Br J Nutr May 2023 PMID 35983775

Efficacy and safety of various oral regimens (three oral doses) and schedules (daily . monthly) of cholecalciferol in North Indian adults with low vitamin D status: evidence from a randomised controlled trial.

Mohd Ashraf Ganie, Shivani Sidana, Mohammad Salem Baba, Tajali Sahar, Aafia Rashid, Mir Mahmood Asrar, R K Marwaha, Ishfaq Ahmad Wani, Riyaz A Misgar, Imtiyaz Ahmad Wani

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Mentions

Peak: 10 in Aug 2022

across 2 sources since Aug 2022

Extended reach

261,090

potential audience

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Video views

450

Mentions per month

Aug 2022 – Apr 2024

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AI synopsis

What people are saying

Participants mainly acknowledge the study's findings supporting higher doses of vitamin D as both safe and effective, with some referencing the importance of dosage regimens, but the tone remains relatively neutral and informational, indicating a moderate level of engagement and impact.

AgreementModerate agreement

Most discussions seem to acknowledge the findings as valid and relevant, with some expressing support for the blood level improvements observed.

InterestModerate interest

Participants show moderate interest by engaging in sharing their own perspectives or related topics, but the overall curiosity about the article appears limited.

EngagementNeutral engagement

The discussions are somewhat superficial, mostly sharing links or brief mentions without deep analysis or critique.

ImpactModerate impact

While the discussion highlights the importance of vitamin D safety and dosing, there is limited evidence of widespread influence changing practices or opinions.

Abstract in brief

The study compared the effectiveness and safety of different doses and schedules of oral cholecalciferol (vitamin D3) in North Indian adults with low vitamin D levels and found that a dose of 2000 mcg daily or 60,000 mcg monthly is both effective and safe for improving vitamin D status.
Serum vitamin D levels increased significantly across all groups during the initial 12 weeks, with the highest increases observed in the groups receiving 2000 mcg daily and monthly dosing, and no adverse long-term effects on calcium or other related markers were reported.
The findings suggest that these higher-dose regimens are optimal for correcting vitamin D deficiency without significant safety concerns, although some cases of transient increased urinary calcium were noted.]

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