Front Cardiovasc Med June 2022 PMID 35722128

Mechanisms of Oxidized LDL-Mediated Endothelial Dysfunction and Its Consequences for the Development of Atherosclerosis.

Hui Jiang, Yongwen Zhou, Seyed M Nabavi, Amirhossein Sahebkar, Peter J Little, Suowen Xu, Jianping Weng, Jianjun Ge

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Peak: 14 in Aug 2022

across 3 sources since Jun 2022

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238,723

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5,675

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169,602

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Jun 2022 – Nov 2025

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AI synopsis

What people are saying

The overall sentiment reflects skepticism, with posts like the hormone diet doctor's dismissing the study as an 'associational study' that cannot establish causation, while others, like the immuno-metabolic disease mention, acknowledge the complex mechanisms involved but do not seem deeply engaged. The tone varies from dismissive to mildly inquisitive, showing that the discussions are more questioning than exploratory.

AgreementLow agreement

Most posts express skepticism or dissent, especially regarding the causal significance of LDL levels, highlighting doubts about the article's conclusions.

InterestModerate interest

Posts show moderate interest, with some expressing curiosity about the mechanisms but also dismissing the study’s relevance.

EngagementLow engagement

Responses are somewhat superficial, with some posts dismissing the research as merely associative without deep scientific discussion.

ImpactNeutral impact

The discussions do not seem to provoke significant changes in opinion or awareness, indicating a neutral impact overall.

Abstract in brief

Oxidized LDL (oxLDL) plays a key role in the development of atherosclerosis by causing endothelial dysfunction, promoting foam cell formation, and contributing to plaque instability through various cellular and molecular mechanisms.
The process involves modifications of LDL particles, such as changes in size and biochemical properties, and the actions of enzymes and receptors that mediate LDL oxidation, which in turn activate proatherogenic pathways in vascular cells.
Potential therapies are being explored to target and reduce LDL oxidation or oxLDL levels, aiming to prevent or slow down the progression of atherosclerosis by mitigating inflammation and vascular damage.

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All mentions

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Oxidized LDL and Endothelial Dysfunction in Atherosclerosis

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Physionic · Oct 6, 2023 21,357 views

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LDL Cholesterol Oxidation and Its Role in Heart Disease

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thalesnemo

@thalesnemo · X

@hormonedietdoc LOL .. another ASSOCIATIONAL STUDY which BY design CAN NOT PROVE CAUSATION! LDL is NOT a metric of concern! https://t.co/kesVilQzyD ➡️ https://t.co/aa3Amh569y ➡️ https://t.co/oB2oR4MYHq ➡️ https://t.co/PkLMm1YjWW ➡️ https://t.co/Fvu39UuEVf https://t.co/GnT6L92nvN

Jan 22, 2023 · 1,109 followers View post →

Oscar Andres

@OscarAndresMD · X

RT @agingdoc1: Mechanisms of Oxidized LDL-Mediated Endothelial Dysfunction and Its Consequences for the Development of Atherosclerosis htt…

Aug 31, 2022 · 1 share · 544 followers View post →

Agingdoc

@agingdoc1 · X

Mechanisms of Oxidized LDL-Mediated Endothelial Dysfunction and Its Consequences for the Development of Atherosclerosis https://t.co/wMafsMzFXg https://t.co/XrYnvmfzNf

Aug 30, 2022 · 4 likes · 1 share · 44,325 followers View post →

Hunter Health

@KetoGaia · X