July 2022 PMID 35794109

Trends in insulin resistance: insights into mechanisms and therapeutic strategy.

Mengwei Li, Xiaowei Chi, Ying Wang, Sarra Setrerrahmane, Wenwei Xie, Hanmei Xu

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Mentions

25
Peak: 8 in Jan 2024
across 3 sources since Jul 2022

Extended reach

191,913
potential audience

Total likes

1,711

Video views

61,029

Mentions per month

Jul 2022 – Oct 2025

Where it's discussed

  • X / Twitter15 posts
  • News8 articles
  • YouTube2 videos

AI synopsis

What people are saying

Discussions show strong interest in intervention methods, with comments emphasizing early lifestyle changes like diet and exercise, and their potential to alter disease progression. The tone underscores the importance of research-driven strategies, with phrases like 'therapy of insulin resistance' and 'be ready to take medications for life,' highlighting concerns about long-term management; overall, the discourse suggests a positive view of the article’s relevance to ongoing health issues.

AgreementModerate agreement

Most comments acknowledge the importance of lifestyle interventions and the relevance of the publication's insights into insulin resistance, indicating a supportive stance.

InterestHigh interest

Discussions reflect high interest, with emphasis on the mechanisms and treatment strategies, evident through mentions of 'therapeutic strategies' and 'metabolic disorders.'

EngagementModerate engagement

There is some depth of engagement, as evidenced by references to specific mechanisms and the importance of early intervention or medication, but mostly it remains at a conversational level.

ImpactModerate impact

The discussions highlight recognition of the article's significance in understanding and treating insulin resistance, suggesting moderate impact on health practices or awareness.

Abstract in brief

  • The discovery of insulin a century ago has opened opportunities to manage diabetes as a chronic condition by understanding insulin's role in glucose metabolism and the mechanisms behind insulin resistance (IR).
  • IR is caused by disruption in molecular pathways within tissues, influenced by factors like obesity, genetics, and substances released from fat tissue, which can lead to various metabolic disorders such as fatty liver disease, cardiovascular problems, and PCOS.
  • While no specific drugs currently target IR directly, lifestyle changes and certain medications can improve insulin sensitivity, and ongoing research into its mechanisms may lead to new treatments for associated metabolic syndromes.

Top posts

Most liked on X and Bluesky
Dr Sudhir Kumar MD DM
@hyderabaddoctor · X

Therapy of Insulin resistance Seriously follow the lower half of the image (physical exercise and healthy dietary pattern) from as early as possible, or be ready to take a number of medicines for life (upper half of the image). Ref: https://t.co/8GtpGU8fI0 (5/n) #MedTwitter https://t.co/IksLrTbUNS

Jan 30, 2024 · 49 likes · 9 shares · 97,139 followers View post →
Adipose Papers
@adipose_papers · X

Trends in insulin resistance: insights into mechanisms and therapeutic strategy https://t.co/Vd4w3M5YVS https://t.co/WhZlHCLesP

Jul 7, 2022 · 4 likes · 1 share · 2,451 followers View post →
javierbutra
@javierbutra · X

Trends in insulin resistance: insights into mechanisms and therapeutic strategy https://t.co/qpcSZUUarK https://t.co/21lgas5Jck

Sep 8, 2022 · 2 likes · 14,340 followers View post →
Dr. Chris Chappel
@ChappelDr · X

Sources: PMID: 32455135 PMID: 22496538 DOI: 10.1186/s13098-020-0523-x DOI: 10.1038/s41392-022-01073-0

Oct 15, 2025 · 2 likes · 13,598 followers View post →
Javed Alam
@jalam1001 · X

RT @hyderabaddoctor: Therapy of Insulin resistance Seriously follow the lower half of the image (physical exercise and healthy dietary pat…

Jan 30, 2024 · 9 shares · 999 followers View post →
#JaiShreeRam
@Sudhakarszz · X

RT @hyderabaddoctor: Therapy of Insulin resistance Seriously follow the lower half of the image (physical exercise and healthy dietary pat…

Jan 30, 2024 · 9 shares · 965 followers View post →

All mentions

Dr. Chris Chappel
@ChappelDr · X

Sources: PMID: 32455135 PMID: 22496538 DOI: 10.1186/s13098-020-0523-x DOI: 10.1038/s41392-022-01073-0

Oct 15, 2025 · 2 likes · 13,598 followers View post →
Soumitri
@Soumitri99 · X

RT @hyderabaddoctor: Therapy of Insulin resistance Seriously follow the lower half of the image (physical exercise and healthy dietary pat…

May 10, 2024 · 9 shares · 480 followers View post →
Madhavan
@Madhava86583754 · X

RT @hyderabaddoctor: Therapy of Insulin resistance Seriously follow the lower half of the image (physical exercise and healthy dietary pat…

Jan 31, 2024 · 9 shares · 20 followers View post →
Javed Alam
@jalam1001 · X

RT @hyderabaddoctor: Therapy of Insulin resistance Seriously follow the lower half of the image (physical exercise and healthy dietary pat…

Jan 30, 2024 · 9 shares · 999 followers View post →
Suruchi
@thisissuruchi · X

RT @hyderabaddoctor: Therapy of Insulin resistance Seriously follow the lower half of the image (physical exercise and healthy dietary pat…

Jan 30, 2024 · 9 shares · 20 followers View post →
#JaiShreeRam
@Sudhakarszz · X

RT @hyderabaddoctor: Therapy of Insulin resistance Seriously follow the lower half of the image (physical exercise and healthy dietary pat…

Jan 30, 2024 · 9 shares · 965 followers View post →
Krishna Pandey
@spamhere081 · X

RT @hyderabaddoctor: Therapy of Insulin resistance Seriously follow the lower half of the image (physical exercise and healthy dietary pat…

Jan 30, 2024 · 9 shares · 23 followers View post →
Chetan
@Bug_vs_ · X

RT @hyderabaddoctor: Therapy of Insulin resistance Seriously follow the lower half of the image (physical exercise and healthy dietary pat…

Jan 30, 2024 · 9 shares · 127 followers View post →
HoneyBadger
@ShumonDas142672 · X

RT @hyderabaddoctor: Therapy of Insulin resistance Seriously follow the lower half of the image (physical exercise and healthy dietary pat…

Jan 30, 2024 · 9 shares · 79 followers View post →
Dr Sudhir Kumar MD DM
@hyderabaddoctor · X

Therapy of Insulin resistance Seriously follow the lower half of the image (physical exercise and healthy dietary pattern) from as early as possible, or be ready to take a number of medicines for life (upper half of the image). Ref: https://t.co/8GtpGU8fI0 (5/n) #MedTwitter https://t.co/IksLrTbUNS

Jan 30, 2024 · 49 likes · 9 shares · 97,139 followers View post →
Jose Daniel Mosquera Lozano
@jdmosqueral · X

Trends in insulin resistance: insights into mechanisms and therapeutic strategy | Signal Transduction and Targeted Therapy https://t.co/xkMyK2MK6N

May 2, 2023 · 233 followers View post →
javierbutra
@javierbutra · X

Trends in insulin resistance: insights into mechanisms and therapeutic strategy https://t.co/qpcSZUUarK https://t.co/21lgas5Jck

Sep 8, 2022 · 2 likes · 14,340 followers View post →
Te-Yueh (Derek) Lin
@Derek_Lin_57 · X

RT @adipose_papers: Trends in insulin resistance: insights into mechanisms and therapeutic strategy https://t.co/Vd4w3M5YVS https://t.co/Wh…

Jul 7, 2022 · 1 share · 92 followers View post →
Cardio-Targets
@CardioTargets · X

Trends in insulin resistance: insights into mechanisms and therapeutic strategy https://t.co/ieh4lOxQ5V

Jul 7, 2022 · 153 followers View post →
Adipose Papers
@adipose_papers · X

Trends in insulin resistance: insights into mechanisms and therapeutic strategy https://t.co/Vd4w3M5YVS https://t.co/WhZlHCLesP

Jul 7, 2022 · 4 likes · 1 share · 2,451 followers View post →