Signal Transduct Target Ther July 2022 PMID 35794102

Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota.

Shu-Rong Ma, Qian Tong, Yuan Lin, Li-Bin Pan, Jie Fu, Ran Peng, Xian-Feng Zhang, Zhen-Xiong Zhao, Yang Li, Jin-Bo Yu, Lin Cong, Pei Han, Zheng-Wei Zhang, Hang Yu, Yan Wang

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Mentions

23
Peak: 3 in Aug 2022
across 5 sources since Jul 2022

Extended reach

477,896
potential audience

Total likes

10,689

Video views

463,865

Mentions per month

Jul 2022 – Feb 2024

Where it's discussed

  • X / Twitter12 posts
  • Facebook3 posts
  • Reddit3 posts
  • News3 articles
  • YouTube2 videos

AI synopsis

What people are saying

Discussions generally support the article's findings, with statements like 'Berberine treats atherosclerosis' and references to vitamin-like effects, highlighting curiosity about its health implications. Users reference multiple papers and mention potential therapeutic benefits, demonstrating moderate engagement and perceived impact based on tone and content.

AgreementModerate agreement

Most discussions acknowledge the findings, though some mention uncertainty or need for dosage clarification.

InterestModerate interest

Posts show moderate curiosity, with some users interested in potential health benefits and mechanisms.

EngagementModerate engagement

Several contributions reference related research or express opinions, indicating active exploration.

ImpactModerate impact

The collective tone suggests recognition of the research's potential significance in cardiovascular health.

Abstract in brief

  • Berberine (BBR) reduces the production of TMAO, a harmful compound linked to atherosclerosis, by interacting with gut bacteria enzymes, acting like a vitamin to downregulate the choline-dependent TMAO pathway.
  • In animal studies and human patients, oral BBR lowered TMAO levels, decreased plaque formation in blood vessels, and reduced atherosclerotic plaque scores, suggesting it can help treat or prevent cardiovascular disease.
  • BBR's way of working is similar to vitamins, as it influences gut microbiota to decrease TMAO production, which may help in managing atherosclerosis, highlighting its potential as a therapeutic option.

Top posts

Most liked on X and Bluesky
Frank Paul Mora
@InTime_49 · X

@_MCRicardo_ @HealthyFellow @_atanas_ @AyusWellness @dronita_de @DrPalmquist @EddieRDMD @EwingT_PhD @guani_vic @ToshiyukiHorie Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota https://t.co/fW5afeTso1

Feb 10, 2024 · 8 likes · 1 share · 393 followers View post →
Orlando_uy
@Orlando_uy · X

Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota. https://t.co/zzSvgeXmhA

Jul 26, 2022 · 4 likes · 1 share · 692 followers View post →
Boazhu
@boazhu1012 · X

Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota https://t.co/9doxXpecH1

Aug 30, 2022 · 2 likes · 66 followers View post →
trainerrueben
@trainerrueben · X

https://t.co/C0tXe5KVWQ Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota

Apr 5, 2023 · 1 like · 947 followers View post →
Sasho Slavov
@SlavovSash96973 · X

Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota It is possible to achieve a reduction in atherosclerotic plaques by 3.2% when taking berberine when taking berberine. Berb....https://t.co/oyUJ0XwDtU

May 20, 2023 · 1 like · 1 followers View post →
Deplora-Bill Crowell
@n4hpg · X

He references these papers: 1/4 https://t.co/uF3YaSm5VJ

Dec 14, 2023 · 5,550 followers View post →

All mentions

DrRPalmquist
@DrPalmquist · X

RT @InTime_49: @_MCRicardo_ @HealthyFellow @_atanas_ @AyusWellness @dronita_de @DrPalmquist @EddieRDMD @EwingT_PhD @guani_vic @ToshiyukiHor…

Feb 10, 2024 · 1 share · 3,168 followers View post →
Frank Paul Mora
@InTime_49 · X

@_MCRicardo_ @HealthyFellow @_atanas_ @AyusWellness @dronita_de @DrPalmquist @EddieRDMD @EwingT_PhD @guani_vic @ToshiyukiHorie Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota https://t.co/fW5afeTso1

Feb 10, 2024 · 8 likes · 1 share · 393 followers View post →
Deplora-Bill Crowell
@n4hpg · X

He references these papers: 1/4 https://t.co/uF3YaSm5VJ

Dec 14, 2023 · 5,550 followers View post →
Frederick Leathers
@FrederickLeath5 · X

Skimmed this so I don't know what the dosage they were using. "Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota" https://t.co/UFfyhI7spT https://t.co/XeftN4Lbvb

Jul 27, 2023 · 878 followers View post →
Sasho Slavov
@SlavovSash96973 · X

Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota It is possible to achieve a reduction in atherosclerotic plaques by 3.2% when taking berberine when taking berberine. Berb....https://t.co/oyUJ0XwDtU

May 20, 2023 · 1 like · 1 followers View post →
Architect Neo
@Neo1Architect · X

⏺️H Βερβερίνη αντιμετωπίζει την αθηροσκλήρωση μέσω μιας δράσης παρόμοια με τις βιταμίνες, ρυθμίζοντας την παραγωγή χολίνης-TMA-TMAO στη μικροχλωρίδα του εντέρου. Η βερβερίνη υπάρχει εδώ και 3.000 χρόνια στην Κίνα ως φάρμακο.. https://t.co/IjZgkiFI1I

Apr 17, 2023 · 446 followers View post →
trainerrueben
@trainerrueben · X

https://t.co/C0tXe5KVWQ Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota

Apr 5, 2023 · 1 like · 947 followers View post →
Boazhu
@boazhu1012 · X

Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota https://t.co/9doxXpecH1

Aug 30, 2022 · 2 likes · 66 followers View post →
Piracetam.Net
@PiracetamNET · X

I just posted "Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota" on Reddit https://t.co/cPTRRIQbLt

Aug 15, 2022 · 78 followers View post →
Orlando_uy
@Orlando_uy · X

RT @Orlando_uy: Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut micr…

Aug 2, 2022 · 1 share · 692 followers View post →
Orlando_uy
@Orlando_uy · X

Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota. https://t.co/zzSvgeXmhA

Jul 26, 2022 · 4 likes · 1 share · 692 followers View post →
Symbiosis papers
@Symbiosispapers · X

Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota https://t.co/wPds2Epn9B

Jul 7, 2022 · 1,113 followers View post →