Biomolecules September 2022 PMID 36139157

The Paradoxical Role of Circulating Ketone Bodies in Glycemic Control of Individuals with Type 2 Diabetes: High Risk, High Reward?

Amarens van der Vaart, Martine G E Knol, Martin H de Borst, Stephan J L Bakker, Margery A Connelly, Erwin Garcia, Henk J G Bilo, Peter R van Dijk, Robin P F Dullaart

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Mentions

Peak: 2 in Jan 2024

across 2 sources since Sep 2022

Extended reach

56,065

potential audience

Total likes

1,793

Video views

55,628

Mentions per month

Sep 2022 – Jan 2024

Where it's discussed

YouTube2 videos
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AI synopsis

What people are saying

The discussions revolve around the paradoxical nature of circulating ketone bodies, with participants noting that initially higher KB levels seem linked to poorer control but may lead to better outcomes with time. Words like 'surprising,' 'potential,' and 'could imply' indicate cautious interest and contemplation of the study's implications, reflecting a balanced engagement with the research findings.

AgreementModerate agreement

Most discussions acknowledge the complex and paradoxical findings of the study, showing general agreement with its nuanced conclusions.

InterestModerate interest

Discussions demonstrate moderate curiosity, as participants consider the potential implications of ketone bodies in diabetes management.

EngagementModerate engagement

Comments reflect thoughtful engagement, with some referencing the study design and potential clinical impacts.

ImpactModerate impact

The debates highlight possible influence on future research directions and clinical approaches, suggesting a moderate level of significance.

Abstract in brief

The study found that higher fasting plasma ketone bodies (KB) are initially associated with poorer glycemic control (higher HbA1c levels) in individuals with type 2 diabetes (T2D).
However, over time, elevated baseline KB levels are linked to improved glycemic outcomes, with a decrease in HbA1c and fasting glucose, suggesting a potential adaptive beneficial role of KB in disease progression.
These findings were consistent across two different cohorts, indicating that circulating KB may have a paradoxical effect—initially signaling worse control but possibly contributing to better regulation with prolonged exposure.]

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All mentions

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DesignedByNature

@DesignedNature · X

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