Front Endocrinol (Lausanne) June 2022 PMID 35663320

The Role of Testosterone in Spermatogenesis: Lessons From Proteome Profiling of Human Spermatozoa in Testosterone Deficiency.

Giuseppe Grande, Ferran Barrachina, Ada Soler-Ventura, Meritxell Jodar, Francesca Mancini, Riccardo Marana, Sabrina Chiloiro, Alfredo Pontecorvi, Rafael Oliva, Domenico Milardi

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Mentions

Peak: 2 in Jul 2025

across 2 sources since Nov 2022

Extended reach

5,786

potential audience

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Video views

5,300

Mentions per month

Nov 2022 – Jul 2025

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AI synopsis

What people are saying

Several discussions highlight the identification of over 900 sperm proteins and the significance of 43 proteins altered in hypogonadic men, indicating a meaningful contribution to understanding male fertility. Words like 'insights,' 'potential impact,' and 'fascinating findings' reflect a cautiously optimistic tone, emphasizing the research's relevance without overstating its immediate applications.

AgreementModerate agreement

Most discussions agree that the study offers valuable insights into how testosterone influences sperm proteins and fertility.

InterestModerate interest

Participants show moderate interest, with some noting the significance of identifying specific proteins affected by testosterone deficiency.

EngagementNeutral engagement

The discussions are somewhat superficial, with limited deep analysis or technical engagement beyond general summaries.

ImpactModerate impact

The publication is seen as moderately impactful, providing important clues for reproductive health and future research but not revolutionizing the field immediately.

Abstract in brief

This study investigates how testosterone deficiency affects sperm proteins by comparing sperm from fertile men and men with secondary hypogonadism, using advanced proteomic techniques.
They identified up to 986 proteins in sperm samples, with 43 showing significant changes in men with hypogonadism, including 13 proteins previously linked to sperm function and reproduction.
The findings, confirmed by Western blot analysis, suggest that testosterone influences sperm protein composition, which could impact fertility and offer insights into male reproductive health.]

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All mentions

Testosterone's Impact on Sperm Protein Composition and Male Fertility

This study examines how testosterone deficiency affects sperm proteins by comparing samples from fertile men and those with hypogonadism, revealing significant protein changes linked to fertility and reproductive health.

HiDrLee · Jul 20, 2025 2,675 views

Testosterone Deficiency's Impact on Sperm Proteins and Fertility

This study explores how testosterone deficiency affects sperm proteins, comparing fertile men to those with hypogonadism using advanced proteomic techniques. Up to 986 proteins were identified, with 43 showing…

HiDrLee · Jul 20, 2025 2,625 views

Dipòsit Digital UB

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The Role of Testosterone in Spermatogenesis: lessons from proteome profiling of human spermatozoa in testosterone deficiency https://t.co/08OGMc6sy3

Nov 25, 2022 · 487 followers View post →