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The social discussions are largely centered around technical concerns, such as mentions of chromosome 14 losses and the presence of aneuploidy, highlighting worries about genetic stability post-CRISPR editing. The tone is cautionary and analytical, reflecting serious consideration of the research findings' implications for future clinical use.
Most discussions express concern or skepticism about the safety of CRISPR-Cas9 proceeding without further monitoring, indicating strong agreement with the negative implications highlighted.
Participants show moderate interest, focusing on specific technical issues like chromosome loss and aneuploidy, rather than broad enthusiasm.
Discussions delve into detailed implications such as chromosomal abnormalities, suggesting deep engagement with the scientific concerns raised.
Many discussions emphasize the potential clinical and research consequences of chromosomal disruptions, underscoring high impact.
"Frequent aneuploidy in primary human T cells after CRISPR–Cas9 cleavage" Nahmad AD, Reuveni E, Goldschmidt E [..] Madi A, Ben-David U, Barzel A. (bioRxiv. 2021-08-20) Nat Biotechnol 2022-06-30. https://t.co/vRwH0ls6qC
T細胞の14番染色体の標的が切断された場合、細胞の約5％で適切な修復が行われず、この染色体が失われました。2、7、14番のすべての染色体上の標的が同時に切断されると、損傷が増加し、それぞれ細胞の3％、10％、9％で切断を修復できませんでした。NatureBiotechnology誌https://t.co/uYPnlRP0Up
CRISPR-Cas9によるゲノム編集の結果生じる染色体異数性細胞の評価を行った論文。 TCRを標的にしたゲノム編集ののち、FISHやデジタルPCRによってコピー数を測定した結果、編集直後で10%弱、14日後でも1%の異数性細胞が生存していたことを報告している。 https://t.co/xUliIOCT46
https://t.co/H9RVPYZiUf
This video discusses gene editing of B cells to produce broadly neutralizing anti-HIV antibodies in mice and explores challenges with CRISPR-Cas9 in primary human T cells, including chromosomal disruptions that impact…
As we age, our methods of discovering new music evolve. By analyzing data from music platforms, we can explore how this change occurs. New studies also reveal the link between fish consumption and melanoma risk…
CRISPR-Cas9によるゲノム編集の結果生じる染色体異数性細胞の評価を行った論文。 TCRを標的にしたゲノム編集ののち、FISHやデジタルPCRによってコピー数を測定した結果、編集直後で10%弱、14日後でも1%の異数性細胞が生存していたことを報告している。 https://t.co/xUliIOCT46
https://t.co/c54j2qlJcB Frequent aneuploidy in primary human T cells after CRISPR–Cas9 cleavage
T細胞の14番染色体の標的が切断された場合、細胞の約5％で適切な修復が行われず、この染色体が失われました。2、7、14番のすべての染色体上の標的が同時に切断されると、損傷が増加し、それぞれ細胞の3％、10％、9％で切断を修復できませんでした。NatureBiotechnology誌https://t.co/uYPnlRP0Up
https://t.co/H9RVPYZiUf
"Frequent aneuploidy in primary human T cells after CRISPR–Cas9 cleavage" Nahmad AD, Reuveni E, Goldschmidt E [..] Madi A, Ben-David U, Barzel A. (bioRxiv. 2021-08-20) Nat Biotechnol 2022-06-30. https://t.co/vRwH0ls6qC