... j.ymben.2022.07.003 ... Metabolic Engineering, 63, 34–60. Fung Shek, C., & Betenbaugh, M. (2021). Taking the pulse of bioprocesses: https://doi.org/10.1016/j.
Data-driven and model-guided systematic framework for media development in CHO cell culture.
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Abstract in brief
- The paper introduces a systematic media development framework that integrates statistical analysis and computer modeling to optimize media recipes for Chinese hamster ovary (CHO) cells, commonly used in biotech manufacturing.
- The process involves collecting cell and metabolite data, analyzing it to understand cell metabolism, running in silico (computer-based) simulations to find bottlenecks, and then identifying specific media components (like Q10) to improve cell growth and productivity.
- An example case with antibody-producing CHO cell lines showed that adding Q10 helped resolve a metabolic issue, leading to better cell growth, demonstrating how this framework can be used to design better media tailored to specific cell needs.]
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the preference of CHO cells to consume asparagine over aspar- Chemical Engineering 22 (2018): 42–47, https://doi.org/10.1016/j.coche. ... 1016/j.ymben.2022.07.003 ...
Machine learning for metabolic engineering: a review. Metab Eng. 2021;63:34–60. doi: 10.1016/j. ymben.2020.10.005. 87. Hernández E, ...
doi: 10.1016/j.ymben.2022.07.003 3. Konno Y, Aoki M, Takagishi M, et ... Can J Chem Eng. 2022. doi: 10.1002/cjce.24752. View Whitepaper.
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