Diabetes Obes Metab August 2022 PMID 35491956

Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes.

David S H Bell

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Peak: 22 in May 2022

across 8 sources since May 2022

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288,165

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May 2022 – Dec 2025

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AI synopsis

What people are saying

The discussions reflect strong agreement with the article, with participants emphasizing the importance of monitoring B12 levels and noting that deficiency can worsen neuropathy and cardiac issues. Words like 'check your B12', 'monitoring recommended', and phrases such as 'can cause or worsen' demonstrate concern and a desire for awareness, indicating a high level of engagement and perceived impact.

AgreementStrong agreement

Most discussions acknowledge the link between metformin and B12 deficiency, supporting the article's findings.

InterestHigh interest

Participants show a high level of curiosity and concern regarding the potential health impacts and monitoring recommendations.

EngagementHigh engagement

Discussions include references to strategies like monitoring and supplementation, indicating deep engagement.

ImpactHigh impact

The conversations highlight significant potential health consequences, such as worsened neuropathy and increased cardiac risks, emphasizing high impact.

Abstract in brief

Metformin can interfere with the absorption of vitamin B12, potentially leading to deficiency, which may contribute to or worsen neuropathy symptoms in diabetic patients.
Studies show that long-term use of metformin is linked to lower vitamin B12 levels and a higher risk of developing peripheral and autonomic neuropathy, including cardiac issues, increasing the risk of adverse cardiac events and mortality.
Regular monitoring of vitamin B12 levels is recommended for metformin users, especially those on therapy for over 5 years or with additional risk factors; treatments include supplementation with vitamin B12 and calcium, and discontinuing metformin if necessary to prevent or manage neuropathy symptoms.

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Impact of Metformin on Micronutrient Absorption and Health Risks

Antidiabetics like Metformin can impair the absorption of key micronutrients such as vitamin B12, vitamin B1, and magnesium, potentially leading to deficiencies that affect overall health and wellbeing. Regular…

Niederrhein Vital · Apr 21, 2024 2,532 views

Pradeep K. Divakar

@PKDivakar · X

https://t.co/rrs8zDgofR

Oct 15, 2025 · 410 followers View post →

endocrinogustavoparra

@gustavendocrino · X

@Marcia457919 5. Metformin-Induced Vitamin B12 Deficiency Can Cause or Worsen Distal Symmetrical, Autonomic and Cardiac Neuropathy in the Patient With Diabetes. Bell DSH. Diabetes, Obesity & Metabolism. 2022;24(8):1423-1428. doi:10.1111/dom.14734.

May 8, 2025 · 13,517 followers View post →

OLA LOA

@OlaLoa · X

Do you take Metformin? Check your B12. Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes. https://t.co/XdT93f0icU #olaloa #b12 #hydroxyB12 https://t.co/BggG8bacvR

Apr 11, 2025 · 1 like · 978 followers View post →

Duckii Duck

@duckii.bsky.social · Bluesky

Metformin and B12 deficiency.. pubmed.ncbi.nlm.nih.gov/35491956/

Feb 16, 2025 View post →

Cardio

@PesarCardio · X

@mr_optixx درسته البته کار که زیاد شده حتی در حد متاآنالیز https://t.co/otDF9vVfci https://t.co/tZ6VFsta8K

Oct 28, 2024 · 1,195 followers View post →

Radio Cobalamin

@nob12deficiency · X

RT @nob12deficiency: "...periodic monitoring of vitamin B12 is recommended in all patients who utilize metformin, particularly if metformin…

Oct 31, 2023 · 1 share · 2,563 followers View post →

Radio Cobalamin

@nob12deficiency · X

"...periodic monitoring of vitamin B12 is recommended in all patients who utilize metformin, particularly if metformin has been used for over 5 years at which stage hepatic stores of vitamin B12 would probably be depleted." #diabetes #neurotwitter #MedEd https://t.co/C4S87HE9TN

Oct 30, 2023 · 1 share · 2,563 followers View post →

Robert Olney

@boretrol · X

Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes https://t.co/uPng4J9zES

Jun 9, 2023 · 1 like · 1,698 followers View post →

JustBeNice

@diane672 · X

https://t.co/D8zu48pd4B Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes

May 6, 2023 · 1 like · 193 followers View post →

bobychouu

@eauriz · X

@pabonnet DOI: 10.1111/dom.14734 via un déficit en B12 que la metformine pourrait provoquer

Mar 8, 2023 · 87 followers View post →

Diana

@PharmphoodTM · X

@Jopo_dr @charlot_summers @mark_toshner https://t.co/gw1fRNbjcd

Mar 6, 2023 · 560 followers View post →

Merith

@Merith02225941 · X

@DrGoblin3 @PharmRJ @NewingSandra @drgandalf52 @ArronThind https://t.co/6sd6xutPV4

Sep 9, 2022 · 103 followers View post →

Edith Valerio

@ValerioEdi · X

La metformina y el omeprazol inhiben la absorción de vit b12 incrementando la #NeuropatiaDiabetica , el dolor en extremidades, la debilidad y el insomnio.

Aug 25, 2022 · 1 share · 255 followers View post →

JORGE FERNANDEZ

@drjorfer · X

Metformin‐induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes - Bell - 2022 - Diabetes, Obesity and Metabolism - Wiley Online Library✅✅✅ https://t.co/BUVyJLf6Vo

Jul 17, 2022 · 1 like · 1,017 followers View post →

Queralt Asla

@QueraltAsla · X

RT @sociedadSEEN:

May 14, 2022 · 3 shares · 357 followers View post →

Miguel Angel Valero

@mavalero_endo · X

RT @sociedadSEEN:

May 14, 2022 · 3 shares · 860 followers View post →

Marcelo Mario Avellanal Leal

@parreshia · X

RT @sociedadSEEN:

May 14, 2022 · 3 shares · 2,002 followers View post →

Sociedad SEEN

@sociedadSEEN · X

May 14, 2022 · 4 likes · 3 shares · 17,247 followers View post →

金森重樹@ダイエットonlineサロン

@ShigekiKanamori · X

RT @kojija: 【メトホルミンとB12】メトホルミンはビタミンB12の吸収をブロック回腸クバム受容体への内因子-B12複合体のCaチャネル依存性結合の干渉？ https://t.co/0JPFgDYRUQ

May 14, 2022 · 2 shares · 124,827 followers View post →

KOJI@プライマルコーチ

@kojija · X

May 13, 2022 · 14 likes · 2 shares · 2,317 followers View post →

Bindikannan

@Bindikannan963 · X

RT @HealthyFellow: #Metformin induced #vitamin #B12 deficiency can cause or worsen distal symmetrical, autonomic & #cardiac #neuropathy in…

May 4, 2022 · 7 shares · 1,096 followers View post →

Best Health 4 You

@besthealthyou · X

RT @HealthyFellow: #Metformin induced #vitamin #B12 deficiency can cause or worsen distal symmetrical, autonomic & #cardiac #neuropathy in…

May 4, 2022 · 7 shares · 511 followers View post →

Black Dragon

@Black_Dragon123 · X

RT @HealthyFellow: #Metformin induced #vitamin #B12 deficiency can cause or worsen distal symmetrical, autonomic & #cardiac #neuropathy in…

May 4, 2022 · 7 shares · 2,167 followers View post →

Inspirational Quotes

@leobeeson · X

RT @HealthyFellow: #Metformin induced #vitamin #B12 deficiency can cause or worsen distal symmetrical, autonomic & #cardiac #neuropathy in…

May 4, 2022 · 7 shares · 260 followers View post →

Science Communication

@ScienceCommuni2 · X

RT @HealthyFellow: #Metformin induced #vitamin #B12 deficiency can cause or worsen distal symmetrical, autonomic & #cardiac #neuropathy in…

May 4, 2022 · 7 shares · 2,890 followers View post →

International Natural Product Sciences Taskforce

@_INPST · X

RT @HealthyFellow: #Metformin induced #vitamin #B12 deficiency can cause or worsen distal symmetrical, autonomic & #cardiac #neuropathy in…

May 3, 2022 · 7 shares · 10,290 followers View post →

मनीष Anand

@ManeeshAnand1 · X

RT @HealthyFellow: #Metformin induced #vitamin #B12 deficiency can cause or worsen distal symmetrical, autonomic & #cardiac #neuropathy in…

May 3, 2022 · 7 shares · 2,509 followers View post →

J P Fanton

@HealthyFellow · X

May 3, 2022 · 13 likes · 7 shares · 26,006 followers View post →

Ranjan Nanda

@RanjanN2022 · X

RT @DanielJDrucker: A reminder and review of the effects of metformin on Vitamin B12 absorption #T2D https://t.co/oy6V5an03F

May 3, 2022 · 7 shares · 390 followers View post →

Maurício Lima

@dj_surfista · X

A deficiência de vitamina B12 induzida por #metformina pode causar ou piorar neuropatia simétrica distal, autonômica e cardíaca no paciente com #diabetes. #Metformin https://t.co/csMustZmdy

May 3, 2022 · 4 likes · 747 followers View post →

Rafael Radaeli

@rfradaeli · X

RT @DanielJDrucker: A reminder and review of the effects of metformin on Vitamin B12 absorption #T2D https://t.co/oy6V5an03F

May 3, 2022 · 7 shares · 383 followers View post →

alephh

@alephh · X

Metformin driven B12 deficiency can cause distal symmetrical, autonomic/cardiac neuropathy in diabetes —#Metformin utilizers have more distal symmetrical polyneuropathy & autonomic neuropathy (=cardiac denervation=more cardiac arrythmias/events, mortality) https://t.co/kiYNatBAgx

May 3, 2022 · 388 followers View post →

Monika Stangl

@stanglmonika · X

RT @DanielJDrucker: A reminder and review of the effects of metformin on Vitamin B12 absorption #T2D https://t.co/oy6V5an03F

May 3, 2022 · 7 shares · 1,078 followers View post →

Eve Beavers-Fain BSN MPH

@espacetimeNOT · X

RT @DanielJDrucker: A reminder and review of the effects of metformin on Vitamin B12 absorption #T2D https://t.co/oy6V5an03F

May 2, 2022 · 7 shares · 1,208 followers View post →

Arnel Carmona

@ecgrhythms · X

RT @DanielJDrucker: A reminder and review of the effects of metformin on Vitamin B12 absorption #T2D https://t.co/oy6V5an03F

May 2, 2022 · 7 shares · 27,676 followers View post →

Daniel J Drucker

@DanielJDrucker · X

A reminder and review of the effects of metformin on Vitamin B12 absorption #T2D https://t.co/oy6V5an03F

May 2, 2022 · 11 likes · 7 shares · 34,761 followers View post →

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Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes.

Mentions per month

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Impact of Metformin on Micronutrient Absorption and Health Risks