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J Gastroenterol June 2022 PMID 35244768

Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells.

Shigeo Hisamori, Junko Mukohyama, Sanjay Koul, Takanori Hayashi, Michael Evan Rothenberg, Masao Maeda, Taichi Isobe, Luis Enrique Valencia Salazar, Xin Qian, Darius Michael Johnston, Dalong Qian, Kaiqin Lao, Naoya Asai, Yoshihiro Kakeji, Vincenzo Alessandro Gennarino

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Mentions

10
Peak: 4 in Mar 2022
across 2 sources since Mar 2022

Extended reach

9,864
potential audience

Total likes

7

Video views

15

Mentions per month

Mar 2022 – Jun 2023

Where it's discussed

  • X / Twitter9 posts
  • YouTube1 videos

AI synopsis

What people are saying

Discussions highlight the importance of miR-200c and miR-203 in colon cell differentiation and cancer suppression, with phrases like 'elucidate their role' and 'significant influence,' which convey both enthusiasm and recognition of the research's importance. The tone indicates that the community sees this work as potentially transformative for understanding colon cancer mechanisms and treatments.

AgreementModerate agreement

Most discussions express support or acknowledgment of the study’s findings, indicating general agreement on the significance of miRNA roles in colon cell differentiation and cancer suppression.

InterestHigh interest

Posts demonstrate high interest, with mentions of key concepts such as microRNAs, differentiation, and cancer relevance, suggesting engagement with the topic.

EngagementModerate engagement

The discussions include references to specific research details and collaborations, reflecting moderate to deep engagement.

ImpactModerate impact

The emphasis on potential implications for colon cancer and the mention of impactful biomarkers suggest perceived high impact of the research.

Abstract in brief

  • This study explores how specific microRNAs, especially miR200c and miR203, increase during the final differentiation of colon epithelial cells and work together to suppress BMI1, a key factor promoting stem cell self-renewal and tumor growth.
  • Researchers identified that miRNAs like miR200a, miR200b, miR200c, and miR203 are highly expressed in differentiated cells and linked to better survival outcomes in colon cancer patients; additionally, miR200c and miR203 can diminish cancer cell proliferation and tumor formation by targeting BMI1.
  • Overall, the findings suggest that the upregulation of these miRNAs during cellular differentiation plays a protective role against colon cancer by inhibiting self-renewal pathways, highlighting their potential as therapeutic targets or biomarkers in colon cancer treatment.]
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Top posts

Most liked on X and Bluesky
Columbia Stem Cell Initiative (CSCI)
@CSCIColumbia · X

Congrats to Junko Mukohyama, Sanjay Koul, Piero Dalerba & team for their paper on BMI1-suppressor miRNAs in #ColonCancer #CancerStemCells #cancer Hisamori et al., J. Gastroenterology, 57:407-422 (2022) https://t.co/tmjDLUiiRt @CSCIColumbia @ColumbiaPS @columbiacancer https://t.co/ttbd3Kdh8E

Jun 2, 2022 · 4 likes · 2 shares · 1,333 followers View post →
Junko Mukohyama 向山 順子
@junkomukohyama · X

co-firstの論文が雑誌に掲載されました㊗️ 主にColumbia大学在籍時に行った研究で、マイクロRNAの協調的発現が腸管上皮細胞の分化や大腸癌の増殖を制御する分子機構を明らかにしました。 ＃大腸癌 #マイクロRNA https://t.co/MUVClGjp9q

Jun 23, 2022 · 3 likes · 1 share · 27 followers View post →
Herbert Irving Comprehensive Cancer Center
@columbiacancer · X

RT @CSCIColumbia: Congrats to Junko Mukohyama, Sanjay Koul, Piero Dalerba & team for their paper on BMI1-suppressor miRNAs in #ColonCancer…

Jun 4, 2022 · 2 shares · 4,672 followers View post →
Intestinal Cell News
@Intestinal_Cell · X

Dr. Piero Dalerba and colleagues identified #miRNAs that are upregulated during terminal differentiation in the human #colon epithelium, and elucidate their role in the mechanistic control of #StemCell properties.

Mar 11, 2022 · 1,779 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells https://t.co/o4385lQotK #pancreaticcancer #oncology https://t.co/dgVoH93bOl

Mar 4, 2022 · 891 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells https://t.co/eKAMVl3mbe #livercancer #oncology https://t.co/k67ukSk3tu

Mar 4, 2022 · 891 followers View post →

All mentions

神撫会東京支部（第三神戸中学校+長田高校同窓会）
@nagata_tokyo · X

RT @junkomukohyama: co-firstの論文が雑誌に掲載されました㊗️ 主にColumbia大学在籍時に行った研究で、マイクロRNAの協調的発現が腸管上皮細胞の分化や大腸癌の増殖を制御する分子機構を明らかにしました。 ＃大腸癌 #マイクロRNA https…

Jun 1, 2023 · 1 share · 134 followers View post →
Junko Mukohyama 向山 順子
@junkomukohyama · X

co-firstの論文が雑誌に掲載されました㊗️ 主にColumbia大学在籍時に行った研究で、マイクロRNAの協調的発現が腸管上皮細胞の分化や大腸癌の増殖を制御する分子機構を明らかにしました。 ＃大腸癌 #マイクロRNA https://t.co/MUVClGjp9q

Jun 23, 2022 · 3 likes · 1 share · 27 followers View post →
CU-DLDRC
@cudldrc · X

RT @CSCIColumbia: Congrats to Junko Mukohyama, Sanjay Koul, Piero Dalerba & team for their paper on BMI1-suppressor miRNAs in #ColonCancer…

Jun 21, 2022 · 2 shares · 100 followers View post →
Herbert Irving Comprehensive Cancer Center
@columbiacancer · X

RT @CSCIColumbia: Congrats to Junko Mukohyama, Sanjay Koul, Piero Dalerba & team for their paper on BMI1-suppressor miRNAs in #ColonCancer…

Jun 4, 2022 · 2 shares · 4,672 followers View post →
Columbia Stem Cell Initiative (CSCI)
@CSCIColumbia · X

Congrats to Junko Mukohyama, Sanjay Koul, Piero Dalerba & team for their paper on BMI1-suppressor miRNAs in #ColonCancer #CancerStemCells #cancer Hisamori et al., J. Gastroenterology, 57:407-422 (2022) https://t.co/tmjDLUiiRt @CSCIColumbia @ColumbiaPS @columbiacancer https://t.co/ttbd3Kdh8E

Jun 2, 2022 · 4 likes · 2 shares · 1,333 followers View post →
Intestinal Cell News
@Intestinal_Cell · X

Dr. Piero Dalerba and colleagues identified #miRNAs that are upregulated during terminal differentiation in the human #colon epithelium, and elucidate their role in the mechanistic control of #StemCell properties.

Mar 11, 2022 · 1,779 followers View post →
-Seq Papers
@SeqTheWorld · X

Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells https://t.co/eUHF4IxYqa

Mar 4, 2022 · 6 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells https://t.co/eKAMVl3mbe #livercancer #oncology https://t.co/k67ukSk3tu

Mar 4, 2022 · 891 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells https://t.co/o4385lQotK #pancreaticcancer #oncology https://t.co/dgVoH93bOl

Mar 4, 2022 · 891 followers View post →