Aging Cell April 2022 PMID 35263032

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging.

Thais R Peclat, Katie L Thompson, Gina M Warner, Claudia C S Chini, Mariana G Tarragó, Delaram Z Mazdeh, Chunlian Zhang, Jose Zavala-Solorio, Ganesh Kolumam, Yao Liang Wong, Robert L Cohen, Eduardo N Chini

Mentions

43
Peak: 29 in Mar 2022
across 5 sources since Mar 2022

Extended reach

441,590
potential audience

Total likes

941

Video views

28,329

Mentions per month

Mar 2022 – Jan 2025

Where it's discussed

  • X / Twitter34 posts
  • News3 articles
  • YouTube2 videos
  • Facebook2 posts
  • Blogs2 articles

AI synopsis

What people are saying

The tone across posts is largely enthusiastic, with phrases like 'game changer' and 'speechless,' which reflect high interest and perceived significance. Examples show engagement through mention of mechanisms like lifespan extension and healthspan, and some highlight the novelty of testing in normally aging mice, signaling recognition of the study's potential impact.

AgreementModerate agreement

Most discussions express strong support or positive views about the findings, highlighting the significance of CD38 inhibitor 78c.

InterestHigh interest

Posts demonstrate high interest, with many users excited about the potential of this research and its implications for aging.

EngagementModerate engagement

The discussions include detailed references to the study's mechanisms and broader implications, showing active engagement.

ImpactHigh impact

Many comments emphasize the importance of this discovery for aging research, indicating perceived high impact.

Top posts

Most liked on X and Bluesky
Michael Ristow, MD
@Prof_M_Ristow · X

The #CD38 inhibitor 78c previously known to prevent #aging-related #NAD+ decline to improve #physiology and #metabolism is now shown to extend #lifespan of #aged mice. @AgingCell https://t.co/G6HuS6sJCS https://t.co/H9NoOZaC4V

Mar 15, 2022 · 40 likes · 7 shares · 6,985 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

CD38 inhibitor 78c increases mice lifespan and healthspan CD38 is upregulated due to inflammaging, which in turn is highly related to gut health. Leaky gut allows inflammatory molecules into the circulation. Highly processed foods promote leaky gut. https://t.co/bH3RHWElN8

Jul 29, 2024 · 32 likes · 292,377 followers View post →
Aging Science News
@AgingBiology · X

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/7U7iOp52CU

Mar 21, 2022 · 20 likes · 8 shares · 30,727 followers View post →
Agingdoc
@agingdoc1 · X

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/eCtu4N4pRV The CD38 inhibitor 78c increases lifespan and healthspan of naturally aged male mice... The increase in median and maximal lifespan was about 10%. https://t.co/EXJpJS4iyA

Mar 8, 2022 · 5 likes · 41,809 followers View post →
Pat Burgermeister
@PBurgermeister · X

This is the 1st study that tested CD38 inhibition in normally ageing mice & it increased both, lifespan & healthspan! https://t.co/HIQCUw43ct

Mar 19, 2022 · 5 likes · 261 followers View post →
Orlando_uy
@Orlando_uy · X

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/UmzU4UDsBS

Mar 28, 2022 · 2 likes · 694 followers View post →

All mentions

Tim Proctor
@tpr720 · X

Source: https://t.co/xt0JXoBm79

Jan 31, 2025 · 1 like · 1,042 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/Q9c2V8BbA8

Sep 13, 2024 · 3,146 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

CD38 inhibitor 78c increases mice lifespan and healthspan CD38 is upregulated due to inflammaging, which in turn is highly related to gut health. Leaky gut allows inflammatory molecules into the circulation. Highly processed foods promote leaky gut. https://t.co/bH3RHWElN8

Jul 29, 2024 · 32 likes · 292,377 followers View post →
Hak Wan
@wan88super · X

A CD38 Inhibitor Increases Lifespan & Healthspan & The Truth About Does ... https://t.co/6fucg0iAGJ via @YouTube

Jan 25, 2024 · 1,085 followers View post →
Yuji Marutani | The Exiled Emperor
@YujiMarutani · X

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/NpitiYQTyh

Dec 1, 2023 · 1,573 followers View post →
Yuji Marutani | The Exiled Emperor
@YujiMarutani · X

A CD38 Inhibitor Increases Lifespan & Healthspan & The Truth About Does ... https://t.co/3kVQrtoqbY via @YouTube

Dec 1, 2023 · 1,577 followers View post →
Orlando_uy
@Orlando_uy · X

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/UmzU4UDsBS

Mar 28, 2022 · 2 likes · 694 followers View post →
Albert J. Sarmentero.
@AlSarmentero · X

RT @AgingBiology: CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/7U7iOp52CU

Mar 26, 2022 · 8 shares · 613 followers View post →
Alan Meng
@AlanMeng3 · X

RT @AgingBiology: CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/7U7iOp52CU

Mar 25, 2022 · 8 shares · 16 followers View post →
Lopa Misra
@lopamisraDO · X

RT @PeclatThais: I am speechless! Just out of the oven, this paper (https://t.co/YYbSxGvHRz) is the result of one of the main projects I ha…

Mar 24, 2022 · 4 shares · 450 followers View post →
Mayo Clinic Department of Anesthesiology
@MayoAnesthesia · X

RT @PeclatThais: I am speechless! Just out of the oven, this paper (https://t.co/YYbSxGvHRz) is the result of one of the main projects I ha…

Mar 23, 2022 · 4 shares · 6,673 followers View post →
Vitória Maia
@vitoriamaiams · X

RT @PeclatThais: I am speechless! Just out of the oven, this paper (https://t.co/YYbSxGvHRz) is the result of one of the main projects I ha…

Mar 23, 2022 · 4 shares · 801 followers View post →
Yurii
@Yurii08720681 · X

RT @AgingBiology: CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/7U7iOp52CU

Mar 22, 2022 · 8 shares · 35 followers View post →
Dr. Boopathi Seenivasan
@iamboopathi · X

RT @AgingBiology: CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/7U7iOp52CU

Mar 21, 2022 · 8 shares · 152 followers View post →
Dutta RK PHD
@RaghbendraDutta · X

RT @AgingBiology: CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/7U7iOp52CU

Mar 21, 2022 · 8 shares · 219 followers View post →
AgingResearch
@TheAgingField · X

RT @AgingBiology: CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/7U7iOp52CU

Mar 21, 2022 · 8 shares · 5,261 followers View post →
Fay
@fay90028966 · X

RT @AgingBiology: CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/7U7iOp52CU

Mar 21, 2022 · 8 shares · 142 followers View post →
Aging Science News
@AgingBiology · X

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/7U7iOp52CU

Mar 21, 2022 · 20 likes · 8 shares · 30,727 followers View post →
Pat Burgermeister
@PBurgermeister · X

This is the 1st study that tested CD38 inhibition in normally ageing mice & it increased both, lifespan & healthspan! https://t.co/HIQCUw43ct

Mar 19, 2022 · 5 likes · 261 followers View post →
Juhana Harju
@JuhanaHarju · X

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/i1Mpb5WxfD

Mar 16, 2022 · 1,691 followers View post →
taobao86
@taobao861 · X

RT @Prof_M_Ristow: The #CD38 inhibitor 78c previously known to prevent #aging-related #NAD+ decline to improve #physiology and #metabolism…

Mar 15, 2022 · 7 shares · 104 followers View post →
Andreea Nitescu RD MSc
@AndreeaNRD · X

New paper in @AgingCell showing 78c (CD38 inhibitor) increased median lifespan in male

Mar 15, 2022 · 1 like · 1,302 followers View post →
Jason Colasanti, PhD
@JasonColasanti · X

RT @Prof_M_Ristow: The #CD38 inhibitor 78c previously known to prevent #aging-related #NAD+ decline to improve #physiology and #metabolism…

Mar 15, 2022 · 7 shares · 1,423 followers View post →
Greg Macpherson
@gregmacpherson · X

RT @Prof_M_Ristow: The #CD38 inhibitor 78c previously known to prevent #aging-related #NAD+ decline to improve #physiology and #metabolism…

Mar 15, 2022 · 7 shares · 432 followers View post →
Satoshi Endo
@biochemer · X

RT @Prof_M_Ristow: The #CD38 inhibitor 78c previously known to prevent #aging-related #NAD+ decline to improve #physiology and #metabolism…

Mar 15, 2022 · 7 shares · 192 followers View post →
Longevity Global
@LongevityGL · X

RT @Prof_M_Ristow: The #CD38 inhibitor 78c previously known to prevent #aging-related #NAD+ decline to improve #physiology and #metabolism…

Mar 15, 2022 · 7 shares · 3,205 followers View post →
Vivia Sthel
@vivia_sthel · X

RT @Prof_M_Ristow: The #CD38 inhibitor 78c previously known to prevent #aging-related #NAD+ decline to improve #physiology and #metabolism…

Mar 15, 2022 · 7 shares · 199 followers View post →
Michael Ristow, MD
@Prof_M_Ristow · X

The #CD38 inhibitor 78c previously known to prevent #aging-related #NAD+ decline to improve #physiology and #metabolism is now shown to extend #lifespan of #aged mice. @AgingCell https://t.co/G6HuS6sJCS https://t.co/H9NoOZaC4V

Mar 15, 2022 · 40 likes · 7 shares · 6,985 followers View post →
Caitlin Connelly
@caitfconnelly · X

'CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging' - paper out from a collaboration between @calico & eduardo chini at the mayo clinic https://t.co/7jhsFpgGoD

Mar 11, 2022 · 192 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/B4SNQPnjRz Bravo @PeclatThais!

Mar 10, 2022 · 1 like · 2,239 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: https://t.co/9RbReS9HIN

Mar 10, 2022 · 1 share · 3,155 followers View post →
Nutriop Longevity
@nutriop · X

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging #NAD https://t.co/bEUnWByA7o https:/... https://t.co/CKe8GbSH6C

Mar 9, 2022 · 80 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/9RbReS9HIN

Mar 9, 2022 · 1 share · 3,155 followers View post →
Agingdoc
@agingdoc1 · X

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging https://t.co/eCtu4N4pRV The CD38 inhibitor 78c increases lifespan and healthspan of naturally aged male mice... The increase in median and maximal lifespan was about 10%. https://t.co/EXJpJS4iyA

Mar 8, 2022 · 5 likes · 41,809 followers View post →