective effects both healthy aging and neurodegeneration." A lot of speculation and not sure why they use neuroprotective word. https://t.co/wyADkpcOUt https://t.co/aX7Vo8eFvZ
All mentions
Comparing NMN and NR Supplements for Healthy Aging
This video explores the growing interest in NMN and NR supplements and their potential benefits. Focused on scientific findings, it examines which supplement may be more effective for boosting NAD levels and the…
@MurgesJohn https://t.co/RksE2zNhpi - promising results from an NAD Precursor
NADPARK 研究: パーキンソン病におけるニコチンアミドリボシド補給のランダム化第 I 相試験 「私たちの研究結果は、ニコチンアミドリポシド が PD の潜在的な神経保護療法であると示唆しており、より大規模な試験でさらに調査する必要があることを示しています。」 https://t.co/6qzLQK1Ebw
RT @Kevin_J_Collins: @AlexJLeaf @CharlesMBrenner https://t.co/6Wg2vS5oxR
@AlexJLeaf @CharlesMBrenner https://t.co/6Wg2vS5oxR
NADの前駆体はNRニコチンアミドリボシド 経口NRでも血液脳関門を通過して脳NADレベル増加 パーキンソン病だとミトコンドリアの電子伝達系がイカれてるから、それをNRが回復させて神経保護作用を示してるっぽい。サイトカインも減って炎症が和らいでる 脂肪合成も減る https://t.co/OrPHaaL2CV
@kanonb05 mean age was 63 https://t.co/12nSJEmeav
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://t.co/mxl1MnoUQk
@LeveneDarren there are mouse data on protection against diabetic neuropathy from my lab since '16 lots of rodent data in chemo-neuropathy & central neuroprotection as well 1st small positive result in human Parkinson's is out more trials in process https://t.co/y19UnOglKv
RT @drmikehart: A randomized controlled trial on NAD+ boosting supplement Nicotinamide ribonucleoside (NR) has concluded that NR may effect…
A randomized controlled trial on NAD+ boosting supplement Nicotinamide ribonucleoside (NR) has concluded that NR may effectively treat symptoms of Parkinson's disease. https://t.co/R9BZvRfjOy
RT @MichaelOkun: Phase I double blind study of NAD in Parkinson: "Boosting cellular levels nicotinamide adenine dinucleotide may confer neu…
RT @MichaelOkun: Phase I double blind study of NAD in Parkinson: "Boosting cellular levels nicotinamide adenine dinucleotide may confer neu…
https://pubmed.ncbi.nlm.nih.gov/35235774/
Phase I double blind study of NAD in Parkinson: "Boosting cellular levels nicotinamide adenine dinucleotide may confer neuroprotective effects both healthy aging and neurodegeneration." A lot of speculation and not sure why they use neuroprotective word. https://t.co/wyADkpcOUt https://t.co/aX7Vo8eFvZ
Niacinamide riboside for Parkinson's treatment. Dosage =1000mg daily Can be achieved by the same amount of regular niacinamide / B3 https://t.co/ahbobyNO90 https://t.co/OISRMxGPNs
▪️ impacts cerebral metabolism in Parkinson's disease
Targeting the brain's energy metabolism may hold the key for treating Parkinson's disease https://t.co/laD1edOj77 https://t.co/HRX51rgGYZ https://t.co/mxCwhH1wht
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease: Cell Metabolism https://t.co/M6tGorIfUm
Trial of nicotinamide riboside supplementation in #Parkinsons. Increased brain NAD+ in 10/15, increased glucose metabolism in those with ⬆️NAD+, ⬇️ inflammatory cytokines and mild improvement in clinical symptoms. https://t.co/9yStXUNUrP https://t.co/vER1S80ayp
RT @Cell_Metabolism: The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://…
RT @NatureAging: In @Cell_Metabolism “The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s…
RT @raphaels7: https://t.co/1Txfv7Ic1k disappointing that nicotinamide riboside supplementation in Parkinson's disease patients didn't tran…
https://t.co/1Txfv7Ic1k disappointing that nicotinamide riboside supplementation in Parkinson's disease patients didn't translate to improved clinical motor symptoms NAD is more NAD levels?
RT @NatureAging: In @Cell_Metabolism “The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s…
RT @NatureAging: In @Cell_Metabolism “The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s…
In @Cell_Metabolism “The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease” https://t.co/wJFqErXPNl
The NADPARK study: A randomized phase I trial of nicotinamide riboside... https://t.co/mQdmIgQkW9
Wake up editors/reviewers! Really a shame that the authors on this paper got away with performing t-tests and Wilcoxon tests on the data. The data analysis clearly confounds the interpretation and should be redone! https://t.co/47UqFNjqln
RT @FinishALS: NR in Parkinson’s Disease. Possible implications for ALS. https://t.co/fsuA8U88iX
RT @FinishALS: NR in Parkinson’s Disease. Possible implications for ALS. https://t.co/fsuA8U88iX
RT @CharlesMBrenner: positive results in small NR phase I trial for Parkinson’s disease. larger trial started https://t.co/6ckMM8bVN7
RT @CharlesMBrenner: positive results in small NR phase I trial for Parkinson’s disease. larger trial started https://t.co/6ckMM8bVN7
RT @FinishALS: NR in Parkinson’s Disease. Possible implications for ALS. https://t.co/fsuA8U88iX
RT @babataiki326: NADはパーキンソン病患者を救うか!?(Cell Metab) 新規診断の未治療PD患者30名を対象に、NR*経口投与 (1000 mg/day, 30 days)の第1相試験が行われた (NR=15 vs placebo=15)。NR投与…
RT @UpToPhate: The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease https://t.co/r…
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease https://t.co/rpRYN5YGTQ
RT @babataiki326: NADはパーキンソン病患者を救うか!?(Cell Metab) 新規診断の未治療PD患者30名を対象に、NR*経口投与 (1000 mg/day, 30 days)の第1相試験が行われた (NR=15 vs placebo=15)。NR投与…
NADはパーキンソン病患者を救うか!?(Cell Metab) 新規診断の未治療PD患者30名を対象に、NR*経口投与 (1000 mg/day, 30 days)の第1相試験が行われた (NR=15 vs placebo=15)。NR投与でのNAD↑ & 炎症性サイトカイン↓ in 血清 & CSF、軽度の臨床的改善! #2022年論文紹介63 https://t.co/MDd3SJsQpp
Trend new: Brakedal B, ..., Tzoulis C (Cell Metab) __The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease__ https://t.co/4curiMxcgR
RT @agingdoc1: The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://t.co/…
RT @Cell_Metabolism: The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://…
RT @ad_papers: The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease. Cell Metab #A…
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease https://t.co/4BVl5dYu0B of note: clinical trial with NR, 31P MRS and 18FDG PET in brains and cerebrospinal fluid, transcriptomics and metabolomics in blood and muscle
RT @CharlesMBrenner: positive results in small NR phase I trial for Parkinson’s disease. larger trial started https://t.co/6ckMM8bVN7
RT @agingdoc1: The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://t.co/…
RT @chtzoulis: Encouraging results from our phase-I trial! The NADPARK study: A randomized phase I trial of nicotinamide riboside supplem…
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease https://t.co/NXNwqjtCUm
RT @Metabbot: The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease. Cell Metab #me…
RT @nick_krontiris: The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease (open acc…
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease. Cell Metab #metabolomics https://t.co/Xo0cDQKI8L
RT @Cell_Metabolism: The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://…
RT @nick_krontiris: The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease (open acc…
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://t.co/WCLuHXeS32
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease (open access) https://t.co/UzOAUE6udu https://t.co/5KEbhic1Wm
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease https://t.co/z19ozyect4 https://t.co/Qw1LCfjaKw
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease https://t.co/7GUJs0R9nI https://t.co/TBhPt7mu66
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease. Cell Metab #Alzheimers https://t.co/56XnCWw46r
RT @CharlesMBrenner: positive results in small NR phase I trial for Parkinson’s disease. larger trial started https://t.co/6ckMM8bVN7
New article: The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease https://t.co/Sft0KG0cW2 #parkinsons #neurology https://t.co/eqFs18vlRG
RT @ScienceofPD: Wow - @brage_ @chtzoulis & colleagues present the results of the NADPARK study: A randomized phase I trial of nicotinamide…
RT @r_calv: The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://t.co/ZDp…
RT @jorgensenmc1: The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease: Cell Metab…
RT @CharlesMBrenner: positive results in small NR phase I trial for Parkinson’s disease. larger trial started https://t.co/6ckMM8bVN7
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://t.co/ZDpQiBdziN
RT @ScienceofPD: Wow - @brage_ @chtzoulis & colleagues present the results of the NADPARK study: A randomized phase I trial of nicotinamide…
RT @CharlesMBrenner: positive results in small NR phase I trial for Parkinson’s disease. larger trial started https://t.co/6ckMM8bVN7
RT @CharlesMBrenner: positive results in small NR phase I trial for Parkinson’s disease. larger trial started https://t.co/6ckMM8bVN7
RT @CharlesMBrenner: positive results in small NR phase I trial for Parkinson’s disease. larger trial started https://t.co/6ckMM8bVN7
RT @ScienceofPD: Wow - @brage_ @chtzoulis & colleagues present the results of the NADPARK study: A randomized phase I trial of nicotinamide…
RT @ScienceofPD: Wow - @brage_ @chtzoulis & colleagues present the results of the NADPARK study: A randomized phase I trial of nicotinamide…
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://t.co/ki11nc5snb
RT @CharlesMBrenner: positive results in small NR phase I trial for Parkinson’s disease. larger trial started https://t.co/6ckMM8bVN7
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease: Cell Metabolism https://t.co/FC2IVge0cH
RT @chtzoulis: Encouraging results from our phase-I trial! The NADPARK study: A randomized phase I trial of nicotinamide riboside supplem…
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://t.co/cWt3JxKCqY
RT @CharlesMBrenner: positive results in small NR phase I trial for Parkinson’s disease. larger trial started https://t.co/6ckMM8bVN7
positive results in small NR phase I trial for Parkinson’s disease. larger trial started https://t.co/6ckMM8bVN7
RT @Padraig1991: @CharlesMBrenner Non-relevant. I’m sure you’re read it. But being that you are the one who discovered NR as a NAD precurso…
RT @Padraig1991: @CharlesMBrenner Non-relevant. I’m sure you’re read it. But being that you are the one who discovered NR as a NAD precurso…
The NADPARK study: A randomized phase I trial of nicotinamide riboside... https://t.co/U6TzlIFCIz
RT @chtzoulis: Encouraging results from our phase-I trial! The NADPARK study: A randomized phase I trial of nicotinamide riboside supplem…
@CharlesMBrenner Non-relevant. I’m sure you’re read it. But being that you are the one who discovered NR as a NAD precursor I thought I might share with you anyhow :) https://t.co/xtE5151zGL
Wow - @brage_ @chtzoulis & colleagues present the results of the NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in #Parkinsons; This was a small pilot (n=30) to the current NOPARK study; Oral NR⬆️brain NAD levels https://t.co/D90aNwm5fR https://t.co/nTvjsDOqjQ
RT @chtzoulis: Encouraging results from our phase-I trial! The NADPARK study: A randomized phase I trial of nicotinamide riboside supplem…
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://t.co/scWLJngpkp 帕金森患者接受30天1000毫克NR治疗后,大脑中的NAD+水平提高,帕金森症状改善。其中9名患者表现出超过基线水平10%的变化。
Targeting the brain’s energy metabolism may hold the key for treating Parkinson’s disease https://t.co/KhHNmOiqD6 The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://t.co/Yr8M9rEmbC
RT @chtzoulis: Encouraging results from our phase-I trial! The NADPARK study: A randomized phase I trial of nicotinamide riboside supplem…
RT @chtzoulis: Encouraging results from our phase-I trial! The NADPARK study: A randomized phase I trial of nicotinamide riboside supplem…
RT @chtzoulis: Encouraging results from our phase-I trial! The NADPARK study: A randomized phase I trial of nicotinamide riboside supplem…
Encouraging results from our phase-I trial! The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease https://t.co/v6j6Clh9vR