Should you supplement Vitamin K2 for artery calcification and heart disease? A look at the balance of evidence from human trials, common claims on the internet and underlying logic full video
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial.
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Apr 2022 – Oct 2025Where it's discussed
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AI synopsis
What people are saying
Many discussions emphasize the study’s results of no significant effect for Vitamin K2 and D on calcification progression, using phrases like 'no influence' and 'no efficacy,' indicating a skeptical tone. The tone is scientific and factual, with references to specific trial details, such as the number of participants and methodology, thus reflecting interest in evidence-based outcomes rather than hype or speculation.
Most discussions highlight that the study found no significant benefit of taking Vitamin K2 and D in reducing aortic valve calcification, indicating general skepticism about claims of positive effects.
The posts show high interest in the research, with many referencing the trial's methodology and results, implying engagement with scientific details.
While some users comment on the relevance and implications of the data, engagement remains moderate, often summarizing findings or sharing opinions without deep discussion.
The discussion suggests the research may influence clinical considerations and supplement use, but the overall consensus reflects limited immediate clinical impact due to negative findings.
Abstract in brief
- Menaquinone-7 (MK-7), a form of vitamin K2, may help slow down aortic valve calcification in patients, particularly those with aortic stenosis.
- In a clinical trial, 365 men were studied over 24 months to assess the effect of a daily MK-7 and vitamin D treatment versus a placebo, measuring changes in aortic valve calcification scores and other heart-related outcomes.
- Results showed no significant differences in aortic valve calcification progression, heart valve surgeries, or major health events between the groups, although MK-7 did lead to a reduction in a specific protein related to calcification.
Top posts
Most liked on X and BlueskyAmong 365 patients with aortic sclerosis (AoV calcium scores > 300 & velocity < 3 m/s), vitamins K2 + D vs placebo did not reduce calcification progression or risk for clinical events https://t.co/j2VYJavAoy @CircAHA https://t.co/lQ1zn1jU4w
In a randomized, double-blind, multicenter trial, 2 years of Vitamin K2 (MK-7) plus vitamin D supplementation did not influence Aortic Valve Calcification. https://t.co/WVv2VzLJWn Very important finding. Video coming shortly
NEW VIDEO - Pivotal Vitamin K2 Study A randomized, double-blind, placebo-controlled trial of 365 adults showed NO EFFECT of Vitamin K2+D on reducing Aortic Valve Calcification https://t.co/WVv2VzLJWn https://t.co/pb9tRpCYdc https://t.co/OepJ11KhTM
More evidence, but yet no efficacy
La importancia de los estudios negativos La suplementación con Vitamina K y D no detuvo la calcificiación valvular aórtica Sólido estudio randomizado, dobre ciego https://t.co/gHeULsLTSO https://t.co/49u9x2cxyU
All mentions
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@PawelVujc @Sonny7094849575 @angeliquedeberg @NaczelnaL A tu jeszcze zapomniałem dorzucić kolejne dwa badania wskazujące na brak działanie które rozwalcowywany pan wyciągnął z otchłani 2014 roku: https://t.co/R7AbFuWIgN oraz https://t.co/TY7zrMpRQy
RT @PPibarot: Vitamin K2 and D to slow the progression of AS: interesting hypothesis to test but this RCT from Denmark led by J. Dahl show…
Fact-checking anti-aging meds | Metformin, Rapamycin, NMN, etc https://t.co/p2CfHOEME3 via @YouTube
Fact-checking anti-aging meds | Metformin, Rapamycin, NMN, etc https://t.co/rVC9JcDlp9 via @YouTube
RT @NutritionMadeS3: https://t.co/M29bPXRpZ1
RT @NutritionMadeS3: https://t.co/M29bPXRpZ1
https://t.co/M29bPXRpZ1
@AdvancedForged @BowTiedOx Dunno about that, brief search suggests benefit https://t.co/Qt1NFTF5Of or no effect https://t.co/eka6sO8OKC & https://t.co/kYgwH8nHwo
Vitamin D: What's the Perfect Dose? https://t.co/hO7miG1C36 via @YouTube
@MohammedAlo https://t.co/L2V2xanaIF
@goddeketal https://t.co/ckSMjuGs4N The need for magnesium with D has much more direct, scientific evidence behind it. https://t.co/53lvSIIodq
@my_busybrain @dvassallo I just came across a study which says it did not improve calcification. Thoughts ? https://t.co/c5fJMIYVfM
RT @eszmun: @Mr_Nejman @NatalieWayne69 miałaś na to wpływ, mogłaś nie dostać po prostu na pizdę i robić uniki jak Chrollo w walce z Hisoką…
@Mr_Nejman @NatalieWayne69 miałaś na to wpływ, mogłaś nie dostać po prostu na pizdę i robić uniki jak Chrollo w walce z Hisoką i dwoma Zoldyckami https://t.co/dCFegNKx5k Patryk ma rację, że interesy lekarzy są inne niż farmacji, lekarze w Polsce są przepracowani, potrzebujemy ich więcej w systemie :/
RT @NutritionMadeS3: Should you supplement Vitamin K2 for artery calcification and heart disease? A look at the balance of evidence from h…
RT @xxtracy09xx: Should you take Vitamin K2 for Calcified Arteries & Heart Disease? https://t.co/kVYYUArtXL via @YouTube
Should you take Vitamin K2 for Calcified Arteries & Heart Disease? https://t.co/kVYYUArtXL via @YouTube
RT @NutritionMadeS3: Should you supplement Vitamin K2 for artery calcification and heart disease? A look at the balance of evidence from h…
RT @NutritionMadeS3: Should you supplement Vitamin K2 for artery calcification and heart disease? A look at the balance of evidence from h…
RT @NutritionMadeS3: Should you supplement Vitamin K2 for artery calcification and heart disease? A look at the balance of evidence from h…
RT @NutritionMadeS3: Should you supplement Vitamin K2 for artery calcification and heart disease? A look at the balance of evidence from h…
Should you supplement Vitamin K2 for artery calcification and heart disease? A look at the balance of evidence from human trials, common claims on the internet and underlying logic full video
RT @EssaHariri: Check out our letter to the editor re: ACADEC “Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized D…
RT @EssaHariri: Check out our letter to the editor re: ACADEC “Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized D…
RT @EssaHariri: Check out our letter to the editor re: ACADEC “Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized D…
Check out our letter to the editor re: ACADEC “Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial" The story of K2 metabolism and CV health is yet to be fully uncovered @kassisMD @tavrkapadia @ADiederichsen @SelmaHasific
RT @Hragy: Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial | Circulation Poll in n…
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial | Circulation Poll in next tweet https://t.co/m22O8o16yg(MK%2D7,in%20patients%20with%20aortic%20stenosis.
@TchotchkeOmnisc @TheNutrivore The progression in aortic and coronary artery calcification score was not significantly different between patients treated with MK-7 plus vitamin D and patients receiving placebo. https://t.co/E99C3d049Y
RT @Nutradvance: @wyadvd https://t.co/nejt0dixBP?
@wyadvd https://t.co/nejt0dixBP?
RT @arvindcanchi: Are there any RCTs to prove the efficacy of Vitamin K2 (menaquinone) in reducing valve or arterial wall calcification esp…
RT @arvindcanchi: Are there any RCTs to prove the efficacy of Vitamin K2 (menaquinone) in reducing valve or arterial wall calcification esp…
RT @arvindcanchi: Are there any RCTs to prove the efficacy of Vitamin K2 (menaquinone) in reducing valve or arterial wall calcification esp…
RT @arvindcanchi: Are there any RCTs to prove the efficacy of Vitamin K2 (menaquinone) in reducing valve or arterial wall calcification esp…
RT @arvindcanchi: Are there any RCTs to prove the efficacy of Vitamin K2 (menaquinone) in reducing valve or arterial wall calcification esp…
Are there any RCTs to prove the efficacy of Vitamin K2 (menaquinone) in reducing valve or arterial wall calcification especially in Diabetic or #ckd pts? I'm getting negative RCTs only... #askrenal https://t.co/tR9XMVldg7 https://t.co/fdBZJ4VA3O https://t.co/jpOuDNPNXA
@Vicesignal Thanks for the reminder! Just checked and it was published in May this year. https://t.co/nejt0dj5rn
BUTT, K2 non-beneficial Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial 2021 https://t.co/pYhIUpuKvp "In elderly men with an AVC score >300 AU, 2 years MK-7 plus vitamin D supplementation did not influence AVC progression.
BUTT, K2 non-beneficial Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial 2021 https://t.co/pYhIUpuKvp "In elderly men with an AVC score >300 AU, 2 years MK-7 plus vitamin D supplementation did not influence AVC progression.
@BioavailableNd Yea, a study in April came out about Mk-7 supp not able to reverse calcification, so i would see one reason ppl are against it. https://t.co/pJKBs15U9X of course, that doesn't really imply any benefits of prevention/reversal via Mk-4 or Mk-7 in healthy peeps. Still some hope.
RT @shivadas29: Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial (MK-7 was used her…
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial (MK-7 was used here) 2022 publised. https://t.co/pYhIUpuKvp
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial (MK-7 was used here) 2022 publised. https://t.co/pYhIUpuKvp
@ParolDamian @lekarzsuwala A łączenie witaminy D z K działa na kalcyfikacje na poziomie placebo https://t.co/2gKwh3KDMa
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial https://t.co/XA3BNGdlks
RT @EstebanDL: La importancia de los estudios negativos La suplementación con Vitamina K y D no detuvo la calcificiación valvular aórtica…
RT @EstebanDL: La importancia de los estudios negativos La suplementación con Vitamina K y D no detuvo la calcificiación valvular aórtica…
La importancia de los estudios negativos La suplementación con Vitamina K y D no detuvo la calcificiación valvular aórtica Sólido estudio randomizado, dobre ciego https://t.co/gHeULsLTSO https://t.co/49u9x2cxyU
RT @CardioIAN: @CardioIAN #CardioTwitter https://t.co/27dhaLHSDZ
@CardioIAN #CardioTwitter https://t.co/27dhaLHSDZ
RT @CircAHA: #OriginalResearch: #RCT testing #VitaminD & VitaminK2 in pts with #AorticValveCalcification found no effect on the progression…
Vitamin K2 and D in Patients With Aortic Valve Calcification https://t.co/pz2VYJ7AJB #cardiology
RT @CircAHA: #OriginalResearch: #RCT testing #VitaminD & VitaminK2 in pts with #AorticValveCalcification found no effect on the progression…
RT @CircAHA: #OriginalResearch: #RCT testing #VitaminD & VitaminK2 in pts with #AorticValveCalcification found no effect on the progression…
RT @CircAHA: #OriginalResearch: #RCT testing #VitaminD & VitaminK2 in pts with #AorticValveCalcification found no effect on the progression…
RT @CircAHA: #OriginalResearch: #RCT testing #VitaminD & VitaminK2 in pts with #AorticValveCalcification found no effect on the progression…
#OriginalResearch: #RCT testing #VitaminD & VitaminK2 in pts with #AorticValveCalcification found no effect on the progression of calcification @ADiederichsen #AHAJournals https://t.co/9i387Zl9vf https://t.co/plo8cAijyl
Can calcification of the #aorticvalve be inhibited or slowed down? Great idea - wrong patient group in my opinion - try it out on patients with valves that are at risk of calcification - bicuspid valves &/or prosthetic valves. https://t.co/WQFod0gf6A
https://t.co/C1CSrsW9I4
RT @HeartOTXHeartMD: #cvVHDav #VitK #VitD https://t.co/lmnXafBzJq
#cvVHDav #VitK #VitD https://t.co/lmnXafBzJq
RT @BradStanfieldMD: NEW VIDEO - Pivotal Vitamin K2 Study A randomized, double-blind, placebo-controlled trial of 365 adults showed NO EFF…
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial https://t.co/JZX1rFf0kw
RT @agingdoc1: Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial https://t.co/P99jS…
RT @BradStanfieldMD: NEW VIDEO - Pivotal Vitamin K2 Study A randomized, double-blind, placebo-controlled trial of 365 adults showed NO EFF…
RT @BradStanfieldMD: NEW VIDEO - Pivotal Vitamin K2 Study A randomized, double-blind, placebo-controlled trial of 365 adults showed NO EFF…
RT @nick_krontiris: Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial (open access)…
NEW VIDEO - Pivotal Vitamin K2 Study A randomized, double-blind, placebo-controlled trial of 365 adults showed NO EFFECT of Vitamin K2+D on reducing Aortic Valve Calcification https://t.co/WVv2VzLJWn https://t.co/pb9tRpCYdc https://t.co/OepJ11KhTM
@ErnMedBlog @kassisMD @dgimev https://t.co/ksMRUS4ZsA
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial (open access) https://t.co/8sFznIMC2W #nutrition #diet #supplements #supplement
RT @agingdoc1: Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial https://t.co/P99jS…
RT @VDelgadoGarcia: More evidence, but yet no efficacy
RT @agingdoc1: Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial https://t.co/P99jS…
RT @VDelgadoGarcia: More evidence, but yet no efficacy
RCT: No influence of supplemental Vitamin K2 and D in the progression of aortic valve calcification. – via @CircAHA https://t.co/nTpECmu6xC Commentary: https://t.co/TEDxpKrKvn
Vitamin D supplementation don't influence AVC progression. Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial https://t.co/ZzBHn5749e
RT @VDelgadoGarcia: More evidence, but yet no efficacy
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial https://t.co/P99jS1PMAj
RT @BradStanfieldMD: In a randomized, double-blind, multicenter trial, 2 years of Vitamin K2 (MK-7) plus vitamin D supplementation did not…
RT @PPibarot: Vitamin K2 and D to slow the progression of AS: interesting hypothesis to test but this RCT from Denmark led by J. Dahl show…
RT @PPibarot: Vitamin K2 and D to slow the progression of AS: interesting hypothesis to test but this RCT from Denmark led by J. Dahl show…
RT @VDelgadoGarcia: More evidence, but yet no efficacy
Vitamin K2 and D to slow the progression of AS: interesting hypothesis to test but this RCT from Denmark led by J. Dahl shows that it does not work. Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial https://t.co/HDWLNMiRmg
RT @VDelgadoGarcia: More evidence, but yet no efficacy
More evidence, but yet no efficacy
RT @Kamil_Paprotny: Zwolennicy ładowania K2MK7 do witaminy D nie mają łatwo. Badanie z przed dwóch dni pokazuje, że dodatek K2 nie zmniej…
Zwolennicy ładowania K2MK7 do witaminy D nie mają łatwo. Badanie z przed dwóch dni pokazuje, że dodatek K2 nie zmniejsza ryzyka kalcyfikacji. Ochrona K2MK7 z wit D to efekt na poziomie placebo. A wiec prawdopodobnie nie działa. https://t.co/6pQQZ3N6uR
RT @pnatarajanmd: Among 365 patients with aortic sclerosis (AoV calcium scores > 300 & velocity < 3 m/s), vitamins K2 + D vs placebo did no…
RT @pnatarajanmd: Among 365 patients with aortic sclerosis (AoV calcium scores > 300 & velocity < 3 m/s), vitamins K2 + D vs placebo did no…
RT @pnatarajanmd: Among 365 patients with aortic sclerosis (AoV calcium scores > 300 & velocity < 3 m/s), vitamins K2 + D vs placebo did no…
RT @pnatarajanmd: Among 365 patients with aortic sclerosis (AoV calcium scores > 300 & velocity < 3 m/s), vitamins K2 + D vs placebo did no…
RT @pnatarajanmd: Among 365 patients with aortic sclerosis (AoV calcium scores > 300 & velocity < 3 m/s), vitamins K2 + D vs placebo did no…
RT @pnatarajanmd: Among 365 patients with aortic sclerosis (AoV calcium scores > 300 & velocity < 3 m/s), vitamins K2 + D vs placebo did no…
RT @pnatarajanmd: Among 365 patients with aortic sclerosis (AoV calcium scores > 300 & velocity < 3 m/s), vitamins K2 + D vs placebo did no…
RT @BradStanfieldMD: In a randomized, double-blind, multicenter trial, 2 years of Vitamin K2 (MK-7) plus vitamin D supplementation did not…
In a randomized, double-blind, multicenter trial, 2 years of Vitamin K2 (MK-7) plus vitamin D supplementation did not influence Aortic Valve Calcification. https://t.co/WVv2VzLJWn Very important finding. Video coming shortly
RT @pnatarajanmd: Among 365 patients with aortic sclerosis (AoV calcium scores > 300 & velocity < 3 m/s), vitamins K2 + D vs placebo did no…
RT @pnatarajanmd: Among 365 patients with aortic sclerosis (AoV calcium scores > 300 & velocity < 3 m/s), vitamins K2 + D vs placebo did no…
RT @rblument1: Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial https://t.co/3aKxun…
I have had the pleasure to be part of this study on the effects of Vitamin K on cardiovascular disease. We working further with the skeletal data that has been presented in this articles supplements. @EfeOuh @OUHhospital https://t.co/Yjuiw4sLS6
Results of the #AVADEC -Trial are out
RT @pnatarajanmd: Among 365 patients with aortic sclerosis (AoV calcium scores > 300 & velocity < 3 m/s), vitamins K2 + D vs placebo did no…
Among 365 patients with aortic sclerosis (AoV calcium scores > 300 & velocity < 3 m/s), vitamins K2 + D vs placebo did not reduce calcification progression or risk for clinical events https://t.co/j2VYJavAoy @CircAHA https://t.co/lQ1zn1jU4w
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial https://t.co/3aKxunfCn5
RT @FormigaFrancesc: Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial https://t.co/…
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial https://t.co/R9Mb1EaaKJ
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