Am J Psychiatry May 2022 PMID 35343756

Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder.

Gloria Roberts, Alistair Perry, Kate Ridgway, Vivian Leung, Megan Campbell, Rhoshel Lenroot, Philip B Mitchell, Michael Breakspear

Mentions

54
Peak: 17 in Mar 2022
across 4 sources since Mar 2022

Extended reach

1,671,864
potential audience

Total likes

2,305

Video views

29,736

Mentions per month

Mar 2022 – Jul 2023

Where it's discussed

  • X / Twitter47 posts
  • YouTube4 videos
  • News2 articles
  • Blogs1 articles

AI synopsis

What people are saying

The collective discussions demonstrate strong support and curiosity, with posts highlighting the importance of weakened neural connections in at-risk youth and their implications for bipolar disorder, using words like 'impressive,' 'important,' and emphasizing the potential for advances in diagnosis and understanding resilience, which shows both high interest and perceived impact.

AgreementModerate agreement

Most discussions acknowledge the importance of the research and support its findings around neural differences in high-risk individuals.

InterestHigh interest

The discussions reflect high interest, highlighted by the enthusiasm in phrases like 'impressive and important work' and detailed summaries of neural changes.

EngagementModerate engagement

Several posts engage deeply by referencing specific brain regions, neural networks, and potential implications for understanding resilience and disease onset.

ImpactHigh impact

The discussions emphasize the significance of the findings for future research and clinical applications, suggesting high potential impact.

Abstract in brief

  • The study investigated how brain connectivity changes over two years in young people at high genetic risk for bipolar disorder compared to controls, using MRI data.
  • Both groups showed overall brain network development, but high-risk individuals experienced specific weakening in certain brain regions related to emotion and cognition, which persisted or worsened over time.
  • These differences in brain network development might help explain why some high-risk individuals develop bipolar disorder, highlighting the importance of neurodevelopmental processes in illness onset and resilience.]

Top posts

Most liked on X and Bluesky
Neuroscience News
@NeuroscienceNew · X

“Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder” by Philip Mitchell et al. American Journal of Psychiatry https://t.co/f9gPvE8t2L

Mar 28, 2022 · 9 likes · 3 shares · 506,664 followers View post →
Stefan Frässle
@stefan_fraessle · X

"Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder" in The American Journal of Psychiatry -- impressive and (clinically) important work by @alistairgperry @DrBreaky and others https://t.co/DhSKVZBjtl

Mar 30, 2022 · 8 likes · 4 shares · 2,199 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

From @UNSW Sydney, individuals at high risk of bipolar disorder exhibit differences in maturational processes in a multisystem network in the brain. This represents a chance for understanding resilience and predicting conversion to bipolar disorder. https://t.co/FJjOJHhOhD

May 13, 2022 · 4 likes · 2 shares · 11,607 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

From @UNSW Sydney, individuals at high risk of bipolar disorder exhibit differences in maturational processes in a multisystem network in the brain. This may represent a chance for understanding resilience + predicting conversion to bipolar disorder. 3/4 https://t.co/MQ1h1Ma1e3

May 24, 2022 · 2 likes · 1 share · 11,607 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

AJP Deputy Editor Danny Pine highlights two articles from the July 2022 issue. https://t.co/SpwtXwT0xZ

Jul 25, 2022 · 2 likes · 1 share · 11,607 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/6SXmX17SBA #SharedFacts #HealthScience #BrainFunction #MentalDisorders

Mar 30, 2022 · 1 like · 1 share · 44,376 followers View post →

All mentions

Martina Bobler
@MartinaBobler · X

Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder https://t.co/11zQG2c1Wk

Jul 16, 2023 · 2 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

RT @allentien: #BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisor…

Jun 6, 2023 · 1 share · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisorders

Jun 6, 2023 · 1 share · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

RT @allentien: #BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisor…

May 17, 2023 · 1 share · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisorders

May 17, 2023 · 1 share · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisorders

May 7, 2023 · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisorders

Feb 21, 2023 · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

RT @allentien: #BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisor…

Feb 14, 2023 · 1 share · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisorders

Feb 14, 2023 · 1 share · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisorders

Jan 28, 2023 · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisorders

Nov 22, 2022 · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wA4kiT #SharedFacts #HealthScience #BrainFunction #MentalDisorders

Nov 8, 2022 · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisorders

Oct 6, 2022 · 1 like · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisorders

Sep 22, 2022 · 1 like · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

RT @allentien: #BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisor…

Sep 8, 2022 · 1 share · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisorders

Sep 8, 2022 · 1 share · 44,376 followers View post →
PulsePilot
@Pulse1Pilot · X

RT @allentien: #BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisor…

Aug 22, 2022 · 2 shares · 5,339 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

RT @allentien: #BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisor…

Aug 22, 2022 · 2 shares · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisorders

Aug 22, 2022 · 1 like · 2 shares · 44,376 followers View post →
NINET Lab
@NinetLab · X

RT @APAPubJournals: AJP Deputy Editor Danny Pine highlights two articles from the July 2022 issue. https://t.co/SpwtXwT0xZ

Jul 25, 2022 · 1 share · 1,270 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

AJP Deputy Editor Danny Pine highlights two articles from the July 2022 issue. https://t.co/SpwtXwT0xZ

Jul 25, 2022 · 2 likes · 1 share · 11,607 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisorders

Jun 24, 2022 · 44,376 followers View post →
Altamiro Bottino
@BottinoAltamiro · X

Scans show weakened connections in brains of adolescents at risk of bipolar disorder https://t.co/2VAIPCw5t0 https://t.co/DF0E5MmSjU https://t.co/OCv3On2Xcw

Jun 20, 2022 · 93 followers View post →
Verónica VQuer
@VeronicaVquer · X

RT @APAPubJournals: From @UNSW Sydney, individuals at high risk of bipolar disorder exhibit differences in maturational processes in a mult…

May 24, 2022 · 1 share · 1 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

From @UNSW Sydney, individuals at high risk of bipolar disorder exhibit differences in maturational processes in a multisystem network in the brain. This may represent a chance for understanding resilience + predicting conversion to bipolar disorder. 3/4 https://t.co/MQ1h1Ma1e3

May 24, 2022 · 2 likes · 1 share · 11,607 followers View post →
Verónica VQuer
@VeronicaVquer · X

RT @APAPubJournals: From @UNSW Sydney, individuals at high risk of bipolar disorder exhibit differences in maturational processes in a mult…

May 13, 2022 · 2 shares · 1 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

From @UNSW Sydney, individuals at high risk of bipolar disorder exhibit differences in maturational processes in a multisystem network in the brain. This represents a chance for understanding resilience and predicting conversion to bipolar disorder. https://t.co/FJjOJHhOhD

May 13, 2022 · 4 likes · 2 shares · 11,607 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

RT @allentien: #BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisor…

Apr 21, 2022 · 1 share · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/xOF6wzMJrl #SharedFacts #HealthScience #BrainFunction #MentalDisorders

Apr 21, 2022 · 1 share · 44,376 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

RT @stefan_fraessle: "Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder" in The Ame…

Apr 5, 2022 · 4 shares · 11,607 followers View post →
Miguel Angel Grullon C.
@miguel78910 · X

Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder. El neurodesarrollo desde la adolescencia-adultez temprana está asociado con reorganización sustancial de las redes cerebrales estructurales. https://t.co/NKDB3aO02N

Mar 31, 2022 · 1 like · 2,785 followers View post →
Emiliano MQ
@NANOxMQ · X

Weakened Connections in Brains of Young People at Risk of Bipolar Disorder https://t.co/g879sT7qaJ

Mar 30, 2022 · 23 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

RT @allentien: #BrainRegions #Connectedness #EmotionLogic https://t.co/6SXmX17SBA #SharedFacts #HealthScience #BrainFunction #MentalDisor…

Mar 30, 2022 · 1 share · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

#BrainRegions #Connectedness #EmotionLogic https://t.co/6SXmX17SBA #SharedFacts #HealthScience #BrainFunction #MentalDisorders

Mar 30, 2022 · 1 like · 1 share · 44,376 followers View post →
Allen Y. Tien MD MHS 田一彦
@allentien · X

https://t.co/6SXmX17SBA

Mar 30, 2022 · 44,376 followers View post →
Martin Dietz
@martinjdietz · X

RT @stefan_fraessle: "Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder" in The Ame…

Mar 30, 2022 · 4 shares · 252 followers View post →
Thomas Wolfers
@ThomasWolfers · X

RT @stefan_fraessle: "Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder" in The Ame…

Mar 30, 2022 · 4 shares · 870 followers View post →
Wendy Burn CBE
@wendyburn · X

RT @stefan_fraessle: "Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder" in The Ame…

Mar 30, 2022 · 4 shares · 27,298 followers View post →
Stefan Frässle
@stefan_fraessle · X

"Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder" in The American Journal of Psychiatry -- impressive and (clinically) important work by @alistairgperry @DrBreaky and others https://t.co/DhSKVZBjtl

Mar 30, 2022 · 8 likes · 4 shares · 2,199 followers View post →
Mar Alonso Hoyas
@MarMarhoyas · X

RT @NeuroscienceNew: “Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder” by Philip…

Mar 29, 2022 · 3 shares · 3,650 followers View post →
Progress
@progressnp · X

People with a high-risk phenotype for bipolar disorder show weakened connectivity in executive and cognitive control networks in the final stages of neurodevelopment compared to controls, approaching a phenotype seen in established bipolar disorder: https://t.co/QCs6mVpLZB

Mar 29, 2022 · 201 followers View post →
The Aegean Society
@aegeansociety · X

Bipolar bozukluk geliştirme riski yüksek olan gençler üzerinde yapılan bir beyin görüntüleme çalışması, ilk kez geç ergenlik döneminde beynin kilit alanları arasındaki bağlantıların zayıfladığına dair kanıt buldu. #bipolar #psikiyatri #psikoloji #beyin https://t.co/mAEeEfhU0O https://t.co/GYEdikLd8O

Mar 29, 2022 · 1 like · 457 followers View post →
Wei Cheng
@WeiFDU · X

RT @NeuroscienceNew: “Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder” by Philip…

Mar 28, 2022 · 3 shares · 442 followers View post →
steen
@steen13663514 · X

RT @APAPubJournals: From @UNSW Sydney, individuals at high genetic risk of bipolar disorder exhibit differences in maturational processes i…

Mar 28, 2022 · 1 share View post →
Debbie Hampton
@dlhampton · X

RT @NeuroscienceNew: “Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder” by Philip…

Mar 28, 2022 · 3 shares · 11,750 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Longitudinal Changes in Structural Connectivity in Young People at High Genetic Risk for Bipolar Disorder” by Philip Mitchell et al. American Journal of Psychiatry https://t.co/f9gPvE8t2L

Mar 28, 2022 · 9 likes · 3 shares · 506,664 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

From @UNSW Sydney, individuals at high genetic risk of bipolar disorder exhibit differences in maturational processes in a multisystem network in the brain. This represents a novel understanding of resilience and predicting conversion to bipolar disorder. https://t.co/FJjOJHhOhD https://t.co/UKTNbjXfhR

Mar 28, 2022 · 1 like · 1 share · 11,607 followers View post →
Differences in neurodevelopmental maturation indicate higher risk ...
News

Am J Psychiatry. 2022;doi: 10.1176/appi.ajp.21010047. Disclosures: Roberts reports no relevant financial disclosures. Please see the study for ...

Mar 31, 2022 View →
Study shows weakened brain connections in young people at risk of ...
Blogs

doi.org/10.1176/appi.ajp.21010047. Currently rated 3.0 by 1 person. Posted in: Child Health News | Medical Research News. Comments (0).

Mar 30, 2022 View →
Evidence of brain changes in those at risk of bipolar disorder ...
News

American Journal of Psychiatry, 2022; DOI: 10.1176/appi.ajp.21010047. Cite This Page: MLA; APA; Chicago. University of New South Wales ...

Mar 29, 2022 View →