J Immunother Cancer June 2022 PMID 35710292

Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research.

Marco Palla, Luigi Scarpato, Rossella Di Trolio, Paolo Antonio Ascierto

Mentions

11
Peak: 8 in Jun 2022
across 2 sources since Jun 2022

Extended reach

40,152
potential audience

Total likes

139

Video views

4,796

Mentions per month

Jun 2022 – Apr 2023

Where it's discussed

  • X / Twitter8 posts
  • YouTube3 videos

AI synopsis

What people are saying

The discussions highlight the therapeutic potential of modulating the Sonic hedgehog pathway, with examples like mentions of drugs targeting the smoothened receptor for cancers and potential treatments for autoimmune and viral diseases. The tone is cautiously optimistic, using phrases like 'implications and opportunities,' and the references to various cancers and immune responses indicate a moderately high interest and perceived impact on future research and therapies.

AgreementModerate agreement

Most discussions support the potential of targeting the Sonic hedgehog pathway for treating inflammatory and other diseases, indicating overall agreement with the article’s significance.

InterestModerate interest

Participants show moderate interest, often referencing specific diseases like lung cancer, AML, melanoma, and breast cancer, and mentioning implications for future research.

EngagementModerate engagement

Comments include references to current research directions and therapeutic implications, suggesting active but not deeply exploratory engagement.

ImpactModerate impact

The discussions recognize the relevance of this research to ongoing treatment strategies, implying a moderate level of potential impact on the medical field.

Abstract in brief

  • The Sonic hedgehog (Shh) signaling pathway is crucial for development and tissue maintenance, but when improperly activated, it can lead to various diseases, including cancers and immune disorders.
  • Current research focuses on inhibiting key components of this pathway as a promising treatment option for cancers like basal cell carcinoma and acute myeloid leukemia, resulting in the approval of drugs targeting the smoothened receptor.
  • Additionally, the Shh pathway may influence immune responses and infections, suggesting that blocking it could offer new therapeutic strategies for both autoimmune diseases and viral infections, like influenza and SARS-CoV-2.

Top posts

Most liked on X and Bluesky
Journal for ImmunoTherapy of Cancer
@jitcancer · X

New #JITC commentary: Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research https://t.co/sP8KmjU6pj @PAscierto https://t.co/wXjkIrJH2Y

Jun 17, 2022 · 9 likes · 2 shares · 9,301 followers View post →
Society for Immunotherapy of Cancer
@sitcancer · X

RT @jitcancer: New #JITC commentary: Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for…

Jun 20, 2022 · 2 shares · 19,846 followers View post →
Paolo A. Ascierto
@PAscierto · X

RT @jitcancer: New #JITC commentary: Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for…

Jun 17, 2022 · 2 shares · 1,964 followers View post →
Paperbirds_Hematology
@PaperbirdsM · X

New article: Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research https://t.co/zEtbloNBKw #AML #leusm #hematology https://t.co/QrMKr51zcM

Jun 17, 2022 · 911 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research https://t.co/VDSm9NpZic #lungcancer #oncology https://t.co/ctV1u8DHRj

Jun 17, 2022 · 892 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research https://t.co/CnN39KipIR #melanoma #oncology https://t.co/LUAJFruvcf

Jun 17, 2022 · 892 followers View post →

All mentions

Society for Immunotherapy of Cancer
@sitcancer · X

RT @jitcancer: New #JITC commentary: Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for…

Jun 20, 2022 · 2 shares · 19,846 followers View post →
Paolo A. Ascierto
@PAscierto · X

RT @jitcancer: New #JITC commentary: Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for…

Jun 17, 2022 · 2 shares · 1,964 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

New #JITC commentary: Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research https://t.co/sP8KmjU6pj @PAscierto https://t.co/wXjkIrJH2Y

Jun 17, 2022 · 9 likes · 2 shares · 9,301 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research https://t.co/VDSm9NpZic #lungcancer #oncology https://t.co/ctV1u8DHRj

Jun 17, 2022 · 892 followers View post →
Paperbirds_Hematology
@PaperbirdsM · X

New article: Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research https://t.co/zEtbloNBKw #AML #leusm #hematology https://t.co/QrMKr51zcM

Jun 17, 2022 · 911 followers View post →
Phage Papers
@Phage_Papers · X

Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research https://t.co/yzs3oAx1pe

Jun 17, 2022 · 647 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research https://t.co/CnN39KipIR #melanoma #oncology https://t.co/LUAJFruvcf

Jun 17, 2022 · 892 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: Sonic hedgehog pathway for the treatment of inflammatory diseases: implications and opportunities for future research https://t.co/ZBM6Ufy6fW #breastcancer #oncology https://t.co/YAJ4vMW1qM

Jun 17, 2022 · 892 followers View post →