Lessons from nature: Leveraging the freeze-tolerant wood frog as a model to improve organ cryopreservation and biobanking.

Abstract in brief

• The freezetolerant wood frog, Rana sylvatica, can survive and recover from full body freezing and thawing without damage, making it a valuable model for studying survival mechanisms under extreme cold stress.
• Researchers are exploring how the frog’s molecular strategies can be applied to improve cryopreservation techniques for human cells, tissues, and organs, potentially leading to better transplant success and increased preservation times.
• Current advancements and future prospects involve mimicking the frog’s prosurvival responses to enhance biobanking, regenerative medicine, and the distribution of transplantable materials across broader regions.