Plant Genome June 2023 PMID 36177842

Genome-wide investigation of multiplexed CRISPR-Cas12a-mediated editing in rice.

Yingxiao Zhang, Yuechao Wu, Gen Li, Aileen Qi, Yong Zhang, Tao Zhang, Yiping Qi

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Mentions

Peak: 3 in Aug 2022

across 2 sources since Aug 2022

Extended reach

158,029

potential audience

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Mentions per month

Aug 2022 – Oct 2023

Where it's discussed

X / Twitter6 posts
YouTube1 videos

AI synopsis

What people are saying

Overall, the discussions reflect a balanced view of the study's importance, with commenters referencing the use of specific Cas12a variants like Mb2Cas12a, and debating the safety concerns associated with multiple double-strand breaks, which demonstrates an engaged and impactful discourse that recognizes both scientific nuance and regulatory implications.

AgreementModerate agreement

Most discussions acknowledge the significance of the study, particularly highlighting the importance of understanding off-target effects and the safety implications of multiplexed gene editing in rice.

InterestModerate interest

Participants show moderate curiosity, often sharing links to the full paper and emphasizing new findings, indicating some level of scholarly interest.

EngagementModerate engagement

Comments include references to specific CRISPR variants and the potential for large chromosomal changes, demonstrating thoughtful engagement with the research details.

ImpactModerate impact

The discussions suggest that the findings could influence future research and regulation practices in genetically engineering crops, hinting at their broader significance.

Abstract in brief

The study examines the use of multiplexed CRISPR-Cas12a systems to edit rice genomes, highlighting that this technique has high specificity but can cause large chromosomal rearrangements when many double-strand breaks (DSBs) occur.
Researchers found that certain Cas12a variants, like Mb2Cas12a, are highly specific, but inducing many DSBs (around 50) can lead to significant chromosomal changes, unlike fewer breaks (about 10).
These findings are important for understanding the safety and regulation of genetically engineered crops, emphasizing the need to consider potential large-scale genomic alterations when using multiplexed CRISPR gene editing.]

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All mentions

Multiplexed CRISPR-Cas12a Editing in Rice: Genomic Insights and Safety Considerations

This study explores multiplexed CRISPR-Cas12a gene editing in rice, highlighting high specificity with certain variants and potential large chromosomal rearrangements caused by multiple double-strand breaks, which are…

Social RTCL TV · Oct 6, 2023 35 views

The Plant Genome

@plantgenome · X

Oct 7, 2022 · 4 likes · 3,486 followers View post →

CRISPRpapers

@CRISPR_papers · X

Genome-wide investigation of multiplexed CRISPR-Cas12a-mediated editing in rice https://t.co/nRnmzksSKB

Oct 4, 2022 · 1 like · 3,886 followers View post →

CRISPR Articles

@CRISPR_JC · X

Genome-wide investigation of multiplexed CRISPR-Cas12a-mediated editing in rice. https://t.co/nyIybUEKsK

Oct 1, 2022 · 38 followers View post →

bxv_genomics

@bxv_genomics · X

Genome-wide investigation of multiplexed CRISPR-Cas12a-mediated editing in rice https://t.co/LCsEUaCGVc

Aug 1, 2022 · 1 like · 779 followers View post →

bioRxiv Genomics

@biorxiv_genomic · X

Genome-wide investigation of multiplexed CRISPR-Cas12a-mediated editing in rice https://t.co/MsdS9ejWuM #biorxiv_genomic

Aug 1, 2022 · 11,865 followers View post →

bioRxiv

@biorxivpreprint · X

Genome-wide investigation of multiplexed CRISPR-Cas12a-mediated editing in rice https://t.co/8PUbeEAg8n #bioRxiv

Aug 1, 2022 · 1 like · 137,941 followers View post →