Biotechnol Bioeng December 2022 PMID 36073082

De novo assembly and annotation of the CHOZN® GS genome supports high-throughput genome-scale screening.

Corey Kretzmer, Rajagopalan Lakshmi Narasimhan, Rahul Deva Lal, Vincent Balassi, James Ravellette, Ajaya Kumar Kotekar Manjunath, Jesvin Joy Koshy, Marta Viano, Serena Torre, Valeria M Zanda, Mausam Kumravat, Keith Metelo Raul Saldanha, Harikrishnan Chandranpillai, Ifra Nihad, Fei Zhong

Mentions

13
Peak: 2 in Dec 2022
across 4 sources since Sep 2022

Extended reach

15,875
potential audience

Total likes

5

Video views

629

Mentions per month

Sep 2022 – Nov 2025

Where it's discussed

  • News6 articles
  • X / Twitter3 posts
  • YouTube3 videos
  • LinkedIn1 posts

AI synopsis

What people are saying

Discussions highlight the technological advancements described in the article, with users referring to terms like 'high-throughput screening' and 'genome assembly' to underline its relevance. The tone is cautiously optimistic, emphasizing the potential for improved cell line engineering and therapeutic production. For instance, mentions of 'supports large-scale screening' and 'advances biomanufacturing' demonstrate recognition of the publication’s practical impact, while the moderate interest levels suggest some users are intrigued but not deeply engaged.

AgreementModerate agreement

Most discussions acknowledge the importance of the genome assembly in advancing biomanufacturing and agree that it supports high-throughput screening efforts.

InterestModerate interest

Participants show moderate engagement, expressing curiosity about the technical aspects of genome assembly and its applications.

EngagementModerate engagement

Comments reveal some depth, as posters reference specific benefits like improved cell line stability facilitated by the research.

ImpactModerate impact

The consensus indicates that the publication could significantly influence future research and industrial practices in biopharmaceutical development.

Abstract in brief

  • The study presents a new, detailed genome assembly and annotation of the CHOZN GS cell line, which is a type of Chinese hamster ovary (CHO) cell used for producing therapeutic antibodies.
  • Advances in next-generation sequencing and CRISPR-Cas9 gene editing have made it more feasible to study and modify the CHO genome, overcoming previous challenges related to cost and complexity.
  • Using the assembled genome, the researchers developed a comprehensive CRISPR guide RNA library, enabling the creation of more robust CHO cell lines for cost-effective production of important medicines.]

Top posts

Most liked on X and Bluesky
hosaka_TE
@Hosaka_TE · X

https://t.co/mgKk5Nvjq8 De novo assembly and annotation of the CHOZN® GS-/- genome supports high-throughput genome-scale screening

Dec 25, 2022 · 1 like · 1 share · 304 followers View post →
草
@n0rr · X

RT @Hosaka_TE: https://t.co/mgKk5Nvjq8 De novo assembly and annotation of the CHOZN® GS-/- genome supports high-throughput genome-scale scr…

Dec 25, 2022 · 1 share · 10,990 followers View post →

All mentions

草
@n0rr · X

RT @Hosaka_TE: https://t.co/mgKk5Nvjq8 De novo assembly and annotation of the CHOZN® GS-/- genome supports high-throughput genome-scale scr…

Dec 25, 2022 · 1 share · 10,990 followers View post →
hosaka_TE
@Hosaka_TE · X

https://t.co/mgKk5Nvjq8 De novo assembly and annotation of the CHOZN® GS-/- genome supports high-throughput genome-scale screening

Dec 25, 2022 · 1 like · 1 share · 304 followers View post →
CRISPRpapers
@CRISPR_papers · X

De-novo assembly and annotation of the CHOZN® GS-/- genome supports high-throughput genome-scale screening https://t.co/82usPkzqds

Sep 8, 2022 · 3,879 followers View post →
Mitigation of Circulating Current With Effective Energy Management ...
News

... bit resolution and 1 Msps conversion speed ... The peer review history for this article is available at https://publons.com/publon/10.1002/2050-7038.12899.

Dec 29, 2025 View →
Handbook of Research On Teacher Education - Pedagogical ...
News

schools would have studied in similar Islamic schools that were a bit more advanced ... 10.1002/sce.21299. Stabback, P. (2016). What Makes a Quality ...

Dec 29, 2025 View →
The Queer and The Vernacular Languages in India (Kaustav ...
News

DOI: 10.1002/9781118786093. iela0206. Calder, J. (2021b). “Language and ... stopped and bit off the ear of the corpse saying “Tell all the dead people in

Dec 29, 2025 View →
Architectural Coordination of Enterprise Transformation | PDF ...
News

... 28226-3. https://doi.org/10.1007/978-3-642-28227-0_10 314 References. de ... 10.1002/sys.20035. Rouse, W. B. (2006). Enterprise transformation ...

Dec 29, 2025 View →
Chronic Fatigue Syndrome2 PDF | PDF | Chronic Fatigue Syndrome ...
News

http://onlinelibrary.wiley.com/doi/10.1002/jclp.20827/abstract?systemMessage= ... bit messy, the relief provided by irrigation is well worth it. In place of a ...

Dec 29, 2025 View →
#tumors #cancer #therapy #bacteria #immunotherapy #inflammation ...
LinkedIn

28,226 followers. 1mo. Report this post; Close menu. Focal therapy ... ➡️ Learn more: bit.ly/479Ye7e #ProstateCancer l #MensHealth. Have ...

Dec 18, 2024 View →
Creating Next-Generation CHO Expression Platforms
News

119, 2022: 3632–3646; https://doi.org/10.1002/bit.28226. 9 Bevan S, et al. High-Resolution Three-Dimensional Chromatin Profiling of the ...

Sep 1, 2024 View →