Drug Deliv Transl Res January 2023 PMID 35672652

Ashwagandha-loaded nanocapsules improved the behavioral alterations, and blocked MAPK and induced Nrf2 signaling pathways in a hepatic encephalopathy rat model.

Heba M A Khalil, Islam A Khalil, Asmaa K Al-Mokaddem, Marwa Hassan, Riham A El-Shiekh, Hesham A Eliwa, Azza M Tawfek, Walaa H El-Maadawy

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Peak: 2 in Aug 2025

across 2 sources since Jun 2022

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The discussion reflects mild interest with a touch of humor, exemplified by a playful comment about cookies potentially being made of curcumin and charcoal and a straightforward acknowledgment of the scientific findings. The tone is casual and light, which influences the subdued scores for engagement and impact.

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The discussion includes a humorous remark about the original publication, but no strong support or disagreement is evident.

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The comment on the scientific study shows some curiosity, though it's limited and casual.

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There is minimal in-depth discussion, with brief mentions and a humorous side note rather than detailed analysis.

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The overall influence of these discussions appears modest, mainly serving entertainment rather than shaping scientific understanding.

Abstract in brief

Ashwagandha (ASH) is a key herb in Ayurvedic medicine with potential liver and brain protective benefits, but its low oral bioavailability limits its effectiveness.
Researchers created chitosan-alginate bipolymeric nanocapsules (ASH-BPNCs) to improve ASH's stability and absorption, achieving a small particle size and high entrapment efficiency.
In tests on a rat model of hepatic encephalopathy, ASH-BPNCs significantly improved survival and cognitive functions compared to free ASH, restored crucial serum levels, and showed enhanced accumulation in both liver and brain tissues, indicating a promising therapeutic potential for treating liver-related neurological disorders.

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All mentions

Ashwagandha's Role in Managing Stress and Enhancing Brain Function

Ashwagandha, known as Indian Ginseng, has long been valued in Ayurvedic medicine for its stress-relieving properties. Recent meta-analyses confirm its safety and effectiveness in reducing stress and improving cognitive…

Dr. med. Ulrich Selz · Aug 18, 2025 57,071 views

Ashwagandha's Effectiveness in Stress Relief and Cognitive Improvement

Ashwagandha, known as Indian Ginseng, has been valued in Ayurvedic medicine for its stress-reducing properties. Recent meta-analyses confirm its safety and effectiveness. It can enhance mood, memory, and reaction times…

Dr. med. Ulrich Selz · Aug 20, 2025 35,970 views

Mu Yang, Ph.D.

@mumumouse · X

Dear Santa, don't go to that house. Their cookies are most likely made of curcumin and charcoal. https://t.co/Ep1AO3xAcR https://t.co/lT4HKwBxuD

Dec 21, 2022 · 1 like · 643 followers View post →

TC_papers

@TC_papers · X

Ashwagandha-loaded nanocapsules improved the behavioral alterations, and blocked MAPK and induced Nrf2 signaling pathways in a hepatic encephalopathy rat model https://t.co/fRG8iAnWf7

Jun 8, 2022 · 215 followers View post →