PubHawk
Signal Transduct Target Ther September 2022 PMID 36100602

Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation.

Ting Gao, Lin Zhu, Hainan Liu, Xiaopeng Zhang, Tingting Wang, Yangbo Fu, Hongzhen Li, Qincai Dong, Yong Hu, Zhang Zhang, Jing Jin, Zijing Liu, Weihong Yang, Yaoning Liu, Yanwen Jin

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Mentions

2
Peak: 1 in Sep 2022
across 2 sources since Sep 2022

Extended reach

34,756
potential audience

Total likes

0

Video views

12

Mentions per month

Sep 2022 – Aug 2023

Where it's discussed

  • X / Twitter1 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions mostly support the article, with users noting how the N protein worsens inflammation by activating the complement pathway, and some highlight the potential for new treatments, as seen in comments about targeting MASP-2 to reduce lung injury. The tone combines technical references with optimistic views on therapeutic implications, demonstrating high engagement and perceived impact.

AgreementStrong agreement

Most discussions fully support the published findings, emphasizing the importance of understanding N protein interactions in coronavirus pathology.

InterestModerate interest

While some users express moderate curiosity about the mechanisms, others highlight strong interest in potential treatments derived from this research.

EngagementModerate engagement

Participants are engaging by referencing molecular details like MASP-2, C4b, and C5b-9, indicating a deeper level of discussion.

ImpactHigh impact

Many believe these findings could significantly influence future therapies, underscoring the research's potential to impact COVID-19 treatment strategies.

Abstract in brief

  • The N proteins of highly pathogenic human coronaviruses like SARS-CoV, MERS-CoV, and SARS-CoV-2 bind to MASP2, a key enzyme in the lectin complement pathway, which leads to overactivation of the immune response and worsens lung injury.
  • This overactivation causes excessive inflammation by increasing the deposition of immune complexes such as MASP2, C4b, activated C3, and C5b9, contributing to more severe lung damage in infected mice and humans.
  • Blocking the interaction between N protein and MASP2, reducing MASP2 levels, or inhibiting complement activation can lessen this hyperinflammation and lung injury, suggesting potential new treatments for coronavirus-induced pneumonia.]
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Top posts

Most liked on X and Bluesky
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactiv: excessive complement activ by potentiating MBL-dependent MASP-2 activ,deposition of MASP-2,C4b,activ C3, C5b-9. https://t.co/5JXTptpSlR

Sep 14, 2022 · 34,744 followers View post →

All mentions

Prof. Dr. Sanjeev Bagai
@BagaiDr · X

Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactiv: excessive complement activ by potentiating MBL-dependent MASP-2 activ,deposition of MASP-2,C4b,activ C3, C5b-9. https://t.co/5JXTptpSlR

Sep 14, 2022 · 34,744 followers View post →