October 2022 PMID 35938774

Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower low-density lipoprotein cholesterol: the cholesterol drop experiment.

David Feldman, Siobhan Huggins, Nicholas G Norwitz

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Mentions

56
Peak: 32 in Aug 2022
across 3 sources since Aug 2022

Extended reach

1,195,765
potential audience

Total likes

4,976

Video views

123,824

Mentions per month

Aug 2022 – Sep 2025

Where it's discussed

  • X / Twitter51 posts
  • Reddit3 posts
  • YouTube2 videos

AI synopsis

What people are saying

Several discussions delve into the validity and implications of the research, with comments questioning the generalized applicability of the study's findings, such as one poster stating, 'the bonkers things are force-feeding 4000 kcal/day of fat-based shakes.' This reflects skepticism yet shows a commitment to understanding the research. Another participant mentions, 'How does LDLR modulation reconcile with the “Feldman protocol”?', indicating a desire to engage in technical discourse. The choice of technical jargon and the analytical tone in these discussions convey a level of seriousness and importance that enhances the overall sentiment towards the research.

AgreementModerate agreement

A majority of the discussions reflect a positive reception towards the findings of the publication, with many expressing overall support for its conclusions.

InterestHigh interest

The tone of the discussions indicates a strong curiosity about the implications of the research and its significance in the health domain.

EngagementHigh engagement

Many users are engaging deeply with the content, discussing specific methodologies and exploring the relevance of the findings in detail.

ImpactHigh impact

Posters generally perceive the research as having meaningful implications for dietary practices and cholesterol management.

Abstract in brief

  • The conventional belief links saturated fat intake to increased LDL-C levels, especially in individuals on low-carb, high-fat diets, but this perspective doesn't fully explain certain lipid patterns.
  • The Lipid Energy Model (LEM) offers a new explanation for LDL-C increases in 'lean mass hyper-responders' and predicts that acute overfeeding should lower LDL-C, even with higher saturated fat intake.
  • A recent study and case series demonstrated that short-term overfeeding on ketogenic diets led to decreased LDL-C levels, aligning with the predictions of the LEM.

Top posts

Most liked on X and Bluesky
Dave Feldman
@realDaveFeldman · X

Me: "What papers has Dave Feldman published on cholesterol?" Dave Feldman, the cholesterol researcher, has published one scientific paper on the topic: Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower low-density lipoprotein cholesterol: the cholesterol

Mar 2, 2024 · 41 likes · 1 share · 84,638 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

3/ 1 year ago, we started researching #LMHR more formally, and in this year, we've published 4 prior papers Cohort Study https://t.co/LVEhOk0vDi Case Report https://t.co/truYXx2pSF Cholesterol drop protocol https://t.co/YL3HjXIhGD Lipid Energy Model https://t.co/LaE4kenaD8

Nov 6, 2022 · 38 likes · 2 shares · 110,178 followers View post →
Remnant | MD
@RemnantMd · X

High-calorie and saturated-fat consumption results in: 1. Reduced LDL-C & ApoB 2. Increased HDL-C 3. Reduced Triglycerides Take that @AHAScience https://t.co/MEUpCQViMP Great work @realDaveFeldman keep it coming!

Aug 14, 2022 · 38 likes · 12 shares · 32,632 followers View post →
Dave Feldman
@realDaveFeldman · X

7/8 Our fourth paper is my "first first author" where I detail my highly controlled three phase diet experiment, performed in duplicate. Myself and others apply principles of the #LEM in demonstrating an acute drop in #LDLc over-consuming saturated fat. https://t.co/A53UReKGMc

Nov 28, 2022 · 12 likes · 84,638 followers View post →
J P Fanton
@HealthyFellow · X

Short-term hyper-caloric high-fat feeding on a #ketogenic #diet can lower #LDL #cholesterol: The cholesterol drop experiment https://t.co/7BFH1XcPl5 Attn: @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @MEATritionCom @shashiiyengar @SBakerMD @Grimhood @FatEmperor @LDLSkeptic @kojija

Aug 11, 2022 · 12 likes · 4 shares · 26,028 followers View post →
Agingdoc
@agingdoc1 · X

Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower low-density lipoprotein cholesterol: the cholesterol drop experiment https://t.co/ufcXhklIcg

Aug 9, 2022 · 10 likes · 2 shares · 41,798 followers View post →

All mentions

Nick
@upRootNutrition · X

@TapaDaBoy @jpegan10 @ethanjweiss @realDaveFeldman He published it. It's absolutely insane with no real value outside of perhaps giving people a way to dodge certain insurance roadblocks, lol. https://t.co/YFmXSnFyU1

Jan 12, 2025 · 2 likes · 9,510 followers View post →
Nick
@upRootNutrition · X

@jpegan10 @TapaDaBoy @ethanjweiss @realDaveFeldman No, the bonkers things are force-feeding 4000 kcal/day of fat-based shakes. This is the data that Dave bases his intuitions on, and they aren't generalizable, as Ethan pointed out. https://t.co/YFmXSnG6Jz

Jan 12, 2025 · 1 like · 9,510 followers View post →
Raphael Sirtoli
@raphaels7 · X

@SteveBrecher @theproof @nicknorwitz @realDaveFeldman Right, but « short-term overfeeding can lower LDL-C in the context of carbohydrate restriction », showing that it’s a worse than useless marker for predicting disease outcomes given the OR will be overwhelmed https://t.co/h3IQfFIhYB

Apr 15, 2024 · 1 like · 8,595 followers View post →
Austin Dudzinski, PharmD, BCACP
@DudzLightLime · X

@DrNadolsky @infeldMD @nicknorwitz @JohnKastelein @ethanjweiss @Lipoprotein @drpablocorral @AllenGreenMD1 @lipiddoc How does LDLR modulation reconcile with the “Feldman protocol”? Increased insulin when SFA is overfed? Curious on your take

Mar 4, 2024 · 1 like · 871 followers View post →
John Cunningham
@jzcjca00 · X

RT @realDaveFeldman: Me: "What papers has Dave Feldman published on cholesterol?" Dave Feldman, the cholesterol researcher, has published…

Mar 2, 2024 · 1 share · 343 followers View post →
Dave Feldman
@realDaveFeldman · X

Me: "What papers has Dave Feldman published on cholesterol?" Dave Feldman, the cholesterol researcher, has published one scientific paper on the topic: Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower low-density lipoprotein cholesterol: the cholesterol

Mar 2, 2024 · 41 likes · 1 share · 84,638 followers View post →
Jodie
@traderjodie · X

@DrNadolsky Have you discussed Feldmen's n=1 paper which suggest that hypercaloric high fat diet lowers LDL-c? Is it possible? Does it mean anything? https://t.co/jbkqSC4DEI

Jan 21, 2024 · 193 followers View post →
Austin Dudzinski, PharmD, BCACP
@DudzLightLime · X

@CaloriesProper @NutritionMadeS3 @Chooi @ATHjournal If ketosis/SFA played predominant role in ⬆️LDL-c then wouldn’t one expect to see ⬆️LDL-c when overfeeding SFA (MCTs eg ketogenesis) in this context? Single case study indicates LDL-c generally goes down w/ this protocol - thoughts? https://t.co/aktGMhjREN

Jun 30, 2023 · 1 like · 871 followers View post →
Dave Feldman
@realDaveFeldman · X

@DIY_Tardis In a sense, it has graduated to a complete paper— it just doesn’t carry that colloquialism anymore. https://t.co/A53UReKGMc

Feb 7, 2023 · 1 like · 84,638 followers View post →
SAVE AMERICA
@1718106J · X

RT @nicknorwitz: 3/ 1 year ago, we started researching #LMHR more formally, and in this year, we've published 4 prior papers Cohort Study…

Dec 31, 2022 · 2 shares · 9,806 followers View post →
SAVE AMERICA
@1718106J · X

RT @nicknorwitz: 3/ 1 year ago, we started researching #LMHR more formally, and in this year, we've published 4 prior papers Cohort Study…

Dec 18, 2022 · 2 shares · 9,806 followers View post →
Reddit Journal of Science
@rsciencejournal · X

1/ Short-term hyper-caloric high-fat feeding on a ketogenic die... : Current Opinion in Endocrinology, Diabetes and Obesity https://t.co/i8SNGJxY35 #science #health #feeding #die

Dec 15, 2022 · 331 followers View post →
Dave Feldman
@realDaveFeldman · X

7/8 Our fourth paper is my "first first author" where I detail my highly controlled three phase diet experiment, performed in duplicate. Myself and others apply principles of the #LEM in demonstrating an acute drop in #LDLc over-consuming saturated fat. https://t.co/A53UReKGMc

Nov 28, 2022 · 12 likes · 84,638 followers View post →
eleanorina
@_eleanorina · X

RT @nicknorwitz: 3/ 1 year ago, we started researching #LMHR more formally, and in this year, we've published 4 prior papers Cohort Study…

Nov 7, 2022 · 2 shares · 3,176 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

3/ 1 year ago, we started researching #LMHR more formally, and in this year, we've published 4 prior papers Cohort Study https://t.co/LVEhOk0vDi Case Report https://t.co/truYXx2pSF Cholesterol drop protocol https://t.co/YL3HjXIhGD Lipid Energy Model https://t.co/LaE4kenaD8

Nov 6, 2022 · 38 likes · 2 shares · 110,178 followers View post →
Sonja Meier MD
@sonjameier2 · X

RT @nicknorwitz: @holmanm 2/ I take issue with ideological dissemination of misinformation. & for those watching on, let me remind you who…

Oct 23, 2022 · 1 share · 2,809 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

@holmanm 2/ I take issue with ideological dissemination of misinformation. & for those watching on, let me remind you who is actually doing the work to push the frontiers of inquiry on this topic of LDL on LowCarb https://t.co/LVEhOk0vDi https://t.co/truYXx2pSF https://t.co/YL3HjXIhGD

Oct 23, 2022 · 9 likes · 1 share · 110,178 followers View post →
Nick Norwitz MD PhD
@nicknorwitz · X

@MarcVanDam @DaleWil39870290 @holmanm @realDaveFeldman 3/ for consideration, some of our recent work https://t.co/LVEhOkhyFi https://t.co/truYXwKgEx https://t.co/YL3HjXq8sv

Oct 23, 2022 · 2 likes · 110,178 followers View post →
Sociedad SEEN
@sociedadSEEN · X

Oct 12, 2022 · 1 like · 17,180 followers View post →
Virgile Faber
@VirgileFaber · X

RT @RemnantMd: High-calorie and saturated-fat consumption results in: 1. Reduced LDL-C & ApoB 2. Increased HDL-C 3. Reduced Triglycerides…

Aug 17, 2022 · 12 shares · 31 followers View post →
Tim Noakes
@ProfTimNoakes · X

RT @RemnantMd: High-calorie and saturated-fat consumption results in: 1. Reduced LDL-C & ApoB 2. Increased HDL-C 3. Reduced Triglycerides…

Aug 16, 2022 · 12 shares · 158,589 followers View post →
Guoda K
@retroguoda · X

RT @RemnantMd: High-calorie and saturated-fat consumption results in: 1. Reduced LDL-C & ApoB 2. Increased HDL-C 3. Reduced Triglycerides…

Aug 16, 2022 · 12 shares · 92 followers View post →
QTCutie
@QTCutieQ · X

RT @RemnantMd: High-calorie and saturated-fat consumption results in: 1. Reduced LDL-C & ApoB 2. Increased HDL-C 3. Reduced Triglycerides…

Aug 15, 2022 · 12 shares · 236 followers View post →
Ed BLeNDr Bertrand
@THeNBLeNDr · X

RT @RemnantMd: High-calorie and saturated-fat consumption results in: 1. Reduced LDL-C & ApoB 2. Increased HDL-C 3. Reduced Triglycerides…

Aug 15, 2022 · 12 shares · 900 followers View post →
Erica
@D31771146D · X

RT @RemnantMd: High-calorie and saturated-fat consumption results in: 1. Reduced LDL-C & ApoB 2. Increased HDL-C 3. Reduced Triglycerides…

Aug 15, 2022 · 12 shares · 1,289 followers View post →
Remnant | MD
@RemnantMd · X

RT @RemnantMd: High-calorie and saturated-fat consumption results in: 1. Reduced LDL-C & ApoB 2. Increased HDL-C 3. Reduced Triglycerides…

Aug 14, 2022 · 12 shares · 32,632 followers View post →
Disillusioned
@dis_illusion_ed · X

RT @RemnantMd: High-calorie and saturated-fat consumption results in: 1. Reduced LDL-C & ApoB 2. Increased HDL-C 3. Reduced Triglycerides…

Aug 14, 2022 · 12 shares · 24 followers View post →
jeffrey morford
@jmrioboiler · X

RT @RemnantMd: High-calorie and saturated-fat consumption results in: 1. Reduced LDL-C & ApoB 2. Increased HDL-C 3. Reduced Triglycerides…

Aug 14, 2022 · 12 shares · 3,550 followers View post →
ShahzadFaisalMD
@HealthHorizon2 · X

RT @RemnantMd: High-calorie and saturated-fat consumption results in: 1. Reduced LDL-C & ApoB 2. Increased HDL-C 3. Reduced Triglycerides…

Aug 14, 2022 · 12 shares · 621 followers View post →
Remnant | MD
@RemnantMd · X

High-calorie and saturated-fat consumption results in: 1. Reduced LDL-C & ApoB 2. Increased HDL-C 3. Reduced Triglycerides Take that @AHAScience https://t.co/MEUpCQViMP Great work @realDaveFeldman keep it coming!

Aug 14, 2022 · 38 likes · 12 shares · 32,632 followers View post →
LAN FITNESS
@LAN_FITNESS · X

RT @ToshiyukiHorie: @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @amarelowbr @thirokazu_uc @shashiiyengar @COSseaton @LoriSheme…

Aug 12, 2022 · 6 shares · 58 followers View post →
TEAM LAN
@TEAM_LAN · X

RT @ToshiyukiHorie: @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @amarelowbr @thirokazu_uc @shashiiyengar @COSseaton @LoriSheme…

Aug 12, 2022 · 6 shares · 15,968 followers View post →
PICO
@msmiminta · X

RT @ToshiyukiHorie: @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @amarelowbr @thirokazu_uc @shashiiyengar @COSseaton @LoriSheme…

Aug 12, 2022 · 6 shares · 858 followers View post →
Black Dragon
@Black_Dragon123 · X

RT @HealthyFellow: Short-term hyper-caloric high-fat feeding on a #ketogenic #diet can lower #LDL #cholesterol: The cholesterol drop experi…

Aug 12, 2022 · 4 shares · 2,161 followers View post →
Science Communication
@ScienceCommuni2 · X

RT @HealthyFellow: Short-term hyper-caloric high-fat feeding on a #ketogenic #diet can lower #LDL #cholesterol: The cholesterol drop experi…

Aug 11, 2022 · 4 shares · 2,881 followers View post →
Science Communication
@ScienceCommuni2 · X

RT @ToshiyukiHorie: @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @amarelowbr @thirokazu_uc @shashiiyengar @COSseaton @LoriSheme…

Aug 11, 2022 · 6 shares · 2,881 followers View post →
Digital Health and Patient Safety Platform
@DHPSP · X

RT @ToshiyukiHorie: @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @amarelowbr @thirokazu_uc @shashiiyengar @COSseaton @LoriSheme…

Aug 11, 2022 · 6 shares · 6,761 followers View post →
International Natural Product Sciences Taskforce
@_INPST · X

RT @ToshiyukiHorie: @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @amarelowbr @thirokazu_uc @shashiiyengar @COSseaton @LoriSheme…

Aug 11, 2022 · 6 shares · 10,288 followers View post →
Toshiyuki Horie|堀江 俊之
@ToshiyukiHorie · X

@HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @amarelowbr @thirokazu_uc @shashiiyengar @COSseaton @LoriShemek @heniek_htw @PreventionMag @wbgrant2 @agingdoc1 @erlesen "Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower low-density lipoprotein cholesterol: the cholesterol drop experiment" https://t.co/QNHc8zyG0Z

Aug 11, 2022 · 8 likes · 6 shares · 25,197 followers View post →
Chuck^₿
@ChuckE412 · X

@VailshireCap “Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower low-density lipoprotein cholesterol: the cholesterol drop experiment” Feldman, Davida; Huggins, Siobhana; Norwitz, Nicholas G.- https://t.co/iU2FX5MbrM

Aug 11, 2022 · 788 followers View post →
Digital Health and Patient Safety Platform
@DHPSP · X

RT @HealthyFellow: Short-term hyper-caloric high-fat feeding on a #ketogenic #diet can lower #LDL #cholesterol: The cholesterol drop experi…

Aug 11, 2022 · 4 shares · 6,761 followers View post →
International Natural Product Sciences Taskforce
@_INPST · X

RT @HealthyFellow: Short-term hyper-caloric high-fat feeding on a #ketogenic #diet can lower #LDL #cholesterol: The cholesterol drop experi…

Aug 11, 2022 · 4 shares · 10,288 followers View post →
J P Fanton
@HealthyFellow · X

Short-term hyper-caloric high-fat feeding on a #ketogenic #diet can lower #LDL #cholesterol: The cholesterol drop experiment https://t.co/7BFH1XcPl5 Attn: @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @MEATritionCom @shashiiyengar @SBakerMD @Grimhood @FatEmperor @LDLSkeptic @kojija

Aug 11, 2022 · 12 likes · 4 shares · 26,028 followers View post →
Post Diabetes Is Possible
@postdiabetic · X

Top story: Short-term hyper-caloric high-fat feeding on a ketogenic die... : Current Opinion in Endocrinology, Diabetes and Obesity https://t.co/7NdXYTMBGK, see more https://t.co/9OrA8wXUOv

Aug 11, 2022 · 34 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower low-density lipoprotein cholesterol: the cholesterol…

Aug 10, 2022 · 2 shares · 132 followers View post →
Anssi H. Manninen | Mass Balance Man
@KingManninen · X

Short-term hyper-caloric high-fat feeding on a ketogenic... : Current Opinion in Endocrinology, Diabetes and Obesity https://t.co/YObN4rL7BS

Aug 10, 2022 · 1,056 followers View post →
Dr. Ugis Kletnieks
@Ugis06209578 · X

RT @agingdoc1: Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower low-density lipoprotein cholesterol: the cholesterol…

Aug 10, 2022 · 2 shares · 11 followers View post →
健康ノート
@JuStADOcToR_Jp · X

Short-term hyper-caloric high-fat feeding on a ketogenic die... : Current Opinion in Endocrinology, Diabetes and Obesity https://t.co/ZIkfgaxb6o

Aug 9, 2022 · 110 followers View post →
Shashi Iyengar | Accredited Metabolic Health Coach
@shashiiyengar · X

RT @DesignedNature: Posting "Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower low-density lipoprotein cholesterol: t…

Aug 9, 2022 · 1 share · 28,970 followers View post →
DesignedByNature
@DesignedNature · X

Posting "Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower low-density lipoprotein cholesterol: the cholesterol drop experiment. (Pub Date: 2022-08-05)" on reddit #ketoscience https://t.co/ACzL5n5dZb

Aug 9, 2022 · 5 likes · 1 share · 440 followers View post →
Agingdoc
@agingdoc1 · X

Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower low-density lipoprotein cholesterol: the cholesterol drop experiment https://t.co/ufcXhklIcg

Aug 9, 2022 · 10 likes · 2 shares · 41,798 followers View post →