Several discussions highlight agreement with the review's findings, mentioning the importance of dose adjustment for atrial fibrillation and cautioning against its use for VTE treatment; for example, users discuss the relevance of low-intensity treatment and references to specific trials, using language that indicates they see this review as significant for future clinical decisions.
AgreementStrong agreement
Most discussions emphasize the importance of dose adjustment strategies and agree with the review's conclusions, reflecting consensus in the community.
InterestHigh interest
The discussions display a high level of attention to the topic, with numerous posts discussing specifics about dose-reduction methods and their implications.
EngagementModerate engagement
Many users reference the article directly, quoting or summarizing key points, indicating active engagement but not deep original analysis.
ImpactModerate impact
The widespread sharing and validation suggest the review influences practices and perceptions around anticoagulant dosing, though some notes about ongoing research temper the perceived immediate impact.
Abstract in brief
Dose-reduced DOACs are used for full-intensity treatment like stroke prevention in atrial fibrillation or for lower-intensity, extended treatments such as venous thromboembolism (VTE).
In clinical trials, dose-adjusted DOACs showed similar safety and effectiveness to full doses in stroke prevention for AF, but they are less studied for acute VTE treatment.
Real-world use of dose-reduced DOACs varies and is sometimes inconsistent with clinical trial data, with different regulations across regions affecting dose adjustment criteria.
Low-intensity DOACs may be used for primary or secondary VTE prevention for studied and approved indications
Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants: A Review https://t.co/Dm1xmIbP3W
This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolism (VTE). Dose-adjustment is relevant for AF and shouldn't be used for VTE. Low-intensity tx may be used for VTE prevention. @bbikdeli https://t.co/A7ZuahGmwH
This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolism (VTE). Dose-adjustment is relevant for AF and shouldn't be used for VTE. Low-intensity tx may be used for VTE prevention. @bbikdeli https://t.co/TK9BhPE5dE
Aug 9, 2022 · 31 likes · 20 shares · 48,131 followersView post →
MM
manuel monreal
@mmonrealriete · X
Dose adjustment of DOACs should not be used for acute VTE therapy
In contrast, low-intensity DOACs may be used for primary or secondary VTE prevention
Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants: A Review https://t.co/Dm1xmIbP3W
Jun 3, 2022 · 31 likes · 16 shares · 2,097 followersView post →
FF
Francesc Formiga
@FormigaFrancesc · X
BASIC: Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants https://t.co/38BkS58com @JAMACardio @JAMANetwork @fikkumamoto @vic_pallares @Medtorek @chemachir @QuirosLopezRaul @mendez_bailon @drmiguelmarcos @roca_ferran @DrMarthaGulati @GiuseppeGalati_
Jun 2, 2022 · 28 likes · 12 shares · 1,970 followersView post →
JC
JAMA Cardiology
@JAMACardio · X
This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolism (VTE). Dose-adjustment is relevant for AF and shouldn't be used for VTE. Low-intensity tx may be used for VTE prevention. @bbikdeli https://t.co/rCkTvaNG2h
Jun 2, 2022 · 22 likes · 11 shares · 48,131 followersView post →
Prof. Bikdeli and Prof. Didier discuss the HIPRO study on extended treatment of provoked venous thromboembolism, presented at the 2025 European Society of Cardiology meeting. The study compares rivaroxaban monotherapy…
RT @JAMACardio: This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolis…
Aug 9, 2022 · 20 shares · 190 followersView post →
LS
Liverpool Centre for Cardiovascular Science
@LiverpoolCCS · X
RT @JAMACardio: This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolis…
Aug 9, 2022 · 20 shares · 1,473 followersView post →
DK
Dr.med. Bernd Kynast
@DrKynast · X
RT @JAMACardio: This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolis…
Aug 9, 2022 · 20 shares · 3,008 followersView post →
EB
Erin T. Pharm.D.,BSPS,BCACP
@eltpharmd · X
RT @JAMACardio: This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolis…
Aug 9, 2022 · 20 shares · 1,474 followersView post →
JB
John P Erwin III MD MBA MACC (#BigPoppy )
@HeartOTXHeartMD · X
RT @JAMACardio: This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolis…
Aug 9, 2022 · 20 shares · 39,891 followersView post →
MK
Michael Klinkhammer
@klinki_hh · X
RT @JAMACardio: This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolis…
Aug 9, 2022 · 20 shares · 679 followersView post →
JC
JAMA Cardiology
@JAMACardio · X
This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolism (VTE). Dose-adjustment is relevant for AF and shouldn't be used for VTE. Low-intensity tx may be used for VTE prevention. @bbikdeli https://t.co/TK9BhPE5dE
Aug 9, 2022 · 31 likes · 20 shares · 48,131 followersView post →
AH
Ascen H
@ascenneumo · X
RT @JAMACardio: This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolis…
This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolism (VTE). Dose-adjustment is relevant for AF and shouldn't be used for VTE. Low-intensity tx may be used for VTE prevention. @bbikdeli https://t.co/A7ZuahGmwH
Dose adjustment and low-intensity treatment are 2 different forms of dose-reduced #DOACs. Dose adjustment is mostly relevant for #AF and should be done based on the approved criteria.
https://t.co/CRerDt7x4V
Low-intensity DOACs may be used for primary or secondary VTE prevention for studied and approved indications
Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants: A Review https://t.co/Dm1xmIbP3W
Jun 5, 2022 · 1 share · 1,828 followersView post →
BB
Behnood Bikdeli
@bbikdeli · X
@gunnar_heine Thx so much! Great comment. Many❓about pts w advanced renal dysfunction & ESRD. #RENAF_AF❌, #VALKYRIE was interesting but not large enough. Regulatory bodies made recs based on not-so-strong data...My hope is more RCTs in the next Ys. Some in Appendix. https://t.co/LVhyAwUhZK
RT @mmonrealriete: Dose adjustment of DOACs should not be used for acute VTE therapy
In contrast, low-intensity DOACs may be used for prima…
Jun 3, 2022 · 16 shares · 4,345 followersView post →
JR
Jorge Cárdenas R.
@JoCardR · X
RT @mmonrealriete: Dose adjustment of DOACs should not be used for acute VTE therapy
In contrast, low-intensity DOACs may be used for prima…
Jun 3, 2022 · 16 shares · 339 followersView post →
BB
Behnood Bikdeli
@bbikdeli · X
RT @mmonrealriete: Dose adjustment of DOACs should not be used for acute VTE therapy
In contrast, low-intensity DOACs may be used for prima…
Jun 3, 2022 · 16 shares · 1,267 followersView post →
GB
Geoff Barnes
@GBarnesMD · X
RT @mmonrealriete: Dose adjustment of DOACs should not be used for acute VTE therapy
In contrast, low-intensity DOACs may be used for prima…
Jun 3, 2022 · 16 shares · 5,373 followersView post →
DV
Dr Jean Pierre Laroche #vacciné 6.0
@Echoraljpangio · X
RT @mmonrealriete: Dose adjustment of DOACs should not be used for acute VTE therapy
In contrast, low-intensity DOACs may be used for prima…
Jun 3, 2022 · 16 shares · 2,716 followersView post →
MS
Manu Morales Sánchez
@Manugrillo2 · X
Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants #DOACS https://t.co/cdgv8HsOq1 vía @JAMACardio part of @JAMANetwork
Jun 3, 2022 · 1 like · 1 share · 2,135 followersView post →
TI
trombo.info
@tromboinfo · X
RT @mmonrealriete: Dose adjustment of DOACs should not be used for acute VTE therapy
In contrast, low-intensity DOACs may be used for prima…
Jun 3, 2022 · 16 shares · 1,592 followersView post →
JA
Jaime Alvarado
@jaialv01 · X
RT @mmonrealriete: Dose adjustment of DOACs should not be used for acute VTE therapy
In contrast, low-intensity DOACs may be used for prima…
Jun 3, 2022 · 16 shares · 230 followersView post →
GP
Geraldine POENOU
@zudenstein · X
RT @mmonrealriete: Dose adjustment of DOACs should not be used for acute VTE therapy
In contrast, low-intensity DOACs may be used for prima…
Jun 3, 2022 · 16 shares · 401 followersView post →
DJ
David Jiménez
@DJC6998 · X
RT @mmonrealriete: Dose adjustment of DOACs should not be used for acute VTE therapy
In contrast, low-intensity DOACs may be used for prima…
Jun 3, 2022 · 16 shares · 1,421 followersView post →
MM
manuel monreal
@mmonrealriete · X
Dose adjustment of DOACs should not be used for acute VTE therapy
In contrast, low-intensity DOACs may be used for primary or secondary VTE prevention
Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants: A Review https://t.co/Dm1xmIbP3W
Jun 3, 2022 · 31 likes · 16 shares · 2,097 followersView post →
RT @JAMACardio: This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolis…
Jun 2, 2022 · 11 shares · 273 followersView post →
BB
Behnood Bikdeli
@bbikdeli · X
RT @JAMACardio: This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolis…
Jun 2, 2022 · 11 shares · 1,267 followersView post →
JC
JAMA Cardiology
@JAMACardio · X
This review evaluates dose-reduced direct oral anticoagulants (DOAC) for atrial fibrillation (AF) and venous thromboembolism (VTE). Dose-adjustment is relevant for AF and shouldn't be used for VTE. Low-intensity tx may be used for VTE prevention. @bbikdeli https://t.co/rCkTvaNG2h
Jun 2, 2022 · 22 likes · 11 shares · 48,131 followersView post →
AL
alfonso piñana lopez
@AlfonsoPinanaMF · X
RT @FormigaFrancesc: BASIC: Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants https://t.co/38BkS58com @JAMAC…
Jun 2, 2022 · 12 shares · 474 followersView post →
RT @DrDeLasSalasGER: Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants: A Review | Venous Thromboembolism | J…
Jun 1, 2022 · 3 shares · 1,877 followersView post →
D
DeLasSalas
@DrDeLasSalasGER · X
Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants: A Review | Venous Thromboembolism | JAMA Cardiology | JAMA Network https://t.co/nF3W3w7oFw
Jun 1, 2022 · 3 likes · 3 shares · 696 followersView post →
IK
Italo Kumamoto
@fikkumamoto · X
Jama cardiology - Efficacy and Safety Considerations With Dose-Reduced Direct Oral Anticoagulants https://t.co/zH76fPkfuQ via @JAMACardio part of @JAMANetwork
Jun 1, 2022 · 15 likes · 1 share · 8,796 followersView post →
BB
Behnood Bikdeli
@bbikdeli · X
@luistrombo Thanks so much! Here it is: https://t.co/LVhyAxbSRi
Jun 1, 2022 · 6 likes · 2 shares · 1,267 followersView post →
TA
Tania Ahuja
@TaniaAhuja · X
Jun 1, 2022 · 7 likes · 3 shares · 1,045 followersView post →
N
_Điều chỉnh liều DOAC theo HDSD_VNODIC.pdf
News
doi:10.1001/jamacardio.2022.1292 2. Công ty Bayer AG (2019), "Tờ thông tin sản phẩm Xarelto 15mg, 20mg” 3. Công ty Bayer AG (2017), "Tờ thông tin sản phẩm ...