JCO Precis Oncol March 2022 PMID 35357903

Hyperthermic Intraperitoneal Chemotherapy-Induced Molecular Changes in Humans Validate Preclinical Data in Ovarian Cancer.

Thanh H Dellinger, Ernest S Han, Mustafa Raoof, Byrne Lee, Xiwei Wu, Hyejin Cho, Ting-Fang He, Peter Lee, Marianne Razavi, Winnie S Liang, Daniel Schmolze, Saul J Priceman, Stephen Lee, Wei-Chien Lin, Jeff F Lin

Mentions

37
Peak: 22 in Oct 2022
across 2 sources since Apr 2022

Extended reach

63,449
potential audience

Total likes

71

Video views

20

Mentions per month

Apr 2022 – Apr 2024

Where it's discussed

  • X / Twitter36 posts
  • YouTube1 videos

AI synopsis

What people are saying

Throughout the discussions, participants express strong support and fascination with the article’s findings, citing terms like 'validate', 'mechanisms of HIPEC', and 'synergism' to emphasize its relevance and promising implications for future ovarian cancer treatments. The tone is enthusiastic and exploratory, reflecting genuine academic interest and recognition of the study's significance.

AgreementStrong agreement

Most discussions highly support the validity and importance of the findings, with phrases like 'validate preclinical data' and 'great work', indicating strong agreement with the publication’s significance.

InterestHigh interest

The posts show keen curiosity and engagement, referencing molecular mechanisms, potential synergistic treatments, and implications for future therapies, demonstrating high interest.

EngagementHigh engagement

Several discussions delve into molecular pathways, biomarkers, and clinical implications, reflecting deep engagement with the research details.

ImpactModerate impact

While users recognize the potential impact of the study, the comments suggest ongoing exploration rather than final judgments, resulting in a moderate score for impact perception.

Abstract in brief

  • The study investigated the molecular effects of HIPEC (hyperthermic intraperitoneal chemotherapy) with cisplatin during surgery for ovarian cancer, finding that HIPEC can induce changes in immune and DNA repair pathways that correlate with better patient outcomes.
  • Patients who responded well to HIPEC showed increased expression of immune-related genes, such as PD-1 in CD8 T cells, and had a longer median progression-free survival (up to nearly 60 months), with minimal severe adverse effects.
  • The research validates preclinical findings by identifying distinct molecular signatures that differentiate responders from non-responders, highlighting potential biomarkers for predicting and improving HIPEC treatment efficacy in ovarian cancer.]

Top posts

Most liked on X and Bluesky
Thanh Dellinger
@TDellingerMD · X

Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signatures to predict HIPEC response and explore mechanisms of HIPEC in TME https://t.co/RiVonOAsN5 @COH_SurgOnc @COH_GynOncology

Oct 19, 2022 · 22 likes · 9 shares · 193 followers View post →
Dr. Iván R. González
@Dr_Ivanoncologo · X

Interesting study

Apr 21, 2022 · 15 likes · 4 shares · 4,201 followers View post →
Thales P. Batista, MD, PhD
@BatistaTP · X

#HIPEC–Induced Molecular Changes in Humans Validate Preclinical Data in #OvarianCancer | JCO Precision Oncology, ⁦@ASCO⁩ ⁦@CBCcirurgioes⁩ ⁦⁩ ⁦@sbco_oficial⁩ ⁦@ESSOnews⁩ ⁩@indepso⁩ ⁦@KurtSpeeten⁩ ⁦@WimCeelen⁩ https://t.co/nZiuDHQpLI

Apr 4, 2022 · 13 likes · 5 shares · 1,288 followers View post →
Thales P. Batista, MD, PhD
@BatistaTP · X

But #HIPEC may play a role in modulating the TME, inhibiting DNA repair, and upregulating HSPs and subsequent immune-associated pathways. @alarjosan @glaucobaiocchi @sbco_oficial @PSOGI_EC @indepso

Oct 17, 2022 · 7 likes · 4 shares · 1,288 followers View post →
Thales P. Batista, MD, PhD
@BatistaTP · X

The #HIPPIE Trial - #HIPEC Plus Imunotherapy in Epithelial #OvaCa also sounds great…

Oct 20, 2022 · 4 likes · 1 share · 1,288 followers View post →
Thanh Dellinger
@TDellingerMD · X

@DemuytereJesse Great work looking into mechanisms of HIPEC at a transcriptomic level! We should share notes https://t.co/htyIcets4O and https://t.co/RiVonOAsN5 #hipec @WimCeelen @COH_SurgOnc

Oct 19, 2022 · 3 likes · 193 followers View post →

All mentions

Peritoneal Surface Oncology Group International
@PSOGI_EC · X

RT @BatistaTP: In line with findings by @TDellingerMD via @JCOPO_ASCO . @zivanovicmd @TeamOvary_MSK @PSOGI_EC @alarjosan https://t.co/r42gs…

May 25, 2023 · 1 share · 1,875 followers View post →
Thales P. Batista, MD, PhD
@BatistaTP · X

In line with findings by @TDellingerMD via @JCOPO_ASCO . @zivanovicmd @TeamOvary_MSK @PSOGI_EC @alarjosan https://t.co/r42gs2F5EM 3/…

May 25, 2023 · 1 like · 1 share · 1,288 followers View post →
GYN Cancer | #GYNCSM
@gyncsm · X

RT @JCOPO_ASCO: Listen: in new #JCOPO Conversations podcast episode, host @thenasheffect speaks w Dr. Thanh Dellinger about her article "Hy…

Oct 26, 2022 · 2 shares · 6,479 followers View post →
Rafeh Naqash, MD, FASCO
@thenasheffect · X

RT @JCOPO_ASCO: Listen: in new #JCOPO Conversations podcast episode, host @thenasheffect speaks w Dr. Thanh Dellinger about her article "Hy…

Oct 24, 2022 · 2 shares · 2,615 followers View post →
Delia Cortés Guiral
@DeliaCortesGuir · X

RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…

Oct 24, 2022 · 9 shares · 4,686 followers View post →
JCO Precision Oncology
@JCOPO_ASCO · X

Listen: in new #JCOPO Conversations podcast episode, host @thenasheffect speaks w Dr. Thanh Dellinger about her article "Hyperthermic Intraperitoneal Chemotherapy–Induced Molecular Changes in Humans Validate Preclinical Data in Ovarian Cancer." https://t.co/TPgOIL9Lqn #gyncsm https://t.co/epFZDtELaA

Oct 24, 2022 · 2 likes · 2 shares · 5,313 followers View post →
Olivia Sgarbura
@oliviawriting · X

RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…

Oct 24, 2022 · 9 shares · 2,711 followers View post →
Pablo Lozano Lominchar
@Pllcg3 · X

RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…

Oct 24, 2022 · 9 shares · 433 followers View post →
Andreas Brandl
@AndreasBrandl8 · X

RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…

Oct 24, 2022 · 9 shares · 1,922 followers View post →
Ji Hyun Kim
@writ__e · X

RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…

Oct 23, 2022 · 9 shares · 347 followers View post →
Thales P. Batista, MD, PhD
@BatistaTP · X

RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…

Oct 23, 2022 · 9 shares · 1,288 followers View post →
Thales P. Batista, MD, PhD
@BatistaTP · X

@TDellingerMD @zivanovicmd @drleslie214 @glaucobaiocchi And there are some data from you suggesting #HIPEC may have sinergism w/ other drugs. So much to explore. Regards @CBCcirurgioes @sbco_oficial @br_gynoncgroup @glaucobaiocchi https://t.co/r42gs2FDuk

Oct 23, 2022 · 1 like · 1,288 followers View post →
Thanh Dellinger
@TDellingerMD · X

RT @BatistaTP: The #HIPPIE Trial - #HIPEC Plus Imunotherapy in Epithelial #OvaCa also sounds great…

Oct 22, 2022 · 1 share · 193 followers View post →
Thales P. Batista, MD, PhD
@BatistaTP · X

The #HIPPIE Trial - #HIPEC Plus Imunotherapy in Epithelial #OvaCa also sounds great…

Oct 20, 2022 · 4 likes · 1 share · 1,288 followers View post →
City of Hope Surgery
@CityofHopeSurg · X

RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…

Oct 19, 2022 · 9 shares · 991 followers View post →
City of Hope Surgical Oncology
@COH_SurgOnc · X

RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…

Oct 19, 2022 · 9 shares · 1,161 followers View post →
Dr. Virginia Sun, PhD, RN
@VirginiaSunPhD · X

RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…

Oct 19, 2022 · 9 shares · 1,092 followers View post →
Thanh Dellinger
@TDellingerMD · X

Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signatures to predict HIPEC response and explore mechanisms of HIPEC in TME https://t.co/RiVonOAsN5 @COH_SurgOnc @COH_GynOncology

Oct 19, 2022 · 22 likes · 9 shares · 193 followers View post →
Thanh Dellinger
@TDellingerMD · X

@DemuytereJesse Great work looking into mechanisms of HIPEC at a transcriptomic level! We should share notes https://t.co/htyIcets4O and https://t.co/RiVonOAsN5 #hipec @WimCeelen @COH_SurgOnc

Oct 19, 2022 · 3 likes · 193 followers View post →
Kiran Turaga
@kturaga · X

RT @BatistaTP: But #HIPEC may play a role in modulating the TME, inhibiting DNA repair, and upregulating HSPs and subsequent immune-associa…

Oct 18, 2022 · 4 shares · 1,268 followers View post →
INDEPSO
@indepso · X

RT @BatistaTP: But #HIPEC may play a role in modulating the TME, inhibiting DNA repair, and upregulating HSPs and subsequent immune-associa…

Oct 17, 2022 · 4 shares · 1,193 followers View post →
Peritoneal Surface Oncology Group International
@PSOGI_EC · X

RT @BatistaTP: But #HIPEC may play a role in modulating the TME, inhibiting DNA repair, and upregulating HSPs and subsequent immune-associa…

Oct 17, 2022 · 4 shares · 1,875 followers View post →
Alvaro Arjona
@alarjosan · X

RT @BatistaTP: But #HIPEC may play a role in modulating the TME, inhibiting DNA repair, and upregulating HSPs and subsequent immune-associa…

Oct 17, 2022 · 4 shares · 3,662 followers View post →
Thales P. Batista, MD, PhD
@BatistaTP · X

But #HIPEC may play a role in modulating the TME, inhibiting DNA repair, and upregulating HSPs and subsequent immune-associated pathways. @alarjosan @glaucobaiocchi @sbco_oficial @PSOGI_EC @indepso

Oct 17, 2022 · 7 likes · 4 shares · 1,288 followers View post →
@diagnos360.uy
@diagnos360uy2 · X

RT @Dr_Ivanoncologo: Interesting study

May 10, 2022 · 4 shares · 85 followers View post →
Rene Arauz
@ReneArauz5 · X

RT @Dr_Ivanoncologo: Interesting study

Apr 26, 2022 · 4 shares · 81 followers View post →
Kristel Gonzalez
@Kristel_GT · X

RT @Dr_Ivanoncologo: Interesting study

Apr 22, 2022 · 4 shares · 1,275 followers View post →
Clinical and Experimental Obstetrics & Gynecology
@CEOGjournal · X

RT @Dr_Ivanoncologo: Interesting study

Apr 21, 2022 · 4 shares · 1,475 followers View post →
Dr. Iván R. González
@Dr_Ivanoncologo · X

Interesting study

Apr 21, 2022 · 15 likes · 4 shares · 4,201 followers View post →
Delia Cortés Guiral
@DeliaCortesGuir · X

RT @BatistaTP: #HIPEC–Induced Molecular Changes in Humans Validate Preclinical Data in #OvarianCancer | JCO Precision Oncology, ⁦@ASCO⁩ ⁦@C…

Apr 6, 2022 · 5 shares · 4,686 followers View post →
Somashekhar SP
@somusp9 · X

RT @BatistaTP: #HIPEC–Induced Molecular Changes in Humans Validate Preclinical Data in #OvarianCancer | JCO Precision Oncology, ⁦@ASCO⁩ ⁦@C…

Apr 5, 2022 · 5 shares · 2,602 followers View post →
Division of Gynecologic Oncology at City of Hope
@COH_GynOncology · X

https://t.co/e4ZYmyICRW

Apr 5, 2022 · 3 likes · 132 followers View post →
INDEPSO
@indepso · X

RT @BatistaTP: #HIPEC–Induced Molecular Changes in Humans Validate Preclinical Data in #OvarianCancer | JCO Precision Oncology, ⁦@ASCO⁩ ⁦@C…

Apr 4, 2022 · 5 shares · 1,193 followers View post →
Ji Hyun Kim
@writ__e · X

RT @BatistaTP: #HIPEC–Induced Molecular Changes in Humans Validate Preclinical Data in #OvarianCancer | JCO Precision Oncology, ⁦@ASCO⁩ ⁦@C…

Apr 4, 2022 · 5 shares · 347 followers View post →
Wim Ceelen
@WimCeelen · X

RT @BatistaTP: #HIPEC–Induced Molecular Changes in Humans Validate Preclinical Data in #OvarianCancer | JCO Precision Oncology, ⁦@ASCO⁩ ⁦@C…

Apr 4, 2022 · 5 shares · 1,083 followers View post →
Thales P. Batista, MD, PhD
@BatistaTP · X

#HIPEC–Induced Molecular Changes in Humans Validate Preclinical Data in #OvarianCancer | JCO Precision Oncology, ⁦@ASCO⁩ ⁦@CBCcirurgioes⁩ ⁦⁩ ⁦@sbco_oficial⁩ ⁦@ESSOnews⁩ ⁩@indepso⁩ ⁦@KurtSpeeten⁩ ⁦@WimCeelen⁩ https://t.co/nZiuDHQpLI

Apr 4, 2022 · 13 likes · 5 shares · 1,288 followers View post →