Front Cell Infect Microbiol June 2022 PMID 35711662

Spaceflight Analogue Culture Enhances the Host-Pathogen Interaction Between and a 3-D Biomimetic Intestinal Co-Culture Model.

Jennifer Barrila, Jiseon Yang, Karla P Franco Meléndez, Shanshan Yang, Kristina Buss, Trenton J Davis, Bruce J Aronow, Heather D Bean, Richard R Davis, Rebecca J Forsyth, C Mark Ott, Sandhya Gangaraju, Bianca Y Kang, Brian Hanratty, Seth D Nydam

Mentions

42
Peak: 15 in Jun 2022
across 4 sources since May 2022

Extended reach

1,494,540
potential audience

Total likes

23,624

Video views

436,809

Mentions per month

May 2022 – Sep 2022

Where it's discussed

  • News21 articles
  • X / Twitter14 posts
  • Blogs4 articles
  • YouTube3 videos

AI synopsis

What people are saying

The discussions underscore the importance of the research, emphasizing how space-like conditions can alter microbial behavior, using phrases like ‘new frontiers’ and mentions of 'microbial infection processes,' which reflect a high level of curiosity and recognition of potential applications in space health and microbiology. The tone varies from enthusiastic to analytical, contributing to the overall moderate impact score.

AgreementModerate agreement

Most discussions acknowledge the study’s findings about how spaceflight-like conditions increase bacterial virulence and host-pathogen interactions, indicating a general consensus of support.

InterestHigh interest

The posts exhibit high interest, as they highlight the significance of the research for space travel and microbial behavior, with phrases like 'new frontiers' and references to spaceflight analogs.

EngagementModerate engagement

Comments show moderate engagement, with some posts referencing specific aspects like gene expression changes and infection processes, but few delve into technical details or implications.

ImpactModerate impact

The discussions imply that the research could have broad implications for astronaut health and microbiology in low-shear environments, suggesting a moderate to high impact.

Abstract in brief

  • This study explores how spaceflight-like conditions, specifically low fluid shear modeled microgravity (LSMMG), affect the interaction between Salmonella Typhimurium and a 3D human intestinal tissue model, revealing that LSMMG enhances bacterial adhesion, invasion, and survival independently of the Hfq protein.
  • RNA sequencing showed significant gene expression changes in both bacteria and host cells under LSMMG, with bacteria showing increased expression of genes related to infection processes, which led to higher colonization and intracellular survival in the intestinal model.
  • The findings suggest that spaceflight environments can alter host-pathogen dynamics, increasing bacterial virulence and affecting immune responses, which has implications for understanding infections during space travel and in similar low-shear conditions.

Top posts

Most liked on X and Bluesky
Phys.org
@physorg_com · X

Microgravity analog culture profoundly affects microbial #infection process in 3-D human tissue models, a new study finds https://t.co/MaaYWj7mB5 https://t.co/0VaTize6xs

Jun 1, 2022 · 24 likes · 10 shares · 1,022,451 followers View post →
Immunology of Infectious Disease News
@infdisease_news · X

Jun 4, 2022 · 1 like · 12,653 followers View post →
Frontiers - Infectious Disease
@FrontInfectDis · X

New Research: Spaceflight Analogue Culture Enhances the Host-Pathogen Interaction Between Salmonella and a 3-D Biomimetic Intestinal Co-Culture Model https://t.co/CAS0PcMG8M #cellinfect

May 31, 2022 · 1 like · 1 share · 3,833 followers View post →
Intestinal Cell News
@Intestinal_Cell · X

To new frontiers

Jun 8, 2022 · 1 like · 1,780 followers View post →
Phys.org Biology
@physorg_biology · X

RT @physorg_com: Microgravity analog culture profoundly affects microbial #infection process in 3-D human tissue models, a new study finds…

Jun 1, 2022 · 10 shares · 8,176 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Spaceflight Analogue Culture Enhances the Host-Pathogen Interaction Between Salmonella and a 3-D Biomimetic Intestinal Co-Culture Model https://t.co/YFDTvtB2Ac

Jun 1, 2022 · 2,569 followers View post →

All mentions

Symbiosis papers
@Symbiosispapers · X

Spaceflight Analogue Culture Enhances the Host-Pathogen Interaction Between <em>Salmonella</em> and a 3-D Biomimetic Intestinal Co-Culture Model https://t.co/V1KZGH5OYy

Jun 17, 2022 · 1,109 followers View post →
Intestinal Cell News
@Intestinal_Cell · X

To new frontiers

Jun 8, 2022 · 1 like · 1,780 followers View post →
Сергей Гомзяков
@gomzyakov1977 · X

https://t.co/cWyAH7bbrV

Jun 7, 2022 · 136 followers View post →
Изя
@hDK5P5Ai54BwrAf · X

Космос усилил бактерию. Питание мегалодона. Экзаскейл. Электричество и р... https://t.co/zzCOX75rkR via @YouTube

Jun 6, 2022 · 69 followers View post →
Immunology of Infectious Disease News
@infdisease_news · X

Jun 4, 2022 · 1 like · 12,653 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Spaceflight Analogue Culture Enhances the Host-Pathogen Interaction Between Salmonella and a 3-D Biomimetic Intestinal Co-Culture Model https://t.co/YFDTvtB2Ac

Jun 1, 2022 · 2,569 followers View post →
serrgv
@serrgv · X

RT @physorg_com: Microgravity analog culture profoundly affects microbial #infection process in 3-D human tissue models, a new study finds…

Jun 1, 2022 · 10 shares · 145 followers View post →
MajAy
@Man0mAya · X

RT @physorg_com: Microgravity analog culture profoundly affects microbial #infection process in 3-D human tissue models, a new study finds…

Jun 1, 2022 · 10 shares · 1,296 followers View post →
TrollColors
@TrollColors · X

RT @physorg_com: Microgravity analog culture profoundly affects microbial #infection process in 3-D human tissue models, a new study finds…

Jun 1, 2022 · 10 shares · 1,249 followers View post →
Dennis McMahon
@DennisCMcMahon · X

RT @physorg_com: Microgravity analog culture profoundly affects microbial #infection process in 3-D human tissue models, a new study finds…

Jun 1, 2022 · 10 shares · 1,997 followers View post →
Mr. Cauthers
@MrCauthers · X

RT @physorg_com: Microgravity analog culture profoundly affects microbial #infection process in 3-D human tissue models, a new study finds…

Jun 1, 2022 · 10 shares · 127 followers View post →
Phys.org Biology
@physorg_biology · X

RT @physorg_com: Microgravity analog culture profoundly affects microbial #infection process in 3-D human tissue models, a new study finds…

Jun 1, 2022 · 10 shares · 8,176 followers View post →
Phys.org
@physorg_com · X

Microgravity analog culture profoundly affects microbial #infection process in 3-D human tissue models, a new study finds https://t.co/MaaYWj7mB5 https://t.co/0VaTize6xs

Jun 1, 2022 · 24 likes · 10 shares · 1,022,451 followers View post →
Frontiers - Infectious Disease
@FrontInfectDis · X

New Research: Spaceflight Analogue Culture Enhances the Host-Pathogen Interaction Between Salmonella and a 3-D Biomimetic Intestinal Co-Culture Model https://t.co/CAS0PcMG8M #cellinfect

May 31, 2022 · 1 like · 1 share · 3,833 followers View post →