Several discussions emphasize the significance of the article's findings by referencing detailed evidence such as detection of viral RNA in tissues months after infection, and using phrases like 'residual reservoir' and 'persistent viral presence,' which convey high interest and engagement. The tone and word choices reflect a consensus on the potential impact of these findings for long COVID treatment and research, making the group highly invested in the topic.
AgreementStrong agreement
Most discussions support the finding that residual viral components persist in tissues, confirming the article's conclusions.
InterestHigh interest
The majority of posts are highly interested, referencing detailed studies, viral persistence, and implications for long COVID understanding.
EngagementHigh engagement
Users are deeply engaged, citing technical evidence like multiplex immunohistochemistry and RNAscope, and discussing implications for research and treatment.
ImpactHigh impact
The discussions highlight a significant potential shift in understanding long COVID, emphasizing the importance of tissue-based viral persistence and influencing future research directions.
Abstract in brief
The case report discusses two patients with long COVID, showing that residual SARS-CoV-2 antigens and RNA persisted in their tissues (appendix, skin, and breast) for several months after initial infection.
Using advanced techniques like multiplex immunohistochemistry and RNAscope, researchers found viral proteins and RNA within immune cells (macrophages), indicating active viral presence and possible ongoing immune response.
The findings suggest that tissues such as the gastrointestinal tract might serve as reservoirs for the virus, potentially contributing to long COVID symptoms, especially in immunocompromised individuals.
Did you know that Dr. Been's @drbeen_medical series, 'Long (COVID) Story Short', is now available on YouTube? Watch latest episode 'When the RNA Won't Go Away' now and subscribe to channel here:
https://t.co/09uSuGiRBD
#longstoryshort #drbeen #flccc #longcovid #covid19
@HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macrophages at 462 days and later in the same Case 1 at 1.120 days without having had reinfection... https://t.co/c2eORFqP9i
Aug 13, 2023 · 84 likes · 28 shares · 1,035 followersView post →
AF
Antoine FLAHAULT
@FLAHAULT · X
3/6 - Dans d’autres travaux, des biopsies réalisées sur différents organes ont aussi permis d’identifier des traces de virus plusieurs mois après l’infection initiale chez des patients atteints de #LongCovid.
https://t.co/0ZendnMz59
May 2, 2023 · 38 likes · 7 shares · 31,823 followersView post →
Nov 4, 2022 · 33 likes · 17 shares · 13,625 followersView post →
TA
Tom Andrews
@0bj3ctivity · X
"For example, two patients with a clinical diagnosis of long COVID who underwent surgery for other reasons 175 and 426 days after initial infection had evidence of SARS-CoV-2 RNA in the breast, appendix, and skin"
https://t.co/4EHAfBco8W
17/x
Jan 3, 2024 · 24 likes · 4 shares · 5,473 followersView post →
This case report demonstrates the persistence of residual SARS-CoV-2 antigens and RNA in tissues of long COVID patients, indicating ongoing viral presence and immune response, especially in immune cells, months after…
This video discusses a case report showing residual SARS-CoV-2 antigens and RNA persisted in tissue for months after infection. It highlights how viral proteins and RNA within immune cells may contribute to ongoing…
@cvamarosa Establecimos la presencia del virus en el apéndice, la piel y los tejidos mamarios de 2 pacientes que presentaron síntomas de Long Covid 163 y 426 días después de la aparición de los síntomas. La NP se observó en macrófagos CD68...https://t.co/b1DBU2GnRu
https://t.co/zPdt2BpF0b
"Using multiplex immunohistochemistry, #SARSCoV2 nucleocapsid proteins (NP) and spike proteins were detected in the appendix, co-localized with myeloid and macrophage markers CD68, CD14, CD206, and CD169."
RT @0bj3ctivity: "For example, two patients with a clinical diagnosis of long COVID who underwent surgery for other reasons 175 and 426 day…
Jan 3, 2024 · 4 shares · 6,103 followersView post →
IW
I_WOULD_❤️_TO_BE_WRONG!…
@pberrini · X
RT @0bj3ctivity: "For example, two patients with a clinical diagnosis of long COVID who underwent surgery for other reasons 175 and 426 day…
Jan 3, 2024 · 4 shares · 1,363 followersView post →
TA
Tom Andrews
@0bj3ctivity · X
"For example, two patients with a clinical diagnosis of long COVID who underwent surgery for other reasons 175 and 426 days after initial infection had evidence of SARS-CoV-2 RNA in the breast, appendix, and skin"
https://t.co/4EHAfBco8W
17/x
Jan 3, 2024 · 24 likes · 4 shares · 5,473 followersView post →
"Our positive finding in the breast tissue also corroborated with recent reports that immunocompromised patients had also experienced LC symptoms & persistent viral replication."
https://t.co/GJq9JH06o1
Dec 13, 2023 · 1 like · 1 share · 7,394 followersView post →
T
Tom
@Opinions_Survey · X
@Jikkyleaks @sonia_elijah @JesslovesMJK @chrismartenson @Kevin_McKernan @AdhesionsOrg For exemple source 6 with long covid patients from 2020 : https://t.co/xOKUNpHN0Y
It's not in the blood.
It's in tissues
@StuartTurville @Iranicelandgirl @pjie2 @DarkaDuna2014 Also in tissue resident macrophages
Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVID
https://t.co/jSJE2nMJZx
Nov 26, 2023 · 2 likes · 1,035 followersView post →
CC
Covid Castaways
@CovidCastaways · X
@LongCovidComms @shedranktheturp “Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVID.”
https://t.co/bjOOUXi0K9
RT @DarkaDuna2014: @NIH Monocytes infected with CoV2 pass into tissues in the form of macrophages where the infection persists for years! h…
Aug 19, 2023 · 2 shares · 122 followersView post →
SB
Sonia Bilbao
@DarkaDuna2014 · X
@NIH Monocytes infected with CoV2 pass into tissues in the form of macrophages where the infection persists for years! has an etiology been sought for this change in the immune system to be perpetuated in the long term? ... https://t.co/HLYxtyVlFb
Aug 19, 2023 · 3 likes · 2 shares · 1,035 followersView post →
SB
Sonia Bilbao
@DarkaDuna2014 · X
@cvamarosa @JesusM_77 @NIH Monocytes infected with CoV2 pass into tissues in the form of macrophages where the infection persists for years! has an etiology been sought for this change in the immune system to be perpetuated in the long term? ... https://t.co/HLYxtyVlFb
Aug 19, 2023 · 2 likes · 1 share · 1,035 followersView post →
I
ICUGasDoc
@IcuGasDr · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 15, 2023 · 28 shares · 452 followersView post →
V
VeroniK.
@BambiniArt · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 14, 2023 · 28 shares · 270 followersView post →
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 14, 2023 · 28 shares · 1,498 followersView post →
F
flaschenpostwurfsendung
@flaschenpostwu1 · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 193 followersView post →
DG
Daya G.✨
@4evrstardancer · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 4,129 followersView post →
S
Suzan
@itssuzann · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 1,446 followersView post →
OA
Observer of the Apocalypse
@apocalobserver · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 1,754 followersView post →
G
Gate
@gaetinx · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 1,848 followersView post →
S
Spatz
@_ulmerspatz · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 2,921 followersView post →
S
#ScreamsAtTrees
@kfgibson · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 965 followersView post →
PB
Prof. Dr. Sanjeev Bagai
@BagaiDr · X
Persistence of residual antigen & RNA of SARS-CoV-2 virus in tissues with long COVID; LC with persistent viral antigen and/or RNA; harbored residual SARSCoV2 in both gastrointestinal & non-gastrointestinal tissues,or non-gastrointestinal tissues only https://t.co/mq6gOSr2u7
Aug 13, 2023 · 1 share · 34,610 followersView post →
C
Cat
@Krazy_Koz · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 632 followersView post →
L
Luis
@lulopson · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 434 followersView post →
E
Evergreen143
@Evergreen1431 · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 506 followersView post →
ME
Mikha’el
@LlamaAlloofs · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 190 followersView post →
V
Volutes
@Volutes12 · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 305 followersView post →
CO
COVID IS NOT OVER
@billiebuttons64 · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 2,834 followersView post →
RJ
Rob Jongsma
@jongs107wxsnl1 · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 3,841 followersView post →
L
LowCov
@falsel_net · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 1,630 followersView post →
NC
nuvolina22 #ControlGroup
@Nuvolina22 · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 1,081 followersView post →
M
Mdez
@kleinesKind · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 232 followersView post →
PP
Penny Powers
@PennyPo54201061 · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 1,445 followersView post →
LF
Liza Tóth JD #FBPE
@ipattorneyliza · X
RT @DarkaDuna2014: @HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macr…
Aug 13, 2023 · 28 shares · 4,184 followersView post →
SB
Sonia Bilbao
@DarkaDuna2014 · X
@HarrySpoelstra Great job!
We found nucleoprotein and viral RNA in perivascular (vesicular) skin lesion, located in macrophages at 462 days and later in the same Case 1 at 1.120 days without having had reinfection... https://t.co/c2eORFqP9i
Aug 13, 2023 · 84 likes · 28 shares · 1,035 followersView post →
や
やっちゃん
@_y_a_s_u_y_o_ · X
RT @hichachu: シンガポールの研究者らは、剖検研究に加えて、症状発現からそれぞれ163日後と426日後に長期にわたる新型コロナウイルス感染症の症状を発症した2人の患者の虫垂、皮膚、乳房組織からウイルスタンパク質とRNAが残留していることを発見した。
Case re…
@amcalber @PovedaJB "Using RNAscope in situ hybridization, we detected viral RNA within both extracellular and intracellular space of the appendix, providing evidence of viral persistence for up to 426 days after symptom onset...https://t.co/c2eORFqP9i
RT @hichachu: シンガポールの研究者らは、剖検研究に加えて、症状発現からそれぞれ163日後と426日後に長期にわたる新型コロナウイルス感染症の症状を発症した2人の患者の虫垂、皮膚、乳房組織からウイルスタンパク質とRNAが残留していることを発見した。
Case re…
May 17, 2023 · 6 shares · 225 followersView post →
QG
quartz gala
@wilsonstheorem · X
RT @hichachu: シンガポールの研究者らは、剖検研究に加えて、症状発現からそれぞれ163日後と426日後に長期にわたる新型コロナウイルス感染症の症状を発症した2人の患者の虫垂、皮膚、乳房組織からウイルスタンパク質とRNAが残留していることを発見した。
Case re…
May 17, 2023 · 6 shares · 1,074 followersView post →
J
javichu73
@javichu73 · X
RT @DarkaDuna2014: @javichu73 @poetricus2 @ejustin46 y por eso mismo son RESERVORIO y lo encontramos en los CD68 de los afectados por Long…
May 16, 2023 · 1 share · 3,936 followersView post →
SB
Sonia Bilbao
@DarkaDuna2014 · X
@javichu73 @poetricus2 @ejustin46 y por eso mismo son RESERVORIO y lo encontramos en los CD68 de los afectados por Long Covid años después de la infección...https://t.co/c2eORFqP9i
May 16, 2023 · 4 likes · 1 share · 1,035 followersView post →
P
pririn_
@pririn_ · X
RT @hichachu: シンガポールの研究者らは、剖検研究に加えて、症状発現からそれぞれ163日後と426日後に長期にわたる新型コロナウイルス感染症の症状を発症した2人の患者の虫垂、皮膚、乳房組織からウイルスタンパク質とRNAが残留していることを発見した。
Case re…
May 10, 2023 · 6 shares · 2,454 followersView post →
ジニ
ジャンボルギ~ニ酸性
@nyappiripiri · X
RT @hichachu: シンガポールの研究者らは、剖検研究に加えて、症状発現からそれぞれ163日後と426日後に長期にわたる新型コロナウイルス感染症の症状を発症した2人の患者の虫垂、皮膚、乳房組織からウイルスタンパク質とRNAが残留していることを発見した。
Case re…
May 10, 2023 · 6 shares · 4,110 followersView post →
ニ
ニューロドクター乱夢
@hichachu · X
シンガポールの研究者らは、剖検研究に加えて、症状発現からそれぞれ163日後と426日後に長期にわたる新型コロナウイルス感染症の症状を発症した2人の患者の虫垂、皮膚、乳房組織からウイルスタンパク質とRNAが残留していることを発見した。
Case report:
https://t.co/8Eb7wQ8vNG
May 10, 2023 · 5 likes · 6 shares · 4,253 followersView post →
CC
Covid Castaways
@CovidCastaways · X
“Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVID.”
https://t.co/bjOOUXi0K9
May 8, 2023 · 3 likes · 1 share · 5,464 followersView post →
B
bbddpp
@bbddpp · X
RT @FLAHAULT: 3/6 - Dans d’autres travaux, des biopsies réalisées sur différents organes ont aussi permis d’identifier des traces de virus…
May 3, 2023 · 7 shares · 3,142 followersView post →
S
SMSanteTravail
@SMSanteTravail · X
RT @FLAHAULT: 3/6 - Dans d’autres travaux, des biopsies réalisées sur différents organes ont aussi permis d’identifier des traces de virus…
RT @FLAHAULT: 3/6 - Dans d’autres travaux, des biopsies réalisées sur différents organes ont aussi permis d’identifier des traces de virus…
May 2, 2023 · 7 shares · 2,825 followersView post →
AF
Antoine FLAHAULT
@FLAHAULT · X
3/6 - Dans d’autres travaux, des biopsies réalisées sur différents organes ont aussi permis d’identifier des traces de virus plusieurs mois après l’infection initiale chez des patients atteints de #LongCovid.
https://t.co/0ZendnMz59
May 2, 2023 · 38 likes · 7 shares · 31,823 followersView post →
S
Scambot_4
@Scambot_4 · X
@ProfPCDoherty @aurashakes @happyaccidents1 @factcheckdotorg Studies show persistence for SARS-CoV-2
https://t.co/O8jjBXiNtx
https://t.co/nqimLAq9EG
https://t.co/SQZ1Pu1PG0
https://t.co/3I6EocEjxw
https://t.co/f2caDnEaAu
https://t.co/lN6YGziekP
https://t.co/b0lMuw8k7N
https://t.co/bIJFcKoGRA
https://t.co/EpW3p1o5vq
https://t.co/S19SPwPnvU
Corrigendum: Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVID https://t.co/eQljNXZLxf #LongCovid #pwLC
Oct 24, 2022 · 2 likes · 1 share · 2,132 followersView post →
銀
銀色の突撃王
@AktsKing · X
RT @K9FCR: [26] Frontiers | Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with lo…
Oct 19, 2022 · 1 share · 2,791 followersView post →
S
Stray
@K9FCR · X
[26] Frontiers | Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVID https://t.co/CAcpWNL3RN
Oct 19, 2022 · 2 likes · 1 share · 13,016 followersView post →
L
LongCovidPapers
@LongCovidPapers · X
Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVID https://t.co/46FOxp9ZkF #LongCovid #pwLC
Did you know that Dr. Been's @drbeen_medical series, 'Long (COVID) Story Short', is now available on YouTube? Watch latest episode 'When the RNA Won't Go Away' now and subscribe to channel here:
https://t.co/09uSuGiRBD
#longstoryshort #drbeen #flccc #longcovid #covid19
Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVID.
*Many of us already have known this from the start!!!
#ItsTheVirus https://t.co/wggyUJh1Pc
Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVID: The World Health Organization has defined long COVID-19 (LC) as a condition that occurs in individuals with… #immunology https://t.co/AiEwpLGVnD https://t.co/TYsfAOPcXR
Case report detected persistence of residual SARS-CoV-2 viral NP and RNA in three tissues of two patients with #longCOVID. Case report findings and emerging LC studies raise the possibility that the GI tract may function as a reservoir for SARS-CoV-2. https://t.co/0ml7H0HNbS https://t.co/LWrRwrb51n
Frontiers | Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVID https://t.co/qbNVOjKbDG
Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVID
Presence of residual virus in appendix, skin, and breast tissues of 2 patients who exhibited Long Covid symptoms 163 and 426 days https://t.co/rBvkKH3i81
New Research: Case report: Persistence of residual antigen and RNA of the SARS-CoV-2 virus in tissues of two patients with long COVID: The World Health Organization has defined long COVID-19 (LC) as a condition that occurs in individuals with… https://t.co/kBmCBKmgFK #immunology