Front Aging March 2022 PMID 35821844

A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage.

Giulia Lizzo, Eugenia Migliavacca, Daniela Lamers, Adrien Frézal, John Corthesy, Gerard Vinyes-Parès, Nabil Bosco, Leonidas G Karagounis, Ulrike Hövelmann, Tim Heise, Maximilian von Eynatten, Philipp Gut

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Mentions

61
Peak: 11 in Aug 2022
across 3 sources since Mar 2022

Extended reach

620,416
potential audience

Total likes

5,633

Video views

179,834

Mentions per month

Mar 2022 – Aug 2025

Where it's discussed

  • X / Twitter52 posts
  • YouTube5 videos
  • News4 articles

AI synopsis

What people are saying

Discussions highlight the potential of GlyNAC as a 'game changer' for longevity, with posts referencing specific findings such as increased glutathione levels and improved health markers, while some express curiosity about dosage details or compare recent studies. The tone varies from enthusiastic to cautious, reflecting both recognition of the study's significance and critical analysis of its results.

AgreementModerate agreement

Most discussions acknowledge the positive findings of the trial, with some emphasizing the potential benefits of GlyNAC supplementation for older adults.

InterestModerate interest

Discussions show moderate interest, focusing on the implications for aging and health, but some posts are more casual or skeptical.

EngagementModerate engagement

Many posts reference specific study details like dosage and outcomes, indicating thoughtful engagement with the research.

ImpactModerate impact

The collective tone suggests that the research has meaningful implications for aging and antioxidant supplementation, though some posts question its generalizability.

Top posts

Most liked on X and Bluesky
Lori Shemek, PhD
@LoriShemek · X

https://t.co/kgb6qicyKt Results: Improved inflammation, endothelial dysfunction, insulin-resistance, genomic-damage, cognition, strength, gait-speed, and exercise capacity; and lowered body-fat and waist-circumference.

Aug 23, 2022 · 40 likes · 5 shares · 167,329 followers View post →
L ❤ V E
@drkohilathas · X

One way to improve glutathione levels is to use Glycine and N-Acetylcysteine (NAC) Supplementation. "In summary GlyNAC supplementation is safe, well tolerated, and may increase glutathione levels in older adults with high glutathione demand." https://t.co/sE7U6RHHMe https://t.co/RFLnAymF3Q

Mar 6, 2023 · 19 likes · 3 shares · 48,112 followers View post →
L ❤ V E
@drkohilathas · X

"We investigated supplementation with glycine and n-acetylcysteine (GlyNAC) at three different daily doses for 2 weeks (low dose: 2.4 g, medium dose: 4.8 g, or high dose: 7.2 g/day, 1:1 ratio)" 1:1 ratio used in this study. https://t.co/sE7U6RHHMe

Mar 7, 2023 · 13 likes · 4 shares · 48,112 followers View post →
Agingdoc
@agingdoc1 · X

A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage (2022) https://t.co/Sq9LtRvXi3

May 7, 2023 · 11 likes · 2 shares · 41,498 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

A more recent study from the same research group: A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage https://t.co/pA6enHybVL

Jan 5, 2023 · 8 likes · 1 share · 9,727 followers View post →
CogniSphere
@jorgensenmc1 · X

“We investigated supplementation with glycine and n-acetylcysteine (GlyNAC) at three different daily doses for 2 weeks (low dose: 2.4 g, medium dose: 4.8 g, or high dose: 7.2 g/day, 1:1 ratio) in a randomized, controlled clinical trial in 114 healthy…” https://t.co/q4thziWAFS

Jul 2, 2022 · 8 likes · 4 shares · 814 followers View post →

All mentions

✨Felicity
@FelicityCWells · X

@EveY448 https://t.co/RlvGx5xv28

Aug 24, 2025 · 1 like · 2,600 followers View post →
nickolaos
@nickolaos16 · X

GlyNAC | THE GAME CHANGER | Glycine + NAC | 24% Lifespan Extension! https://t.co/mpA1wh63zM via @YouTube

Apr 11, 2025 · 16 followers View post →
JA&B
@belikejustin · X

@cingolani_oscar Y la Glycine? Junto con N-Acetylcysteine (NAC). https://t.co/Gp4Xoe7l7K https://t.co/hWN3TkuEyA

Oct 22, 2024 · 1 like · 458 followers View post →
JX Chen
@Burly426 · X

RT @Mito_Therapy: https://t.co/6A24fXWRCy

Apr 9, 2024 · 1 share · 87 followers View post →
shane novik
@shiliang123987 · X

GlyNAC | THE GAME CHANGER | Glycine + NAC | 24% Lifespan Extension! https://t.co/CAS4QL6ljQ via @YouTube

Oct 21, 2023 · 2,617 followers View post →
PC ⛓
@PC65049955 · X

RT @drkohilathas: One way to improve glutathione levels is to use Glycine and N-Acetylcysteine (NAC) Supplementation. "In summary GlyNAC…

Oct 18, 2023 · 3 shares · 1,474 followers View post →
Tarun TejpaŁ
@TTejpal · X

GlyNAC | THE GAME CHANGER | Glycine + NAC | 24% Lifespan Extension! https://t.co/xZQB4ZoNIN via @YouTube

Jul 22, 2023 · 1,683 followers View post →
Murarrie Castle
@MurarrieCastle · X

https://t.co/NyF93SCDCl #LONGEVITY

Jul 20, 2023 · 201 followers View post →
Tarun TejpaŁ
@TTejpal · X

GlyNAC | THE GAME CHANGER | Glycine + NAC | 24% Lifespan Extension! https://t.co/xZQB4ZoNIN via @YouTube

Jul 16, 2023 · 1,683 followers View post →
AMERICA'S BEST PATRIOT☄️
@AlisonBoxxer · X

GlyNAC | THE GAME CHANGER | Glycine + NAC | 24% Lifespan Extension! https://t.co/NUXqKhOdhd via @YouTube

Jul 15, 2023 · 9,674 followers View post →
Vita Sanas
@Sanitas_Carus · X

https://t.co/9bfuq4T9V9

Jul 15, 2023 · 51 followers View post →
Shashi Iyengar | Accredited Metabolic Health Coach
@shashiiyengar · X

RT @agingdoc1: A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplem…

May 7, 2023 · 2 shares · 28,849 followers View post →
Agingdoc
@agingdoc1 · X

A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage (2022) https://t.co/Sq9LtRvXi3

May 7, 2023 · 11 likes · 2 shares · 41,498 followers View post →
mkenoyer #HumanityForward
@mkenoyer · X

@ConnectingODots @PeterDiamandis Curious about your longevity hacks. Here are mine: - Supplemental NAC + Glycine - Low Omega-6 Diet - 6 day fasts - Daily sauna - Ice baths - 2.2 ATM Hyperbaric Oxygen https://t.co/x1NZ5gJEn1

Mar 21, 2023 · 3,539 followers View post →
Duncan Oxman
@DuncanOxman · X

RT @drkohilathas: "We investigated supplementation with glycine and n-acetylcysteine (GlyNAC) at three different daily doses for 2 weeks (l…

Mar 8, 2023 · 4 shares · 20 followers View post →
smart guy
@smartguy7555 · X

RT @drkohilathas: "We investigated supplementation with glycine and n-acetylcysteine (GlyNAC) at three different daily doses for 2 weeks (l…

Mar 7, 2023 · 4 shares · 333 followers View post →
Sil Ari
@adelantevamos · X

RT @drkohilathas: "We investigated supplementation with glycine and n-acetylcysteine (GlyNAC) at three different daily doses for 2 weeks (l…

Mar 7, 2023 · 4 shares · 163 followers View post →
Oscar Andres
@OscarAndresMD · X

RT @drkohilathas: "We investigated supplementation with glycine and n-acetylcysteine (GlyNAC) at three different daily doses for 2 weeks (l…

Mar 7, 2023 · 4 shares · 551 followers View post →
L ❤ V E
@drkohilathas · X

"We investigated supplementation with glycine and n-acetylcysteine (GlyNAC) at three different daily doses for 2 weeks (low dose: 2.4 g, medium dose: 4.8 g, or high dose: 7.2 g/day, 1:1 ratio)" 1:1 ratio used in this study. https://t.co/sE7U6RHHMe

Mar 7, 2023 · 13 likes · 4 shares · 48,112 followers View post →
dormiens giant
@paradoxon77 · X

RT @drkohilathas: One way to improve glutathione levels is to use Glycine and N-Acetylcysteine (NAC) Supplementation. "In summary GlyNAC…

Mar 7, 2023 · 3 shares · 818 followers View post →
L ❤ V E
@drkohilathas · X

One way to improve glutathione levels is to use Glycine and N-Acetylcysteine (NAC) Supplementation. "In summary GlyNAC supplementation is safe, well tolerated, and may increase glutathione levels in older adults with high glutathione demand." https://t.co/sE7U6RHHMe https://t.co/RFLnAymF3Q

Mar 6, 2023 · 19 likes · 3 shares · 48,112 followers View post →
Jeff A ⚜️
@JeffA000 · X

@jorgensenmc1 @Mangan150 https://t.co/VHoMRjjYhb

Jan 22, 2023 · 122 followers View post →
Rene Sugar
@renesugar · X

RT @mike_lustgarten: A more recent study from the same research group: A Randomized Controlled Clinical Trial in Healthy Older Adults to D…

Jan 5, 2023 · 1 share · 3,960 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

A more recent study from the same research group: A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage https://t.co/pA6enHybVL

Jan 5, 2023 · 8 likes · 1 share · 9,727 followers View post →
taiping zhu
@TaipingZhu · X

@Baer987654 @Plague_Hunter @369Jessica369 举个例子。NAC是增加谷胱甘肽的,可以治长新冠。正常剂量是600-1200mg/d, 我很多年坚持吃都没效果。根据这个最新研究https://t.co/V9fzLh1tAs,80KG的人可以吃到8g/d, 配合等量的Glycine,只吃14天,效果非常明显。 另外60倍正常剂量的Niacin(维生素B3)可以治精神分裂症和抑郁症。

Nov 22, 2022 · 2 likes · 97 followers View post →
Mark
@Supertelomerase · X

@Blagosklonny Unless you take two of the components of glutathione that is...https://t.co/9TBEM63M3z

Nov 9, 2022 · 3 likes · 32 followers View post →
John Barry Gallagher
@JohnBarryGalla2 · X

@BradStanfieldMD Please comment on a more recent study that NAC Glycine only benefits older adukts with high glutathione demand " A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status....

Sep 15, 2022 · 9 followers View post →
Roshan
@Roshan_Karia · X

NAC + Glycine supplementation improved Glutathione status only in older adults with existing low base glutathione levels , but not in younger people So maybe not for daily supplementation in all people @Thinkerks https://t.co/4L1iVyh1wW

Sep 4, 2022 · 2 likes · 308 followers View post →
Julia B.
@JuliaB_fitness · X

RT @JuliaB_fitness: @topologic_apple @mike_lustgarten And: «GlyNAC supplementation in Older adults significantly improved tGSH (by 173% aft…

Sep 3, 2022 · 1 share · 2,271 followers View post →
Julia B.
@JuliaB_fitness · X

@topologic_apple @mike_lustgarten And: «GlyNAC supplementation in Older adults significantly improved tGSH (by 173% after 2-weeks).» ‼️New much better/larger study: «2 weeks of GlyNAC supplementation (in older adults) did not increase GSH-T or the GSH-F:GSSG ratio.» https://t.co/OzzInwLpoZ

Sep 2, 2022 · 4 likes · 1 share · 2,271 followers View post →
Eartipped
@FeralGreg · X

@mccordmdmd @CaloriesProper @Cernovich Based on a search of the internet, these high doses probably are correct and has been demonstrated safe by other studies: https://t.co/V33dP7qEt3

Aug 31, 2022 · 2 likes · 239 followers View post →
John Siracusa
@john_siracusa · X

RT @LoriShemek: https://t.co/kgb6qicyKt Results: Improved inflammation, endothelial dysfunction, insulin-resistance, genomic-damage, cogni…

Aug 31, 2022 · 5 shares · 19,789 followers View post →
Orlando_uy
@Orlando_uy · X

A randomized controlled clinical trial in healthy older adults to determine efficacy of glycine and N-Acetylcysteine supplementation on glutathione redox status. Supplementation is safe, well tolerated, and may increase glutathione levels. https://t.co/wHUFweKwEa

Aug 26, 2022 · 5 likes · 692 followers View post →
Fern
@fern_gullie · X

RT @LoriShemek: https://t.co/kgb6qicyKt Results: Improved inflammation, endothelial dysfunction, insulin-resistance, genomic-damage, cogni…

Aug 24, 2022 · 5 shares · 395 followers View post →
John Siracusa
@john_siracusa · X

RT @LoriShemek: https://t.co/kgb6qicyKt Results: Improved inflammation, endothelial dysfunction, insulin-resistance, genomic-damage, cogni…

Aug 23, 2022 · 5 shares · 19,789 followers View post →
Claudia Moreno
@ClausUdg · X

RT @LoriShemek: https://t.co/kgb6qicyKt Results: Improved inflammation, endothelial dysfunction, insulin-resistance, genomic-damage, cogni…

Aug 23, 2022 · 5 shares · 749 followers View post →
Lori Shemek, PhD
@LoriShemek · X

https://t.co/kgb6qicyKt Results: Improved inflammation, endothelial dysfunction, insulin-resistance, genomic-damage, cognition, strength, gait-speed, and exercise capacity; and lowered body-fat and waist-circumference.

Aug 23, 2022 · 40 likes · 5 shares · 167,329 followers View post →
Mitochondrial Medicine
@Mito_Therapy · X

https://t.co/6A24fXWRCy

Aug 20, 2022 · 2 likes · 1 share · 7,146 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage @FrontAging https://t.co/vFdBzkdB4K

Aug 19, 2022 · 4 likes · 6,433 followers View post →
Oh Ay
@oahaih · X

@agingdoc1 https://t.co/IcWvMxXDfr

Aug 18, 2022 · 12 followers View post →
Chris Linnell
@ChrisPollyanna1 · X

A second human study of GlyNAC in older people which I had somehow missed from back in March: https://t.co/wTbP2mvxkd

Aug 17, 2022 · 2 likes · 702 followers View post →
UpToPhate
@UpToPhate · X

A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage https://t.co/MN6Hh31lBx

Jul 18, 2022 · 196 followers View post →
Samsara
@LivingSamsara · X

RT @jorgensenmc1: “We investigated supplementation with glycine and n-acetylcysteine (GlyNAC) at three different daily doses for 2 weeks (l…

Jul 3, 2022 · 4 shares · 782 followers View post →
dormiens giant
@paradoxon77 · X

RT @jorgensenmc1: “We investigated supplementation with glycine and n-acetylcysteine (GlyNAC) at three different daily doses for 2 weeks (l…

Jul 3, 2022 · 4 shares · 818 followers View post →
Loreley
@Loreley98469527 · X

RT @jorgensenmc1: “We investigated supplementation with glycine and n-acetylcysteine (GlyNAC) at three different daily doses for 2 weeks (l…

Jul 3, 2022 · 4 shares · 51 followers View post →
Mkrtich Sargsyan
@MkrtichSargsyan · X

RT @jorgensenmc1: “We investigated supplementation with glycine and n-acetylcysteine (GlyNAC) at three different daily doses for 2 weeks (l…

Jul 2, 2022 · 4 shares · 335 followers View post →
CogniSphere
@jorgensenmc1 · X

“We investigated supplementation with glycine and n-acetylcysteine (GlyNAC) at three different daily doses for 2 weeks (low dose: 2.4 g, medium dose: 4.8 g, or high dose: 7.2 g/day, 1:1 ratio) in a randomized, controlled clinical trial in 114 healthy…” https://t.co/q4thziWAFS

Jul 2, 2022 · 8 likes · 4 shares · 814 followers View post →
Staffan
@StaffanOlsson13 · X

@BradStanfieldMD I think the massive amount of data in this study give us more clues about who might benefit from a gly/nac combo ..."may support GSH biosynthesis in individuals with increased oxidative stress and compromised GSH stores." https://t.co/E1eAuadvvO

May 12, 2022 · 2 likes · 337 followers View post →
Orlando_uy
@Orlando_uy · X

GlyNAC supplementation is safe, well tolerated, and may increase glutathione levels in older adults with high glutathione demand. https://t.co/nrYQCLxvZr

Apr 22, 2022 · 2 likes · 692 followers View post →
starspawn0
@starspawn0 · X

@mike_lustgarten @agingdoc1 @LifespanIO @LifespanNews This Nestle study isn't as encouraging, as far as boosting glutathione (though they do say levels in tissue, instead of blood, may be higher): https://t.co/Pv4sYGHvmE

Mar 29, 2022 · 1 like · 75 followers View post →
Frontiers - Aging
@FrontAging · X

New Research: A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage https://t.co/ARlNKxYS9u #Aging

Mar 7, 2022 · 1 like · 1,701 followers View post →
Jenny Mivo
@jennymivo · X

https://t.co/5O4M92Nkcb

Mar 7, 2022 · 3 followers View post →