The overall tone indicates strong support and interest, with posts highlighting the importance of brain control, water retention, and hormonal influences—examples like 'brain controls metabolism' and 'water retention or excretion matter' demonstrate deep engagement with the scientific content. Words like 'important new thoughts' and 'challenging our views' reflect the perceived impact of the publication on obesity theories.
AgreementModerate agreement
Most discussions support the ideas presented in the publication, acknowledging the complexity of obesity beyond simple calorie models.
InterestHigh interest
Posts demonstrate strong curiosity, with many sharing new research updates and nuanced ideas about metabolic processes.
EngagementModerate engagement
Comments show moderate to deep engagement, referencing specific models, biochemical mechanisms, and ongoing debates.
ImpactModerate impact
Participants recognize the publication's significance, emphasizing its challenging of conventional thinking and its role in advancing obesity research.
Abstract in brief
The text compares two main ideas about what causes obesity: the traditional energy balance model (EBM), which suggests overeating and low activity are the primary causes, and the carbohydrate-insulin model (CIM), which proposes that processed carbs trigger hormonal responses that increase fat storage and lead to overeating.
It discusses that the EBM has limitations, especially in fully explaining obesity, and emphasizes that understanding these differences is crucial for developing better prevention and treatment strategies.
Both models agree that processed carbohydrates play a significant role in obesity, but they differ in how they interpret the underlying biological mechanisms and causes.
Other animal models with similar features – obesity WITHOUT overeating – reviewed in our new @ejcneditor paper (see Table 2) https://t.co/A5f4tXv56D https://t.co/kTP7JNHYnY
Final version of our paper on competing views of obesity cause & effect, now available in the Sept issue of @ejcneditor
https://t.co/A5f4tXMGvd https://t.co/79EC4ju7J1
Important new thoughts on the
Carbohydrate-Insulin Model of obesity
from Dr Ludwig and his team.
https://t.co/AMMMPzTQ0u.
@davidludwigmd https://t.co/EUg51zcQuZ
Aug 9, 2022 · 35 likes · 11 shares · 147,308 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@garytaubes @DrKarlNadolsky @DrNadolsky We address the central issue to this debate explicitly in our recent @ejcneditor paper.
Does energy balance alter body fat?
Or does changing body fat alter energy balance?
(Not an especially radical notion, when considering the adolescent growth spurt).
https://t.co/A5f4tXNekL
Nov 15, 2022 · 12 likes · 2 shares · 43,682 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
And another contributor to variability is … insulin secretion, just as predicted by the carbohydrate-insulin model of obesity
https://t.co/MxPAgHQarY
https://t.co/A5f4tXNekL
10/13 https://t.co/BYqzj70ahO
Jan 9, 2023 · 11 likes · 43,682 followersView post →
MM
Marco Melgarejo
@manut82004 · X
Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models https://t.co/NKfJ2DGqHV
Dr Ludwig discusses the two main theories of obesity: the traditional energy balance model and the carbohydrate-insulin model. Understanding these mechanisms is essential for effective prevention and treatment…
This video questions the traditional view that high energy intake is the main cause of obesity, presenting an alternative model that links processed carbs to hormonal responses and fat storage, emphasizing the need to…
Calories In Calories Out often fails due to hidden factors like gut microbiome, hormones, and inflammation that sabotage weight loss. Understand how these elements influence metabolism and fat loss for more effective…
Struggling with weight loss despite counting calories? Explore why the calories in calories out model may be flawed due to factors like gut microbiome, hormones, inflammation, and metabolic adaptation.
@PaulNWilliamz It’s definitely hard and definitely not as simple as “calories in, calories out.”
Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models
https://t.co/SX8MoW46iH
RT @robertlufkinmd: Important new thoughts on the
Carbohydrate-Insulin Model of obesity
from Dr Ludwig and his team.
https://t.co/AMMM…
Jan 26, 2024 · 11 shares · 381 followersView post →
L
Ltwo
@PatriotLadytwo · X
RT @robertlufkinmd: Important new thoughts on the
Carbohydrate-Insulin Model of obesity
from Dr Ludwig and his team.
https://t.co/AMMM…
Jan 25, 2024 · 11 shares · 10,516 followersView post →
TM
Thabo Mogašwa
@thabomogaswa · X
RT @robertlufkinmd: Important new thoughts on the
Carbohydrate-Insulin Model of obesity
from Dr Ludwig and his team.
https://t.co/AMMM…
Jan 25, 2024 · 11 shares · 171 followersView post →
MA
Mahito L'apostolos
@OMaMihai · X
RT @robertlufkinmd: Important new thoughts on the
Carbohydrate-Insulin Model of obesity
from Dr Ludwig and his team.
https://t.co/AMMM…
Jan 25, 2024 · 11 shares · 305 followersView post →
MY
May The Fork Be With You
@RadicalGaiz · X
RT @robertlufkinmd: Important new thoughts on the
Carbohydrate-Insulin Model of obesity
from Dr Ludwig and his team.
https://t.co/AMMM…
Jan 25, 2024 · 11 shares · 326 followersView post →
P
Paul
@pauldshin · X
RT @robertlufkinmd: Important new thoughts on the
Carbohydrate-Insulin Model of obesity
from Dr Ludwig and his team.
https://t.co/AMMM…
Jan 25, 2024 · 11 shares · 126 followersView post →
CE
Citizen of EU
@wavetossed · X
RT @davidludwigmd: Final version of our paper on competing views of obesity cause & effect, now available in the Sept issue of @ejcneditor…
Feb 19, 2023 · 11 shares · 9,810 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@nicknorwitz @DrEenfeldt @TuckerGoodrich @bigfatsurprise @KenDBerryMD @garytaubes @tednaiman Right. Satiety is a complicated phenomenon, influenced by food combinations, individual factors and much more.
Scoring systems for processed foods inevitably require assumptions and work-around, like "hedonic factors" -- itself of unclear validity:
https://t.co/A5f4tXNekL
Feb 7, 2023 · 3 likes · 43,682 followersView post →
CE
Citizen of EU
@wavetossed · X
RT @davidludwigmd: Final version of our paper on competing views of obesity cause & effect, now available in the Sept issue of @ejcneditor…
Feb 7, 2023 · 11 shares · 9,810 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@singareddynm Thanks for the kind words @singareddynm
Here's Part 2, a head-to-head comparison of the obesity models
(open access)
https://t.co/A5f4tXNekL
an ignored part of these theories is water...
does water retention or excretion matter?
do we process the hydrogen & oxygen we take in daily?
I sincerely believe some of the genes associated w/Type 2 diabetes involve water retention.
https://t.co/rGbSjNUQhA
And another contributor to variability is … insulin secretion, just as predicted by the carbohydrate-insulin model of obesity
https://t.co/MxPAgHQarY
https://t.co/A5f4tXNekL
10/13 https://t.co/BYqzj70ahO
Jan 9, 2023 · 11 likes · 43,682 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@tednaiman @TyRBeal @MaritKolby @deirdre_tobias @sguyenet @vanvlietphd @fleroy1974 @kevinnbass @maxlugavere @MarkLawrence_Oz @theproof @NutritionMadeS3 @mario_kratz @AnthonyFardet @CMonteiro_USP @PhilBakerNZ @GyorgyScrinis Hi Ted,
Great to see you backing off the protein brink
Dec 27, 2022 · 4 likes · 43,682 followersView post →
AA
Amy Alkon
@amyalkon · X
RT @davidludwigmd: @amyalkon @SteAssent Hi Amy, here are our two recent papers, updating the model and comparing with the conventional view…
Dec 17, 2022 · 1 share · 30,062 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@amyalkon @SteAssent Hi Amy, here are our two recent papers, updating the model and comparing with the conventional view. Both open access:
EJCN https://t.co/A5f4tXv56D
AJCN https://t.co/MxPAgI7dtY
Dec 17, 2022 · 1 like · 1 share · 43,682 followersView post →
MA
Michael John Axtens
@mjaxtens · X
RT @davidludwigmd: Critics of the Carbohydrate-Insulin Model built a new Energy Balance Model of obesity.
My 15 coauthors and I have a few…
Dec 13, 2022 · 107 shares · 145 followersView post →
SV
SAP for better tech and value
@digitalhealthxx · X
https://t.co/dfwUfJDkw4
Dec 12, 2022 · 1 like · 8,498 followersView post →
CC
Claus Carlsen
@ClausCarlsen1 · X
RT @davidludwigmd: @ScepticalDoctor Energy density has a major acute effect which does not persist, based on the few long-term trials.
Fu…
Nov 27, 2022 · 1 share · 15,807 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@ScepticalDoctor Energy density has a major acute effect which does not persist, based on the few long-term trials.
Further, the highest energy dense foods (nuts, olive oil, even dark chocolate) seem benign for body weight.
See recent review, p1215 in pdf (open access)
https://t.co/A5f4tXNekL
Nov 27, 2022 · 3 likes · 1 share · 43,682 followersView post →
NT
#No2Treason
@netzona · X
RT @davidludwigmd: @hormonedietdoc If you make it through the @AJCNutrition paper, with have another on the #CarbInsulinModel of #obesity i…
Nov 27, 2022 · 1 share · 1,692 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@hormonedietdoc If you make it through the @AJCNutrition paper, with have another on the #CarbInsulinModel of #obesity in @ejcneditor -- exploring contrasts with the conventional Energy Balance Model.
(Open access full text)
https://t.co/A5f4tXNekL
Nov 27, 2022 · 2 likes · 1 share · 43,682 followersView post →
CE
Citizen of EU
@wavetossed · X
RT @davidludwigmd: Critics of the Carbohydrate-Insulin Model built a new Energy Balance Model of obesity.
My 15 coauthors and I have a few…
Nov 23, 2022 · 107 shares · 9,810 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@jflier @MichaelDavSmith In the growth spurt, a team eats more than (s)he used to and grows fast. But we don't say ⬆️ intake causes the growth, clearly it's a consequence.
Now posit that adipose tissue has been stimulated to become too anabolic and you have the carb-insulin model https://t.co/A5f4tXMGvd
Nov 21, 2022 · 1 like · 43,682 followersView post →
M
Merz
@Josef3Merz · X
RT @davidludwigmd: @garytaubes @DrKarlNadolsky @DrNadolsky We address the central issue to this debate explicitly in our recent @ejcneditor…
RT @davidludwigmd: @garytaubes @DrKarlNadolsky @DrNadolsky We address the central issue to this debate explicitly in our recent @ejcneditor…
Nov 15, 2022 · 2 shares · 120,007 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@garytaubes @DrKarlNadolsky @DrNadolsky We address the central issue to this debate explicitly in our recent @ejcneditor paper.
Does energy balance alter body fat?
Or does changing body fat alter energy balance?
(Not an especially radical notion, when considering the adolescent growth spurt).
https://t.co/A5f4tXNekL
Nov 15, 2022 · 12 likes · 2 shares · 43,682 followersView post →
CE
Citizen of EU
@wavetossed · X
RT @davidludwigmd: Critics of the Carbohydrate-Insulin Model built a new Energy Balance Model of obesity.
My 15 coauthors and I have a few…
Nov 4, 2022 · 107 shares · 9,810 followersView post →
CE
Citizen of EU
@wavetossed · X
RT @davidludwigmd: @JohnSpeakman4 Authors: "increases in lean and fat mass were measurable several weeks before any detectable hyperphagia"…
Nov 1, 2022 · 1 share · 9,810 followersView post →
FM
food_maven
@food_maven · X
Whole foods for the win again!
Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models | European Journal of Clinical Nutrition https://t.co/AP4CE8hNbu
RT @davidludwigmd: Critics of the Carbohydrate-Insulin Model built a new Energy Balance Model of obesity.
My 15 coauthors and I have a few…
Oct 24, 2022 · 107 shares · 1,666 followersView post →
SG
Sneh Gupta
@IndiabilitySneh · X
RT @davidludwigmd: Critics of the Carbohydrate-Insulin Model built a new Energy Balance Model of obesity.
My 15 coauthors and I have a few…
Oct 20, 2022 · 107 shares · 646 followersView post →
FG
Fred Schultz JD for California Gov!
@FredericEsq · X
RT @davidludwigmd: Other animal models with similar features – obesity WITHOUT overeating – reviewed in our new @ejcneditor paper (see Tab…
Oct 8, 2022 · 18 shares · 1,083 followersView post →
D
DiscoStew
@DiscoStew66 · X
RT @davidludwigmd: @PeterFaberSP @JohnSpeakman4 Energy Balance as physics is always true.
This animal model and others (Table 2 of our rev…
Oct 3, 2022 · 2 shares · 10,780 followersView post →
AA
Agnes Ayton
@AgnesAyton · X
RT @davidludwigmd: @PeterFaberSP @JohnSpeakman4 Energy Balance as physics is always true.
This animal model and others (Table 2 of our rev…
Oct 2, 2022 · 2 shares · 7,422 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@PeterFaberSP @JohnSpeakman4 Energy Balance as physics is always true.
This animal model and others (Table 2 of our review) seem clear evidence of opposite causality to EBM. Hard to dismiss these all as measurement error.
As you say, Peter, both could be true in different conditions https://t.co/A5f4tXv56D
Oct 2, 2022 · 3 likes · 2 shares · 43,682 followersView post →
DL
Dr. Lauryn Lax
@drlaurynlax · X
RT @davidludwigmd: Other animal models with similar features – obesity WITHOUT overeating – reviewed in our new @ejcneditor paper (see Tab…
Oct 2, 2022 · 18 shares · 147 followersView post →
S
skillsoverpills
@skillsoverpillz · X
RT @davidludwigmd: Other animal models with similar features – obesity WITHOUT overeating – reviewed in our new @ejcneditor paper (see Tab…
@Gonzalez_JT These are the authors' conclusions, eg: "increases in lean and fat mass were measurable several weeks before any detectable hyperphagia"
Always good to replicate. Our review (Table 2) shows similar features often occur (⬆️adiposity without ⬆️food intake) https://t.co/A5f4tXv56D
Oct 1, 2022 · 2 likes · 43,682 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@JohnSpeakman4 Authors: "increases in lean and fat mass were measurable several weeks before any detectable hyperphagia" (data seem clear)
Finding is not unique. Our new review (Table 2 first 9 animal models) shows ⬆️adiposity often occurs before (without) ⬆️food intake https://t.co/A5f4tXv56D
Oct 1, 2022 · 3 likes · 1 share · 43,682 followersView post →
LH
LALA HUTCHISON
@lala_hutchison · X
RT @davidludwigmd: Other animal models with similar features – obesity WITHOUT overeating – reviewed in our new @ejcneditor paper (see Tab…
@Tellit007 These drugs chronically decrease insulin secretion. Some of this effect might relate to weight loss, but not necessarily all, related to direct effects on gastric emptying, insulin economy and adipose insulin sensitivity. We discuss briefly here: https://t.co/A5f4tXv56D
Other animal models with similar features – obesity WITHOUT overeating – reviewed in our new @ejcneditor paper (see Table 2) https://t.co/A5f4tXv56D https://t.co/kTP7JNHYnY
Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models
@davidludwigmd
https://t.co/ccASC3zhb6
[compare with: https://t.co/V1DFBbIfNZ]
Final version of our paper on competing views of obesity cause & effect, now available in the Sept issue of @ejcneditor
https://t.co/A5f4tXMGvd https://t.co/79EC4ju7J1
RT @davidludwigmd: Critics of the Carbohydrate-Insulin Model built a new Energy Balance Model of obesity.
My 15 coauthors and I have a few…
Aug 21, 2022 · 107 shares · 1,161 followersView post →
T
Tom
@curioustgeorge3 · X
RT @davidludwigmd: Critics of the Carbohydrate-Insulin Model built a new Energy Balance Model of obesity.
My 15 coauthors and I have a few…
Aug 16, 2022 · 107 shares · 243 followersView post →
CU
Claire U
@ClaireU51525255 · X
RT @davidludwigmd: Critics of the Carbohydrate-Insulin Model built a new Energy Balance Model of obesity.
My 15 coauthors and I have a few…
Aug 15, 2022 · 107 shares · 2 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@rulethejungle99 @JohnSpeakman4 @BCH_Innovation A positive energy balance must co-exist with weight gain. Question is cause vs effect.
Does pregnant woman's "overeating" cause fetus to grow? Or does growing fetus cause the mother to overeat?
Distinction has major significance to prevention, treatment. https://t.co/A5f4tXMGvd
Aug 10, 2022 · 2 likes · 43,682 followersView post →
LB
Lars not Behrenroth
@Lars_Maks_ · X
RT @robertlufkinmd: Important new thoughts on the
Carbohydrate-Insulin Model of obesity
from Dr Ludwig and his team.
https://t.co/AMMM…
Aug 10, 2022 · 11 shares · 354 followersView post →
MC
Michael Carmody
@m_carmody · X
RT @robertlufkinmd: Important new thoughts on the
Carbohydrate-Insulin Model of obesity
from Dr Ludwig and his team.
https://t.co/AMMM…
Aug 10, 2022 · 11 shares · 186 followersView post →
TN
Tim Noakes
@ProfTimNoakes · X
RT @robertlufkinmd: Important new thoughts on the
Carbohydrate-Insulin Model of obesity
from Dr Ludwig and his team.
https://t.co/AMMM…
Aug 10, 2022 · 11 shares · 157,830 followersView post →
MV
Manuel Villegas
@M3xico3nl4b4nC4 · X
RT @robertlufkinmd: Important new thoughts on the
Carbohydrate-Insulin Model of obesity
from Dr Ludwig and his team.
https://t.co/AMMM…
Aug 10, 2022 · 11 shares · 1,069 followersView post →
SP
Steven M. Belknap, MD PGY43
@StevenMBelknap · X
RT @robertlufkinmd: Important new thoughts on the
Carbohydrate-Insulin Model of obesity
from Dr Ludwig and his team.
https://t.co/AMMM…
Aug 10, 2022 · 11 shares · 2,299 followersView post →
RM
Robert Lufkin MD
@robertlufkinmd · X
Important new thoughts on the
Carbohydrate-Insulin Model of obesity
from Dr Ludwig and his team.
https://t.co/AMMMPzTQ0u.
@davidludwigmd https://t.co/EUg51zcQuZ
Aug 9, 2022 · 35 likes · 11 shares · 147,308 followersView post →
SD
Stephen Pedro Diehl
@fossilrabbit · X
RT @davidludwigmd: Critics of the Carbohydrate-Insulin Model built a new Energy Balance Model of obesity.
My 15 coauthors and I have a few…
Aug 8, 2022 · 107 shares · 351 followersView post →
OE
Olivier Elemento
@ElementoLab · X
RT @WeightlessSelf: The obesity wars continue. Check out the newly published paper by Ludwig et al, including Weill Cornell's Dr. Lou Aron…
Aug 2, 2022 · 2 shares · 6,248 followersView post →
WM
Weill Cornell Medicine
@WeillCornell · X
RT @WeightlessSelf: The obesity wars continue. Check out the newly published paper by Ludwig et al, including Weill Cornell's Dr. Lou Aron…
Aug 2, 2022 · 2 shares · 40,404 followersView post →
A
Aaharanammahakku
@aharanammahakku · X
RT @davidludwigmd: Critics of the Carbohydrate-Insulin Model built a new Energy Balance Model of obesity.
My 15 coauthors and I have a few…
Aug 2, 2022 · 107 shares · 306 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@JohnSpeakman4 John, issue of selective citations in a tweet is a petard that could hoist many.
Anyway, you seen to disregard that brain affects metabolism. If we're using rodent data (as you do), explain the effect of "satiety" hormones on weight independent of intake https://t.co/A5f4tXv56D https://t.co/g44fOjB2XR
Aug 2, 2022 · 2 likes · 43,682 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@DanielJDrucker @JohnSpeakman4 Thank you for these relevant data. The issue regarding brain control of metabolism remains, such as made in Table 2 of the EJCN paper, with pair-feeding involving numerous "satiety" and "hunger" hormones. I haven't heard your thoughts on that main point. https://t.co/A5f4tXMGvd
Aug 2, 2022 · 1 like · 43,682 followersView post →
DL
Dr. David Ludwig
@davidludwigmd · X
@JohnSpeakman4 Yes, brain controls food intake. Showing this isn’t "anti-CIM"
Brain also controls metabolism. Actions of many “hunger” & “satiety” hormones on wt can’t be explained by intake alone.
(EG, hard to argue ⬇️ gastric emptying couldn’t play a role in humans) https://t.co/A5f4tXMGvd https://t.co/QuEPkkKETh
Aug 2, 2022 · 1 like · 43,682 followersView post →
HR
Helen Reynolds
@helenreynolds39 · X
RT @robertlufkinmd: Important new thoughts on the Carbohydrate-Insulin Model of obesity from Dr Ludwig and his team.
https://t.co/AMMMPzTQ…
RT @robertlufkinmd: Important new thoughts on the Carbohydrate-Insulin Model of obesity from Dr Ludwig and his team.
https://t.co/AMMMPzTQ…
Aug 1, 2022 · 4 shares · 2,787 followersView post →
PO
Pickleball OBSESSED
@PbObsessed · X
Why many still don’t lose weight even playing #pickleball—insulin-resistance. See: “Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models” | European Journal of Clinical Nutrition https://t.co/VQeoIBKDuw
Top story: Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models | European Journal of Clinical Nutrition https://t.co/5wUJq0mxjx, see more https://t.co/VQUUnjFK8J
Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models | European Journal of Clinical Nutrition https://t.co/m8sxhgWQPi
Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models. A new perspective by Prof David Ludwig @davidludwigmd and his co-authors is challenging our views on the pathogenesis of obesity. Read all about it here: https://t.co/1VdEOQI85i
"Although sometimes designed with animal-sourced foods, a low-Glycemic Load diet may be vegetarian or vegan, as most of these examples highlight" https://t.co/VqRht4Ogra
technically true, but that would make the diet worse
Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models | European Journal of Clinical Nutrition https://t.co/XaXrwnxCxy
Top story: Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models | European Journal of Clinical Nutrition https://t.co/iVFFQtyVCw, see more https://t.co/9OrA8wXmYX
Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models | European Journal of Clinical Nutrition #obesity #weightgain #weight https://t.co/1hI6tqx2BA
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