Aging Cell September 2022 PMID 35980826

B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reaction.

Jia Le Lee, Sigrid C Fra-Bido, Alice R Burton, Silvia Innocentin, Danika L Hill, Michelle A Linterman

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Mentions

Peak: 4 in Sep 2022

across 4 sources since Aug 2022

Extended reach

45,613

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279

Mentions per month

Aug 2022 – Oct 2023

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AI synopsis

What people are saying

Discussions emphasize that B cells from older individuals can respond normally, with phrases like 'no intrinsic defects,' and explore implications such as delayed germinal center participation, which reflects a thoughtful engagement with the research. The tone is analytical yet optimistic, highlighting the potential for improved vaccine strategies based on these findings.

AgreementModerate agreement

Most discussions acknowledge that intrinsic B cell functions remain unaffected by age, aligning with the publication's findings.

InterestHigh interest

There is high curiosity about how aging affects immune responses, reflected in detailed analyses and focus on the germinal center process.

EngagementModerate engagement

Comments include references to prior research and detailed explanations, indicating moderate but meaningful participation.

ImpactModerate impact

The discussions suggest recognition of the study's importance for understanding aging and immune response, though debates about broader implications are limited.

Abstract in brief

The study found that B cells from older individuals can still proliferate and differentiate into antibody-secreting cells in vitro, meaning they are not intrinsically defective.
In aged mice, B cells tend to favor early extrafollicular plasma cell formation over entering the germinal center (GC) reaction initially, which delays the overall immune response.
The impaired antibody response seen with aging is likely due to extrinsic factors affecting B cell function, rather than inherent B cell defects, as the GC response can reach normal levels in older B cells during later stages.]

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All mentions

Impact of Age on B Cell Function and Germinal Center Response

Linterman Lab · Sep 21, 2022 221 views

Impact of Aging on B Cell Function and Germinal Center Response

B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reaction. Research shows that aged B cells can proliferate and differentiate…

Linterman Lab · Sep 21, 2022 59 views

Jia Le Lee

@plusle17 · X

Previously, we reported that B cells from older people and aged mice have no intrinsic defects in responding to stimulation and differentiating into plasma cells. https://t.co/hrgxSY7WC3 2/11

Oct 4, 2023 · 204 followers View post →

Agingdoc

@agingdoc1 · X

B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reaction

Sep 10, 2022 · 3 likes · 41,797 followers View post →

Orlando_uy

@Orlando_uy · X

B cell‐intrinsic changes with age do not impact antibody‐secreting cell formation but delay B cell participation in the germinal centre reaction https://t.co/Ynv2SYyAn9

Sep 2, 2022 · 2 likes · 694 followers View post →

Kelly A. Hogan Ph.D.

@Loose_Lab_Rat · X

B cell‐intrinsic changes with age do not impact antibody‐secreting cell formation but delay B cell participation in the germinal centre reaction https://t.co/Mfp15Lu3az

Aug 26, 2022 · 2 likes · 2,239 followers View post →

ImmuneGCPapers

@ImmuneGC_Papers · X

GC | B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reaction https://t.co/okj3XxyHZ2

Aug 19, 2022 · 8 likes · 401 followers View post →