Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one-exercise program: A randomized dose-response trial of knee-extensor resistance exercise in patients eligible for knee replacement https://t.co/8YX1q4td1Q https://t.co/ddPu8bW7wV
Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one-exercise program: a randomized dose-response trial of knee-extensor resistance exercise in patients eligible for knee replacement (the QUADX-1 trial).
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Mar 2022 – Sep 2025Where it's discussed
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X / Twitter80 posts
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YouTube2 videos
AI synopsis
What people are saying
In the discussions, numerous posts highlight key findings from the QUADX-1 trial, especially noting that 2/3 of patients chose not to undergo knee replacement surgery after engaging in a home-based exercise program. Phrases like 'changing the narrative for prehabilitation' and 'fascinating trial' illustrate a positive and dynamic tone, underscoring the perceived importance and practical relevance of the research in improving patient outcomes.
The majority of discussions reflect support for the study's findings, indicating a consensus on its relevance.
There is a strong level of curiosity about the implications of the research, signaling its importance to the audience.
While many discussions mention the study, the depth of engagement varies; some provide insights while others merely reference the publication.
Participants generally view the findings as having significant implications for treatment decisions in knee rehabilitation, especially regarding surgery.
Abstract in brief
- The QUADX1 trial investigated the effects of varying dosages (2, 4, or 6 sessions per week) of a home-based knee extensor resistance exercise program on knee extensor strength and symptoms among 140 patients eligible for knee replacement.
- Primary results showed no significant differences in isometric knee extensor strength after 12 weeks across the different exercise groups.
- However, secondary analyses indicated that patients engaging in two sessions per week reported better outcomes in terms of knee function (measured by the Oxford Knee Score) and lower average pain, while surgery decisions were not influenced by the intensity of exercise.
Top posts
Most liked on X and BlueskyKnee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one-exercise program
Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one-exercise program: A randomized dose-response trial https://t.co/mDVHBp4Wqy
Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one-exercise program: a randomized doseeresponse trial of knee-extensor resistance exercise in patients eligible for knee replacement https://t.co/8c4TeRCTBm https://t.co/lBmyffKpEr
QUADX-1; fascinating trial by @TBandholm @MichaelRathleff and colleagues https://t.co/2fUCKmImep 2/3 of patients opted not to proceed with total knee replacement after the physiotherapist supported exercise programme! Is this relevant in the UK? @garethphysio1 @mmoffatt408
Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one-exercise program: A randomized dose-response trial of knee-extensor resistance exercise in patients eligible for knee replacement https://t.co/v46hND1f2X
All mentions
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@MSKPhysioJnl agree that short-term pain should not be destiny. Clinical work in line with this work have been done and it shows non-superior effects of higher volume: https://t.co/P5ljGLuXwc
RT @ChrisLittlew00d: QUADX-1; fascinating trial by @TBandholm @MichaelRathleff and colleagues https://t.co/2fUCKmImep 2/3 of patients opted…
RT @ChrisLittlew00d: QUADX-1; fascinating trial by @TBandholm @MichaelRathleff and colleagues https://t.co/2fUCKmImep 2/3 of patients opted…
RT @ChrisLittlew00d: QUADX-1; fascinating trial by @TBandholm @MichaelRathleff and colleagues https://t.co/2fUCKmImep 2/3 of patients opted…
RT @ChrisLittlew00d: QUADX-1; fascinating trial by @TBandholm @MichaelRathleff and colleagues https://t.co/2fUCKmImep 2/3 of patients opted…
RT @ChrisLittlew00d: QUADX-1; fascinating trial by @TBandholm @MichaelRathleff and colleagues https://t.co/2fUCKmImep 2/3 of patients opted…
RT @ChrisLittlew00d: QUADX-1; fascinating trial by @TBandholm @MichaelRathleff and colleagues https://t.co/2fUCKmImep 2/3 of patients opted…
RT @ChrisLittlew00d: QUADX-1; fascinating trial by @TBandholm @MichaelRathleff and colleagues https://t.co/2fUCKmImep 2/3 of patients opted…
RT @ChrisLittlew00d: QUADX-1; fascinating trial by @TBandholm @MichaelRathleff and colleagues https://t.co/2fUCKmImep 2/3 of patients opted…
RT @ChrisLittlew00d: QUADX-1; fascinating trial by @TBandholm @MichaelRathleff and colleagues https://t.co/2fUCKmImep 2/3 of patients opted…
RT @ChrisLittlew00d: QUADX-1; fascinating trial by @TBandholm @MichaelRathleff and colleagues https://t.co/2fUCKmImep 2/3 of patients opted…
RT @ChrisLittlew00d: QUADX-1; fascinating trial by @TBandholm @MichaelRathleff and colleagues https://t.co/2fUCKmImep 2/3 of patients opted…
QUADX-1; fascinating trial by @TBandholm @MichaelRathleff and colleagues https://t.co/2fUCKmImep 2/3 of patients opted not to proceed with total knee replacement after the physiotherapist supported exercise programme! Is this relevant in the UK? @garethphysio1 @mmoffatt408
@saraa861 https://t.co/UMcKmWEoY5 + ice bag 2t/1day
https://t.co/TxvkcyJ2b3 https://t.co/jAMCFu1868 https://t.co/OuLELvke7D https://t.co/9kI6n1uLJh
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four... https://t.co/gw5c1QsUYR
Knee-extensor strength, symptoms, and need for surgery after two, four... https://t.co/gw5c1QsUYR
Exercises for pre-habilitation or pre-evaluation Knee-extensor strength, symptoms, and need for surgery: https://t.co/H8N2LgvHMp Changing the narrative for prehabilitation: https://t.co/qCaOSBCbNf
RT @ExploredPhysio:
RT @TBandholm: @henriksen_mh Similar pattern for simple 1-exercise programs: https://t.co/nYeEKsXHBG
@henriksen_mh Similar pattern for simple 1-exercise programs: https://t.co/nYeEKsXHBG
RT @TBandholm: This review builds on knowledge gained from our previous research in the area of prehabilitation in TKA (#openaccess): https…
This review builds on knowledge gained from our previous research in the area of prehabilitation in TKA (#openaccess): https://t.co/qW9ndls4Jw & https://t.co/nYeEKsX9M8 https://t.co/JD4oL84wft
■ note link:https://t.co/Pa1YbLYsh9 ■ Ref info:Husted et al. "Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one-exercise program" Osteoarthritis Cartilage (2022). ■ Ref link:https://t.co/JroDZX1yaw
RT @Retlouping: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one-exercise program: a randomized doseeresponse trial of knee-extensor resistance exercise in patients eligible for knee replacement https://t.co/8c4TeRCTBm https://t.co/lBmyffKpEr
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one-exercise program: a randomized dose–response trial https://t.co/XF6A0UpF9U
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @KThorborg: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
RT @KThorborg: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one…
RT @KThorborg: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one…
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @KThorborg: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
RT @KThorborg: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @KThorborg: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one…
RT @KThorborg: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one-exercise program: A randomized dose-response trial of knee-extensor resistance exercise in patients eligible for knee replacement https://t.co/v46hND1f2X
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
RT @HinmanRana: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based on…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one-exercise program: A randomized dose-response trial https://t.co/mDVHBp4Wqy
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one-exercise program: A randomized dose-response trial of knee-extensor resistance exercise in patients eligible for knee replacement https://t.co/8YX1q4td1Q https://t.co/ddPu8bW7wV
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
RT @PhysioMeScience: Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-bas…
Knee-extensor strength, symptoms, and need for surgery after two, four, or six exercise sessions/week using a home-based one-exercise program