Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora de los antígenos de glóbulos rojos Er, lo que establece un nuevo sistema de grupos sanguíneos. https://t.co/UPNnVOor1u
Missense mutations in PIEZO1, which encodes the Piezo1 mechanosensor protein, define Er red blood cell antigens.
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Sep 2022 – Nov 2024Where it's discussed
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What people are saying
The discussions around the publication emphasize its scientific significance, with participants mentioning how this new blood group can help explain rare cases of hemolytic disease in newborns. Phrases like 'a decades-long mystery solved' and 'this is big news!' express enthusiasm and the potential implications for transfusion medicine, indicating that the discovery is seen as both impactful and transformative.
The discussions show general support for the findings related to the PIEZO1 mutations and their implications for the Er blood group system.
There is a high level of curiosity regarding the newly discovered blood group and its relevance to transfusion medicine.
Many posts highlight scientific details and implications, indicating participants are deeply engaging with the topic rather than simply commenting.
The sentiment reflects a belief that this discovery may significantly influence blood transfusion practices and our understanding of blood group antigens.
Abstract in brief
- Missense mutations in the PIEZO1 gene, which encodes the Piezo1 mechanosensor protein, define new Er blood group antigens, including the high-incidence antigen Era that has puzzled researchers for decades.
- Through whole exome and Sanger sequencing, researchers identified several mutations leading to amino acid changes that clarify the molecular basis of the Er blood group antigens.
- The study indicates that Piezo1 is present in small amounts on red blood cells, suggesting that even low-abundance proteins can be significant for blood group classification and may play a role in hemolytic disease in newborns.
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Most liked on X and Bluesky赤血球のEr抗原が、遺伝子PIEZO1の変異によって定義され、5種類が存在するという "新しい血液型" に関する論文が発表されたみたいだよ。胎児や新生児の重度な溶血性疾患にも関係しているね。PIEZO1と言えば、去年のノーベル生理学医学賞の対象にもなった遺伝子だね。 https://t.co/krolsg5UZ9
Researchers discover a rare new #blood group system https://t.co/CaAqB82lw3 https://t.co/vxbNIUCeuy
Discovery: A rare new blood group. Everyone is aware of A B O & Rh+ or Rh-. But there's been a decades-long mystery about 3 known but genetically undefined antigens that didn't fit a category. Now the identification of the rare Er red blood cell antigens https://t.co/GkF27Tw3IJ https://t.co/cUNRz1MOw7
Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens https://t.co/SKolUzfkkm #immunobiology #immunotherapy
Missense mutations in the gene encoding PIEZO1 protein (mechanosensitive cation channel) give rise to five ER blood group antigens https://t.co/OqlI5AbLZq Nonsense mutation in the same gene was shown to protect from cerebral malaria https://t.co/e1GQdSiivT #blood_groups https://t.co/aVKj7pUV7K
All mentions
New Insights into Er Blood Group Antigens from PIEZO1 Mutations
This video explores the relationship between missense mutations in the PIEZO1 gene and their role in defining new Er blood group antigens. Discover how these mutations clarify the molecular basis of these antigens and…
Introduction to the New Er Blood Group System and Antigens
Discover the newly identified Er blood group system, including its five antigen variants, Era, Erb, Er3, Er4, and Er5. This video explores the implications of missense mutations in the PIEZO1 gene on blood transfusions…
RT @angryhacademic: Fun fact: most of us know the main blood group systems (ABO/Rh) but theres many more. The Er system is the 44th & recen…
RT @angryhacademic: Fun fact: most of us know the main blood group systems (ABO/Rh) but theres many more. The Er system is the 44th & recen…
Crew, Tilley, Satchwell, AlSubhi, Jones, Spring, Walser, Freire, Murciano, Rotordam, Woestmann, Hamed, Alradwan, AlKhrousey, Skidmore, Lewis, Hussain, Jackson, Latham, Kilby, Lester, Becker, Rapedius, @AshToye_Bristol & Thornton (2023) Missense mutatio... https://t.co/ScYHOdckNn
https://t.co/xyBPecbCwL
https://t.co/iHmSdyG9AW
Fun fact: most of us know the main blood group systems (ABO/Rh) but theres many more. The Er system is the 44th & recently 2 new Er variations were found, explaining unusual cases of haemolytic disease in foetuses/newborns https://t.co/KrocRinOjX Easy read https://t.co/RhEkt6jsrM
第44組血型分類系統(Er),同red cell 表面一 Piezo1 蛋白質有關。 Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens https://t.co/C6WM2h3dfa
Researchers in the UK have identified a new blood group system associated with missense mutations within the ion channel protein Piezo1. Called the Er group, it consists of five blood group antigens, Era, Erb, Er3, Er4 and Er5. https://t.co/AKJrJtregT
RT @physorg_com: Researchers discover a rare new #blood group system https://t.co/CaAqB82lw3 https://t.co/vxbNIUCeuy
Scientists have discovered a new group of blood types: it's calles Er. According to the journal "Blood," there are a total of five E-R antigens in this group based on genetic variations. The blood type can cause immune cells to ⤵️ https://t.co/q5FpNNpTa8 https://t.co/razCDtmYug
For all my #TransfusionMedicine friends: Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens https://t.co/15tHISaAfW
Identificación mediante secuenciación de exoma y por Sanger del grupo sanguíneo 44: Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens | Blood | American Society of Hematology @MIUI| https://t.co/QpHKbKgdJj
RT @DelthiaRicks: Discovery: A rare new blood group. Everyone is aware of A B O & Rh+ or Rh-. But there's been a decades-long mystery about…
A 30-year-old mystery solved by scientists: A discovery of a new blood group system, Er. While the variations are rare, they have implications in hemolytic disease of the fetus & newborn; when the mother’s immune system attacks their unborn child’s blood. https://t.co/OXzIarLdGA
RT @DelthiaRicks: Discovery: A rare new blood group. Everyone is aware of A B O & Rh+ or Rh-. But there's been a decades-long mystery about…
RT @DelthiaRicks: Discovery: A rare new blood group. Everyone is aware of A B O & Rh+ or Rh-. But there's been a decades-long mystery about…
RT @DelthiaRicks: Discovery: A rare new blood group. Everyone is aware of A B O & Rh+ or Rh-. But there's been a decades-long mystery about…
RT @DelthiaRicks: Discovery: A rare new blood group. Everyone is aware of A B O & Rh+ or Rh-. But there's been a decades-long mystery about…
RT @DelthiaRicks: Discovery: A rare new blood group. Everyone is aware of A B O & Rh+ or Rh-. But there's been a decades-long mystery about…
RT @DelthiaRicks: Discovery: A rare new blood group. Everyone is aware of A B O & Rh+ or Rh-. But there's been a decades-long mystery about…
RT @DelthiaRicks: Discovery: A rare new blood group. Everyone is aware of A B O & Rh+ or Rh-. But there's been a decades-long mystery about…
RT @DelthiaRicks: Discovery: A rare new blood group. Everyone is aware of A B O & Rh+ or Rh-. But there's been a decades-long mystery about…
RT @DelthiaRicks: Discovery: A rare new blood group. Everyone is aware of A B O & Rh+ or Rh-. But there's been a decades-long mystery about…
RT @DelthiaRicks: Discovery: A rare new blood group. Everyone is aware of A B O & Rh+ or Rh-. But there's been a decades-long mystery about…
RT @DelthiaRicks: Discovery: A rare new blood group. Everyone is aware of A B O & Rh+ or Rh-. But there's been a decades-long mystery about…
Discovery: A rare new blood group. Everyone is aware of A B O & Rh+ or Rh-. But there's been a decades-long mystery about 3 known but genetically undefined antigens that didn't fit a category. Now the identification of the rare Er red blood cell antigens https://t.co/GkF27Tw3IJ https://t.co/cUNRz1MOw7
Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens https://t.co/uDUXb5NDSx
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
@LtdAkbar @Ferdyan_SN Ini 0m https://t.co/1icdQJdG6d
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens | Blood | American Society of Hematology https://t.co/azroMA0RFf
Blood types (ABO, Rh) have important insights not only for a blood transfusion but also into susceptibility to infections and other phenotypes. Mutation in PIEZO1 mechanosensor present on RBCs defines a new blood subtype: https://t.co/uXIDCfAXMl
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @Science_Release: 赤血球のEr抗原が、遺伝子PIEZO1の変異によって定義され、5種類が存在するという "新しい血液型" に関する論文が発表されたみたいだよ。胎児や新生児の重度な溶血性疾患にも関係しているね。PIEZO1と言えば、去年のノーベル生理学医学…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
RT @IlindelatorreMD: Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora d…
Se ha descubierto un nuevo grupo sanguíneo : 'Er'. El canal iónico mecanosensorial Piezo1 es la molécula portadora de los antígenos de glóbulos rojos Er, lo que establece un nuevo sistema de grupos sanguíneos. https://t.co/UPNnVOor1u
Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens https://t.co/9XM62NUX5E
RT @Science_Release: 赤血球のEr抗原が、遺伝子PIEZO1の変異によって定義され、5種類が存在するという "新しい血液型" に関する論文が発表されたみたいだよ。胎児や新生児の重度な溶血性疾患にも関係しているね。PIEZO1と言えば、去年のノーベル生理学医学…
RT @Science_Release: 赤血球のEr抗原が、遺伝子PIEZO1の変異によって定義され、5種類が存在するという "新しい血液型" に関する論文が発表されたみたいだよ。胎児や新生児の重度な溶血性疾患にも関係しているね。PIEZO1と言えば、去年のノーベル生理学医学…
RT @Science_Release: 赤血球のEr抗原が、遺伝子PIEZO1の変異によって定義され、5種類が存在するという "新しい血液型" に関する論文が発表されたみたいだよ。胎児や新生児の重度な溶血性疾患にも関係しているね。PIEZO1と言えば、去年のノーベル生理学医学…
RT @Science_Release: 赤血球のEr抗原が、遺伝子PIEZO1の変異によって定義され、5種類が存在するという "新しい血液型" に関する論文が発表されたみたいだよ。胎児や新生児の重度な溶血性疾患にも関係しているね。PIEZO1と言えば、去年のノーベル生理学医学…
RT @Science_Release: 赤血球のEr抗原が、遺伝子PIEZO1の変異によって定義され、5種類が存在するという "新しい血液型" に関する論文が発表されたみたいだよ。胎児や新生児の重度な溶血性疾患にも関係しているね。PIEZO1と言えば、去年のノーベル生理学医学…
赤血球のEr抗原が、遺伝子PIEZO1の変異によって定義され、5種類が存在するという "新しい血液型" に関する論文が発表されたみたいだよ。胎児や新生児の重度な溶血性疾患にも関係しているね。PIEZO1と言えば、去年のノーベル生理学医学賞の対象にもなった遺伝子だね。 https://t.co/krolsg5UZ9
Huh? What? Someone explain if this is an accurate description below of this study
Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens https://t.co/uuRVZyOHpB
RT @physorg_com: Researchers discover a rare new #blood group system https://t.co/CaAqB82lw3 https://t.co/vxbNIUCeuy
RT @physorg_com: Researchers discover a rare new #blood group system https://t.co/CaAqB82lw3 https://t.co/vxbNIUCeuy
RT @physorg_com: Researchers discover a rare new #blood group system https://t.co/CaAqB82lw3 https://t.co/vxbNIUCeuy
RT @physorg_com: Researchers discover a rare new #blood group system https://t.co/CaAqB82lw3 https://t.co/vxbNIUCeuy
RT @physorg_com: Researchers discover a rare new #blood group system https://t.co/CaAqB82lw3 https://t.co/vxbNIUCeuy
Researchers discover a rare new #blood group system https://t.co/CaAqB82lw3 https://t.co/vxbNIUCeuy
新しい血液型システム Er抗原に対する抗体がPiezo1に結合する(キャリアとして働く)ことを証明しErを新しい血液型システムとして提案。レアな血液型の患者さんでも最善の治療をできるようになるかも。 これもPiezo1 https://t.co/lWnJvU1qYW
Scientists discovered a new blood type! Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens | Blood | American Society of Hematology https://t.co/yBkVk2TSZM
https://t.co/dsT06PAlXH
Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens https://t.co/WceMQsAhAY
https://t.co/1hNjXZ6Oua
RT @margitangyal: @WIRED This is big news! Our beloved world of transfusion medicine is always fresh & never tires of understanding, ca…
@WIRED This is big news! Our beloved world of transfusion medicine is always fresh & never tires of understanding, cataloguing, and giving care in response to the wonders & ramifications of our human erythrodiversity.
https://t.co/R707os1I5a https://t.co/dF54DIhC0H
Paper: 'Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens' by Vanja Karamatic Crew, Louise A Tilley, Timothy J Satchwell et al. in American Society of Hematology https://t.co/wdckiRCh45
V Crew et al (2022) Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens, Blood. https://t.co/sm7372hZl8
RT @CzerwinsMarcin: Missense mutations in the gene encoding PIEZO1 protein (mechanosensitive cation channel) give rise to five ER blood gro…
RT @CzerwinsMarcin: Missense mutations in the gene encoding PIEZO1 protein (mechanosensitive cation channel) give rise to five ER blood gro…
Missense mutations in the gene encoding PIEZO1 protein (mechanosensitive cation channel) give rise to five ER blood group antigens https://t.co/OqlI5AbLZq Nonsense mutation in the same gene was shown to protect from cerebral malaria https://t.co/e1GQdSiivT #blood_groups https://t.co/aVKj7pUV7K
A new blood group system highlights the potential antigenicity of even low abundance membrane proteins and contributes to our understanding of the in vivo characteristics of this important and widely studied protein in #transfusion #biology and beyond. https://t.co/SkxKe9rXxw
RT @BloodJournal: Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens https://t.…
Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens https://t.co/SKolUzfkkm #immunobiology #immunotherapy
Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens https://t.co/bzQXzsYgVK https://t.co/4SANmqpa9Z