PubHawk
March 2022 PMID 35303871

Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing.

Alexander Dimitri, Friederike Herbst, Joseph A Fraietta

Full text PDF Download social card

Mentions

13
Peak: 4 in Mar 2022
across 4 sources since Mar 2022

Extended reach

21,036
potential audience

Total likes

12

Video views

86

Mentions per month

Mar 2022 – Oct 2024

Where it's discussed

  • X / Twitter6 posts
  • Blogs3 articles
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

The discussions highlight excitement about the revolutionary potential of CRISPR technology in enhancing CAR T-cell therapy, with examples like mentions of 'future directions' and 'combining advanced techniques,' reflecting both technical interest and optimism about impact. The tone and choice of words such as 'next-generation' and 'transformative' emphasize the significance of these innovations in cancer treatment.

AgreementModerate agreement

Most discussions acknowledge the promise of CRISPR-Cas9 in advancing CAR T-cell therapy, shown by mentions of ongoing research and future directions.

InterestHigh interest

The posts express high interest through enthusiasm about breakthroughs and potential clinical impact, using words like 'next-generation' and 'future directions.'

EngagementModerate engagement

Participants delve into technical aspects like gene editing precision and therapeutic implications, indicating meaningful engagement.

ImpactHigh impact

Given references to improving cancer immunotherapy and creating universal off-the-shelf products, discussions suggest these developments could significantly influence treatment options.

Abstract in brief

  • CAR T cells are a groundbreaking personalized cancer treatment where synthetic receptors reprogram T cells to attack tumors, but challenges like T cell exhaustion and manufacturing issues limit their effectiveness, especially in solid tumors.
  • CRISPR-Cas9 gene editing offers new possibilities to improve CAR T cell therapy by precisely modifying T cells to overcome these limitations, such as knocking out negative regulators or making universal off-the-shelf products.
  • Ongoing research is focusing on combining advanced CRISPR techniques with synthetic biology to create safer, more effective CAR T cells, paving the way for improved clinical outcomes and a new era in cancer immunotherapy.]
Read the full abstract

Top posts

Most liked on X and Bluesky
CRISPRpapers
@CRISPR_Articles · X

Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing https://t.co/7rYq9fZ6cT https://t.co/2XCWikEksU

Mar 20, 2022 · 4 likes · 1,441 followers View post →
ESC & iPSC News
@ESC_iPSC_News · X

Dr. Joseph Fraietta's team at @PennMedicine discusses ongoing and future directions of combining #CRISPR-Cas9 gene editing

Mar 26, 2022 · 3 likes · 2 shares · 8,330 followers View post →
Chimeric Antigen Receptor T-Cell (CAR-T) & Gene Rx
@CARTTherapy · X

Engineering the next-generation of CAR T-cells with #CRISPR -Cas9 gene editing https://t.co/ZDCt8NU4XP #CART #bmtsm #CARTcell #immunotherapy #tcellrx #ICAN #CRS #CARTcells #CellTherapy #Gene #Genetherapy @ASTCT @CRISPR_News

Mar 19, 2022 · 2 likes · 4,457 followers View post →
Randall Parker #VaccinesForMoreViruses
@futurepundit · X

@EvilVizier @RokoMijic @Outsideness It is hard to make genetic editing precise enough for making super babies. But since it is very useful in agriculture and cancer therapies a lot of work is going into improving gene editing. Consider: https://t.co/bT1hUK9qFU

Mar 19, 2023 · 2 likes · 2,405 followers View post →
synbiopapers
@synbio_papers · X

Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing https://t.co/Rdu1c2lL1H https://t.co/O46jchaqpz

Apr 3, 2022 · 4,053 followers View post →
P. A-M
@PAMJ84 · X

RT @ESC_iPSC_News: Dr. Joseph Fraietta's team at @PennMedicine discusses ongoing and future directions of combining #CRISPR-Cas9 gene editi…

Mar 26, 2022 · 2 shares · 257 followers View post →

All mentions

Randall Parker #VaccinesForMoreViruses
@futurepundit · X

@EvilVizier @RokoMijic @Outsideness It is hard to make genetic editing precise enough for making super babies. But since it is very useful in agriculture and cancer therapies a lot of work is going into improving gene editing. Consider: https://t.co/bT1hUK9qFU

Mar 19, 2023 · 2 likes · 2,405 followers View post →
synbiopapers
@synbio_papers · X

Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing https://t.co/Rdu1c2lL1H https://t.co/O46jchaqpz

Apr 3, 2022 · 4,053 followers View post →
P. A-M
@PAMJ84 · X

RT @ESC_iPSC_News: Dr. Joseph Fraietta's team at @PennMedicine discusses ongoing and future directions of combining #CRISPR-Cas9 gene editi…

Mar 26, 2022 · 2 shares · 257 followers View post →
ESC & iPSC News
@ESC_iPSC_News · X

Dr. Joseph Fraietta's team at @PennMedicine discusses ongoing and future directions of combining #CRISPR-Cas9 gene editing

Mar 26, 2022 · 3 likes · 2 shares · 8,330 followers View post →
CRISPRpapers
@CRISPR_Articles · X

Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing https://t.co/7rYq9fZ6cT https://t.co/2XCWikEksU

Mar 20, 2022 · 4 likes · 1,441 followers View post →
Chimeric Antigen Receptor T-Cell (CAR-T) & Gene Rx
@CARTTherapy · X

Engineering the next-generation of CAR T-cells with #CRISPR -Cas9 gene editing https://t.co/ZDCt8NU4XP #CART #bmtsm #CARTcell #immunotherapy #tcellrx #ICAN #CRS #CARTcells #CellTherapy #Gene #Genetherapy @ASTCT @CRISPR_News

Mar 19, 2022 · 2 likes · 4,457 followers View post →