Analgesic drug use in pregnancy and neurodevelopment outcomes: an umbrella review.

Abstract in brief

• This umbrella review examines whether the use of analgesic drugs like acetaminophen during pregnancy is linked to neurodevelopmental issues such as ADHD and ASD in children, with evidence suggesting a potential association particularly with ADHD.
• The review analyzed multiple high-quality studies and found consistent reports that prenatal acetaminophen use may increase the risk of ADHD, with some evidence suggesting a dose-dependent relationship, although results vary based on timing and dosage.
• The findings imply that pregnant women should minimize acetaminophen use to reduce potential neurodevelopmental risks, but more research is needed to understand the mechanisms and to develop clear clinical guidelines.]