If this applies to even ONE person, why aren't we asking more questions?
The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets.
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May 2022 – Sep 2025Where it's discussed
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What people are saying
The discussions highlight varying interpretations of the Lipid Energy Model, with exchanges focusing on its implications for cholesterol profiles on low-carb diets. For instance, one user notes that 'LDL is not a metric of concern' while others emphasize that increased cholesterol might not equate to increased risk for cardiovascular disease, suggesting a shift in how we view lipid measurements. The tone across these discussions ranges from inquisitive to critical, often employing phrases like 'high LDL with low triglycerides' to illustrate their points, contributing to the overall engagement and impact of the topic.
The reactions to the study are mixed, with some expressing skepticism about its conclusions, while others support the emerging arguments.
Many users show a high level of curiosity and are actively discussing the complexities surrounding the Lipid Energy Model.
The discussions range from surface-level comments to deeper analyses of the publication's mechanisms, indicating moderate engagement.
Overall, the perceived impact of the publication seems to be debated, with some acknowledging its potential significance while others remain doubtful.
Abstract in brief
- Carbohydrate-restricted diets (CRDs) can lead to a unique lipid profile in lean individuals, characterized by high LDL and HDL cholesterol levels and low triglycerides, particularly in those with a lower BMI.
- A specific group known as Lean Mass Hyper-Responders (LMHR) shows extreme increases in LDL-C and HDL-C on CRDs, with some individuals reaching LDL-C levels exceeding 500 mg/dL, despite having normal pre-diet levels and no genetic predisposition to high cholesterol.
- The Lipid Energy Model (LEM) explains this phenomenon by suggesting that carbohydrate restriction increases reliance on fat metabolism, which in turn boosts the secretion and uptake of triglycerides, leading to higher LDL and HDL levels while keeping triglycerides low.
Top posts
Most liked on X and BlueskyThe proposed mechanism is the Lipid Energy Model (#LEM) - https://t.co/nLixtBo0Gs @CaloriesProper It hasn’t changed since our publication, but we list several testable aspects to it within the paper itself. https://t.co/f4KbhKx6N0
Yes. Here's three levels of understanding the Lipid Energy Model: 1) ⭐️Basics video: https://t.co/XY57gOjC6K 2) ⭐️⭐️Intermediate (video abstract to our LEM paper): https://t.co/ZMp8AyweCG 3) ⭐️⭐️⭐️Advanced (our LEM paper itself): https://t.co/nLixtBoyw0
@vapidbobcat @Oreo Test of this... https://t.co/LaE4kemCNA And see... https://t.co/XrdcR5Qt9D
The #OreoVsStatin experiment was designed around the principles of #LEM — full paper detailing it here: https://t.co/nLixtBoyw0 I’m not sure what the mechanism proposed on “keto diet makes” lipids so bad that even Oreos improves them… can you expand, @kcisney? https://t.co/CmlpasidKT
WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
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@CasualCrypt @MasalaFry69 @DoctorTro @FructoseNo LDL is not a metric of concern. There is ZERO RCT proof that LDL ( really there are 2 forms ) has NO direct causation to any disease ! https://t.co/IvWvNBskcm Dr. Nader Ali why cholesterol LDL rises on low carb diet https://t.co/hW3dtc9aLa https://t.co/LSHHe9snlT https://t.co/qxaXSfmfHJ
@TheSupak https://t.co/FtReeMHTvz
@caloriesproper2 @AviBittMD You’ve read the Lipid Energy Model mechanism paper, no? https://t.co/6lhYa7lbOL Coupled w/
The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets https://t.co/4Vj5AswTqw
Still not convinced .@BioLayne has understood this paper. Published in May 2022 where does the time go? https://t.co/9iKM5pwQxT https://t.co/4QUh9HrDJK
@AudereEstValere Cholesterol helps transport fat through your bloodstream. When you restrict carbohydrates you rely more on fat for energy. https://t.co/FtReeMHTvz
@schmittpaula 3/3 Literatura s/ Metabolismo: 1 - LEM https://t.co/WJabK7I3JF 2 - CIM https://t.co/FMUT6vPW2D 3 - https://t.co/UuuXH5VOG6 Esse 3 estudos vai lhe dar uma ideia sobre o senhor do metabolismo: O hormônio Insulina.
RT @EstebanDL: Link a la publicación del modelo de energía proveniente de los lípidos https://t.co/2mQYjyxsly https://t.co/wzrXVEj3To
RT @EstebanDL: Link a la publicación del modelo de energía proveniente de los lípidos https://t.co/2mQYjyxsly https://t.co/wzrXVEj3To
RT @EstebanDL: Link a la publicación del modelo de energía proveniente de los lípidos https://t.co/2mQYjyxsly https://t.co/wzrXVEj3To
Link a la publicación del modelo de energía proveniente de los lípidos https://t.co/2mQYjyxsly https://t.co/wzrXVEj3To
RT @realDaveFeldman: Yes. Here's three levels of understanding the Lipid Energy Model: 1) ⭐️Basics video: https://t.co/XY57gOjC6K 2) ⭐️⭐️…
RT @DrJNurse: Questionable theories in an MDPI journal. Never. Alan Flanagan unpicks some of the ideas proposed in this controversial pape…
RT @DrJNurse: Questionable theories in an MDPI journal. Never. Alan Flanagan unpicks some of the ideas proposed in this controversial pape…
RT @DrJNurse: Questionable theories in an MDPI journal. Never. Alan Flanagan unpicks some of the ideas proposed in this controversial pape…
Questionable theories in an MDPI journal. Never. Alan Flanagan unpicks some of the ideas proposed in this controversial paper: The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets https://t.co/Zl82Z0LfOP #hukconf https://t.co/1an4SghhOn
@DrNadolsky @theproof @nicknorwitz https://t.co/AcSMt8ihp4
High HDL is a result and cause of efficient lipoprotein lipase-mediated triglyceride-rich lipoprotein metabolism, and vice versa https://t.co/KFQDPs6yw6 #Epigenetics #microrna #neuroscience #MedTwitter #ImmuneSystem #Nutrition #cancer #schizophrenia #microglia https://t.co/KqZeC5vBBd
Lipoprotein lipase-mediated increase in LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) https://t.co/KFQDPs6yw6 #Epigenetics #microrna #neuroscience #MedTwitter #ImmuneSystem #Nutrition #cancer #schizophrenia #microglia https://t.co/hbkZNsbhyY
The Lipid Energy Model https://t.co/KFQDPs6yw6 #Epigenetics #microrna #neuroscience #MedTwitter #ImmuneSystem #Nutrition #cancer #schizophrenia #microglia https://t.co/GErXBxCoxw
@r55414771 @theproof @nicknorwitz https://t.co/kuvo8vMyQA
@nicknorwitz @theproof @realDaveFeldman @Lipoprotein @PeterAttiaMD So far it seems like this is an under discussed topic among LMHR advocates and definitely something that hasn’t been articulated in your published work https://t.co/kuvo8vMyQA
@oldmanskin68 @AnouarElHaji @MigraineBook @MEATritionCom To convert to US units, you have: total: 10.0 = 386 trigs: 1.0 = 89 HDL: 1.4 = 54 LDL = 8.1 = 313 These are considered "normal" levels on low carb for lean healthy people. Perhaps send your doctor this paper: https://t.co/fTeF8TElKy
RT @nicknorwitz: @Drlipid @Jenjen12310 @BenHe69435073 Here @Drlipid is factually incorrect Cc @Lipoprotein @theproof @realDaveFeldman can…
RT @nicknorwitz: @Drlipid @Jenjen12310 @BenHe69435073 Here @Drlipid is factually incorrect Cc @Lipoprotein @theproof @realDaveFeldman can…
RT @nicknorwitz: @Drlipid @Jenjen12310 @BenHe69435073 Here @Drlipid is factually incorrect Cc @Lipoprotein @theproof @realDaveFeldman can…
@Drlipid @Jenjen12310 @BenHe69435073 Here @Drlipid is factually incorrect Cc @Lipoprotein @theproof @realDaveFeldman can all confirm https://t.co/RV94fh507i https://t.co/LaE4kemCNA
@ichudov Igor, I tried to write you a DM, but I think I couldn't. My account is not verified, something like that. I don't know if you're familiar with LEM, links below, But the guys brought a whole new idea about lipidology. Take a look. https://t.co/RJUrROLLgV https://t.co/WJabK7I3JF
Check out this great article on the Lipid Energy Model! https://t.co/hqnqNL4jtj #KetoResearch #PotterKeto #KetogenicMetabolicTherapy #AKT #KMT #LipidEnergyModel
RT @realDaveFeldman: @ethanjweiss @nicknorwitz @Drlipid @Lipoprotein @AdrianSotoMota The original #LEM paper is here: https://t.co/nLixtBoy…
RT @realDaveFeldman: @ethanjweiss @nicknorwitz @Drlipid @Lipoprotein @AdrianSotoMota The original #LEM paper is here: https://t.co/nLixtBoy…
RT @realDaveFeldman: @ethanjweiss @nicknorwitz @Drlipid @Lipoprotein @AdrianSotoMota The original #LEM paper is here: https://t.co/nLixtBoy…
@ethanjweiss @And41111 @PeterFaberSP @nicknorwitz It’s here in our #LEM paper, @ethanjweiss – https://t.co/nLixtBo0Gs Not to be a bit redundant in kind, but in the process of getting our model published, we needed to support various aspects of the #LEM with studies which are cited throughout. It’s still a hypothesis – like all
@MohammedAlo @WORLDN0MAD "The Lipid Energy Model could explain the observed inverse association between BMI and LDL-C change in the context of carbohydrate restriction, as well as the Lean Mass Hyper-Responder phenotype." https://t.co/9GQ9CyIq6Z
@ethanjweiss @nicknorwitz @Drlipid @Lipoprotein @AdrianSotoMota The original #LEM paper is here: https://t.co/nLixtBoyw0 We have 101 citations, much of which are specific to existing studies around components of the proposed model. You have read the paper, yes? If so, are you objecting to any specific studies we're citing in support of
@Tellit007 @Drlipid @ethanjweiss @realDaveFeldman @Lipoprotein Incorrect. https://t.co/LaE4kemCNA
@SentientBlobBob @ElieJarrougeMD Another utterly factually WRONG statement! LDL has ZERO RCT proof of any causation of any disease or process ! In fact HIGH LDL with LOW. TRIGLYCERIDES and HIGH HDL — is protective of diseases ! https://t.co/PMuVF3s2pA ➡️ https://t.co/J1wb4NwWEN ➡️ https://t.co/ySLQ4teXWm
@ratwell0x @McNyale but what is normal and for whom? There is a lot of new science around LDL especially in conjunction with Keto https://t.co/p8ITFn3Xv7 If you are interested
@CaloriesProper @raphaels7 Here’s the paper: https://t.co/nLixtBoyw0
RT @realDaveFeldman: The proposed mechanism is the Lipid Energy Model (#LEM) - https://t.co/nLixtBo0Gs @CaloriesProper It hasn’t changed…
RT @realDaveFeldman: The proposed mechanism is the Lipid Energy Model (#LEM) - https://t.co/nLixtBo0Gs @CaloriesProper It hasn’t changed…
The proposed mechanism is the Lipid Energy Model (#LEM) - https://t.co/nLixtBo0Gs @CaloriesProper It hasn’t changed since our publication, but we list several testable aspects to it within the paper itself. https://t.co/f4KbhKx6N0
@DietHeartNews This is patently false. https://t.co/b7DVyx9Ui1 https://t.co/QgWAor62pf https://t.co/BhMS0texEj
5. “Why did this happen?” I would encourage @BioLayne to review the proposed mechanism paper: https://t.co/6lhYa7lbOL As well as the recent papers outlining very reasonable mediating variables for change in LDLc on LCD: https://t.co/kOdsuhuiuU https://t.co/06xsYO4IsF
@Mikejulian26 @robbwolf @TuckerGoodrich @nicknorwitz @Drlipid Absolutely https://t.co/SFIRgPKMH4
2/2 – See our paper on the Lipid Energy Model here: https://t.co/SFIRgPKMH4 Or watch the Video Abstract here: https://t.co/ZMp8AyweCG
RT @nicknorwitz: @vapidbobcat @Oreo Test of this... https://t.co/LaE4kemCNA And see... https://t.co/XrdcR5Qt9D
RT @DudzLightLime: @theproof I’m a nutshell, ⬆️hepatic glycogen results in ⬇️ demand for TG as metabolic fuel therefore less VLDL synthesis…
@TomaszLaszcz @s3zol @WkurzonaLady Pewnie Ty znowu o rosnącym LDL na dietach LC/Keto i rzekomym prowadzeniu tego do miażdżycy. Poczytaj sobie o Modelu Energii Lipidów i tym, że rosnące LDL wcale nie jest aterogenne wbrew temu, to twierdzą kardiolodzy https://t.co/iIwwy4CV76 Słyszałeś o badaniu z Oreo?
‘The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets’ https://t.co/mA9cX78ITT
@DrScottMurray @realDaveFeldman Be careful what you ask for… https://t.co/LaE4kemCNA
RT @realDaveFeldman: The #OreoVsStatin experiment was designed around the principles of #LEM — full paper detailing it here: https://t.co/n…
RT @realDaveFeldman: The #OreoVsStatin experiment was designed around the principles of #LEM — full paper detailing it here: https://t.co/n…
RT @agingdoc1: The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets (2022) @nicknorwit…
@PrimaryCarePAC @trikebum @SamueleMarcora @Oreo @MichaelAlbertMD @deirdre_tobias It’s evidence in line with the Lipid Energy Model. Those who don’t understand that apparently can only poke fun at it. Instead of learning why it happened. Here is the hypothesis if anyone wants to understand it. https://t.co/r5pHOuJizn
RT @realDaveFeldman: The #OreoVsStatin experiment was designed around the principles of #LEM — full paper detailing it here: https://t.co/n…
RT @realDaveFeldman: The #OreoVsStatin experiment was designed around the principles of #LEM — full paper detailing it here: https://t.co/n…
The #OreoVsStatin experiment was designed around the principles of #LEM — full paper detailing it here: https://t.co/nLixtBoyw0 I’m not sure what the mechanism proposed on “keto diet makes” lipids so bad that even Oreos improves them… can you expand, @kcisney? https://t.co/CmlpasidKT
@SamueleMarcora Then why aren't Oreo cookies the standard of care in situations when lowering LDL-C is deemed medically prudent? This paper also supports the Lipid Energy Model (which is novel) in the context of a low-carb diet. What is unknown is the ASCVD risk. https://t.co/Wrao21MQib
@drpablocorral @ethanjweiss @JohnKastelein @MichaelAlbertMD @Lipoprotein @lipiddoc @Drlipid It’s discordant from their model https://t.co/sbHHGvz8CE
RT @agingdoc1: The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets (2022) @nicknorwit…
RT @agingdoc1: The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets (2022) @nicknorwit…
The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets (2022) @nicknorwitz @AdrianSotoMota @bobkaplan @davidludwigmd @BudoffMd @AnatolKontush @realDaveFeldman @MetabolitesMDPI https://t.co/7CVDY22QmC https://t.co/YBk53ttSOh
RT @nicknorwitz: @vapidbobcat @Oreo Test of this... https://t.co/LaE4kemCNA And see... https://t.co/XrdcR5Qt9D
The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets - PubMed https://t.co/P0QzohFKlS
RT @nicknorwitz: @vapidbobcat @Oreo Test of this... https://t.co/LaE4kemCNA And see... https://t.co/XrdcR5Qt9D
RT @nicknorwitz: @vapidbobcat @Oreo Test of this... https://t.co/LaE4kemCNA And see... https://t.co/XrdcR5Qt9D
Manger des Oréos a davantage abaissé (2x plus!) le taux de cholestérol LDL que la prise de statines à haute dose chez cet adepte du régime cétogène qui a publié son étude de cas n=1. L'étude: https://t.co/xf012GFlzI Pour plus de contexte: https://t.co/GjFQh3M56q
@vapidbobcat @Oreo Test of this... https://t.co/LaE4kemCNA And see... https://t.co/XrdcR5Qt9D
RT @AdrianSotoMota: @Peter_Cipov @AJCNutrition @nicknorwitz @realDaveFeldman @davidludwigmd Sure but most studies report BMI only. The mech…
@CrabMan631 @SomosCarnivoros @SBakerMD What makes it a false analogy is putting healthy and yellow shoes in the same bucket. One is highly relevant pathophysiologically and the other is not. LDL matters little or not at all for healthy people (CAC=0): https://t.co/86EuzsD5cm Rationale:https://t.co/Txv7Ucyi7C
@Peter_Cipov @AJCNutrition @nicknorwitz @realDaveFeldman @davidludwigmd Sure but most studies report BMI only. The mechanism would be this : https://t.co/Txv7UcyPXa
@CrabMan631 @SBakerMD Or maybe, since carb restriction wasn't optional for our ancestors, the lipid changes we observed among the healthy volunteers of those trials are simply part of the physiologically normal adaptive response Humans evolved to survive carb scarcity? https://t.co/Txv7Ucyi7C https://t.co/85JCtnHWqs
@lipo_fan @gatordadsteve @drpablocorral @PeterAttiaMD @foundmyfitness Dave avoids diet discussions completely. Why are experts ignoring his LEM paper? https://t.co/r5pHOuJizn
leaner people with are insulin sensitive have higher LDL when they do therapeutic carbohydrate restriction and go in to nutritional ketosis as show in lipid energy model -- https://t.co/bPAtH9hDC8 and when carbohydrates are added the LDL falls as show in -
↓引用文献 https://t.co/Shn9oY49ac
RT @AdrianSotoMota: If you are not familiarized yet with the hypotheses of the Lipid Energy Model, you can read about them here: https://…
RT @AdrianSotoMota: If you are not familiarized yet with the hypotheses of the Lipid Energy Model, you can read about them here: https://…
If you are not familiarized yet with the hypotheses of the Lipid Energy Model, you can read about them here: https://t.co/yMMEhFpmby
@JesperLundbom @nicknorwitz @theproof https://t.co/DiWHT0Q2Dd That probably has some references.
RT @KetoCarnivore: @goonersanti LDL is what's left after using VLDL to distribute triglycerides. https://t.co/fTeF8TElKy
@goonersanti LDL is what's left after using VLDL to distribute triglycerides. https://t.co/fTeF8TElKy
https://t.co/oB2xT0fCVQ
The Lipid Energy Model: https://t.co/clrFz4elwu
@hubermanlab Ask about @Oreo Cookies @hubermanlab! Ref https://t.co/whD4Tbvszn LEM: https://t.co/LaE4kemCNA https://t.co/YU25eYK9Mi https://t.co/kLexEe9XBq
@mario_kratz Hi Mario! Welcome to the world of the lipid energy model! It is not ketosis causing the high LDL. Nor is it the high saturated fats. It’s fascinating stuff and to do with glycogen in the liver. Read this ! https://t.co/vrQoaCReRe
RT @realDaveFeldman: 1/2
RT @nicknorwitz: @JohnKastelein The first link is our best guess. https://t.co/LaE4kemCNA This is definitely reproducible in others, altho…
@JohnKastelein The first link is our best guess. https://t.co/LaE4kemCNA This is definitely reproducible in others, although the degree of genetic “permissiveness” is unclear. We would love to do a prospective controlled trial. My personal ideal would be something like 18-55 M/F < 15%BF (M)
@ianriddockmd @lipo_fan @JohnKastelein @ann_seclow @realDaveFeldman @Drlipid @calmdiscuss @drpablocorral @lansberg You realize by saying that you’re painting all the authors of this paper with the same brush. https://t.co/r5pHOuJizn
@ianriddockmd @lipo_fan @JohnKastelein @ann_seclow @realDaveFeldman @Drlipid @calmdiscuss @drpablocorral @lansberg Have you proposed an alternative hypothesis the the LEM? Have you read the LEM? Do you know the authors on the LEM paper? https://t.co/r5pHOuJizn
@JohnKastelein @BHBEnjoyer @drpablocorral @lipo_fan @Drlipid Have you written any comments on this paper? Would be interested to read that in case you have.
@lipo_fan @JohnKastelein @Drlipid @calmdiscuss @drpablocorral Has there been an alternative hypothesis for the LMHR phenotype? https://t.co/r5pHOuJizn
Linear thinking led to the flawed cholesterol hypothesis. Good to see more interconnected approaches ⬇️ ... that will ultimately confirm the Lipid Energy Model https://t.co/f5aMO6P0vt I have no doubt about that, Bayesian inference to evidence evaluation should be taught in https://t.co/dCAQ7OUbMi
@Chooi @Drlipid @nationallipid @society_eas @realDaveFeldman Again, it’s explained in the links and videos. See section 4 https://t.co/2VPV7tpd4Y
Enjoy your videos @NutritionMadeS3 recently watched https://t.co/QvGPbWToRy What's your take on current research by @realDaveFeldman @nicknorwitz on the #lmhr phenotype https://t.co/AY8xZYmNTE . increased cholesterol does not mean increase CVD. See also https://t.co/srQXNnAdyP
@RlyAverageDave @shelly_187 @Konzepts @RichardWebste16 1️⃣ https://t.co/PMuVF3s2pA 2️⃣ https://t.co/J1wb4NwWEN 3️⃣ https://t.co/ySLQ4teXWm 4️⃣ https://t.co/1U71Q8LS5r 5️⃣ https://t.co/oB2oR4MYHq
@AncestralTho @vardaanbhat @SentientBlobBob @shelly_187 @DrDeborahMD https://t.co/6lhYa7lbOL
RT @thalesnemo: @swatigar What an utterly TOXIC MENU ! Wholly unfit for human consumption! Any daily total over 100 grams of carbohydrates…
@swatigar What an utterly TOXIC MENU ! Wholly unfit for human consumption! Any daily total over 100 grams of carbohydrates is TOXIC! https://t.co/KyEnRK2SiH 2️⃣ https://t.co/YlTgnpLpci 3️⃣ https://t.co/PMuVF3s2pA 4️⃣ https://t.co/Ulou4SNL22 https://t.co/IGQraNwxkU
@mario_kratz Yes, this is the basis of the Lipid Energy Model. The key is to couple this flux in the VLDL with a higher rate of turnover in the periphery due to greater lipoprotein lipase activity. This would explain the successively higher HDL cholesterol as well https://t.co/nLixtBoyw0
@DrNadolsky @ZKForTre @ScepticalDoctor @PlantChompers Global supply v demand for fuel - high demand for energy, low TG supply from adipocytes w/ depleted hepatic glycogen stores… Oversimplified but ⬆️VLDL secretion
RT @KetoCarnivore: For more on the Energy Model, see https://t.co/fTeF8TETA6 from @nicknorwitz @AdrianSotoMota @bobkaplan @davidludwigmd @B…
For more on the Energy Model, see https://t.co/fTeF8TETA6 from @nicknorwitz @AdrianSotoMota @bobkaplan @davidludwigmd @BudoffMd @AnatolKontush and @realDaveFeldman
RT @nicknorwitz: @thelowcarb_rd @ingold22 @agingdoc1 90% chance no reply. 9.9% chance quip. Won’t hold my breath for a fair and thoughtful…
RT @nicknorwitz: @thelowcarb_rd @ingold22 @agingdoc1 90% chance no reply. 9.9% chance quip. Won’t hold my breath for a fair and thoughtful…
@thelowcarb_rd @ingold22 @agingdoc1 90% chance no reply. 9.9% chance quip. Won’t hold my breath for a fair and thoughtful evaluation. But in case @Drlipid decides to step up, here are 4 starter pubs https://t.co/k8J9OUgK7q https://t.co/2VPV7tpd4Y https://t.co/5rQzioRUzZ https://t.co/rwK3tNknzY
@leehammondMX BMI increase vs LDL is the point of the graph … the PUFA and Sat fat shifts are blips. This is just a case report but exemplified a model #LEM and will present consistent RCT-based data hopefully by end-of-year https://t.co/2VPV7tpd4Y https://t.co/RxF5dYw8Rn
@sguyenet @nicknorwitz Stephan, have you read the lipid energy model paper? https://t.co/boT3xNYtwC(LEM,%2Ddensity%20lipoproteins%20(VLDL)%20by
RT @nicknorwitz: @pdx_charlie @realDaveFeldman @lowcarbGP @AdrianSotoMota @KenDBerryMD @DoctorTro @hubermanlab @KetoCarnivore @DrEenfeldt h…
RT @nicknorwitz: If this applies to even ONE person, why aren't we asking more questions?
RT @realDaveFeldman: 1/2
@Want2RunAgain https://t.co/LVEhOjZXNK https://t.co/2VPV7tpd4Y https://t.co/truYXx1S37
@yoursimmo @ClausCarlsen1 @TonyPumps1 May be of interest to you, FWIW. I don’t know what your whole lipid panel looked like https://t.co/LVEhOjZXNK https://t.co/2VPV7tpd4Y
@JoshJwageman @DudzLightLime @nicknorwitz @TuitNutrition Josh -- have you read our paper for #LEM? We discuss ANGPTL3-4-8 in detail, particularly on this whole body lipolytic turnover. https://t.co/SFIRgPKMH4
@davidjgiordano @Drlipid https://t.co/mBp0kBA82A hypothesis on why this happens
RT @realDaveFeldman: 1/2
@drpablocorral @JohnKastelein @lipo_fan Different topic. What are your thoughts on the LEM paper? Different mechanisms proposed to result in high LDL. One mechanism with Insulin Resistance. Near the opposite mechanism in lean mass hyper responders. Risk aside any thoughts on mechanisms here. https://t.co/r5pHOuJizn
RT @nicknorwitz: If this applies to even ONE person, why aren't we asking more questions?
RT @nicknorwitz: If this applies to even ONE person, why aren't we asking more questions?
RT @nicknorwitz: If this applies to even ONE person, why aren't we asking more questions?
RT @nicknorwitz: If this applies to even ONE person, why aren't we asking more questions?
RT @nicknorwitz: If this applies to even ONE person, why aren't we asking more questions?
RT @nicknorwitz: If this applies to even ONE person, why aren't we asking more questions?
@kevtharris @shelly_187 LDL has ZERO proven cause to any disease process. @LDLSkeptic @ProfTimNoakes @garytaubes @FructoseNo 1️⃣ https://t.co/PMuVF3s2pA 2️⃣ https://t.co/J1wb4NwWEN 3️⃣ https://t.co/ySLQ4teXWm 4️⃣ https://t.co/jNNjpOW7Rl 5️⃣ https://t.co/r53tKC9zo5️⃣ https://t.co/B5AzKSo1tp
RT @nicknorwitz: If this applies to even ONE person, why aren't we asking more questions?
RT @nicknorwitz: If this applies to even ONE person, why aren't we asking more questions?
RT @nicknorwitz: If this applies to even ONE person, why aren't we asking more questions?
RT @nicknorwitz: If this applies to even ONE person, why aren't we asking more questions?
RT @nicknorwitz: If this applies to even ONE person, why aren't we asking more questions?
RT @nicknorwitz: If this applies to even ONE person, why aren't we asking more questions?
RT @nicknorwitz: If this applies to even ONE person, why aren't we asking more questions?
If this applies to even ONE person, why aren't we asking more questions?
RT @LowCarbEyeDoc: What if looking at LMHR patients (LMHR study) and the LEM hypothesis leads us to ask some of the right questions about h…
@fipco Did you read this paper? https://t.co/r5pHOuJizn
RT @LowCarbEyeDoc: What if looking at LMHR patients (LMHR study) and the LEM hypothesis leads us to ask some of the right questions about h…
What if looking at LMHR patients (LMHR study) and the LEM hypothesis leads us to ask some of the right questions about heart disease? All 100 LMHR participants have had their initial scan. @realDaveFeldman @nicknorwitz @PeterAttiaMD @Drlipid @bobkaplan https://t.co/r5pHOuJizn
RT @realDaveFeldman: 1/2
@DrDeborahMD @LDLSkeptic @PeterAttiaMD @ethanjweiss @ProfTimNoakes @KenDBerryMD @lowcarbGP @ifixhearts @DrPascalMeier Last point. If @PeterAttiaMD or @ethanjweiss could find flaws in the LEM hypothesis I am certain we would be hearing about it by now. https://t.co/r5pHOuJizn
RT @LowCarbEyeDoc: @LDLSkeptic @ethanjweiss @NutritionDanny I’m willing to bet @ethanjweiss hasn’t read your paper or this paper. Once Dave…
RT @LowCarbEyeDoc: @LDLSkeptic @ethanjweiss @NutritionDanny I’m willing to bet @ethanjweiss hasn’t read your paper or this paper. Once Dave…
@LDLSkeptic @ethanjweiss @NutritionDanny I’m willing to bet @ethanjweiss hasn’t read your paper or this paper. Once Dave started publishing papers it’s been radio silence from both Weiss and @PeterAttiaMD sad but that’s fine their avoidance of the topic doesn’t stop the study of it. https://t.co/r5pHOuJizn
@realDaveFeldman I just over here waiting for evidence to disprove the LEM hypothesis. So far all I’ve heard are crickets
@0xNiJo I'm coming from a very different perspective. I don't care much for ApoB/ApoA1 ratio vs just understanding the context of both under the #LEM. https://t.co/6stRMjBHpH
@aga_pallavi @woundphysician Fits #LMHR phenotype. See our #LMHRpaper here: https://t.co/4fTaaxfbc1 Our proposed Lipid Energy Model (#LEM) here: https://t.co/SFIRgPKMH4 -- Or its video abstract (5min) here: https://t.co/ZMp8AyweCG And of course, our present #LMHRstudy underway https://t.co/NAM8QnUWNw
RT @realDaveFeldman: Definitely not surprised given context. Why would "normal-weight" and metabolic health matter? See our original #LMHR…
@theproof I’m a nutshell, ⬆️hepatic glycogen results in ⬇️ demand for TG as metabolic fuel therefore less VLDL synthesis and therefore less LDL and LDL-c.
RT @realDaveFeldman: Definitely not surprised given context. Why would "normal-weight" and metabolic health matter? See our original #LMHR…
RT @realDaveFeldman: Definitely not surprised given context. Why would "normal-weight" and metabolic health matter? See our original #LMHR…
RT @realDaveFeldman: Definitely not surprised given context. Why would "normal-weight" and metabolic health matter? See our original #LMHR…
Definitely not surprised given context. Why would "normal-weight" and metabolic health matter? See our original #LMHRpaper here: https://t.co/4fTaaxeDmt And for the model we posit around it, see: #LEM here: https://t.co/SFIRgPKeRw https://t.co/9RAZxtLCnr
RT @realDaveFeldman: Yes. Here's three levels of understanding the Lipid Energy Model: 1) ⭐️Basics video: https://t.co/XY57gOjC6K 2) ⭐️⭐️…
RT @realDaveFeldman: @DudzLightLime @vardaanbhat @CaloriesProper @Pseudome17 @NutritionMadeS3 @Metabolic_Mind @CharlieFndation @ethanjweiss…
@DudzLightLime @vardaanbhat @CaloriesProper @Pseudome17 @NutritionMadeS3 @Metabolic_Mind @CharlieFndation @ethanjweiss Link to paper here
@Wind94Rain @Peter_InNorfolk @KetoCarnivore https://t.co/6lhYa7lJEj
@yuman31 Well... I obviously have very complex opinion on that mechanism in particular. Fortunately, it's published and you can read about it here: https://t.co/SFIRgPKMH4
@gatordadsteve @KetoCarnivore @tednaiman Our paper @realDaveFeldman @AdrianSotoMota explains this phenomenon. At present, I don’t think there is another model that can explain all aspects of the LMHR phenotype. I assume you’re lean and/or athletic. https://t.co/LaE4kenaD8 Also see: https://t.co/DIa7a6Cp2V
RT @realDaveFeldman: Yes. Here's three levels of understanding the Lipid Energy Model: 1) ⭐️Basics video: https://t.co/XY57gOjC6K 2) ⭐️⭐️…
RT @realDaveFeldman: Yes. Here's three levels of understanding the Lipid Energy Model: 1) ⭐️Basics video: https://t.co/XY57gOjC6K 2) ⭐️⭐️…
RT @realDaveFeldman: Yes. Here's three levels of understanding the Lipid Energy Model: 1) ⭐️Basics video: https://t.co/XY57gOjC6K 2) ⭐️⭐️…
RT @realDaveFeldman: Yes. Here's three levels of understanding the Lipid Energy Model: 1) ⭐️Basics video: https://t.co/XY57gOjC6K 2) ⭐️⭐️…
RT @realDaveFeldman: Yes. Here's three levels of understanding the Lipid Energy Model: 1) ⭐️Basics video: https://t.co/XY57gOjC6K 2) ⭐️⭐️…
RT @realDaveFeldman: Yes. Here's three levels of understanding the Lipid Energy Model: 1) ⭐️Basics video: https://t.co/XY57gOjC6K 2) ⭐️⭐️…
RT @realDaveFeldman: Yes. Here's three levels of understanding the Lipid Energy Model: 1) ⭐️Basics video: https://t.co/XY57gOjC6K 2) ⭐️⭐️…
RT @realDaveFeldman: Yes. Here's three levels of understanding the Lipid Energy Model: 1) ⭐️Basics video: https://t.co/XY57gOjC6K 2) ⭐️⭐️…
RT @realDaveFeldman: Yes. Here's three levels of understanding the Lipid Energy Model: 1) ⭐️Basics video: https://t.co/XY57gOjC6K 2) ⭐️⭐️…
Yes. Here's three levels of understanding the Lipid Energy Model: 1) ⭐️Basics video: https://t.co/XY57gOjC6K 2) ⭐️⭐️Intermediate (video abstract to our LEM paper): https://t.co/ZMp8AyweCG 3) ⭐️⭐️⭐️Advanced (our LEM paper itself): https://t.co/nLixtBoyw0
RT @nicknorwitz: 3/ 1 year ago, we started researching #LMHR more formally, and in this year, we've published 4 prior papers Cohort Study…
https://t.co/RR3wHxFWZ1
@rryan0117 @ShutterbugCTX @rebelcreamery I am not as worried about high cholesterol as is the norm. I worry more about my Trig/HDL ratio (last measured 1.5 in Oct 2022) and fasting insulin level. Look up Lean Mass Hyper Responder and Lipid Energy Model for Cholesterol. https://t.co/PQVwCWhcMY
RT @nicknorwitz: 3/ 1 year ago, we started researching #LMHR more formally, and in this year, we've published 4 prior papers Cohort Study…
8/ My understanding was very crude back then but eventually it further developed its way to the now published #LipidEnergyModel (https://t.co/nLixtBFBy0 — special thanks to my co-authors, particularly lead @nicknorwitz, and my co-senior author, Anatol Kontush)
5/8 Our third paper details the Lipid Energy Model (#LEM), a comprehensive hypothesis detailing *why* we believe #LDL #cholesterol rises substantially in the context of very #lowcarb, #keto diet. https://t.co/SFIRgPKMH4
@diegojehu It's a great paper.
RT @nicknorwitz: 3/ 1 year ago, we started researching #LMHR more formally, and in this year, we've published 4 prior papers Cohort Study…
3/ 1 year ago, we started researching #LMHR more formally, and in this year, we've published 4 prior papers Cohort Study https://t.co/LVEhOk0vDi Case Report https://t.co/truYXx2pSF Cholesterol drop protocol https://t.co/YL3HjXIhGD Lipid Energy Model https://t.co/LaE4kenaD8
@theproof @DrNadolsky @ethanjweiss @DrMarthaGulati Yes -- we reference Burén's paper in our papers for both #LMHRs and #LEM. (https://t.co/4fTaawX1XT, https://t.co/SFIRgQ1PJ4)
@DocOck222 @Hlazard4 @ifixhearts LDL in isolation is meaningless! https://t.co/7SfGNsVPsR ➡️ https://t.co/y7AJCbs5lA ➡️ https://t.co/PMuVF3sAf8 ➡️ https://t.co/J1wb4Nxuul
@JesseLunsford @Dr__Guess @ethanjweiss @BudoffMd Theoretical basis is already published. https://t.co/kLeS693p64
https://t.co/3ZIKSh0Iob will the authors of this paper explain to me why they continue to use the word "carb" without identifying which sub-type of "carb" is involved? well known, very important, incretin responses to FIBER & RESISTANT STARCH.
@operichart @DrMijailTapia Esas elevaciones de LDL tienen MUCHO que ver con el IMC basal y se resuelven pronto con un poco de carbohidratos. https://t.co/m2GHuG4p5L Hay varias explicaciones posibles. https://t.co/Txv7Ucyi7C Pero el el consumo de grasa saturada no es una de ellas. https://t.co/8HgGyvEj0j
2/2 As to the “why” here’s a link to our newly published paper on this phenomenon: https://t.co/nLixtBFBy0 And here’s a short video abstract (5min) that goes into it: https://t.co/ZMp8AyNhEG
@RZubiranS @Drlipid @Hragy @SABOURETCardio @drscottyk Or, the ⬆️ dependence on fat as a metabolic substrate drives increased hepatic secretion and peripheral uptake of TG contained within very low-density lipoproteins (VLDL) by lipoprotein lipase, resulting in marked elevations of LDL-C and HDL-C, and low TG. https://t.co/Txv7Ucyi7C https://t.co/bTaRbiCGwD
The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets https://t.co/9EuExAiP3M https://t.co/nvxNACKVgl
The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets https://t.co/JsBygeDHCq #mdpimetabolites via @MDPIOpenAccess
The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets https://t.co/ZreCeLeBsh #mdpimetabolites via @MDPIOpenAccess
#Health: 'The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets' @NickNorwitz @DaveFeldman et al (May 2022) https://t.co/E8uKstWagx #LowCarb #cholesterol #diet #BMI
RT @nicknorwitz: WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
RT @nicknorwitz: WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
RT @nicknorwitz: WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
RT @heniek_htw: The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets
RT @heniek_htw: The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets
The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets
RT @nicknorwitz: WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
RT @nicknorwitz: WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
RT @nicknorwitz: WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets https://t.co/CZQoeWG8ZM
The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets https://t.co/cO5rFZwUKE #mdpimetabolites via @MDPIOpenAccess
RT @nicknorwitz: WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
RT @nicknorwitz: WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
RT @nicknorwitz: WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
RT @nicknorwitz: WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
RT @nicknorwitz: WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
RT @nicknorwitz: WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
RT @nicknorwitz: WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
WOW! >300 retweets in first 24 hours! 1/ Now for a thread from the first author on the #LEM Paper:
1/ The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets — lean mass hyper responders have a lipid profile consisting of elevated LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) with https://t.co/3IX7hJWdLd
Top story: Metabolites | Free Full-Text | The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets https://t.co/tfBnfcOuK5, see more https://t.co/9OrA8wXmYX
Top story: Getting Started with Google Metabolites | Free Full-Text | The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets https://t.co/qPCdK7uHmd, see more https://t.co/7Fws6hwrxv
The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets https://t.co/AmRZ1LXLdd #mdpimetabolites via @MDPIOpenAccess
Metabolites | Free Full-Text | The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets https://t.co/tRDDPVJpLs