Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signatures to predict HIPEC response and explore mechanisms of HIPEC in TME https://t.co/RiVonOAsN5 @COH_SurgOnc @COH_GynOncology
Hyperthermic Intraperitoneal Chemotherapy-Induced Molecular Changes in Humans Validate Preclinical Data in Ovarian Cancer.
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Apr 2022 – Apr 2024Where it's discussed
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X / Twitter36 posts
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YouTube1 videos
AI synopsis
What people are saying
Throughout the discussions, participants express strong support and fascination with the article’s findings, citing terms like 'validate', 'mechanisms of HIPEC', and 'synergism' to emphasize its relevance and promising implications for future ovarian cancer treatments. The tone is enthusiastic and exploratory, reflecting genuine academic interest and recognition of the study's significance.
Most discussions highly support the validity and importance of the findings, with phrases like 'validate preclinical data' and 'great work', indicating strong agreement with the publication’s significance.
The posts show keen curiosity and engagement, referencing molecular mechanisms, potential synergistic treatments, and implications for future therapies, demonstrating high interest.
Several discussions delve into molecular pathways, biomarkers, and clinical implications, reflecting deep engagement with the research details.
While users recognize the potential impact of the study, the comments suggest ongoing exploration rather than final judgments, resulting in a moderate score for impact perception.
Abstract in brief
- The study investigated the molecular effects of HIPEC (hyperthermic intraperitoneal chemotherapy) with cisplatin during surgery for ovarian cancer, finding that HIPEC can induce changes in immune and DNA repair pathways that correlate with better patient outcomes.
- Patients who responded well to HIPEC showed increased expression of immune-related genes, such as PD-1 in CD8 T cells, and had a longer median progression-free survival (up to nearly 60 months), with minimal severe adverse effects.
- The research validates preclinical findings by identifying distinct molecular signatures that differentiate responders from non-responders, highlighting potential biomarkers for predicting and improving HIPEC treatment efficacy in ovarian cancer.]
Top posts
Most liked on X and BlueskyInteresting study
#HIPEC–Induced Molecular Changes in Humans Validate Preclinical Data in #OvarianCancer | JCO Precision Oncology, @ASCO @CBCcirurgioes @sbco_oficial @ESSOnews @indepso @KurtSpeeten @WimCeelen https://t.co/nZiuDHQpLI
But #HIPEC may play a role in modulating the TME, inhibiting DNA repair, and upregulating HSPs and subsequent immune-associated pathways. @alarjosan @glaucobaiocchi @sbco_oficial @PSOGI_EC @indepso
The #HIPPIE Trial - #HIPEC Plus Imunotherapy in Epithelial #OvaCa also sounds great…
@DemuytereJesse Great work looking into mechanisms of HIPEC at a transcriptomic level! We should share notes https://t.co/htyIcets4O and https://t.co/RiVonOAsN5 #hipec @WimCeelen @COH_SurgOnc
All mentions
Molecular Effects of HIPEC in Ovarian Cancer Validation of Preclinical Data
This study investigates the molecular effects of HIPEC with cisplatin during ovarian cancer surgery. It found HIPEC induces immune and DNA repair pathway changes associated with improved patient outcomes, validating…
RT @BatistaTP: In line with findings by @TDellingerMD via @JCOPO_ASCO . @zivanovicmd @TeamOvary_MSK @PSOGI_EC @alarjosan https://t.co/r42gs…
In line with findings by @TDellingerMD via @JCOPO_ASCO . @zivanovicmd @TeamOvary_MSK @PSOGI_EC @alarjosan https://t.co/r42gs2F5EM 3/…
RT @JCOPO_ASCO: Listen: in new #JCOPO Conversations podcast episode, host @thenasheffect speaks w Dr. Thanh Dellinger about her article "Hy…
RT @JCOPO_ASCO: Listen: in new #JCOPO Conversations podcast episode, host @thenasheffect speaks w Dr. Thanh Dellinger about her article "Hy…
RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…
Listen: in new #JCOPO Conversations podcast episode, host @thenasheffect speaks w Dr. Thanh Dellinger about her article "Hyperthermic Intraperitoneal Chemotherapy–Induced Molecular Changes in Humans Validate Preclinical Data in Ovarian Cancer." https://t.co/TPgOIL9Lqn #gyncsm https://t.co/epFZDtELaA
RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…
RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…
RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…
RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…
RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…
@TDellingerMD @zivanovicmd @drleslie214 @glaucobaiocchi And there are some data from you suggesting #HIPEC may have sinergism w/ other drugs. So much to explore. Regards @CBCcirurgioes @sbco_oficial @br_gynoncgroup @glaucobaiocchi https://t.co/r42gs2FDuk
RT @BatistaTP: The #HIPPIE Trial - #HIPEC Plus Imunotherapy in Epithelial #OvaCa also sounds great…
The #HIPPIE Trial - #HIPEC Plus Imunotherapy in Epithelial #OvaCa also sounds great…
RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…
RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…
RT @TDellingerMD: Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signa…
Proud to be part of the inaugural JCO Precision Oncology Podcast! https://t.co/MzVQ97BtFM to discuss transcriptomic signatures to predict HIPEC response and explore mechanisms of HIPEC in TME https://t.co/RiVonOAsN5 @COH_SurgOnc @COH_GynOncology
@DemuytereJesse Great work looking into mechanisms of HIPEC at a transcriptomic level! We should share notes https://t.co/htyIcets4O and https://t.co/RiVonOAsN5 #hipec @WimCeelen @COH_SurgOnc
RT @BatistaTP: But #HIPEC may play a role in modulating the TME, inhibiting DNA repair, and upregulating HSPs and subsequent immune-associa…
RT @BatistaTP: But #HIPEC may play a role in modulating the TME, inhibiting DNA repair, and upregulating HSPs and subsequent immune-associa…
RT @BatistaTP: But #HIPEC may play a role in modulating the TME, inhibiting DNA repair, and upregulating HSPs and subsequent immune-associa…
RT @BatistaTP: But #HIPEC may play a role in modulating the TME, inhibiting DNA repair, and upregulating HSPs and subsequent immune-associa…
But #HIPEC may play a role in modulating the TME, inhibiting DNA repair, and upregulating HSPs and subsequent immune-associated pathways. @alarjosan @glaucobaiocchi @sbco_oficial @PSOGI_EC @indepso
RT @Dr_Ivanoncologo: Interesting study
RT @Dr_Ivanoncologo: Interesting study
RT @Dr_Ivanoncologo: Interesting study
RT @Dr_Ivanoncologo: Interesting study
Interesting study
RT @BatistaTP: #HIPEC–Induced Molecular Changes in Humans Validate Preclinical Data in #OvarianCancer | JCO Precision Oncology, @ASCO @C…
RT @BatistaTP: #HIPEC–Induced Molecular Changes in Humans Validate Preclinical Data in #OvarianCancer | JCO Precision Oncology, @ASCO @C…
https://t.co/e4ZYmyICRW
RT @BatistaTP: #HIPEC–Induced Molecular Changes in Humans Validate Preclinical Data in #OvarianCancer | JCO Precision Oncology, @ASCO @C…
RT @BatistaTP: #HIPEC–Induced Molecular Changes in Humans Validate Preclinical Data in #OvarianCancer | JCO Precision Oncology, @ASCO @C…
RT @BatistaTP: #HIPEC–Induced Molecular Changes in Humans Validate Preclinical Data in #OvarianCancer | JCO Precision Oncology, @ASCO @C…
#HIPEC–Induced Molecular Changes in Humans Validate Preclinical Data in #OvarianCancer | JCO Precision Oncology, @ASCO @CBCcirurgioes @sbco_oficial @ESSOnews @indepso @KurtSpeeten @WimCeelen https://t.co/nZiuDHQpLI