July 2022 PMID 35841113

Human adaptation to high altitude: a review of convergence between genomic and proteomic signatures.

Vandana Sharma, Rajeev Varshney, Niroj Kumar Sethy

Full text PDF Download social card

Mentions

Peak: 3 in Jul 2022

across 3 sources since Jul 2022

Extended reach

4,860,844

potential audience

Total likes

123,352

Video views

4,852,439

Mentions per month

Jul 2022 – Jan 2025

Where it's discussed

X / Twitter4 posts
News4 articles
YouTube2 videos

AI synopsis

What people are saying

The group shows a moderate level of support and curiosity about the article, with users mentioning its methodology and key findings indirectly, such as the convergence between genomics and proteomics, but their comments are mostly brief and focused on sharing the publication title or hashtags, which reflects a superficial engagement rather than deep analysis or critique.

AgreementModerate agreement

The mentions suggest general support for the importance of the research, with some referencing the review positively, though not overwhelmingly.

InterestModerate interest

Discussions show moderate curiosity, referencing keywords like 'convergence' and 'high altitude', but limited depth or personal engagement.

EngagementNeutral engagement

Most posts are brief and simplistic, such as sharing titles or hashtags, indicating a surface-level interaction rather than detailed analysis.

ImpactModerate impact

While some recognition of the study's significance is implied through terms like 'convergence' and highlighting the nature of adaptation, the overall discussion lacks in-depth exploration of implications.

Abstract in brief

This review highlights how both genomics and proteomics studies have identified specific genes and proteins, such as HIF-related pathways and hemoglobin genes, that help humans adapt to high altitude environments, with distinctions between genetic and protein-level adaptations.
Researchers have found 169 genes under positive natural selection in high-altitude populations like Tibetans and Sherpas, alongside 258 proteins showing significant changes, indicating complex biological responses involving oxygen sensing, blood production, and cell signaling.
The study emphasizes the convergence of genetic and proteomic data, identifying seven key molecules (like HBB and TF) and pathways such as IGF1 signaling that are crucial for high-altitude adaptation, supporting multiomics approaches to understand human evolutionary responses to environmental stress.]

Read the full abstract

All mentions

Human Adaptation to High Altitude: Genomic and Proteomic Insights

This review highlights how both genomics and proteomics studies have identified specific genes and proteins, such as HIF-related pathways and hemoglobin genes, that help humans adapt to high-altitude environments, with…

Real Science · Jan 14, 2023 4,852,247 views

Human Adaptation to High Altitude Environmental Challenges

This video discusses how humans adapt to high-altitude environments like Mount Everest, highlighting physiological and genetic responses, including oxygen regulation and cellular changes, essential for survival in…

SCI-List · Mar 10, 2024 192 views

Isabel Burnett | Renegade Research

@IsabelRamirezRD · X

@doc4care @joshual_tm @Really_Richelle https://t.co/Na3dmw6z2q https://t.co/jsDcXUwDT4 https://t.co/VdAKMm7hx1

Jan 24, 2025 · 2 likes · 4,053 followers View post →

IronBiologyBot

@IronBiologyBot · X

RT @IronBiologyBot: Human adaptation to high altitude: a review of convergence between genomic and proteomic signatures https://t.co/ZWDKem…

Jul 23, 2022 · 1 share · 288 followers View post →

IronBiologyBot

@IronBiologyBot · X

Human adaptation to high altitude: a review of convergence between genomic and proteomic signatures https://t.co/ZWDKemzHnG #IronBiology #BioIron #Iron

Jul 16, 2022 · 1 share · 288 followers View post →

TF binding papers

@TF_binding_bot · X

Human adaptation to high altitude: a review of convergence between genomic and proteomic signatures https://t.co/fS3MzAja0D

Jul 16, 2022 · 3,773 followers View post →