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Nat Commun September 2022 PMID 36175420

MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis.

Mary P LaPierre, Katherine Lawler, Svenja Godbersen, I Sadaf Farooqi, Markus Stoffel

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Mentions

24
Peak: 8 in Oct 2022
across 4 sources since Oct 2022

Extended reach

544,768
potential audience

Total likes

15

Video views

189

Mentions per month

Oct 2022 – Dec 2022

Where it's discussed

  • X / Twitter11 posts
  • News8 articles
  • YouTube3 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions emphasize the significance of the research by mentioning specific components like the melanocortin pathway and microRNA-7's role in energy homeostasis, with words like 'regulates' and 'involved' demonstrating factual rather than emotional engagement. The tone is analytical and appreciative, reflecting a collective recognition of the study's potential influence on metabolic research and therapies.

AgreementModerate agreement

Most posts express support and recognition of the importance of the research, especially when referencing collaborations and the novelty of the findings.

InterestModerate interest

Discussions show moderate interest, with many posts highlighting key aspects of the study, such as its roles in energy regulation and potential implications.

EngagementModerate engagement

Posts often include technical details, mentions of specific gene interactions, and calls to consider the research's significance, indicating a moderate level of engagement.

ImpactModerate impact

There’s a consensus that this research could have meaningful implications for understanding obesity and metabolic disorders, suggesting a perceived moderate to high impact.

Abstract in brief

  • MicroRNA7 (miR7) plays a key role in regulating energy balance in mammals by modulating the hypothalamic melanocortin pathway, with its deletion leading to obesity and increased growth in mice.
  • Targeted removal of miR7 in Sim1 neurons causes behaviors like hyperphagia (overeating), obesity, and rapid growth, similar to conditions seen in humans with certain genetic mutations affecting this pathway.
  • miR7 influences specific genes, such as Snca and Igsf8, within Sim1 neurons, and genetic variations at the human HNRNPK locus (where MIR7 is located) are linked to traits like increased height and fat distribution, highlighting its role in body weight and endocrine regulation.
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Top posts

Most liked on X and Bluesky
Neuroscience News
@NeuroscienceNew · X

“MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis” by Mary P. LaPierre et al. Nature Communications https://t.co/WUGrNvcrMD

Oct 10, 2022 · 6 likes · 1 share · 506,973 followers View post →
NCCR RNA & Disease
@NCCR_RNADisease · X

Publication by the Stoffel lab (@ETH_DBIOL, @ETH_en ) in collaboration with the @Farooqi_Lab (@Cambridge_Uni) "MicroRNA-7 regulates #melanocortin circuits involved in mammalian #energy #homeostasis" @NatureComms https://t.co/5ELHKeAQoM #miRNA #RNAi #metabolism https://t.co/hawQMG5OKg

Oct 3, 2022 · 4 likes · 1 share · 1,417 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

“MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis” by Mary P. LaPierre et al. Nature Communications https://t.co/AGhFgLgxwG https://t.co/mzWX0FPQ2x

Oct 10, 2022 · 1 like · 1 share · 24,131 followers View post →
DR.BALENDRA KUMAR YADAV(BKY)
@drkumarpmch2000 · X

RT @DrImranSheikh: “MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis” by Mary P. LaPierre et al. Nature…

Oct 10, 2022 · 1 share · 5,310 followers View post →
Farooqi Lab
@Farooqi_Lab · X

RT @NCCR_RNADisease: Publication by the Stoffel lab (@ETH_DBIOL, @ETH_en ) in collaboration with the @Farooqi_Lab (@Cambridge_Uni) "MicroRN…

Oct 17, 2022 · 1 share · 3,369 followers View post →
M
@micmicmic1 · X

MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis | Nature Communications https://t.co/6L6WO1JVbC

Oct 10, 2022 · 1,628 followers View post →

All mentions

ivLab
@vinnikovLAB · X

5/5

Dec 13, 2022 · 59 followers View post →
ivLab
@vinnikovLAB · X

3/5

Dec 13, 2022 · 59 followers View post →
ivLab
@vinnikovLAB · X

2/5

Dec 13, 2022 · 59 followers View post →
Farooqi Lab
@Farooqi_Lab · X

RT @NCCR_RNADisease: Publication by the Stoffel lab (@ETH_DBIOL, @ETH_en ) in collaboration with the @Farooqi_Lab (@Cambridge_Uni) "MicroRN…

Oct 17, 2022 · 1 share · 3,369 followers View post →
DR.BALENDRA KUMAR YADAV(BKY)
@drkumarpmch2000 · X

RT @DrImranSheikh: “MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis” by Mary P. LaPierre et al. Nature…

Oct 10, 2022 · 1 share · 5,310 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

“MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis” by Mary P. LaPierre et al. Nature Communications https://t.co/AGhFgLgxwG https://t.co/mzWX0FPQ2x

Oct 10, 2022 · 1 like · 1 share · 24,131 followers View post →
Marcelo Buratto
@MarBty25 · X

RT @NeuroscienceNew: “MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis” by Mary P. LaPierre et al. Natur…

Oct 10, 2022 · 1 share · 12 followers View post →
Neuroscience News
@NeuroscienceNew · X

“MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis” by Mary P. LaPierre et al. Nature Communications https://t.co/WUGrNvcrMD

Oct 10, 2022 · 6 likes · 1 share · 506,973 followers View post →
M
@micmicmic1 · X

MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis | Nature Communications https://t.co/6L6WO1JVbC

Oct 10, 2022 · 1,628 followers View post →
Europe PMC articles
@EuropePMC · X

New from #wellcometrust https://t.co/hA6GayBByC MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis.

Oct 3, 2022 · 1,551 followers View post →
NCCR RNA & Disease
@NCCR_RNADisease · X

Publication by the Stoffel lab (@ETH_DBIOL, @ETH_en ) in collaboration with the @Farooqi_Lab (@Cambridge_Uni) "MicroRNA-7 regulates #melanocortin circuits involved in mammalian #energy #homeostasis" @NatureComms https://t.co/5ELHKeAQoM #miRNA #RNAi #metabolism https://t.co/hawQMG5OKg

Oct 3, 2022 · 4 likes · 1 share · 1,417 followers View post →