Menopause February 2022 PMID 35357369

Safety and efficacy of compounded bioidentical hormone therapy (cBHT) in perimenopausal and postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.

Yi Liu, Ying Yuan, A J Day, Wen Zhang, Princy John, Danielle J Ng, Daniel Banov

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Mentions

31
Peak: 5 in Mar 2022
across 3 sources since Mar 2022

Extended reach

1,353,203
potential audience

Total likes

25,024

Video views

1,321,640

Mentions per month

Mar 2022 – Aug 2025

Where it's discussed

  • News16 articles
  • X / Twitter8 posts
  • YouTube7 videos

AI synopsis

What people are saying

The groups of discussions mainly consist of reposts and mentions of the systematic review, emphasizing its focus on safety, efficacy, and relevance to menopausal health, using descriptive phrases like 'review' and highlighting topics like 'breast cancer' and 'hormone therapy'. The tone remains informative and neutral, indicating curiosity and recognition of its importance without deep emotional engagement or controversy.

AgreementNeither agree nor disagree

The discussions are primarily neutral, simply acknowledging the article without expressing strong support or disagreement.

InterestModerate interest

There is moderate interest, as many posts highlight the publication and its relevance to menopause and hormone therapy.

EngagementModerate engagement

Posts show some depth by referencing the study’s focus and mentioning specific themes like safety and efficacy.

ImpactNeutral impact

The overall impact appears moderate, with the articles gaining visibility but not necessarily driving immediate actions or debates.

Abstract in brief

  • This systematic review and meta-analysis examined the safety and effectiveness of compounded bioidentical hormone therapy (cBHT) for women going through menopause, finding limited data but indicating no major risks related to lipid profiles, blood sugar, or endometrial thickness, though some side effects like androgenic symptoms were noted.
  • The study analyzed 29 randomized controlled trials involving over 1,800 women, comparing cBHT with placebo or approved hormone treatments, and found that compounded androgen didn't negatively impact cardiovascular risk factors, but there were some side effects with specific hormones like dehydroepiandrosterone.
  • The research suggests that compounded vaginal androgen may help improve symptoms of vaginal atrophy, but overall, more comprehensive studies are needed to fully understand the safety and long-term effects of cBHT, especially regarding serious health outcomes like breast cancer and cardiovascular events.]

Top posts

Most liked on X and Bluesky
Menopause Journal
@MenopauseJrnl · X

Open Access: Systematic Review: Safety and efficacy of compounded bioidentical hormone therapy (#cBHT) in perimenopausal and postmenopausal women: a systematic review and meta-analysis of randomized controlled trials https://t.co/fDejYbcmYu @MenopauseOrg @Lippincott #menopause

Mar 3, 2022 · 5 likes · 4 shares · 5,404 followers View post →
The Menopause Society
@MenopauseOrg · X

RT @MenopauseJrnl: Review: Safety and efficacy of compounded #bioidentical hormone therapy (cBHT) in perimenopausal and postmenopausal wome…

Apr 12, 2022 · 2 shares · 8,997 followers View post →
The Menopause Society
@MenopauseOrg · X

RT @MenopauseJrnl: Open Access: Systematic Review: Safety and efficacy of compounded bioidentical hormone therapy (#cBHT) in perimenopausal…

Mar 3, 2022 · 4 shares · 8,997 followers View post →
Menopause Journal
@MenopauseJrnl · X

Review: Safety and efficacy of compounded #bioidentical hormone therapy (cBHT) in perimenopausal and postmenopausal women: a systematic review and meta-analysis of randomized controlled trials https://t.co/pFI6S48ZkJ @MenopauseOrg @lippincott #menopause #hormonetherapy

Apr 12, 2022 · 2 shares · 5,404 followers View post →
Vikram Sinai Talaulikar
@VikramSinai · X

RT @MenopauseJrnl: Open Access: Systematic Review: Safety and efficacy of compounded bioidentical hormone therapy (#cBHT) in perimenopausal…

Mar 4, 2022 · 4 shares · 1,469 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: Safety and efficacy of compounded bioidentical hormone therapy (cBHT) in perimenopausal and postmenopausal women: a systematic review and meta-analysis of randomized controlled trials https://t.co/GCOq4lUB38 #breastcancer #oncology https://t.co/ZjavKP6ho3

Mar 31, 2022 · 891 followers View post →

All mentions

The Menopause Society
@MenopauseOrg · X

RT @MenopauseJrnl: Review: Safety and efficacy of compounded #bioidentical hormone therapy (cBHT) in perimenopausal and postmenopausal wome…

Apr 12, 2022 · 2 shares · 8,997 followers View post →
Manuel Sánchez-Prieto
@snchez_manu · X

RT @MenopauseJrnl: Review: Safety and efficacy of compounded #bioidentical hormone therapy (cBHT) in perimenopausal and postmenopausal wome…

Apr 12, 2022 · 2 shares · 263 followers View post →
Menopause Journal
@MenopauseJrnl · X

Review: Safety and efficacy of compounded #bioidentical hormone therapy (cBHT) in perimenopausal and postmenopausal women: a systematic review and meta-analysis of randomized controlled trials https://t.co/pFI6S48ZkJ @MenopauseOrg @lippincott #menopause #hormonetherapy

Apr 12, 2022 · 2 shares · 5,404 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: Safety and efficacy of compounded bioidentical hormone therapy (cBHT) in perimenopausal and postmenopausal women: a systematic review and meta-analysis of randomized controlled trials https://t.co/GCOq4lUB38 #breastcancer #oncology https://t.co/ZjavKP6ho3

Mar 31, 2022 · 891 followers View post →
Vikram Sinai Talaulikar
@VikramSinai · X

RT @MenopauseJrnl: Open Access: Systematic Review: Safety and efficacy of compounded bioidentical hormone therapy (#cBHT) in perimenopausal…

Mar 4, 2022 · 4 shares · 1,469 followers View post →
The Menopause Society
@MenopauseOrg · X

RT @MenopauseJrnl: Open Access: Systematic Review: Safety and efficacy of compounded bioidentical hormone therapy (#cBHT) in perimenopausal…

Mar 3, 2022 · 4 shares · 8,997 followers View post →
punkybrewster
@punkybr62679560 · X

RT @MenopauseJrnl: Open Access: Systematic Review: Safety and efficacy of compounded bioidentical hormone therapy (#cBHT) in perimenopausal…

Mar 3, 2022 · 4 shares · 97 followers View post →
Menopause Journal
@MenopauseJrnl · X

Open Access: Systematic Review: Safety and efficacy of compounded bioidentical hormone therapy (#cBHT) in perimenopausal and postmenopausal women: a systematic review and meta-analysis of randomized controlled trials https://t.co/fDejYbcmYu @MenopauseOrg @Lippincott #menopause

Mar 3, 2022 · 5 likes · 4 shares · 5,404 followers View post →