PubHawk
March 2022 PMID 35241173

Aβ promotes CD38 expression in senescent microglia in Alzheimer's disease.

Yiran Hu, Yan Huang, Sanli Xing, Chuan Chen, Dingzhu Shen, Jiulin Chen

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Mentions

5
Peak: 2 in Mar 2022
across 3 sources since Mar 2022

Extended reach

3,569
potential audience

Total likes

3

Video views

75

Mentions per month

Mar 2022 – Apr 2023

Where it's discussed

  • X / Twitter2 posts
  • YouTube2 videos
  • News1 articles

AI synopsis

What people are saying

Various explorations highlight the significance of Aβ's effect on microglia and CD38, with mentions of neuroinflammation reduction and cognitive improvements, suggesting that the publication may guide future research directions and has notable implications for understanding AD pathology.

AgreementModerate agreement

Most discussions acknowledge the significance of Aβ's role in promoting CD38 expression and its implications for AD therapy.

InterestModerate interest

Participants show moderate curiosity, discussing potential therapeutic avenues and microglia behavior.

EngagementModerate engagement

Comments include some technical insights and reflections on microglial mechanisms, indicating a moderate level of engagement.

ImpactModerate impact

The discussions suggest that the research could influence ongoing AD studies and potential treatments.

Abstract in brief

  • The study explores the relationship between energy metabolism in aging microglia and neuroinflammation in Alzheimer's disease (AD) by using CD38 knockdown in both cell and mouse models.
  • CD38 knockdown was found to improve energy metabolism and reduce neuroinflammatory factors in BV2 cells injured by Aβ1-40, as well as decrease senile plaque deposition and improve cognitive function in AD model mice.
  • The results highlight the role of senescent microglia in AD and suggest that targeting CD38 could be a potential therapy for mitigating neuroinflammation and cognitive decline associated with the disease.
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Top posts

Most liked on X and Bluesky
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Aβ promotes CD38 expression in senescent microglia in Alzheimer's disease https://t.co/Eg76oWRe1y

Mar 5, 2022 · 1 like · 2,240 followers View post →
Biological Research
@Bio_Research · X

Aβ promotes CD38 expression in senescent microglia in Alzheimer’s disease https://t.co/8MkSgZaA8i

Mar 4, 2022 · 1 like · 1,244 followers View post →

All mentions

NAD and Its Role in Aging and Neuroinflammation

This video explains NAD as a vital coenzyme involved in energy transportation and vital chemical reactions in cells. It discusses how declining NAD levels with age impact health and may be linked to neurological…

Vitality Pro · Oct 30, 2022 42 views
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Aβ promotes CD38 expression in senescent microglia in Alzheimer's disease https://t.co/Eg76oWRe1y

Mar 5, 2022 · 1 like · 2,240 followers View post →
Biological Research
@Bio_Research · X

Aβ promotes CD38 expression in senescent microglia in Alzheimer’s disease https://t.co/8MkSgZaA8i

Mar 4, 2022 · 1 like · 1,244 followers View post →
2023NMN市场洞察报告| PDF
News

doi: 10.1186/s40659-022-00379-1. PMID: 35241173; PMCID: PMC8892694. 61. Liu X, Dilxat T, Shi Q, Qiu T, Lin J. The combination of nicotinamide mononucleotide ...

Dec 14, 2025 View →