The collective discussions reveal strong agreement and high interest, exemplified by posts calling the study a 'great work' and describing the viral genome’s organization as 'elegant,' which conveys admiration and intrigue. The tone reflects excitement about the structural insights and potential implications for understanding viruses, emphasizing the study's significance in the field.
AgreementStrong agreement
Most discussions highlight approval and admiration for the research, emphasizing its significance and clarity.
InterestHigh interest
Discussions show high curiosity, with multiple posts praising the innovative organization of the mimivirus genome.
EngagementHigh engagement
Posts go beyond simple praise, referencing the methodology and implications, indicating deep engagement.
ImpactModerate impact
While many recognize the study's importance, some discussions focus on its contributions to evolution and virology, indicating a high but not maximal perceived impact.
Abstract in brief
The giant mimivirus has a 12 Mb genome organized inside a 30nm helical protein shell made of two GMC-type oxidoreductases, which also form glycosylated fibrils on the capsid.
Its DNA is arranged in 5 or 6 left-handed superhelices with a central channel that can host proteins like RNA polymerase and those involved in oxidative stress response, facilitating rapid transcription once inside the host.
The use of the same proteins for both the protective shell and other structural parts of the virus showcases a highly efficient evolutionary strategy, despite the virus having thousands of genes.]
Congratulations @chantal_abergel and all coauthors for this huge work !
The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield
https://t.co/N2OFsvlWth https://t.co/UeRTtybo8R
Feb 18, 2022 · 31 likes · 4,564 followersView post →
CP
cryoEM Papers
@cryoEM_Papers · X
The giant mimivirus 1.2 Mb genome is elegantly organized into a 30 nm diameter helical protein shield https://t.co/toIRHwDwBU
The recent CryoEM structure of the Mimivirus genomic fiber reveals a 6-start helix in high resolution. The study details the virus's compact organization of its large genome within a helical protein shell, facilitating…
The giant mimivirus has a 12 Mb genome organized inside a 30nm helical protein shell made of two GMC-type oxidoreductases, which also form glycosylated fibrils on the capsid. This efficient design facilitates rapid…
Our data suggest that the fundamental unit of eukaryotic chromatin is an oxidoreductase enzyme complex. This arrangement may be more widespread than previously thought: a giant virus genome encased by two oxidoreductases 2/3 https://t.co/wdpiPAWXbK @chantal_abergel
Das gigantische Mimivirus:
neues Paper von Grünewald lab @CssbHamburg / @LeibnizLIV über riesige dsDNA Viren entschlüsselt, wie sich das ca. 1Mb große Genom organisiert. https://t.co/1l4WTCTocb
The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield
シリンダー状のキャプシドの中にDNAが左巻の超螺旋形成して沿うように配置するという、なんかかっこいい構造
https://t.co/NxG5rlizM6
RT @EMDB_EMPIAR: Explore this & the other newly released data now @EMDB_EMPIAR
EMDB: https://t.co/sbf2CDDAHT
PDBe: https://t.co/hXkJryLpYx…
Aug 10, 2022 · 1 share · 8,185 followersView post →
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EMDB - EMPIAR @EBI
@EMDB_EMPIAR · X
Explore this & the other newly released data now @EMDB_EMPIAR
EMDB: https://t.co/sbf2CDDAHT
PDBe: https://t.co/hXkJryLpYx
Paper: https://t.co/93gNzdMoap
#StructuralBiology #CryoEM #SingleParticle #Virus #Mimiviridae
Aug 10, 2022 · 2 likes · 1 share · 6,120 followersView post →
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Ankit Singla
@In_AnkitSingla · X
RT @eLife:
Aug 7, 2022 · 2 shares · 1,481 followersView post →
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eLife - the journal
@eLife · X
Aug 7, 2022 · 22 likes · 2 shares · 172,840 followersView post →
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Philosophers' Links
@philosophylinks · X
RT @the_fischer_lab: Great study on genome organization in a giant virus by @chantal_abergel & colleagues:
https://t.co/6zaNmn2Hm6
Aug 5, 2022 · 14 shares · 468 followersView post →
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Michael Day
@dayjm1 · X
The giant mimivirus 1.2 Mb genome is elegantly organized into a 30 nm diameter helical protein shield https://t.co/jP72rUhPVk
Finally out after 2 years of reviewing, at Nature first and eLife, to convince reviewers that:
No, it was not an artifact,
Yes, the same protein is composing mimivirus glycosylated fibrils surrounding the capsid and the genomic fiber !
https://t.co/Yq2waBb0Ee @eLife
RT @yokadzaki: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/3QHTxn3vsq
Feb 20, 2022 · 5 shares · 229 followersView post →
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M Moniruzzaman
@giant_virus · X
RT @yokadzaki: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/3QHTxn3vsq
Feb 20, 2022 · 5 shares · 1,110 followersView post →
YO
Yusuke Okazaki
@yokadzaki · X
The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/3QHTxn3vsq
Feb 20, 2022 · 5 likes · 5 shares · 799 followersView post →
FS
Fernando Santos Sánchez
@Fer_Nando_SS · X
RT @cryoEM_Papers: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/po1TRSMwQL
Feb 19, 2022 · 8 shares · 385 followersView post →
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xxy
@xxy07255392 · X
RT @cryoEM_Papers: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/po1TRSMwQL
Feb 19, 2022 · 8 shares · 267 followersView post →
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Matthew Martinez
@MattMartinez44 · X
RT @cryoEM_Papers: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/po1TRSMwQL
Feb 19, 2022 · 8 shares · 380 followersView post →
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Israel Fernandez
@IsraelF96135088 · X
RT @cryoEM_Papers: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/po1TRSMwQL
Feb 19, 2022 · 8 shares · 3,586 followersView post →
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Cascales Lab
@CascalesLab · X
Congratulations @chantal_abergel and all coauthors for this huge work !
The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield
https://t.co/N2OFsvlWth https://t.co/UeRTtybo8R
Feb 18, 2022 · 31 likes · 4,564 followersView post →
RZ
Rui Zhang
@RuiZhangWUSTL · X
RT @cryoEM_Papers: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/po1TRSMwQL
Feb 18, 2022 · 8 shares · 2,833 followersView post →
VL
VN2M team - Durand lab
@VN2Mteam · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 318 followersView post →
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2438@ROM
@t2438 · X
RT @cryoEM_Papers: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/po1TRSMwQL
Feb 18, 2022 · 8 shares · 818 followersView post →
IK
Ilnam Kang
@ilnam_kang · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 235 followersView post →
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Paul V Thomas
@paul_v_thomas · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 252 followersView post →
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Lehman Ellis
@oyster_doctor · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 3,508 followersView post →
DH
Daniel Hurdiss
@DanielHurdiss · X
RT @cryoEM_Papers: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/po1TRSMwQL
Feb 18, 2022 · 8 shares · 2,802 followersView post →
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Sota yagi
@yagi_sota · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 196 followersView post →
CP
cryoEM Papers
@cryoEM_Papers · X
The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/po1TRSMwQL
Feb 18, 2022 · 18 likes · 8 shares · 11,817 followersView post →
LB
LAL BADSHAH
@LALBADSHAH1 · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 271 followersView post →
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Joost Snijder
@joostsnijder · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 1,363 followersView post →
IF
Israel Fernandez
@IsraelF96135088 · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 3,586 followersView post →
FS
Frederik Schulz
@frederikschu · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 374 followersView post →
SR
Simon Roux
@simroux_virus · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 3,777 followersView post →
FN
Franklin Nobrega
@NobregaFL · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 2,427 followersView post →
MH
Mario Peña-Hernández
@marioph13 · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 2,084 followersView post →
CT
Cameron Thrash
@jcamthrash · X
The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/cAbx6iUnCg
Feb 18, 2022 · 6 likes · 17,499 followersView post →
FP
FORTERRE Patrick
@PatrickForterre · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 2,564 followersView post →
WS
Wiep Klaas Smits
@SmitsLab · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 2,362 followersView post →
AH
Alexander Harms
@AHarms485 · X
RT @biorxiv_micrbio: The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI…
Feb 18, 2022 · 17 shares · 9,323 followersView post →
BM
bioRxiv Microbiology
@biorxiv_micrbio · X
The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/x4GEiFc6aI #biorxiv_micrbio
Feb 18, 2022 · 44 likes · 17 shares · 20,976 followersView post →
B
bioRxiv
@biorxivpreprint · X
The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield https://t.co/XjrddlmCfx #bioRxiv
Feb 18, 2022 · 2 likes · 138,056 followersView post →
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Journal Pone 0308642 | PDF
News
Elife. 2022; 11: e70510. https://doi.org/10.7554/eLife.70510 PMID: 35107419 25. Yokoi A, Weiler J. Pupil diameter tracked during motor adaptation in humans ...
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