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Nat Methods May 2022 PMID 35545715

A hybrid open-top light-sheet microscope for versatile multi-scale imaging of cleared tissues.

Adam K Glaser, Kevin W Bishop, Lindsey A Barner, Etsuo A Susaki, Shimpei I Kubota, Gan Gao, Robert B Serafin, Pooja Balaram, Emily Turschak, Philip R Nicovich, Hoyin Lai, Luciano A G Lucas, Yating Yi, Eva K Nichols, Hongyi Huang

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Mentions

99
Peak: 32 in May 2022
across 5 sources since May 2022

Extended reach

1,074,134
potential audience

Total likes

27

Video views

1,589

Mentions per month

May 2022 – Mar 2025

Where it's discussed

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  • YouTube3 videos
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AI synopsis

What people are saying

The overall sentiment reflects general acknowledgment of the hybrid microscope's capabilities, with phrases like 'versatile multi-scale imaging' and mentions of applications such as 'imaging structures in a mouse brain.' Words like 'new article' and hashtags like '#Imaging' suggest a focus on dissemination rather than critical evaluation, which aligns with moderate interest and impact scores.

AgreementNeither agree nor disagree

Discussions mainly acknowledge the publication without showing strong positive or negative positions, indicating neutrality or moderate support.

InterestModerate interest

The conversation demonstrates some curiosity, especially around the technical aspects, but lacks widespread enthusiasm or deep engagement.

EngagementNeutral engagement

Remarks mostly share brief summaries or references to the system, with minimal in-depth analysis or critical discussion.

ImpactModerate impact

The posts recognize the potential significance of the imaging technology but do not convincingly depict a groundbreaking shift or intense debate.

Abstract in brief

  • Light-sheet microscopy is key for high-throughput imaging of cleared tissues, but there is a demand for a flexible system that meets diverse imaging needs.
  • The proposed 'hybrid' system integrates non-orthogonal dual-objective and conventional open-top light-sheet designs to support various volumetric imaging applications.
  • This hybrid system has shown success in efficiently imaging structures in a cleared mouse brain, allowing for both targeted sub-micrometer imaging and high-throughput analysis of multiple specimens.
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Phys.org
@physorg_com · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging @naturemethods https://t.co/j2B63SnfVX https://t.co/H8cMAjk2r7

May 18, 2022 · 11 likes · 9 shares · 1,023,946 followers View post →
Michael Wu
@Neurodigitech · X

Light Sheet Fluorescent Miscorscopy of a mouse brain. https://t.co/iJxC9gWZIy via @YouTube

May 21, 2022 · 3 likes · 174 followers View post →
IS&T
@ImagingOrg · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/O8aTlo3NTE #Imaging #microscopy https://t.co/3jpN4ScO8b

May 18, 2022 · 1 like · 2 shares · 2,169 followers View post →
GenBio Inc
@GenBioUSA · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/a5nGpasYv4 #Biotech #Pharmaceutical #News

May 18, 2022 · 1 like · 1,138 followers View post →
Dr. M. Bernardo
@mbernardo321 · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging of cleared tissues | Nature Methods https://t.co/QmeWKCYdWa

May 24, 2022 · 1 like · 349 followers View post →
Cell Bio News
@CellBioNews · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/drLucDWw4I

May 18, 2022 · 1 like · 188 followers View post →

All mentions

Lucky Seven
@anto_nocxp · X

@uservrl Dans les neurosciences. On sait rendre le cerveau transparent et voir les neurones à l’intérieur au microscope https://t.co/qoypfvIppE

Oct 26, 2024 · 110 followers View post →
DZ Gong | 龚 | ゴン | 공
@dz_gong · X

Paper read today #133 A hybrid open-top light-sheet microscope for versatile multi-scale imaging of cleared tissues https://t.co/gndHq6fYBq A hybrid light sheet combining a high NA non-original dual objective and a low NA original objective.

Jul 15, 2022 · 621 followers View post →
NP AGARWAL世界一フォローを目指しますAiming best in world.
@np_grwl · X

RT @physorg_com: A hybrid open-top light-sheet microscope for versatile multi-scale imaging @naturemethods https://t.co/j2B63SnfVX https://…

May 25, 2022 · 9 shares · 1,786 followers View post →
Dr. M. Bernardo
@mbernardo321 · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging of cleared tissues | Nature Methods https://t.co/QmeWKCYdWa

May 24, 2022 · 1 like · 349 followers View post →
理系新聞
@rikei_shinbun · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/Q7X9AgCj9k

May 23, 2022 · 1,751 followers View post →
Binh Nguyen
@dtbnguyen · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/8MQGaAIyzY https://t.co/M4iHESHfhZ

May 22, 2022 · 1,138 followers View post →
MW
@neuro_geek · X

Light-Sheet Fluorescent Microscopy of a mouse brain. https://t.co/LL9akAOUUa via @YouTube

May 21, 2022 View post →
Michael Wu
@Neurodigitech · X

Light Sheet Fluorescent Miscorscopy of a mouse brain. https://t.co/iJxC9gWZIy via @YouTube

May 21, 2022 · 3 likes · 174 followers View post →
USBrainAlliance
@USBrainAlliance · X

RT @physorg_com: A hybrid open-top light-sheet microscope for versatile multi-scale imaging @naturemethods https://t.co/j2B63SnfVX https://…

May 21, 2022 · 9 shares · 4,388 followers View post →
Thamarasee Jeewandara
@Jeew333T · X

RT @ImagingOrg: A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/O8aTlo3NTE #Imaging #microscopy htt…

May 21, 2022 · 2 shares · 1,289 followers View post →
ScienceStop
@B0tSci · X

RT @Jeew333T: Notes on a hybrid open-top light-sheet microscope for versatile multi-scale imaging, from @naturemethods via Adam K. Glaser,…

May 21, 2022 · 1 share · 4,080 followers View post →
Thamarasee Jeewandara
@Jeew333T · X

Notes on a hybrid open-top light-sheet microscope for versatile multi-scale imaging, from @naturemethods via Adam K. Glaser, briefly covered by me

May 21, 2022 · 1 share · 1,289 followers View post →
Paul McCullough
@ThePostsynaptic · X

RT @ThePostsynaptic: A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/SAJAgeDbZR https://t.co/uTLFVz…

May 20, 2022 · 1 share · 2,590 followers View post →
IS&T
@ImagingOrg · X

RT @ImagingOrg: A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/O8aTlo3NTE #Imaging #microscopy htt…

May 20, 2022 · 2 shares · 2,169 followers View post →
Paul McCullough
@ThePostsynaptic · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/SAJAgeDbZR https://t.co/uTLFVzcUwS

May 19, 2022 · 1 share · 2,590 followers View post →
Hugo Indalecio
@hugo_indalecio · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/4cIFLFsIJd

May 18, 2022 · 65 followers View post →
IS&T
@ImagingOrg · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/O8aTlo3NTE #Imaging #microscopy https://t.co/3jpN4ScO8b

May 18, 2022 · 1 like · 2 shares · 2,169 followers View post →
EcoTopical
@EcoTopicalNews · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/pZOWNgnHrO https://t.co/mOWRPwB6ki

May 18, 2022 · 486 followers View post →
Cell Bio News
@CellBioNews · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/drLucDWw4I

May 18, 2022 · 1 like · 188 followers View post →
雲黒斎
@Qweere · X

RT @physorg_com: A hybrid open-top light-sheet microscope for versatile multi-scale imaging @naturemethods https://t.co/j2B63SnfVX https://…

May 18, 2022 · 9 shares · 1,139 followers View post →
Abelus
@abelusmx · X

RT @physorg_com: A hybrid open-top light-sheet microscope for versatile multi-scale imaging @naturemethods https://t.co/j2B63SnfVX https://…

May 18, 2022 · 9 shares · 378 followers View post →
Zyite (E-Scooters World)
@ZyiteGadgets · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/3hAjatVnEO https://t.co/QCf23EGFCB

May 18, 2022 · 3,351 followers View post →
GenBio Inc
@GenBioUSA · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging https://t.co/a5nGpasYv4 #Biotech #Pharmaceutical #News

May 18, 2022 · 1 like · 1,138 followers View post →
Arne Battefeld
@arne_feld · X

RT @physorg_com: A hybrid open-top light-sheet microscope for versatile multi-scale imaging @naturemethods https://t.co/j2B63SnfVX https://…

May 18, 2022 · 9 shares · 299 followers View post →
Jason Cunliffe
@nomadics · X

RT @physorg_com: A hybrid open-top light-sheet microscope for versatile multi-scale imaging @naturemethods https://t.co/j2B63SnfVX https://…

May 18, 2022 · 9 shares · 762 followers View post →
DeepakPatrewal
@DeepakPatrewal · X

RT @physorg_com: A hybrid open-top light-sheet microscope for versatile multi-scale imaging @naturemethods https://t.co/j2B63SnfVX https://…

May 18, 2022 · 9 shares · 371 followers View post →
Science X
@sciencex_com · X

RT @physorg_com: A hybrid open-top light-sheet microscope for versatile multi-scale imaging @naturemethods https://t.co/j2B63SnfVX https://…

May 18, 2022 · 9 shares · 3,530 followers View post →
Phys.org Biology
@physorg_biology · X

RT @physorg_com: A hybrid open-top light-sheet microscope for versatile multi-scale imaging @naturemethods https://t.co/j2B63SnfVX https://…

May 18, 2022 · 9 shares · 8,223 followers View post →
Phys.org
@physorg_com · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging @naturemethods https://t.co/j2B63SnfVX https://t.co/H8cMAjk2r7

May 18, 2022 · 11 likes · 9 shares · 1,023,946 followers View post →
Czexpats papers
@Czexpats_papers · X

A hybrid open-top light-sheet microscope for versatile multi-scale imaging of cleared tissues https://t.co/p4YW3AfFkI https://t.co/nShTuiWgiQ

May 12, 2022 · 194 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: A hybrid open-top light-sheet microscope for versatile multi-scale imaging of cleared tissues https://t.co/go407lDbjR #kidneycancer #oncology https://t.co/GGhXM4ut0r

May 12, 2022 · 892 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: A hybrid open-top light-sheet microscope for versatile multi-scale imaging of cleared tissues https://t.co/fdldM6bZgc #prostatecancer #oncology https://t.co/xHfEMzxqEi

May 12, 2022 · 892 followers View post →